ZEB1-AS1 as a TRPML1 Inhibitor to Cause Lysosome Dysfunction and Cardiac Damage in Aged Mice Article Swipe
Heng Liu
,
Haiying Zhang
,
Han Lou
,
Jennifer Wang
,
Siyu Hao
,
Hui Chen
,
Chen Chen
,
Lei Wang
,
Huimin Li
,
Ziyu Meng
,
Wenjie Zhao
,
Tong Zhao
,
Lin Yuan
,
Zhimin Du
,
Xin Liu
,
Baofeng Yang
,
Yong Zhang
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.eng.2024.09.020
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.eng.2024.09.020
The prevalence of cardiovascular diseases (CVDs) has increased markedly as the world population has aged. Long non-coding RNAs (lncRNAs) have been reported as novel regulators in diverse pathophysiological conditions. Here, we performed RNA sequencing (RNA-seq) and observed that the lncRNA Zeb1os1 (zinc finger E-box binding homeobox 1, opposite strand 1), which is known as ZEB1-AS1 (zinc finger E-box binding homeobox 1 antisense 1) in humans, was upregulated in the aged mice hearts, senescent cardiomyocytes, and human blood from elderly individuals. The human blood ZEB1-AS1 level was positively relevant to human age but negatively relevant to peak E to peak A (E/A). Silencing Zeb1os1 ameliorated diastolic dysfunction and cardiac senescence in aged mice. On the other hand, Zeb1os1 overexpression triggered cardiac dysfunction resembling that observed in aged mice. Mechanistically, we provide compelling evidence that Zeb1os1 interacts with the transient receptor potential mucolipin 1 (TRPML1) for ubiquitination (UB)-mediated degradation. This process inhibits lysosomal Ca2+ efflux, impairing lysosome function. In addition, the functional domain of Zeb1os1, which contains the key nucleotides responsible for the pro-senescence property of full-length Zeb1os1 in cardiomyocytes. Together, these data suggest that Zeb1os1 is a potential target for ameliorating lysosomal dysfunction and aging-related cardiac impairment.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.eng.2024.09.020
- OA Status
- gold
- Cited By
- 1
- References
- 74
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4403926067
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4403926067Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1016/j.eng.2024.09.020Digital Object Identifier
- Title
-
ZEB1-AS1 as a TRPML1 Inhibitor to Cause Lysosome Dysfunction and Cardiac Damage in Aged MiceWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-10-31Full publication date if available
- Authors
-
Heng Liu, Haiying Zhang, Han Lou, Jennifer Wang, Siyu Hao, Hui Chen, Chen Chen, Lei Wang, Huimin Li, Ziyu Meng, Wenjie Zhao, Tong Zhao, Lin Yuan, Zhimin Du, Xin Liu, Baofeng Yang, Yong ZhangList of authors in order
- Landing page
-
https://doi.org/10.1016/j.eng.2024.09.020Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1016/j.eng.2024.09.020Direct OA link when available
- Concepts
-
Lysosome, Cardiac dysfunction, Medicine, Internal medicine, Biology, Heart failure, Biochemistry, EnzymeTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1Per-year citation counts (last 5 years)
- References (count)
-
74Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4403926067 |
|---|---|
| doi | https://doi.org/10.1016/j.eng.2024.09.020 |
| ids.doi | https://doi.org/10.1016/j.eng.2024.09.020 |
| ids.openalex | https://openalex.org/W4403926067 |
| fwci | 0.79039471 |
| type | article |
| title | ZEB1-AS1 as a TRPML1 Inhibitor to Cause Lysosome Dysfunction and Cardiac Damage in Aged Mice |
| awards[0].id | https://openalex.org/G4568224858 |
| awards[0].funder_id | https://openalex.org/F4320321543 |
| awards[0].display_name | |
| awards[0].funder_award_id | 2023T160176 |
| awards[0].funder_display_name | China Postdoctoral Science Foundation |
| awards[1].id | https://openalex.org/G8894868219 |
| awards[1].funder_id | https://openalex.org/F4320321001 |
| awards[1].display_name | |
| awards[1].funder_award_id | U21A20339 |
| awards[1].funder_display_name | National Natural Science Foundation of China |
| awards[2].id | https://openalex.org/G4087480644 |
| awards[2].funder_id | https://openalex.org/F4320321001 |
| awards[2].display_name | |
| awards[2].funder_award_id | 82270396 |
| awards[2].funder_display_name | National Natural Science Foundation of China |
| awards[3].id | https://openalex.org/G3917592002 |
| awards[3].funder_id | https://openalex.org/F4320321001 |
| awards[3].display_name | |
| awards[3].funder_award_id | 82273919 |
| awards[3].funder_display_name | National Natural Science Foundation of China |
| biblio.issue | |
| biblio.volume | 43 |
| biblio.last_page | 200 |
| biblio.first_page | 183 |
| topics[0].id | https://openalex.org/T13415 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9998999834060669 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1314 |
| topics[0].subfield.display_name | Physiology |
| topics[0].display_name | Calcium signaling and nucleotide metabolism |
| topics[1].id | https://openalex.org/T10212 |
| topics[1].field.id | https://openalex.org/fields/22 |
| topics[1].field.display_name | Engineering |
| topics[1].score | 0.9700999855995178 |
| topics[1].domain.id | https://openalex.org/domains/3 |
| topics[1].domain.display_name | Physical Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2208 |
| topics[1].subfield.display_name | Electrical and Electronic Engineering |
| topics[1].display_name | Electrochemical sensors and biosensors |
| topics[2].id | https://openalex.org/T12683 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.9613000154495239 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1312 |
| topics[2].subfield.display_name | Molecular Biology |
| topics[2].display_name | Studies on Chitinases and Chitosanases |
| funders[0].id | https://openalex.org/F4320315254 |
| funders[0].ror | |
| funders[0].display_name | Innovative Research Group Project of the National Natural Science Foundation of China |
| funders[1].id | https://openalex.org/F4320321001 |
| funders[1].ror | https://ror.org/01h0zpd94 |
| funders[1].display_name | National Natural Science Foundation of China |
| funders[2].id | https://openalex.org/F4320321543 |
| funders[2].ror | https://ror.org/0426zh255 |
| funders[2].display_name | China Postdoctoral Science Foundation |
| funders[3].id | https://openalex.org/F4320335445 |
| funders[3].ror | |
| funders[3].display_name | Outstanding Youth Foundation of Jiangsu Province of China |
| is_xpac | False |
| apc_list.value | 1000 |
| apc_list.currency | USD |
| apc_list.value_usd | 1000 |
| apc_paid.value | 1000 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 1000 |
| concepts[0].id | https://openalex.org/C2780216420 |
| concepts[0].level | 3 |
| concepts[0].score | 0.8562031984329224 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q83330 |
| concepts[0].display_name | Lysosome |
| concepts[1].id | https://openalex.org/C2993469949 |
| concepts[1].level | 3 |
| concepts[1].score | 0.6751478910446167 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q181754 |
| concepts[1].display_name | Cardiac dysfunction |
| concepts[2].id | https://openalex.org/C71924100 |
| concepts[2].level | 0 |
| concepts[2].score | 0.4087090492248535 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[2].display_name | Medicine |
| concepts[3].id | https://openalex.org/C126322002 |
| concepts[3].level | 1 |
| concepts[3].score | 0.29070138931274414 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[3].display_name | Internal medicine |
| concepts[4].id | https://openalex.org/C86803240 |
| concepts[4].level | 0 |
| concepts[4].score | 0.2703099250793457 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[4].display_name | Biology |
| concepts[5].id | https://openalex.org/C2778198053 |
| concepts[5].level | 2 |
| concepts[5].score | 0.14629969000816345 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q181754 |
| concepts[5].display_name | Heart failure |
| concepts[6].id | https://openalex.org/C55493867 |
| concepts[6].level | 1 |
| concepts[6].score | 0.12514135241508484 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[6].display_name | Biochemistry |
| concepts[7].id | https://openalex.org/C181199279 |
| concepts[7].level | 2 |
| concepts[7].score | 0.058524906635284424 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q8047 |
| concepts[7].display_name | Enzyme |
| keywords[0].id | https://openalex.org/keywords/lysosome |
| keywords[0].score | 0.8562031984329224 |
| keywords[0].display_name | Lysosome |
| keywords[1].id | https://openalex.org/keywords/cardiac-dysfunction |
| keywords[1].score | 0.6751478910446167 |
| keywords[1].display_name | Cardiac dysfunction |
| keywords[2].id | https://openalex.org/keywords/medicine |
| keywords[2].score | 0.4087090492248535 |
| keywords[2].display_name | Medicine |
| keywords[3].id | https://openalex.org/keywords/internal-medicine |
| keywords[3].score | 0.29070138931274414 |
| keywords[3].display_name | Internal medicine |
| keywords[4].id | https://openalex.org/keywords/biology |
| keywords[4].score | 0.2703099250793457 |
| keywords[4].display_name | Biology |
| keywords[5].id | https://openalex.org/keywords/heart-failure |
| keywords[5].score | 0.14629969000816345 |
| keywords[5].display_name | Heart failure |
| keywords[6].id | https://openalex.org/keywords/biochemistry |
| keywords[6].score | 0.12514135241508484 |
| keywords[6].display_name | Biochemistry |
| keywords[7].id | https://openalex.org/keywords/enzyme |
| keywords[7].score | 0.058524906635284424 |
| keywords[7].display_name | Enzyme |
| language | en |
| locations[0].id | doi:10.1016/j.eng.2024.09.020 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4210192142 |
| locations[0].source.issn | 2095-8099, 2096-0026 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2095-8099 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Engineering |
| locations[0].source.host_organization | https://openalex.org/P4310320990 |
| locations[0].source.host_organization_name | Elsevier BV |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320990 |
| locations[0].source.host_organization_lineage_names | Elsevier BV |
| locations[0].license | |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Engineering |
| locations[0].landing_page_url | https://doi.org/10.1016/j.eng.2024.09.020 |
| locations[1].id | pmh:oai:doaj.org/article:2b7ca2ef1f24488da016372d90382a56 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306401280 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[1].source.host_organization | |
| locations[1].source.host_organization_name | |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | submittedVersion |
| locations[1].raw_type | article |
| locations[1].license_id | |
| locations[1].is_accepted | False |
| locations[1].is_published | False |
| locations[1].raw_source_name | Engineering, Vol 43, Iss , Pp 183-200 (2024) |
| locations[1].landing_page_url | https://doaj.org/article/2b7ca2ef1f24488da016372d90382a56 |
| indexed_in | crossref, doaj |
| authorships[0].author.id | https://openalex.org/A5115596064 |
| authorships[0].author.orcid | https://orcid.org/0009-0005-2882-6474 |
| authorships[0].author.display_name | Heng Liu |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Heng Liu |
| authorships[0].is_corresponding | False |
| authorships[1].author.id | https://openalex.org/A5100764107 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-7158-2373 |
| authorships[1].author.display_name | Haiying Zhang |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Haiying Zhang |
| authorships[1].is_corresponding | False |
| authorships[2].author.id | https://openalex.org/A5100527006 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Han Lou |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Han Lou |
| authorships[2].is_corresponding | False |
| authorships[3].author.id | https://openalex.org/A5086506838 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-9659-7152 |
| authorships[3].author.display_name | Jennifer Wang |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Jennifer Wang |
| authorships[3].is_corresponding | False |
| authorships[4].author.id | https://openalex.org/A5006314071 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-9624-3642 |
| authorships[4].author.display_name | Siyu Hao |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Shengxin Hao |
| authorships[4].is_corresponding | False |
| authorships[5].author.id | https://openalex.org/A5100334134 |
| authorships[5].author.orcid | https://orcid.org/0000-0001-6883-3752 |
| authorships[5].author.display_name | Hui Chen |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Hui Chen |
| authorships[5].is_corresponding | False |
| authorships[6].author.id | https://openalex.org/A5100418420 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-2769-4554 |
| authorships[6].author.display_name | Chen Chen |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Chen Chen |
| authorships[6].is_corresponding | False |
| authorships[7].author.id | https://openalex.org/A5115594996 |
| authorships[7].author.orcid | https://orcid.org/0009-0006-8680-3737 |
| authorships[7].author.display_name | Lei Wang |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Lei Wang |
| authorships[7].is_corresponding | False |
| authorships[8].author.id | https://openalex.org/A5100410838 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-6846-2610 |
| authorships[8].author.display_name | Huimin Li |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Huimin Li |
| authorships[8].is_corresponding | False |
| authorships[9].author.id | https://openalex.org/A5009601203 |
| authorships[9].author.orcid | |
| authorships[9].author.display_name | Ziyu Meng |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Ziyu Meng |
| authorships[9].is_corresponding | False |
| authorships[10].author.id | https://openalex.org/A5102692460 |
| authorships[10].author.orcid | |
| authorships[10].author.display_name | Wenjie Zhao |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Wenjie Zhao |
| authorships[10].is_corresponding | False |
| authorships[11].author.id | https://openalex.org/A5101547885 |
| authorships[11].author.orcid | https://orcid.org/0009-0007-6734-3621 |
| authorships[11].author.display_name | Tong Zhao |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Tong Zhao |
| authorships[11].is_corresponding | False |
| authorships[12].author.id | https://openalex.org/A5100697783 |
| authorships[12].author.orcid | https://orcid.org/0000-0002-6583-7333 |
| authorships[12].author.display_name | Lin Yuan |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Yuan Lin |
| authorships[12].is_corresponding | False |
| authorships[13].author.id | https://openalex.org/A5101871323 |
| authorships[13].author.orcid | https://orcid.org/0009-0007-7762-7468 |
| authorships[13].author.display_name | Zhimin Du |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Zhimin Du |
| authorships[13].is_corresponding | False |
| authorships[14].author.id | https://openalex.org/A5100352152 |
| authorships[14].author.orcid | https://orcid.org/0009-0006-2118-3549 |
| authorships[14].author.display_name | Xin Liu |
| authorships[14].author_position | middle |
| authorships[14].raw_author_name | Xin Liu |
| authorships[14].is_corresponding | False |
| authorships[15].author.id | https://openalex.org/A5100442434 |
| authorships[15].author.orcid | https://orcid.org/0000-0002-0125-1608 |
| authorships[15].author.display_name | Baofeng Yang |
| authorships[15].author_position | middle |
| authorships[15].raw_author_name | Baofeng Yang |
| authorships[15].is_corresponding | False |
| authorships[16].author.id | https://openalex.org/A5100419828 |
| authorships[16].author.orcid | https://orcid.org/0000-0002-8754-8938 |
| authorships[16].author.display_name | Yong Zhang |
| authorships[16].author_position | last |
| authorships[16].raw_author_name | Yong Zhang |
| authorships[16].is_corresponding | False |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.1016/j.eng.2024.09.020 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | ZEB1-AS1 as a TRPML1 Inhibitor to Cause Lysosome Dysfunction and Cardiac Damage in Aged Mice |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T13415 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9998999834060669 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1314 |
| primary_topic.subfield.display_name | Physiology |
| primary_topic.display_name | Calcium signaling and nucleotide metabolism |
| related_works | https://openalex.org/W2899084033, https://openalex.org/W2748952813, https://openalex.org/W3031052312, https://openalex.org/W4389568370, https://openalex.org/W3032375762, https://openalex.org/W1995515455, https://openalex.org/W2080531066, https://openalex.org/W3108674512, https://openalex.org/W1506200166, https://openalex.org/W1489783725 |
| cited_by_count | 1 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 1 |
| locations_count | 2 |
| best_oa_location.id | doi:10.1016/j.eng.2024.09.020 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4210192142 |
| best_oa_location.source.issn | 2095-8099, 2096-0026 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2095-8099 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Engineering |
| best_oa_location.source.host_organization | https://openalex.org/P4310320990 |
| best_oa_location.source.host_organization_name | Elsevier BV |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320990 |
| best_oa_location.source.host_organization_lineage_names | Elsevier BV |
| best_oa_location.license | |
| best_oa_location.pdf_url | |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Engineering |
| best_oa_location.landing_page_url | https://doi.org/10.1016/j.eng.2024.09.020 |
| primary_location.id | doi:10.1016/j.eng.2024.09.020 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4210192142 |
| primary_location.source.issn | 2095-8099, 2096-0026 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2095-8099 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Engineering |
| primary_location.source.host_organization | https://openalex.org/P4310320990 |
| primary_location.source.host_organization_name | Elsevier BV |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320990 |
| primary_location.source.host_organization_lineage_names | Elsevier BV |
| primary_location.license | |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Engineering |
| primary_location.landing_page_url | https://doi.org/10.1016/j.eng.2024.09.020 |
| publication_date | 2024-10-31 |
| publication_year | 2024 |
| referenced_works | https://openalex.org/W3088880246, https://openalex.org/W2033989169, https://openalex.org/W2057547167, https://openalex.org/W3159922673, https://openalex.org/W4313638435, https://openalex.org/W2525423931, https://openalex.org/W4211247359, https://openalex.org/W2991456852, https://openalex.org/W4224009577, https://openalex.org/W6857356245, https://openalex.org/W2763693150, https://openalex.org/W2464503524, https://openalex.org/W3008394508, https://openalex.org/W2070658923, https://openalex.org/W3169128515, https://openalex.org/W3137099831, https://openalex.org/W4311928702, https://openalex.org/W2791154661, https://openalex.org/W2761624970, https://openalex.org/W2751840483, https://openalex.org/W2782389896, https://openalex.org/W6804016993, https://openalex.org/W3156990170, https://openalex.org/W2625886873, https://openalex.org/W3044100889, https://openalex.org/W4380422160, https://openalex.org/W4308890652, https://openalex.org/W2128821161, https://openalex.org/W3128881954, https://openalex.org/W3093514813, https://openalex.org/W2114104545, https://openalex.org/W2974795043, https://openalex.org/W3193598686, https://openalex.org/W2092557231, https://openalex.org/W4220898042, https://openalex.org/W2742007963, https://openalex.org/W4283010274, https://openalex.org/W4214635066, https://openalex.org/W2088784736, https://openalex.org/W4283031510, https://openalex.org/W4295155921, https://openalex.org/W3011274914, https://openalex.org/W4388966580, https://openalex.org/W2950849215, https://openalex.org/W2936570294, https://openalex.org/W2791609551, https://openalex.org/W4306252705, https://openalex.org/W4389792159, https://openalex.org/W4313530683, https://openalex.org/W4365139844, https://openalex.org/W4387266925, https://openalex.org/W6842674475, https://openalex.org/W4282939243, https://openalex.org/W4283586078, https://openalex.org/W4313531093, https://openalex.org/W3147508125, https://openalex.org/W2050971602, https://openalex.org/W2631298157, https://openalex.org/W3045202678, https://openalex.org/W3022725247, https://openalex.org/W3090320429, https://openalex.org/W4225156263, https://openalex.org/W4210421573, https://openalex.org/W3154549633, https://openalex.org/W4223433289, https://openalex.org/W3115880421, https://openalex.org/W4210333760, https://openalex.org/W2806749647, https://openalex.org/W3039366069, https://openalex.org/W3147421112, https://openalex.org/W2746907027, https://openalex.org/W4387128945, https://openalex.org/W4294770424, https://openalex.org/W4221002359 |
| referenced_works_count | 74 |
| abstract_inverted_index.1 | 60, 141 |
| abstract_inverted_index.A | 99 |
| abstract_inverted_index.E | 96 |
| abstract_inverted_index.a | 185 |
| abstract_inverted_index.1) | 62 |
| abstract_inverted_index.1, | 46 |
| abstract_inverted_index.In | 156 |
| abstract_inverted_index.On | 112 |
| abstract_inverted_index.as | 9, 22, 53 |
| abstract_inverted_index.in | 25, 63, 67, 109, 124, 176 |
| abstract_inverted_index.is | 51, 184 |
| abstract_inverted_index.of | 2, 161, 173 |
| abstract_inverted_index.to | 88, 94, 97 |
| abstract_inverted_index.we | 30, 128 |
| abstract_inverted_index.1), | 49 |
| abstract_inverted_index.RNA | 32 |
| abstract_inverted_index.The | 0, 80 |
| abstract_inverted_index.age | 90 |
| abstract_inverted_index.and | 35, 74, 106, 192 |
| abstract_inverted_index.but | 91 |
| abstract_inverted_index.for | 143, 169, 188 |
| abstract_inverted_index.has | 6, 13 |
| abstract_inverted_index.key | 166 |
| abstract_inverted_index.the | 10, 38, 68, 113, 136, 158, 165, 170 |
| abstract_inverted_index.was | 65, 85 |
| abstract_inverted_index.Ca2+ | 151 |
| abstract_inverted_index.Long | 15 |
| abstract_inverted_index.RNAs | 17 |
| abstract_inverted_index.This | 147 |
| abstract_inverted_index.aged | 69, 110, 125 |
| abstract_inverted_index.been | 20 |
| abstract_inverted_index.data | 180 |
| abstract_inverted_index.from | 77 |
| abstract_inverted_index.have | 19 |
| abstract_inverted_index.mice | 70 |
| abstract_inverted_index.peak | 95, 98 |
| abstract_inverted_index.that | 37, 122, 132, 182 |
| abstract_inverted_index.with | 135 |
| abstract_inverted_index.(zinc | 41, 55 |
| abstract_inverted_index.E-box | 43, 57 |
| abstract_inverted_index.Here, | 29 |
| abstract_inverted_index.aged. | 14 |
| abstract_inverted_index.blood | 76, 82 |
| abstract_inverted_index.hand, | 115 |
| abstract_inverted_index.human | 75, 81, 89 |
| abstract_inverted_index.known | 52 |
| abstract_inverted_index.level | 84 |
| abstract_inverted_index.mice. | 111, 126 |
| abstract_inverted_index.novel | 23 |
| abstract_inverted_index.other | 114 |
| abstract_inverted_index.these | 179 |
| abstract_inverted_index.which | 50, 163 |
| abstract_inverted_index.world | 11 |
| abstract_inverted_index.(CVDs) | 5 |
| abstract_inverted_index.(E/A). | 100 |
| abstract_inverted_index.domain | 160 |
| abstract_inverted_index.finger | 42, 56 |
| abstract_inverted_index.lncRNA | 39 |
| abstract_inverted_index.strand | 48 |
| abstract_inverted_index.target | 187 |
| abstract_inverted_index.Zeb1os1 | 40, 102, 116, 133, 175, 183 |
| abstract_inverted_index.binding | 44, 58 |
| abstract_inverted_index.cardiac | 107, 119, 194 |
| abstract_inverted_index.diverse | 26 |
| abstract_inverted_index.efflux, | 152 |
| abstract_inverted_index.elderly | 78 |
| abstract_inverted_index.hearts, | 71 |
| abstract_inverted_index.humans, | 64 |
| abstract_inverted_index.process | 148 |
| abstract_inverted_index.provide | 129 |
| abstract_inverted_index.suggest | 181 |
| abstract_inverted_index.(TRPML1) | 142 |
| abstract_inverted_index.ZEB1-AS1 | 54, 83 |
| abstract_inverted_index.Zeb1os1, | 162 |
| abstract_inverted_index.contains | 164 |
| abstract_inverted_index.diseases | 4 |
| abstract_inverted_index.evidence | 131 |
| abstract_inverted_index.homeobox | 45, 59 |
| abstract_inverted_index.inhibits | 149 |
| abstract_inverted_index.lysosome | 154 |
| abstract_inverted_index.markedly | 8 |
| abstract_inverted_index.observed | 36, 123 |
| abstract_inverted_index.opposite | 47 |
| abstract_inverted_index.property | 172 |
| abstract_inverted_index.receptor | 138 |
| abstract_inverted_index.relevant | 87, 93 |
| abstract_inverted_index.reported | 21 |
| abstract_inverted_index.(RNA-seq) | 34 |
| abstract_inverted_index.(lncRNAs) | 18 |
| abstract_inverted_index.Silencing | 101 |
| abstract_inverted_index.Together, | 178 |
| abstract_inverted_index.addition, | 157 |
| abstract_inverted_index.antisense | 61 |
| abstract_inverted_index.diastolic | 104 |
| abstract_inverted_index.function. | 155 |
| abstract_inverted_index.impairing | 153 |
| abstract_inverted_index.increased | 7 |
| abstract_inverted_index.interacts | 134 |
| abstract_inverted_index.lysosomal | 150, 190 |
| abstract_inverted_index.mucolipin | 140 |
| abstract_inverted_index.performed | 31 |
| abstract_inverted_index.potential | 139, 186 |
| abstract_inverted_index.senescent | 72 |
| abstract_inverted_index.transient | 137 |
| abstract_inverted_index.triggered | 118 |
| abstract_inverted_index.compelling | 130 |
| abstract_inverted_index.functional | 159 |
| abstract_inverted_index.negatively | 92 |
| abstract_inverted_index.non-coding | 16 |
| abstract_inverted_index.population | 12 |
| abstract_inverted_index.positively | 86 |
| abstract_inverted_index.prevalence | 1 |
| abstract_inverted_index.regulators | 24 |
| abstract_inverted_index.resembling | 121 |
| abstract_inverted_index.senescence | 108 |
| abstract_inverted_index.sequencing | 33 |
| abstract_inverted_index.ameliorated | 103 |
| abstract_inverted_index.conditions. | 28 |
| abstract_inverted_index.dysfunction | 105, 120, 191 |
| abstract_inverted_index.full-length | 174 |
| abstract_inverted_index.impairment. | 195 |
| abstract_inverted_index.nucleotides | 167 |
| abstract_inverted_index.responsible | 168 |
| abstract_inverted_index.upregulated | 66 |
| abstract_inverted_index.ameliorating | 189 |
| abstract_inverted_index.degradation. | 146 |
| abstract_inverted_index.individuals. | 79 |
| abstract_inverted_index.(UB)-mediated | 145 |
| abstract_inverted_index.aging-related | 193 |
| abstract_inverted_index.cardiovascular | 3 |
| abstract_inverted_index.overexpression | 117 |
| abstract_inverted_index.pro-senescence | 171 |
| abstract_inverted_index.ubiquitination | 144 |
| abstract_inverted_index.cardiomyocytes, | 73 |
| abstract_inverted_index.cardiomyocytes. | 177 |
| abstract_inverted_index.Mechanistically, | 127 |
| abstract_inverted_index.pathophysiological | 27 |
| cited_by_percentile_year.max | 95 |
| cited_by_percentile_year.min | 91 |
| countries_distinct_count | 0 |
| institutions_distinct_count | 17 |
| citation_normalized_percentile.value | 0.69534525 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |