YTHDC2 Is Essential for Pachytene Progression and Prevents Aberrant Microtubule-Driven Telomere Clustering in Male Meiosis Article Swipe
Rong Liu
,
Seth D. Kasowitz
,
David Homolka
,
N. Adrian Leu
,
Jordan T. Shaked
,
Gordon Ruthel
,
Devanshi Jain
,
Scott Keeney
,
Mengcheng Luo
,
Ramesh S. Pillai
,
P. Jeremy Wang
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1101/2021.04.12.439470
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1101/2021.04.12.439470
SUMMARY Mechanisms driving the prolonged meiotic prophase I are poorly understood. The RNA helicase YTHDC2 is critical for mitosis to meiosis transition, as YTHDC2-deficient mouse germ cells initiate meiosis but arrest with mixed characteristics of mitotic and meiotic cell types. However, YTHDC2 is also highly expressed in normal pachytene cells. Here we identify an essential role for YTHDC2 in meiotic progression. Specifically, we find that YTHDC2 deficiency causes microtubule-dependent telomere clustering and apoptosis at the pachytene stage of prophase I, and thus a failure to advance to the diplotene stage. Depletion of YTHDC2 results in a massively dysregulated transcriptome in pachytene cells, with a tendency toward upregulation of genes normally expressed in mitotic germ cells and downregulation of meiotic transcripts. Dysregulation does not correlate with the m 6 A status of RNAs and YTHDC2-bound mRNAs are enriched in genes upregulated in mutant germ cells, revealing that YTHDC2 primarily targets its substrate mRNAs for degradation. Finally, altered transcripts in YTHDC2-deficient pachytene cells encode microtubule network proteins and inhibition of microtubule polymerization disperses clustered telomeres. Together, our results demonstrate that YTHDC2 regulates the prolonged pachytene stage of prophase I by perpetuating a meiotic transcriptome and preventing changes in the microtubule network that could lead to aberrant telomere clustering.
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- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2021.04.12.439470
- https://www.biorxiv.org/content/biorxiv/early/2021/04/12/2021.04.12.439470.full.pdf
- OA Status
- green
- Cited By
- 2
- References
- 64
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3153247267
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3153247267Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2021.04.12.439470Digital Object Identifier
- Title
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YTHDC2 Is Essential for Pachytene Progression and Prevents Aberrant Microtubule-Driven Telomere Clustering in Male MeiosisWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-04-12Full publication date if available
- Authors
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Rong Liu, Seth D. Kasowitz, David Homolka, N. Adrian Leu, Jordan T. Shaked, Gordon Ruthel, Devanshi Jain, Scott Keeney, Mengcheng Luo, Ramesh S. Pillai, P. Jeremy WangList of authors in order
- Landing page
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https://doi.org/10.1101/2021.04.12.439470Publisher landing page
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https://www.biorxiv.org/content/biorxiv/early/2021/04/12/2021.04.12.439470.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://www.biorxiv.org/content/biorxiv/early/2021/04/12/2021.04.12.439470.full.pdfDirect OA link when available
- Concepts
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Biology, Meiosis, Cell biology, Prophase, Telomere, Mitosis, Downregulation and upregulation, Microtubule, RAD51, Genetics, Homologous recombination, GeneTop concepts (fields/topics) attached by OpenAlex
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2Total citation count in OpenAlex
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2024: 1, 2022: 1Per-year citation counts (last 5 years)
- References (count)
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64Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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