Zebrafish Neuromesodermal Progenitors Undergo a Critical State Transition in vivo Article Swipe
Kane Toh
,
Dillan Saunders
,
Berta Verd
,
Benjamin Steventon
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1101/2022.02.25.481986
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1101/2022.02.25.481986
Summary The transition state model of cell differentiation proposes that a transient window of gene expression stochasticity precedes entry into a differentiated state. As this has been assessed primarily in vitro , we sought to explore whether it can also be observed in vivo . Zebrafish neuromesodermal progenitors (NMps) differentiate into spinal cord and paraxial mesoderm at the late somitogenesis stages. We observed an increase in gene expression variability at the 24 somite stage (24ss) prior to their differentiation. From our analysis of a published 18ss scRNA-seq dataset, we showed that the NMp population possesses a signature consistent with a population undergoing a critical transition. By building in silico composite gene expression maps from our image data, we were able to assign an ‘NM index’ to each in silico NMp based on the cumulative expression of its neural and mesodermal markers. With the NM index distributions, we demonstrated that cell population heterogeneity of the NMps peaked at 24ss. We then incorporated stochasticity and non-autonomy into a genetic toggle switch model and uncovered the existence of rebellious cells, which we then confirmed by reexamining the composite maps. Taken together, our work supports the transition state model within an endogenous cell fate decision making event.
Related Topics
Concepts
Somitogenesis
Paraxial mesoderm
Zebrafish
Biology
Population
Somite
In silico
Progenitor
Progenitor cell
Mesoderm
Gene expression
Gastrulation
Cell biology
Genetics
Gene
Stem cell
Embryonic stem cell
Demography
Sociology
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2022.02.25.481986
- https://www.biorxiv.org/content/biorxiv/early/2022/02/25/2022.02.25.481986.full.pdf
- OA Status
- green
- Cited By
- 1
- References
- 101
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4214520733
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4214520733Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2022.02.25.481986Digital Object Identifier
- Title
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Zebrafish Neuromesodermal Progenitors Undergo a Critical State Transition in vivoWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-02-25Full publication date if available
- Authors
-
Kane Toh, Dillan Saunders, Berta Verd, Benjamin SteventonList of authors in order
- Landing page
-
https://doi.org/10.1101/2022.02.25.481986Publisher landing page
- PDF URL
-
https://www.biorxiv.org/content/biorxiv/early/2022/02/25/2022.02.25.481986.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
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https://www.biorxiv.org/content/biorxiv/early/2022/02/25/2022.02.25.481986.full.pdfDirect OA link when available
- Concepts
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Somitogenesis, Paraxial mesoderm, Zebrafish, Biology, Population, Somite, In silico, Progenitor, Progenitor cell, Mesoderm, Gene expression, Gastrulation, Cell biology, Genetics, Gene, Stem cell, Embryonic stem cell, Demography, SociologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
- Citations by year (recent)
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2022: 1Per-year citation counts (last 5 years)
- References (count)
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101Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| publication_date | 2022-02-25 |
| publication_year | 2022 |
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