Aydar A. Ishmukhametov
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View article: Atomic Force Microscopy of Poliovirus Particles After Inactivation by Chemical Methods and Accelerated Electrons
Atomic Force Microscopy of Poliovirus Particles After Inactivation by Chemical Methods and Accelerated Electrons Open
The traditional method used in the production of inactivated vaccines is chemical inactivation using beta-propiolactone or formaldehyde. An alternative method is inactivation by irradiation. Virus inactivation is often accompanied by a cha…
View article: Generation of Polyclonal Antibodies Against Sabin Poliovirus D- and H-Antigens and Their Application in ELISA
Generation of Polyclonal Antibodies Against Sabin Poliovirus D- and H-Antigens and Their Application in ELISA Open
Background/Objectives: The World Health Organization (WHO) recommends the use of attenuated Sabin strains for the production of inactivated poliovirus vaccine (IPV), offering improved biosafety while retaining immunogenicity. To better cha…
View article: Immunization route-mediated differences in long-term maturation of humoral immune response induced by adenovirus vector-based COVID-19 vaccine Sputnik V in nonhuman primates
Immunization route-mediated differences in long-term maturation of humoral immune response induced by adenovirus vector-based COVID-19 vaccine Sputnik V in nonhuman primates Open
Introduction On the background of kaleidoscopic changes of SARS-CoV-2 circulating variants, constant presence of SARS-CoV-2 in the human population hampers the dissection of native long-term immunogenicity of COVID-19 vaccines. Methods For…
View article: Degradation of Poliovirus Sabin 2 Genome After Electron Beam Irradiation
Degradation of Poliovirus Sabin 2 Genome After Electron Beam Irradiation Open
Objectives: Most antiviral vaccines are created by inactivating the virus using chemical methods. The inactivation and production of viral vaccine preparations after the irradiation of viruses with accelerated electrons has a number of sig…
View article: Degradation of Poliovirus Sabin 2 Genome after Electron Beam Irradiation
Degradation of Poliovirus Sabin 2 Genome after Electron Beam Irradiation Open
Objectives: Most antiviral vaccines are created by inactivating the virus using chemical methods. Inactivation and production of viral vaccine preparations after irradiation of viruses with accelerated electrons has a number of significant…
View article: Modern clinical and laboratory indicators of severe Plasmodium falciparum malaria
Modern clinical and laboratory indicators of severe Plasmodium falciparum malaria Open
According to WHO Report 2024, malaria is still a global health challenge, especially in Africa, Asia and South America. In the opinion of the authors, errors made in adequate assessment of clinical and laboratory indicators of P. falciparu…
View article: Effect of inactivated whole-virion concentrated purified vaccine for the prevention of COVID-19 on clinical and biochemical blood parameters of immature rats
Effect of inactivated whole-virion concentrated purified vaccine for the prevention of COVID-19 on clinical and biochemical blood parameters of immature rats Open
Introduction. The prevalence of new coronavirus infection (COVID-19) in 2021-2022 in the pediatric population was 9.5%, and fatal outcomes began to be recorded. In 2022–2023, the proportion of children infected with COVID-19 increased to 1…
View article: Clinical Manifestations of Hemorrhagic Fever with Renal Syndrome, Various Nosologic Forms and Issues of Hantavirus Infections Terminology
Clinical Manifestations of Hemorrhagic Fever with Renal Syndrome, Various Nosologic Forms and Issues of Hantavirus Infections Terminology Open
Hemorrhagic fever with renal syndrome (HFRS) is the result of acute, zoonotic, natural foci hantavirus infections. It has serious social and medical importance due to its widespread distribution and the disease’s severity. There is a lack …
View article: Study of the General Toxic Properties of the Vaccine CoviVac in Immature Rats
Study of the General Toxic Properties of the Vaccine CoviVac in Immature Rats Open
Relevance . During 2021 and early 2022, the prevalence of COVID-19 in the child population was 9.5%, the frequency of hospitalizations of children and adolescents increased, and fatal outcomes began to be recorded. And in 2022–2023, the pr…
View article: Intensification of Vero cell adherence to microcarrier particles during cultivation in a wave bioreactor
Intensification of Vero cell adherence to microcarrier particles during cultivation in a wave bioreactor Open
Vaccination is the most effective strategy for fighting viral diseases, with both live and inactivated vaccines remaining crucial despite advancements in subunit vaccine technologies. A key player in vaccine production is the Vero cell lin…
View article: Fusion protein-based COVID-19 vaccines exemplified by a chimeric vaccine based on a single fusion protein (W-PreS-O)
Fusion protein-based COVID-19 vaccines exemplified by a chimeric vaccine based on a single fusion protein (W-PreS-O) Open
In this article we discuss characteristics of fusion protein-based SARS-CoV-2 vaccines. We focus on recombinant vaccine antigens comprising fusion proteins consisting of combinations of SARS-CoV-2-derived antigens or peptides or combinatio…
View article: Neutralising and Non-neutralising Antibodies to SARS-CoV-2: Role during Infection and in the Evolution of Antigenic structure
Neutralising and Non-neutralising Antibodies to SARS-CoV-2: Role during Infection and in the Evolution of Antigenic structure Open
Relevance . COVID-19, caused by the SARS-CoV-2 virus, remains a global public health threat despite the end of the pandemic. In the four years since the onset of the pandemic, the SARS-CoV-2 genome has undergone significant changes, partic…
View article: Immunotherapeutic Potential of the Yellow Fever Virus Vaccine Strain 17D for Intratumoral Therapy in a Murine Model of Pancreatic Cancer
Immunotherapeutic Potential of the Yellow Fever Virus Vaccine Strain 17D for Intratumoral Therapy in a Murine Model of Pancreatic Cancer Open
Objective: We evaluate the immunotherapeutic potential of the yellow fever virus vaccine strain 17D (YFV 17D) for intratumoral therapy of pancreatic cancer in mice. Methods: The cytopathic effect of YFV 17D on mouse syngeneic pancreatic ca…
View article: The SPR analysis of the interaction of inactivated poliovirus vaccine attenuated strains with antibodies
The SPR analysis of the interaction of inactivated poliovirus vaccine attenuated strains with antibodies Open
The interaction of inactivated poliovirus vaccine strains with oriented antibodies immobilized to protein A via Fc fragments has been investigated. Using an SPR biosensor, the kinetic and equilibrium parameters of the interaction of vaccin…
View article: Viral-Porphyrin Combo: Photodynamic and Oncolytic Viral Therapy for Potent Glioblastoma Treatment
Viral-Porphyrin Combo: Photodynamic and Oncolytic Viral Therapy for Potent Glioblastoma Treatment Open
Combined viral and photodynamic therapy for oncological diseases has great potential to treat aggressive tumors such as glioblastomas. A conjugate of vesicular stomatitis virus (VSV) with protoporphyrin IX was prepared, and its oncolytic e…
View article: Epidemiological Analysis of the Incidence of Hemorrhagic Fever with Renal Syndrome and Tick-Borne Encephalitis in the Russian Federation
Epidemiological Analysis of the Incidence of Hemorrhagic Fever with Renal Syndrome and Tick-Borne Encephalitis in the Russian Federation Open
Relevance. Hemorrhagic fever with renal syndrome (HFRS) and tick-borne encephalitis (TBE) are the most common natural focal diseases of viral etiology in Russia. The medical and social significance of these two infections is determined by …
View article: Neutralizing Antibody Spectrum in COVID-19 Patients who Became Ill During the Circulation of Different SARS-CoV-2 Variants
Neutralizing Antibody Spectrum in COVID-19 Patients who Became Ill During the Circulation of Different SARS-CoV-2 Variants Open
SARS-CoV-2 has been actively circulating in the human population since late 2019. During this time, the virus acquired more than 140 nucleotide mutations and 20 deletions per genome from the original variant identified in Wuhan. As the vir…
View article: Clinical and laboratory characteristics of patients with false positive IgM test for SARS-CoV-2
Clinical and laboratory characteristics of patients with false positive IgM test for SARS-CoV-2 Open
The widespread occurrence of COVID-19 places significant pressure on diagnostic laboratories, potentially compromising the accuracy of tests performed and leading to an increase in false-positive results. The aim was to assess the incidenc…
View article: Applied and Theoretical Aspects of the Ecology of Pathogens of Hemorrhagic Fever with Renal Syndrome and Tick-Borne Encephalitis
Applied and Theoretical Aspects of the Ecology of Pathogens of Hemorrhagic Fever with Renal Syndrome and Tick-Borne Encephalitis Open
Relevance. Hemorrhagic fever with renal syndrome (HFRS) and tick-borne encephalitis (TBE) are the most common natural focal diseases of viral etiology In Russia. The medical and social significance of these two infections is determined by …
View article: Experimental Use of Common Marmosets (<i>Callithrix jacchus</i>) in Preclinical Trials of Antiviral Vaccines
Experimental Use of Common Marmosets (<i>Callithrix jacchus</i>) in Preclinical Trials of Antiviral Vaccines Open
Common marmoset (Callithrix jacchus, CM) is a New World primate species that is of interest for preclinical trials of immunobiological products. In this study, we describe the approaches to long-term laboratory breeding and maintenance of …
View article: The Specificity of Epizootic and Epidemiological Processes in Natural Foci of Hemorrhagic Fever with Renal Syndrome and Tick-Borne Encephalitis in Russia, as the Basis for the Prospects of Creating a Combined Vaccine for the Prevention of These Infections
The Specificity of Epizootic and Epidemiological Processes in Natural Foci of Hemorrhagic Fever with Renal Syndrome and Tick-Borne Encephalitis in Russia, as the Basis for the Prospects of Creating a Combined Vaccine for the Prevention of These Infections Open
Hemorrhagic fever with renal syndrome (HFRS) and tick-borne encephalitis (TBE) are the most common viral diseases in Russia. HFRS is caused by six different types of hantaviruses: Hantaan, Amur, Seoul, Puumala, Kurkino, and Sochi, which ar…
View article: Prevalence and Clinical Impact of Viral and Bacterial Coinfections in Hospitalized Children and Adolescents Aged under 18 Years with COVID-19 during the Omicron Wave in Russia
Prevalence and Clinical Impact of Viral and Bacterial Coinfections in Hospitalized Children and Adolescents Aged under 18 Years with COVID-19 during the Omicron Wave in Russia Open
The COVID-19 pandemic has altered respiratory infection patterns in pediatric populations. The emergence of the SARS-CoV-2 Omicron variant and relaxation of public health measures have increased the likelihood of coinfections. Previous stu…
View article: An Integrative Approach to the Study of Cognitive Abilities in a Non-Human Primate Model in a Virology Laboratory Environment
An Integrative Approach to the Study of Cognitive Abilities in a Non-Human Primate Model in a Virology Laboratory Environment Open
Non-human primates, due to their similarities in immune response to humans, are the preferred model for studying infectious processes and any associated cognitive impairments. Behavioral tests are indispensable for investigating pathogenes…
View article: A Chimeric Vaccine Based on a Single Fusion Protein (W-PreS-O) Combining RBDs from Wuhan hu-1 Wild Type and Omicron Shows Protective Effect against Omicron Infection in Syrian Hamsters
A Chimeric Vaccine Based on a Single Fusion Protein (W-PreS-O) Combining RBDs from Wuhan hu-1 Wild Type and Omicron Shows Protective Effect against Omicron Infection in Syrian Hamsters Open
Omicron SARS-CoV-2 variants have dominated the strains of COVID-19 circulating worldwide for the last two years. Although the mortality rate of the COVID-19 Omicron variants is only approximately half that of previous variants, vaccines ef…
View article: Current Strategies for Vaccine Prophylaxis of Lyme Disease
Current Strategies for Vaccine Prophylaxis of Lyme Disease Open
Relevance. Lyme disease (LD) remains an important public health problem, especially in Russia, where the incidence is consistently high. To date, there is still no available vaccine against LD, and prevention involves non-specific measures…
View article: The structure of inactivated mature tick-borne encephalitis virus at 3.0 Å resolution
The structure of inactivated mature tick-borne encephalitis virus at 3.0 Å resolution Open
Tick-borne encephalitis virus (TBEV) causes a severe disease, tick-borne encephalitis (TBE), that has a substantial epidemiological importance for Northern Eurasia. Between 10,000 and 15,000 TBE cases are registered annually despite the av…
View article: Comprehensive Elucidation of the Role of L and 2A Security Proteins on Cell Death during EMCV Infection
Comprehensive Elucidation of the Role of L and 2A Security Proteins on Cell Death during EMCV Infection Open
The EMCV L and 2A proteins are virulence factors that counteract host cell defense mechanisms. Both L and 2A exhibit antiapoptotic properties, but the available data were obtained in different cell lines and under incomparable conditions. …
View article: Electrochemical profiling of poliovirus particles inactivated by chemical method and ionizing radiation
Electrochemical profiling of poliovirus particles inactivated by chemical method and ionizing radiation Open
Electrochemical profiling of formaldehyde-inactivated poliovirus particles demonstrated a relationship between the D-antigen concentration and the intensity of the maximum amplitude currents of the poliovirus samples. The resultant signal …
View article: Investigation of oncolytic potential of vaccine strains of yellow fever and tick-borne encephalitis viruses against glioblastoma and pancreatic carcinoma cell lines
Investigation of oncolytic potential of vaccine strains of yellow fever and tick-borne encephalitis viruses against glioblastoma and pancreatic carcinoma cell lines Open
Introduction. Flaviviruses, possessing natural neurotropicity could be used in glioblastoma therapy using attenuated strains or as a delivery system for antitumor agents in an inactivated form. Objective. To investigate the sensitivity of …