Zebrafish Mbd5 binds to RNA m5C and regulates histone deubiquitylation and gene expression in development metabolism and behavior Article Swipe
Jianhua Guo
,
Zhongyu Zou
,
Xiaoyang Dou
,
Xiang Zhao
,
Yimin Wang
,
Liqiang Wei
,
Yan Pi
,
Yi Wang
,
Chuan He
,
Su Guo
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1093/nar/gkae093
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1093/nar/gkae093
Complex biological processes are regulated by both genetic and epigenetic programs. One class of epigenetic modifications is methylation. Evolutionarily conserved methyl-CpG-binding domain (MBD)-containing proteins are known as readers of DNA methylation. MBD5 is linked to multiple human diseases but its mechanism of action remains unclear. Here we report that the zebrafish Mbd5 does not bind to methylated DNA; but rather, it directly binds to 5-methylcytosine (m5C)-modified mRNAs and regulates embryonic development, erythrocyte differentiation, iron metabolism, and behavior. We further show that Mbd5 facilitates removal of the monoubiquitin mark at histone H2A-K119 through an interaction with the Polycomb repressive deubiquitinase (PR-DUB) complex in vivo. The direct target genes of Mbd5 are enriched with both RNA m5C and H2A-K119 ubiquitylation signals. Together, we propose that zebrafish MBD5 is an RNA m5C reader that potentially links RNA methylation to histone modification and in turn transcription regulation in vivo.
Related Topics
Concepts
Biology
Zebrafish
Epigenetics
Histone
RNA
Methylation
DNA methylation
Histone methylation
Cell biology
Transcription (linguistics)
Regulation of gene expression
Epigenomics
Gene expression
DNA
Genetics
Gene
Molecular biology
Linguistics
Philosophy
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/nar/gkae093
- https://academic.oup.com/nar/advance-article-pdf/doi/10.1093/nar/gkae093/56685925/gkae093.pdf
- OA Status
- gold
- Cited By
- 7
- References
- 63
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4391915530
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4391915530Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1093/nar/gkae093Digital Object Identifier
- Title
-
Zebrafish Mbd5 binds to RNA m5C and regulates histone deubiquitylation and gene expression in development metabolism and behaviorWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-02-15Full publication date if available
- Authors
-
Jianhua Guo, Zhongyu Zou, Xiaoyang Dou, Xiang Zhao, Yimin Wang, Liqiang Wei, Yan Pi, Yi Wang, Chuan He, Su GuoList of authors in order
- Landing page
-
https://doi.org/10.1093/nar/gkae093Publisher landing page
- PDF URL
-
https://academic.oup.com/nar/advance-article-pdf/doi/10.1093/nar/gkae093/56685925/gkae093.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://academic.oup.com/nar/advance-article-pdf/doi/10.1093/nar/gkae093/56685925/gkae093.pdfDirect OA link when available
- Concepts
-
Biology, Zebrafish, Epigenetics, Histone, RNA, Methylation, DNA methylation, Histone methylation, Cell biology, Transcription (linguistics), Regulation of gene expression, Epigenomics, Gene expression, DNA, Genetics, Gene, Molecular biology, Linguistics, PhilosophyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
7Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 5, 2024: 2Per-year citation counts (last 5 years)
- References (count)
-
63Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4391915530 |
|---|---|
| doi | https://doi.org/10.1093/nar/gkae093 |
| ids.doi | https://doi.org/10.1093/nar/gkae093 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/38366571 |
| ids.openalex | https://openalex.org/W4391915530 |
| fwci | 3.36173058 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D000818 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Animals |
| mesh[1].qualifier_ui | Q000378 |
| mesh[1].descriptor_ui | D006657 |
| mesh[1].is_major_topic | True |
| mesh[1].qualifier_name | metabolism |
| mesh[1].descriptor_name | Histones |
| mesh[2].qualifier_ui | Q000235 |
| mesh[2].descriptor_ui | D015027 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | genetics |
| mesh[2].descriptor_name | Zebrafish |
| mesh[3].qualifier_ui | Q000378 |
| mesh[3].descriptor_ui | D015027 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | metabolism |
| mesh[3].descriptor_name | Zebrafish |
| mesh[4].qualifier_ui | Q000378 |
| mesh[4].descriptor_ui | D029961 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | metabolism |
| mesh[4].descriptor_name | Zebrafish Proteins |
| mesh[5].qualifier_ui | Q000235 |
| mesh[5].descriptor_ui | D029961 |
| mesh[5].is_major_topic | True |
| mesh[5].qualifier_name | genetics |
| mesh[5].descriptor_name | Zebrafish Proteins |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D054875 |
| mesh[6].is_major_topic | True |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Ubiquitination |
| mesh[7].qualifier_ui | Q000378 |
| mesh[7].descriptor_ui | D044503 |
| mesh[7].is_major_topic | True |
| mesh[7].qualifier_name | metabolism |
| mesh[7].descriptor_name | 5-Methylcytosine |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D018507 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Gene Expression Regulation, Developmental |
| mesh[9].qualifier_ui | Q000378 |
| mesh[9].descriptor_ui | D004268 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | metabolism |
| mesh[9].descriptor_name | DNA-Binding Proteins |
| mesh[10].qualifier_ui | Q000235 |
| mesh[10].descriptor_ui | D004268 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | genetics |
| mesh[10].descriptor_name | DNA-Binding Proteins |
| mesh[11].qualifier_ui | Q000378 |
| mesh[11].descriptor_ui | D012333 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | metabolism |
| mesh[11].descriptor_name | RNA, Messenger |
| mesh[12].qualifier_ui | Q000235 |
| mesh[12].descriptor_ui | D012333 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | genetics |
| mesh[12].descriptor_name | RNA, Messenger |
| mesh[13].qualifier_ui | |
| mesh[13].descriptor_ui | D019175 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | |
| mesh[13].descriptor_name | DNA Methylation |
| mesh[14].qualifier_ui | Q000235 |
| mesh[14].descriptor_ui | D047108 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | genetics |
| mesh[14].descriptor_name | Embryonic Development |
| mesh[15].qualifier_ui | |
| mesh[15].descriptor_ui | D044127 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | |
| mesh[15].descriptor_name | Epigenesis, Genetic |
| mesh[16].qualifier_ui | |
| mesh[16].descriptor_ui | D000818 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | |
| mesh[16].descriptor_name | Animals |
| mesh[17].qualifier_ui | Q000378 |
| mesh[17].descriptor_ui | D006657 |
| mesh[17].is_major_topic | True |
| mesh[17].qualifier_name | metabolism |
| mesh[17].descriptor_name | Histones |
| mesh[18].qualifier_ui | Q000235 |
| mesh[18].descriptor_ui | D015027 |
| mesh[18].is_major_topic | True |
| mesh[18].qualifier_name | genetics |
| mesh[18].descriptor_name | Zebrafish |
| mesh[19].qualifier_ui | Q000378 |
| mesh[19].descriptor_ui | D015027 |
| mesh[19].is_major_topic | True |
| mesh[19].qualifier_name | metabolism |
| mesh[19].descriptor_name | Zebrafish |
| mesh[20].qualifier_ui | Q000378 |
| mesh[20].descriptor_ui | D029961 |
| mesh[20].is_major_topic | True |
| mesh[20].qualifier_name | metabolism |
| mesh[20].descriptor_name | Zebrafish Proteins |
| mesh[21].qualifier_ui | Q000235 |
| mesh[21].descriptor_ui | D029961 |
| mesh[21].is_major_topic | True |
| mesh[21].qualifier_name | genetics |
| mesh[21].descriptor_name | Zebrafish Proteins |
| mesh[22].qualifier_ui | |
| mesh[22].descriptor_ui | D054875 |
| mesh[22].is_major_topic | True |
| mesh[22].qualifier_name | |
| mesh[22].descriptor_name | Ubiquitination |
| mesh[23].qualifier_ui | Q000378 |
| mesh[23].descriptor_ui | D044503 |
| mesh[23].is_major_topic | True |
| mesh[23].qualifier_name | metabolism |
| mesh[23].descriptor_name | 5-Methylcytosine |
| mesh[24].qualifier_ui | |
| mesh[24].descriptor_ui | D018507 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | |
| mesh[24].descriptor_name | Gene Expression Regulation, Developmental |
| mesh[25].qualifier_ui | Q000378 |
| mesh[25].descriptor_ui | D004268 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | metabolism |
| mesh[25].descriptor_name | DNA-Binding Proteins |
| mesh[26].qualifier_ui | Q000235 |
| mesh[26].descriptor_ui | D004268 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | genetics |
| mesh[26].descriptor_name | DNA-Binding Proteins |
| mesh[27].qualifier_ui | Q000378 |
| mesh[27].descriptor_ui | D012333 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | metabolism |
| mesh[27].descriptor_name | RNA, Messenger |
| mesh[28].qualifier_ui | Q000235 |
| mesh[28].descriptor_ui | D012333 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | genetics |
| mesh[28].descriptor_name | RNA, Messenger |
| mesh[29].qualifier_ui | |
| mesh[29].descriptor_ui | D019175 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | |
| mesh[29].descriptor_name | DNA Methylation |
| mesh[30].qualifier_ui | Q000235 |
| mesh[30].descriptor_ui | D047108 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | genetics |
| mesh[30].descriptor_name | Embryonic Development |
| mesh[31].qualifier_ui | |
| mesh[31].descriptor_ui | D044127 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | |
| mesh[31].descriptor_name | Epigenesis, Genetic |
| mesh[32].qualifier_ui | |
| mesh[32].descriptor_ui | D000818 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | |
| mesh[32].descriptor_name | Animals |
| mesh[33].qualifier_ui | Q000378 |
| mesh[33].descriptor_ui | D006657 |
| mesh[33].is_major_topic | True |
| mesh[33].qualifier_name | metabolism |
| mesh[33].descriptor_name | Histones |
| mesh[34].qualifier_ui | Q000235 |
| mesh[34].descriptor_ui | D015027 |
| mesh[34].is_major_topic | True |
| mesh[34].qualifier_name | genetics |
| mesh[34].descriptor_name | Zebrafish |
| mesh[35].qualifier_ui | Q000378 |
| mesh[35].descriptor_ui | D015027 |
| mesh[35].is_major_topic | True |
| mesh[35].qualifier_name | metabolism |
| mesh[35].descriptor_name | Zebrafish |
| mesh[36].qualifier_ui | Q000378 |
| mesh[36].descriptor_ui | D029961 |
| mesh[36].is_major_topic | True |
| mesh[36].qualifier_name | metabolism |
| mesh[36].descriptor_name | Zebrafish Proteins |
| mesh[37].qualifier_ui | Q000235 |
| mesh[37].descriptor_ui | D029961 |
| mesh[37].is_major_topic | True |
| mesh[37].qualifier_name | genetics |
| mesh[37].descriptor_name | Zebrafish Proteins |
| mesh[38].qualifier_ui | |
| mesh[38].descriptor_ui | D054875 |
| mesh[38].is_major_topic | True |
| mesh[38].qualifier_name | |
| mesh[38].descriptor_name | Ubiquitination |
| mesh[39].qualifier_ui | Q000378 |
| mesh[39].descriptor_ui | D044503 |
| mesh[39].is_major_topic | True |
| mesh[39].qualifier_name | metabolism |
| mesh[39].descriptor_name | 5-Methylcytosine |
| mesh[40].qualifier_ui | |
| mesh[40].descriptor_ui | D018507 |
| mesh[40].is_major_topic | False |
| mesh[40].qualifier_name | |
| mesh[40].descriptor_name | Gene Expression Regulation, Developmental |
| mesh[41].qualifier_ui | Q000378 |
| mesh[41].descriptor_ui | D004268 |
| mesh[41].is_major_topic | False |
| mesh[41].qualifier_name | metabolism |
| mesh[41].descriptor_name | DNA-Binding Proteins |
| mesh[42].qualifier_ui | Q000235 |
| mesh[42].descriptor_ui | D004268 |
| mesh[42].is_major_topic | False |
| mesh[42].qualifier_name | genetics |
| mesh[42].descriptor_name | DNA-Binding Proteins |
| mesh[43].qualifier_ui | Q000378 |
| mesh[43].descriptor_ui | D012333 |
| mesh[43].is_major_topic | False |
| mesh[43].qualifier_name | metabolism |
| mesh[43].descriptor_name | RNA, Messenger |
| mesh[44].qualifier_ui | Q000235 |
| mesh[44].descriptor_ui | D012333 |
| mesh[44].is_major_topic | False |
| mesh[44].qualifier_name | genetics |
| mesh[44].descriptor_name | RNA, Messenger |
| mesh[45].qualifier_ui | |
| mesh[45].descriptor_ui | D019175 |
| mesh[45].is_major_topic | False |
| mesh[45].qualifier_name | |
| mesh[45].descriptor_name | DNA Methylation |
| mesh[46].qualifier_ui | Q000235 |
| mesh[46].descriptor_ui | D047108 |
| mesh[46].is_major_topic | False |
| mesh[46].qualifier_name | genetics |
| mesh[46].descriptor_name | Embryonic Development |
| mesh[47].qualifier_ui | |
| mesh[47].descriptor_ui | D044127 |
| mesh[47].is_major_topic | False |
| mesh[47].qualifier_name | |
| mesh[47].descriptor_name | Epigenesis, Genetic |
| mesh[48].qualifier_ui | |
| mesh[48].descriptor_ui | D000818 |
| mesh[48].is_major_topic | False |
| mesh[48].qualifier_name | |
| mesh[48].descriptor_name | Animals |
| mesh[49].qualifier_ui | Q000378 |
| mesh[49].descriptor_ui | D006657 |
| mesh[49].is_major_topic | True |
| mesh[49].qualifier_name | metabolism |
| mesh[49].descriptor_name | Histones |
| type | article |
| title | Zebrafish Mbd5 binds to RNA m5C and regulates histone deubiquitylation and gene expression in development metabolism and behavior |
| awards[0].id | https://openalex.org/G392277358 |
| awards[0].funder_id | https://openalex.org/F4320329926 |
| awards[0].display_name | |
| awards[0].funder_award_id | 2019sys-kfkt-0005 |
| awards[0].funder_display_name | National Health Commission of the People's Republic of China |
| awards[1].id | https://openalex.org/G833980832 |
| awards[1].funder_id | https://openalex.org/F4320321001 |
| awards[1].display_name | |
| awards[1].funder_award_id | 81628006 |
| awards[1].funder_display_name | National Natural Science Foundation of China |
| biblio.issue | 8 |
| biblio.volume | 52 |
| biblio.last_page | 4275 |
| biblio.first_page | 4257 |
| topics[0].id | https://openalex.org/T11482 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 1.0 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1312 |
| topics[0].subfield.display_name | Molecular Biology |
| topics[0].display_name | RNA modifications and cancer |
| topics[1].id | https://openalex.org/T10269 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9987999796867371 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1312 |
| topics[1].subfield.display_name | Molecular Biology |
| topics[1].display_name | Epigenetics and DNA Methylation |
| topics[2].id | https://openalex.org/T13157 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.9983999729156494 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1312 |
| topics[2].subfield.display_name | Molecular Biology |
| topics[2].display_name | Cancer-related gene regulation |
| funders[0].id | https://openalex.org/F4320321001 |
| funders[0].ror | https://ror.org/01h0zpd94 |
| funders[0].display_name | National Natural Science Foundation of China |
| funders[1].id | https://openalex.org/F4320329926 |
| funders[1].ror | |
| funders[1].display_name | National Health Commission of the People's Republic of China |
| is_xpac | False |
| apc_list.value | 3630 |
| apc_list.currency | USD |
| apc_list.value_usd | 3630 |
| apc_paid.value | 3630 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 3630 |
| concepts[0].id | https://openalex.org/C86803240 |
| concepts[0].level | 0 |
| concepts[0].score | 0.8666762709617615 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[0].display_name | Biology |
| concepts[1].id | https://openalex.org/C2776878037 |
| concepts[1].level | 3 |
| concepts[1].score | 0.7588285207748413 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q169444 |
| concepts[1].display_name | Zebrafish |
| concepts[2].id | https://openalex.org/C41091548 |
| concepts[2].level | 3 |
| concepts[2].score | 0.6623555421829224 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q26939 |
| concepts[2].display_name | Epigenetics |
| concepts[3].id | https://openalex.org/C64927066 |
| concepts[3].level | 3 |
| concepts[3].score | 0.6136114597320557 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q36293 |
| concepts[3].display_name | Histone |
| concepts[4].id | https://openalex.org/C67705224 |
| concepts[4].level | 3 |
| concepts[4].score | 0.5255533456802368 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q11053 |
| concepts[4].display_name | RNA |
| concepts[5].id | https://openalex.org/C33288867 |
| concepts[5].level | 3 |
| concepts[5].score | 0.5202911496162415 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q518328 |
| concepts[5].display_name | Methylation |
| concepts[6].id | https://openalex.org/C190727270 |
| concepts[6].level | 4 |
| concepts[6].score | 0.513297975063324 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q874745 |
| concepts[6].display_name | DNA methylation |
| concepts[7].id | https://openalex.org/C22709980 |
| concepts[7].level | 5 |
| concepts[7].score | 0.47420385479927063 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q4117777 |
| concepts[7].display_name | Histone methylation |
| concepts[8].id | https://openalex.org/C95444343 |
| concepts[8].level | 1 |
| concepts[8].score | 0.4618925154209137 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[8].display_name | Cell biology |
| concepts[9].id | https://openalex.org/C179926584 |
| concepts[9].level | 2 |
| concepts[9].score | 0.4566534757614136 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q207714 |
| concepts[9].display_name | Transcription (linguistics) |
| concepts[10].id | https://openalex.org/C165864922 |
| concepts[10].level | 3 |
| concepts[10].score | 0.45167794823646545 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q411391 |
| concepts[10].display_name | Regulation of gene expression |
| concepts[11].id | https://openalex.org/C121912465 |
| concepts[11].level | 5 |
| concepts[11].score | 0.4356982409954071 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q3589153 |
| concepts[11].display_name | Epigenomics |
| concepts[12].id | https://openalex.org/C150194340 |
| concepts[12].level | 3 |
| concepts[12].score | 0.42409682273864746 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q26972 |
| concepts[12].display_name | Gene expression |
| concepts[13].id | https://openalex.org/C552990157 |
| concepts[13].level | 2 |
| concepts[13].score | 0.3717540502548218 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q7430 |
| concepts[13].display_name | DNA |
| concepts[14].id | https://openalex.org/C54355233 |
| concepts[14].level | 1 |
| concepts[14].score | 0.3537619411945343 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[14].display_name | Genetics |
| concepts[15].id | https://openalex.org/C104317684 |
| concepts[15].level | 2 |
| concepts[15].score | 0.34236472845077515 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[15].display_name | Gene |
| concepts[16].id | https://openalex.org/C153911025 |
| concepts[16].level | 1 |
| concepts[16].score | 0.32978343963623047 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q7202 |
| concepts[16].display_name | Molecular biology |
| concepts[17].id | https://openalex.org/C41895202 |
| concepts[17].level | 1 |
| concepts[17].score | 0.0 |
| concepts[17].wikidata | https://www.wikidata.org/wiki/Q8162 |
| concepts[17].display_name | Linguistics |
| concepts[18].id | https://openalex.org/C138885662 |
| concepts[18].level | 0 |
| concepts[18].score | 0.0 |
| concepts[18].wikidata | https://www.wikidata.org/wiki/Q5891 |
| concepts[18].display_name | Philosophy |
| keywords[0].id | https://openalex.org/keywords/biology |
| keywords[0].score | 0.8666762709617615 |
| keywords[0].display_name | Biology |
| keywords[1].id | https://openalex.org/keywords/zebrafish |
| keywords[1].score | 0.7588285207748413 |
| keywords[1].display_name | Zebrafish |
| keywords[2].id | https://openalex.org/keywords/epigenetics |
| keywords[2].score | 0.6623555421829224 |
| keywords[2].display_name | Epigenetics |
| keywords[3].id | https://openalex.org/keywords/histone |
| keywords[3].score | 0.6136114597320557 |
| keywords[3].display_name | Histone |
| keywords[4].id | https://openalex.org/keywords/rna |
| keywords[4].score | 0.5255533456802368 |
| keywords[4].display_name | RNA |
| keywords[5].id | https://openalex.org/keywords/methylation |
| keywords[5].score | 0.5202911496162415 |
| keywords[5].display_name | Methylation |
| keywords[6].id | https://openalex.org/keywords/dna-methylation |
| keywords[6].score | 0.513297975063324 |
| keywords[6].display_name | DNA methylation |
| keywords[7].id | https://openalex.org/keywords/histone-methylation |
| keywords[7].score | 0.47420385479927063 |
| keywords[7].display_name | Histone methylation |
| keywords[8].id | https://openalex.org/keywords/cell-biology |
| keywords[8].score | 0.4618925154209137 |
| keywords[8].display_name | Cell biology |
| keywords[9].id | https://openalex.org/keywords/transcription |
| keywords[9].score | 0.4566534757614136 |
| keywords[9].display_name | Transcription (linguistics) |
| keywords[10].id | https://openalex.org/keywords/regulation-of-gene-expression |
| keywords[10].score | 0.45167794823646545 |
| keywords[10].display_name | Regulation of gene expression |
| keywords[11].id | https://openalex.org/keywords/epigenomics |
| keywords[11].score | 0.4356982409954071 |
| keywords[11].display_name | Epigenomics |
| keywords[12].id | https://openalex.org/keywords/gene-expression |
| keywords[12].score | 0.42409682273864746 |
| keywords[12].display_name | Gene expression |
| keywords[13].id | https://openalex.org/keywords/dna |
| keywords[13].score | 0.3717540502548218 |
| keywords[13].display_name | DNA |
| keywords[14].id | https://openalex.org/keywords/genetics |
| keywords[14].score | 0.3537619411945343 |
| keywords[14].display_name | Genetics |
| keywords[15].id | https://openalex.org/keywords/gene |
| keywords[15].score | 0.34236472845077515 |
| keywords[15].display_name | Gene |
| keywords[16].id | https://openalex.org/keywords/molecular-biology |
| keywords[16].score | 0.32978343963623047 |
| keywords[16].display_name | Molecular biology |
| language | en |
| locations[0].id | doi:10.1093/nar/gkae093 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S134668137 |
| locations[0].source.issn | 0305-1048, 1362-4954, 1362-4962 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 0305-1048 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Nucleic Acids Research |
| locations[0].source.host_organization | https://openalex.org/P4310311648 |
| locations[0].source.host_organization_name | Oxford University Press |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310311648, https://openalex.org/P4310311647 |
| locations[0].source.host_organization_lineage_names | Oxford University Press, University of Oxford |
| locations[0].license | other-oa |
| locations[0].pdf_url | https://academic.oup.com/nar/advance-article-pdf/doi/10.1093/nar/gkae093/56685925/gkae093.pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/other-oa |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Nucleic Acids Research |
| locations[0].landing_page_url | https://doi.org/10.1093/nar/gkae093 |
| locations[1].id | pmid:38366571 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Nucleic acids research |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/38366571 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:11077058 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Nucleic Acids Res |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/11077058 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5005999266 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-4732-9175 |
| authorships[0].author.display_name | Jianhua Guo |
| authorships[0].countries | CN |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I24943067, https://openalex.org/I4391768242 |
| authorships[0].affiliations[0].raw_affiliation_string | State Key Laboratory of Genetic Engineering, National Demonstration Center for Experimental Biology Education, School of Life Sciences, Fudan University , Shanghai , China |
| authorships[0].institutions[0].id | https://openalex.org/I4391768242 |
| authorships[0].institutions[0].ror | https://ror.org/01n3rg866 |
| authorships[0].institutions[0].type | facility |
| authorships[0].institutions[0].lineage | https://openalex.org/I24943067, https://openalex.org/I4391768242 |
| authorships[0].institutions[0].country_code | |
| authorships[0].institutions[0].display_name | State Key Laboratory of Genetic Engineering |
| authorships[0].institutions[1].id | https://openalex.org/I24943067 |
| authorships[0].institutions[1].ror | https://ror.org/013q1eq08 |
| authorships[0].institutions[1].type | education |
| authorships[0].institutions[1].lineage | https://openalex.org/I24943067 |
| authorships[0].institutions[1].country_code | CN |
| authorships[0].institutions[1].display_name | Fudan University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Jianhua Guo |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | State Key Laboratory of Genetic Engineering, National Demonstration Center for Experimental Biology Education, School of Life Sciences, Fudan University , Shanghai , China |
| authorships[1].author.id | https://openalex.org/A5074688214 |
| authorships[1].author.orcid | https://orcid.org/0000-0001-7152-5435 |
| authorships[1].author.display_name | Zhongyu Zou |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I1344073410, https://openalex.org/I40347166 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Chemistry and Howard Hughes Medical Institute, The University of Chicago , Chicago , IL 60637 , USA |
| authorships[1].institutions[0].id | https://openalex.org/I1344073410 |
| authorships[1].institutions[0].ror | https://ror.org/006w34k90 |
| authorships[1].institutions[0].type | facility |
| authorships[1].institutions[0].lineage | https://openalex.org/I1344073410 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | Howard Hughes Medical Institute |
| authorships[1].institutions[1].id | https://openalex.org/I40347166 |
| authorships[1].institutions[1].ror | https://ror.org/024mw5h28 |
| authorships[1].institutions[1].type | education |
| authorships[1].institutions[1].lineage | https://openalex.org/I40347166 |
| authorships[1].institutions[1].country_code | US |
| authorships[1].institutions[1].display_name | University of Chicago |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Zhongyu Zou |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Chemistry and Howard Hughes Medical Institute, The University of Chicago , Chicago , IL 60637 , USA |
| authorships[2].author.id | https://openalex.org/A5082644637 |
| authorships[2].author.orcid | https://orcid.org/0000-0003-3742-1813 |
| authorships[2].author.display_name | Xiaoyang Dou |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I1344073410, https://openalex.org/I40347166 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Chemistry and Howard Hughes Medical Institute, The University of Chicago , Chicago , IL 60637 , USA |
| authorships[2].institutions[0].id | https://openalex.org/I1344073410 |
| authorships[2].institutions[0].ror | https://ror.org/006w34k90 |
| authorships[2].institutions[0].type | facility |
| authorships[2].institutions[0].lineage | https://openalex.org/I1344073410 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | Howard Hughes Medical Institute |
| authorships[2].institutions[1].id | https://openalex.org/I40347166 |
| authorships[2].institutions[1].ror | https://ror.org/024mw5h28 |
| authorships[2].institutions[1].type | education |
| authorships[2].institutions[1].lineage | https://openalex.org/I40347166 |
| authorships[2].institutions[1].country_code | US |
| authorships[2].institutions[1].display_name | University of Chicago |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Xiaoyang Dou |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Chemistry and Howard Hughes Medical Institute, The University of Chicago , Chicago , IL 60637 , USA |
| authorships[3].author.id | https://openalex.org/A5046121905 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-3339-4806 |
| authorships[3].author.display_name | Xiang Zhao |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I180670191 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Bioengineering and Therapeutic Sciences, Programs in Human Genetics and Biological Sciences, University of California , San Francisco , CA 94143 , USA |
| authorships[3].institutions[0].id | https://openalex.org/I180670191 |
| authorships[3].institutions[0].ror | https://ror.org/043mz5j54 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I180670191 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | University of California, San Francisco |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Xiang Zhao |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Bioengineering and Therapeutic Sciences, Programs in Human Genetics and Biological Sciences, University of California , San Francisco , CA 94143 , USA |
| authorships[4].author.id | https://openalex.org/A5100384237 |
| authorships[4].author.orcid | https://orcid.org/0000-0003-2515-6602 |
| authorships[4].author.display_name | Yimin Wang |
| authorships[4].countries | CN |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I4210159329 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Neurology, Children's Hospital of Fudan University, National Children's Medical Center , No. 399, Wanyuan Road , Minhang District , Shanghai , China |
| authorships[4].institutions[0].id | https://openalex.org/I4210159329 |
| authorships[4].institutions[0].ror | https://ror.org/05n13be63 |
| authorships[4].institutions[0].type | healthcare |
| authorships[4].institutions[0].lineage | https://openalex.org/I4210159329 |
| authorships[4].institutions[0].country_code | CN |
| authorships[4].institutions[0].display_name | Children's Hospital of Fudan University |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Yimin Wang |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Neurology, Children's Hospital of Fudan University, National Children's Medical Center , No. 399, Wanyuan Road , Minhang District , Shanghai , China |
| authorships[5].author.id | https://openalex.org/A5110001621 |
| authorships[5].author.orcid | |
| authorships[5].author.display_name | Liqiang Wei |
| authorships[5].countries | CN, US |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I24943067, https://openalex.org/I4391768242 |
| authorships[5].affiliations[0].raw_affiliation_string | State Key Laboratory of Genetic Engineering, National Demonstration Center for Experimental Biology Education, School of Life Sciences, Fudan University , Shanghai , China |
| authorships[5].affiliations[1].institution_ids | https://openalex.org/I180670191 |
| authorships[5].affiliations[1].raw_affiliation_string | Department of Bioengineering and Therapeutic Sciences, Programs in Human Genetics and Biological Sciences, University of California , San Francisco , CA 94143 , USA |
| authorships[5].institutions[0].id | https://openalex.org/I4391768242 |
| authorships[5].institutions[0].ror | https://ror.org/01n3rg866 |
| authorships[5].institutions[0].type | facility |
| authorships[5].institutions[0].lineage | https://openalex.org/I24943067, https://openalex.org/I4391768242 |
| authorships[5].institutions[0].country_code | |
| authorships[5].institutions[0].display_name | State Key Laboratory of Genetic Engineering |
| authorships[5].institutions[1].id | https://openalex.org/I24943067 |
| authorships[5].institutions[1].ror | https://ror.org/013q1eq08 |
| authorships[5].institutions[1].type | education |
| authorships[5].institutions[1].lineage | https://openalex.org/I24943067 |
| authorships[5].institutions[1].country_code | CN |
| authorships[5].institutions[1].display_name | Fudan University |
| authorships[5].institutions[2].id | https://openalex.org/I180670191 |
| authorships[5].institutions[2].ror | https://ror.org/043mz5j54 |
| authorships[5].institutions[2].type | education |
| authorships[5].institutions[2].lineage | https://openalex.org/I180670191 |
| authorships[5].institutions[2].country_code | US |
| authorships[5].institutions[2].display_name | University of California, San Francisco |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Liqiang Wei |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Bioengineering and Therapeutic Sciences, Programs in Human Genetics and Biological Sciences, University of California , San Francisco , CA 94143 , USA, State Key Laboratory of Genetic Engineering, National Demonstration Center for Experimental Biology Education, School of Life Sciences, Fudan University , Shanghai , China |
| authorships[6].author.id | https://openalex.org/A5103526455 |
| authorships[6].author.orcid | |
| authorships[6].author.display_name | Yan Pi |
| authorships[6].countries | CN, US |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I24943067, https://openalex.org/I4391768242 |
| authorships[6].affiliations[0].raw_affiliation_string | State Key Laboratory of Genetic Engineering, National Demonstration Center for Experimental Biology Education, School of Life Sciences, Fudan University , Shanghai , China |
| authorships[6].affiliations[1].institution_ids | https://openalex.org/I180670191 |
| authorships[6].affiliations[1].raw_affiliation_string | Department of Bioengineering and Therapeutic Sciences, Programs in Human Genetics and Biological Sciences, University of California , San Francisco , CA 94143 , USA |
| authorships[6].institutions[0].id | https://openalex.org/I4391768242 |
| authorships[6].institutions[0].ror | https://ror.org/01n3rg866 |
| authorships[6].institutions[0].type | facility |
| authorships[6].institutions[0].lineage | https://openalex.org/I24943067, https://openalex.org/I4391768242 |
| authorships[6].institutions[0].country_code | |
| authorships[6].institutions[0].display_name | State Key Laboratory of Genetic Engineering |
| authorships[6].institutions[1].id | https://openalex.org/I24943067 |
| authorships[6].institutions[1].ror | https://ror.org/013q1eq08 |
| authorships[6].institutions[1].type | education |
| authorships[6].institutions[1].lineage | https://openalex.org/I24943067 |
| authorships[6].institutions[1].country_code | CN |
| authorships[6].institutions[1].display_name | Fudan University |
| authorships[6].institutions[2].id | https://openalex.org/I180670191 |
| authorships[6].institutions[2].ror | https://ror.org/043mz5j54 |
| authorships[6].institutions[2].type | education |
| authorships[6].institutions[2].lineage | https://openalex.org/I180670191 |
| authorships[6].institutions[2].country_code | US |
| authorships[6].institutions[2].display_name | University of California, San Francisco |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Yan Pi |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Bioengineering and Therapeutic Sciences, Programs in Human Genetics and Biological Sciences, University of California , San Francisco , CA 94143 , USA, State Key Laboratory of Genetic Engineering, National Demonstration Center for Experimental Biology Education, School of Life Sciences, Fudan University , Shanghai , China |
| authorships[7].author.id | https://openalex.org/A5100721619 |
| authorships[7].author.orcid | https://orcid.org/0000-0003-4028-2471 |
| authorships[7].author.display_name | Yi Wang |
| authorships[7].countries | CN |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I4210159329 |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Neurology, Children's Hospital of Fudan University, National Children's Medical Center , No. 399, Wanyuan Road , Minhang District , Shanghai , China |
| authorships[7].institutions[0].id | https://openalex.org/I4210159329 |
| authorships[7].institutions[0].ror | https://ror.org/05n13be63 |
| authorships[7].institutions[0].type | healthcare |
| authorships[7].institutions[0].lineage | https://openalex.org/I4210159329 |
| authorships[7].institutions[0].country_code | CN |
| authorships[7].institutions[0].display_name | Children's Hospital of Fudan University |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Yi Wang |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Neurology, Children's Hospital of Fudan University, National Children's Medical Center , No. 399, Wanyuan Road , Minhang District , Shanghai , China |
| authorships[8].author.id | https://openalex.org/A5091114864 |
| authorships[8].author.orcid | https://orcid.org/0000-0003-4319-7424 |
| authorships[8].author.display_name | Chuan He |
| authorships[8].countries | US |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I1344073410, https://openalex.org/I40347166 |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Chemistry and Howard Hughes Medical Institute, The University of Chicago , Chicago , IL 60637 , USA |
| authorships[8].institutions[0].id | https://openalex.org/I1344073410 |
| authorships[8].institutions[0].ror | https://ror.org/006w34k90 |
| authorships[8].institutions[0].type | facility |
| authorships[8].institutions[0].lineage | https://openalex.org/I1344073410 |
| authorships[8].institutions[0].country_code | US |
| authorships[8].institutions[0].display_name | Howard Hughes Medical Institute |
| authorships[8].institutions[1].id | https://openalex.org/I40347166 |
| authorships[8].institutions[1].ror | https://ror.org/024mw5h28 |
| authorships[8].institutions[1].type | education |
| authorships[8].institutions[1].lineage | https://openalex.org/I40347166 |
| authorships[8].institutions[1].country_code | US |
| authorships[8].institutions[1].display_name | University of Chicago |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Chuan He |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Department of Chemistry and Howard Hughes Medical Institute, The University of Chicago , Chicago , IL 60637 , USA |
| authorships[9].author.id | https://openalex.org/A5085722199 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-7342-0108 |
| authorships[9].author.display_name | Su Guo |
| authorships[9].countries | US |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I180670191 |
| authorships[9].affiliations[0].raw_affiliation_string | Department of Bioengineering and Therapeutic Sciences, Programs in Human Genetics and Biological Sciences, University of California , San Francisco , CA 94143 , USA |
| authorships[9].institutions[0].id | https://openalex.org/I180670191 |
| authorships[9].institutions[0].ror | https://ror.org/043mz5j54 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I180670191 |
| authorships[9].institutions[0].country_code | US |
| authorships[9].institutions[0].display_name | University of California, San Francisco |
| authorships[9].author_position | last |
| authorships[9].raw_author_name | Su Guo |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Department of Bioengineering and Therapeutic Sciences, Programs in Human Genetics and Biological Sciences, University of California , San Francisco , CA 94143 , USA |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://academic.oup.com/nar/advance-article-pdf/doi/10.1093/nar/gkae093/56685925/gkae093.pdf |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Zebrafish Mbd5 binds to RNA m5C and regulates histone deubiquitylation and gene expression in development metabolism and behavior |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11482 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 1.0 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1312 |
| primary_topic.subfield.display_name | Molecular Biology |
| primary_topic.display_name | RNA modifications and cancer |
| related_works | https://openalex.org/W4256528904, https://openalex.org/W1597543017, https://openalex.org/W4245153001, https://openalex.org/W4243165149, https://openalex.org/W3147492987, https://openalex.org/W2938575486, https://openalex.org/W4318473910, https://openalex.org/W4296785489, https://openalex.org/W2966258113, https://openalex.org/W1979411201 |
| cited_by_count | 7 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 5 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 2 |
| locations_count | 3 |
| best_oa_location.id | doi:10.1093/nar/gkae093 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S134668137 |
| best_oa_location.source.issn | 0305-1048, 1362-4954, 1362-4962 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 0305-1048 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Nucleic Acids Research |
| best_oa_location.source.host_organization | https://openalex.org/P4310311648 |
| best_oa_location.source.host_organization_name | Oxford University Press |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310311648, https://openalex.org/P4310311647 |
| best_oa_location.source.host_organization_lineage_names | Oxford University Press, University of Oxford |
| best_oa_location.license | other-oa |
| best_oa_location.pdf_url | https://academic.oup.com/nar/advance-article-pdf/doi/10.1093/nar/gkae093/56685925/gkae093.pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/other-oa |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Nucleic Acids Research |
| best_oa_location.landing_page_url | https://doi.org/10.1093/nar/gkae093 |
| primary_location.id | doi:10.1093/nar/gkae093 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S134668137 |
| primary_location.source.issn | 0305-1048, 1362-4954, 1362-4962 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 0305-1048 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Nucleic Acids Research |
| primary_location.source.host_organization | https://openalex.org/P4310311648 |
| primary_location.source.host_organization_name | Oxford University Press |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310311648, https://openalex.org/P4310311647 |
| primary_location.source.host_organization_lineage_names | Oxford University Press, University of Oxford |
| primary_location.license | other-oa |
| primary_location.pdf_url | https://academic.oup.com/nar/advance-article-pdf/doi/10.1093/nar/gkae093/56685925/gkae093.pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/other-oa |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Nucleic Acids Research |
| primary_location.landing_page_url | https://doi.org/10.1093/nar/gkae093 |
| publication_date | 2024-02-15 |
| publication_year | 2024 |
| referenced_works | https://openalex.org/W2040875973, https://openalex.org/W1520127479, https://openalex.org/W2125603023, https://openalex.org/W1976980117, https://openalex.org/W1975791071, https://openalex.org/W2791103809, https://openalex.org/W1992400870, https://openalex.org/W1983487070, https://openalex.org/W3197062604, https://openalex.org/W2171449998, https://openalex.org/W2123036594, https://openalex.org/W1977820989, https://openalex.org/W1984101059, https://openalex.org/W2020702702, https://openalex.org/W3164622592, https://openalex.org/W2125349610, https://openalex.org/W1976391205, https://openalex.org/W2003171404, https://openalex.org/W164317671, https://openalex.org/W1994304920, https://openalex.org/W2079978401, https://openalex.org/W2021483780, https://openalex.org/W2131271579, https://openalex.org/W2964849163, https://openalex.org/W2134526812, https://openalex.org/W2179438025, https://openalex.org/W3046591340, https://openalex.org/W2124985265, https://openalex.org/W3131055609, https://openalex.org/W2171808845, https://openalex.org/W2939392127, https://openalex.org/W2053218283, https://openalex.org/W2128071342, https://openalex.org/W2096251733, https://openalex.org/W1541267199, https://openalex.org/W2271752557, https://openalex.org/W917998901, https://openalex.org/W2032893305, https://openalex.org/W2580415908, https://openalex.org/W2120579517, https://openalex.org/W2147140183, https://openalex.org/W2082023836, https://openalex.org/W2407310112, https://openalex.org/W4229030257, https://openalex.org/W2108196925, https://openalex.org/W2093800333, https://openalex.org/W3122900780, https://openalex.org/W3047534432, https://openalex.org/W2471487767, https://openalex.org/W2896819517, https://openalex.org/W4229051563, https://openalex.org/W4220849398, https://openalex.org/W3011680390, https://openalex.org/W3137826863, https://openalex.org/W2553014556, https://openalex.org/W2803271184, https://openalex.org/W2934310150, https://openalex.org/W4200104643, https://openalex.org/W2964888213, https://openalex.org/W3195969836, https://openalex.org/W3208691473, https://openalex.org/W4226397607, https://openalex.org/W2320983896 |
| referenced_works_count | 63 |
| abstract_inverted_index.We | 78 |
| abstract_inverted_index.an | 93, 127 |
| abstract_inverted_index.as | 27 |
| abstract_inverted_index.at | 89 |
| abstract_inverted_index.by | 6 |
| abstract_inverted_index.in | 102, 140, 144 |
| abstract_inverted_index.is | 17, 33, 126 |
| abstract_inverted_index.it | 61 |
| abstract_inverted_index.of | 14, 29, 42, 85, 108 |
| abstract_inverted_index.to | 35, 56, 64, 136 |
| abstract_inverted_index.we | 47, 121 |
| abstract_inverted_index.DNA | 30 |
| abstract_inverted_index.One | 12 |
| abstract_inverted_index.RNA | 114, 128, 134 |
| abstract_inverted_index.The | 104 |
| abstract_inverted_index.and | 9, 68, 76, 116, 139 |
| abstract_inverted_index.are | 4, 25, 110 |
| abstract_inverted_index.but | 39, 59 |
| abstract_inverted_index.its | 40 |
| abstract_inverted_index.m5C | 115, 129 |
| abstract_inverted_index.not | 54 |
| abstract_inverted_index.the | 50, 86, 96 |
| abstract_inverted_index.DNA; | 58 |
| abstract_inverted_index.Here | 46 |
| abstract_inverted_index.MBD5 | 32, 125 |
| abstract_inverted_index.Mbd5 | 52, 82, 109 |
| abstract_inverted_index.bind | 55 |
| abstract_inverted_index.both | 7, 113 |
| abstract_inverted_index.does | 53 |
| abstract_inverted_index.iron | 74 |
| abstract_inverted_index.mark | 88 |
| abstract_inverted_index.show | 80 |
| abstract_inverted_index.that | 49, 81, 123, 131 |
| abstract_inverted_index.turn | 141 |
| abstract_inverted_index.with | 95, 112 |
| abstract_inverted_index.binds | 63 |
| abstract_inverted_index.class | 13 |
| abstract_inverted_index.genes | 107 |
| abstract_inverted_index.human | 37 |
| abstract_inverted_index.known | 26 |
| abstract_inverted_index.links | 133 |
| abstract_inverted_index.mRNAs | 67 |
| abstract_inverted_index.vivo. | 103, 145 |
| abstract_inverted_index.action | 43 |
| abstract_inverted_index.direct | 105 |
| abstract_inverted_index.domain | 22 |
| abstract_inverted_index.linked | 34 |
| abstract_inverted_index.reader | 130 |
| abstract_inverted_index.report | 48 |
| abstract_inverted_index.target | 106 |
| abstract_inverted_index.Complex | 1 |
| abstract_inverted_index.complex | 101 |
| abstract_inverted_index.further | 79 |
| abstract_inverted_index.genetic | 8 |
| abstract_inverted_index.histone | 90, 137 |
| abstract_inverted_index.propose | 122 |
| abstract_inverted_index.rather, | 60 |
| abstract_inverted_index.readers | 28 |
| abstract_inverted_index.remains | 44 |
| abstract_inverted_index.removal | 84 |
| abstract_inverted_index.through | 92 |
| abstract_inverted_index.(PR-DUB) | 100 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.H2A-K119 | 91, 117 |
| abstract_inverted_index.Polycomb | 97 |
| abstract_inverted_index.directly | 62 |
| abstract_inverted_index.diseases | 38 |
| abstract_inverted_index.enriched | 111 |
| abstract_inverted_index.multiple | 36 |
| abstract_inverted_index.proteins | 24 |
| abstract_inverted_index.signals. | 119 |
| abstract_inverted_index.unclear. | 45 |
| abstract_inverted_index.Together, | 120 |
| abstract_inverted_index.behavior. | 77 |
| abstract_inverted_index.conserved | 20 |
| abstract_inverted_index.embryonic | 70 |
| abstract_inverted_index.mechanism | 41 |
| abstract_inverted_index.processes | 3 |
| abstract_inverted_index.programs. | 11 |
| abstract_inverted_index.regulated | 5 |
| abstract_inverted_index.regulates | 69 |
| abstract_inverted_index.zebrafish | 51, 124 |
| abstract_inverted_index.biological | 2 |
| abstract_inverted_index.epigenetic | 10, 15 |
| abstract_inverted_index.methylated | 57 |
| abstract_inverted_index.regulation | 143 |
| abstract_inverted_index.repressive | 98 |
| abstract_inverted_index.erythrocyte | 72 |
| abstract_inverted_index.facilitates | 83 |
| abstract_inverted_index.interaction | 94 |
| abstract_inverted_index.metabolism, | 75 |
| abstract_inverted_index.methylation | 135 |
| abstract_inverted_index.potentially | 132 |
| abstract_inverted_index.development, | 71 |
| abstract_inverted_index.methylation. | 18, 31 |
| abstract_inverted_index.modification | 138 |
| abstract_inverted_index.modifications | 16 |
| abstract_inverted_index.monoubiquitin | 87 |
| abstract_inverted_index.transcription | 142 |
| abstract_inverted_index.(m5C)-modified | 66 |
| abstract_inverted_index.Evolutionarily | 19 |
| abstract_inverted_index.deubiquitinase | 99 |
| abstract_inverted_index.ubiquitylation | 118 |
| abstract_inverted_index.(MBD)-containing | 23 |
| abstract_inverted_index.5-methylcytosine | 65 |
| abstract_inverted_index.differentiation, | 73 |
| abstract_inverted_index.methyl-CpG-binding | 21 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 94 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 10 |
| citation_normalized_percentile.value | 0.87150259 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |