xiVIEW: Visualisation of Crosslinking Mass Spectrometry Data Article Swipe
Colin Combe
,
Martin Graham
,
Lars Kolbowski
,
Lutz Fischer
,
Juri Rappsilber
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.jmb.2024.168656
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.jmb.2024.168656
Crosslinking mass spectrometry (MS) has emerged as an important technique for elucidating the in-solution structures of protein complexes and the topology of protein-protein interaction networks. However, the expanding user community lacked an integrated visualisation tool that helped them make use of the crosslinking data for investigating biological mechanisms. We addressed this need by developing xiVIEW, a web-based application designed to streamline crosslinking MS data analysis, which we present here. xiVIEW provides a user-friendly interface for accessing coordinated views of mass spectrometric data, network visualisation, annotations extracted from trusted repositories like UniProtKB, and available 3D structures. In accordance with recent recommendations from the crosslinking MS community, xiVIEW (i) provides a standards compliant parser to improve data integration and (ii) offers accessible visualisation tools. By promoting the adoption of standard file formats and providing a comprehensive visualisation platform, xiVIEW empowers both experimentalists and modellers alike to pursue their respective research interests. We anticipate that xiVIEW will advance crosslinking MS-inspired research, and facilitate broader and more effective investigations into complex biological systems.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.jmb.2024.168656
- OA Status
- hybrid
- Cited By
- 67
- References
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- Related Works
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- OpenAlex ID
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All OpenAlex metadata
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https://openalex.org/W4399796432Canonical identifier for this work in OpenAlex
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https://doi.org/10.1016/j.jmb.2024.168656Digital Object Identifier
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xiVIEW: Visualisation of Crosslinking Mass Spectrometry DataWork title
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articleOpenAlex work type
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enPrimary language
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2024Year of publication
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2024-06-19Full publication date if available
- Authors
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Colin Combe, Martin Graham, Lars Kolbowski, Lutz Fischer, Juri RappsilberList of authors in order
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https://doi.org/10.1016/j.jmb.2024.168656Publisher landing page
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://doi.org/10.1016/j.jmb.2024.168656Direct OA link when available
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Visualization, UniProt, Computer science, Parsing, Interface (matter), World Wide Web, Data visualization, Data science, Chemistry, Data mining, Programming language, Bubble, Biochemistry, Gene, Maximum bubble pressure method, Parallel computingTop concepts (fields/topics) attached by OpenAlex
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67Total citation count in OpenAlex
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2025: 54, 2024: 13Per-year citation counts (last 5 years)
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