ZFP90 drives the initiation of colitis-associated colorectal cancer via a microbiota-dependent strategy Article Swipe
Ji‐Xuan Han
,
Zhi‐Hang Tao
,
Yun Qian
,
Chenyang Yu
,
Jialu Li
,
Zi‐Ran Kang
,
Shiyuan Lu
,
Yuanhong Xie
,
Jie Hong
,
Haoyan Chen
,
Yingxuan Chen
,
Jing‐Yuan Fang
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1080/19490976.2021.1917269
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1080/19490976.2021.1917269
Chronic inflammation and gut microbiota dysbiosis are risk factors for colorectal cancer. In clinical practice, patients with inflammatory bowel disease (IBD) have a greatly increased risk of developing colitis-associated colorectal cancer (CAC). However, the underlying mechanism of the initiation of CAC remains unknown. Systematic analyses using an existing genome-wide association study (GWAS) and conditional deletion of Zfp90 (encoding zinc finger protein 90 homolog) in a CAC mouse model indicated that Zfp90 is a putative oncogene in CAC development. Strikingly, depletion of the gut microbiota eliminated the tumorigenic effect of Zfp90 in the CAC mouse model. Moreover, fecal microbiota transplantation demonstrated that Zfp90 promoted CAC dependent on the gut microbiota. Analysis of 16s rDNA sequences in fecal specimens from the CAC mouse model allowed us to speculate that a Prevotella copri-defined microbiota might mediate the oncogenic role of Zfp90 in the development of CAC. Mechanistic studies revealed Zfp90 accelerated CAC development through the TLR4-PI3K-AKT-NF-κB pathway. Our findings revealed the crucial role of the Zfp90-microbiota-NF-κB axis in creating a tumor-promoting environment and suggested therapeutic targets for CAC prevention and treatment.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1080/19490976.2021.1917269
- https://www.tandfonline.com/doi/pdf/10.1080/19490976.2021.1917269?needAccess=true
- OA Status
- gold
- Cited By
- 30
- References
- 58
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3157971639
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3157971639Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1080/19490976.2021.1917269Digital Object Identifier
- Title
-
ZFP90 drives the initiation of colitis-associated colorectal cancer via a microbiota-dependent strategyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-01-01Full publication date if available
- Authors
-
Ji‐Xuan Han, Zhi‐Hang Tao, Yun Qian, Chenyang Yu, Jialu Li, Zi‐Ran Kang, Shiyuan Lu, Yuanhong Xie, Jie Hong, Haoyan Chen, Yingxuan Chen, Jing‐Yuan FangList of authors in order
- Landing page
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https://doi.org/10.1080/19490976.2021.1917269Publisher landing page
- PDF URL
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https://www.tandfonline.com/doi/pdf/10.1080/19490976.2021.1917269?needAccess=trueDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.tandfonline.com/doi/pdf/10.1080/19490976.2021.1917269?needAccess=trueDirect OA link when available
- Concepts
-
Biology, Gut flora, Inflammatory bowel disease, Colorectal cancer, Colitis, Dysbiosis, PI3K/AKT/mTOR pathway, Disease, Immunology, Prevotella, Cancer research, Carcinogenesis, Cancer, Genetics, Signal transduction, Medicine, Internal medicine, BacteriaTop concepts (fields/topics) attached by OpenAlex
- Cited by
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30Total citation count in OpenAlex
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2025: 8, 2024: 8, 2023: 10, 2022: 3, 2021: 1Per-year citation counts (last 5 years)
- References (count)
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58Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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