Aamer Saeed
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View article: <b>Historical Context of Legal Pluralism in Pakistan</b>
<b>Historical Context of Legal Pluralism in Pakistan</b> Open
The legal pluralism in Pakistan has a very complicated history of overlaying indigenous, colonial, and religious systems of law. This pluralistic system was a legacy of the pre-colonial tradition and changed dramatically by the introductio…
View article: RETRACTED: El-Garawani et al. In Vitro Induction of Apoptosis in Isolated Acute Myeloid Leukemia Cells: The Role of Anastatica hierochuntica Methanolic Extract. Metabolites 2022, 12, 878
RETRACTED: El-Garawani et al. In Vitro Induction of Apoptosis in Isolated Acute Myeloid Leukemia Cells: The Role of Anastatica hierochuntica Methanolic Extract. Metabolites 2022, 12, 878 Open
The journal Metabolites retracts the article “In Vitro Induction of Apoptosis in Isolated Acute Myeloid Leukemia Cells: The Role of Anastatica hierochuntica Methanolic Extract” [...]
View article: Efficient synthesis of N-(ethylcarbamothioyl)-1-naphthamide: X-ray structure, Hirshfeld surface analysis, DFTs, and molecular modelling investigations as selective inhibitor of alkaline phosphatase
Efficient synthesis of N-(ethylcarbamothioyl)-1-naphthamide: X-ray structure, Hirshfeld surface analysis, DFTs, and molecular modelling investigations as selective inhibitor of alkaline phosphatase Open
View article: Synthesis, in vitro evaluation and computational modelling of benzene sulfonamide derivatives as Dickkopf 1 inhibitors for anticancer drug development
Synthesis, in vitro evaluation and computational modelling of benzene sulfonamide derivatives as Dickkopf 1 inhibitors for anticancer drug development Open
View article: Synthesis and evaluation of thiazolyl coumarin drug conjugates as carbonic anhydrase isozyme inhibitors by using integrated invitro and insilico approaches
Synthesis and evaluation of thiazolyl coumarin drug conjugates as carbonic anhydrase isozyme inhibitors by using integrated invitro and insilico approaches Open
View article: Innovative Pivaloyl Fixed 1,3‐Thiazole‐2‐imines as Multitarget Inhibitors: Synthesis, Enzyme Inhibition, Molecular Docking and Structure Activity Relationship (SAR) Studies
Innovative Pivaloyl Fixed 1,3‐Thiazole‐2‐imines as Multitarget Inhibitors: Synthesis, Enzyme Inhibition, Molecular Docking and Structure Activity Relationship (SAR) Studies Open
A small library of Pivaloyl‐Fixed 1,3‐Thiazole‐2‐imine pharmacophores ( 5a‐j ) was synthesized in three steps, starting with the reaction of pivaloyl chloride with potassium thiocyanate, followed by condensation with p‐toluidine. In the fi…
View article: (Z)-N-(3-([1,1'-biphenyl]-2-yl)-4-heptyl-4-hydroxythiazolidin-2-ylidene)-4-bromobenzamide as carbonic anhydrase inhibitor: exploration of its in vitro and in silico studies
(Z)-N-(3-([1,1'-biphenyl]-2-yl)-4-heptyl-4-hydroxythiazolidin-2-ylidene)-4-bromobenzamide as carbonic anhydrase inhibitor: exploration of its in vitro and in silico studies Open
View article: DETERMINATION AND DETOXIFICATION OF TOTAL AFLATOXINS AND DEOXYNIVALENOL FROM DIFFERENT TYPES OF CEREALS AND PULSES COLLECTED FROM DIFFERENT AREAS
DETERMINATION AND DETOXIFICATION OF TOTAL AFLATOXINS AND DEOXYNIVALENOL FROM DIFFERENT TYPES OF CEREALS AND PULSES COLLECTED FROM DIFFERENT AREAS Open
View article: Novel guanidine derivatives as mechanistic scaffolds for anticancer agents: synthesis, characterization, DNA-binding, and computational studies
Novel guanidine derivatives as mechanistic scaffolds for anticancer agents: synthesis, characterization, DNA-binding, and computational studies Open
Novel guanidines are synthesized as DNA minor groove binders. Spectroscopic and DFT studies revealed that EDGs synergize with halogens to enhance binding affinity, offering promising scaffolds for anticancer drug design.
View article: Exploration of novel triazolo-thiadiazine hybrids of deferasirox as multi-target-directed anti-neuroinflammatory agents with structure–activity relationship (SAR): a new treatment opportunity for Alzheimer's disease
Exploration of novel triazolo-thiadiazine hybrids of deferasirox as multi-target-directed anti-neuroinflammatory agents with structure–activity relationship (SAR): a new treatment opportunity for Alzheimer's disease Open
We present a thorough evaluation of deferasirox derivative drugs that can interact with many targets by utilizing a mix of several pharmacophores for Alzheimer's treatment.
View article: Synthesis of 2-(4-Methyl-Phenoxymethyl) Benzoic Acid; Cresol and its Metal Coordinate Complexes
Synthesis of 2-(4-Methyl-Phenoxymethyl) Benzoic Acid; Cresol and its Metal Coordinate Complexes Open
A series of phenoxymethylbenzoic acid derivatives were synthesized by reacting p-cresol with phthalide. The resulting phenoxymethyl benzoic acid was converted into corresponding acid chloride by reacting with cyanuric chloride. These pheno…
View article: An In‐Depth Review on Recent Progress in Synthetic Approaches and Biological Activities of Thiazol‐2( <i>3H</i> )‐Imine Derivatives
An In‐Depth Review on Recent Progress in Synthetic Approaches and Biological Activities of Thiazol‐2( <i>3H</i> )‐Imine Derivatives Open
This review presents the in‐dept analysis of the synthetic approaches towards thiazol‐2( 3H )‐imine and embarks at its various biological properties published during 2000 to 2023. The most important method of synthesis involves the reactio…
View article: Efficacy assessment of novel methanimine derivatives in chronic constriction injury-induced neuropathic model: An in-vivo, ex-vivo and In-Silico approach
Efficacy assessment of novel methanimine derivatives in chronic constriction injury-induced neuropathic model: An in-vivo, ex-vivo and In-Silico approach Open
The multicomponent etiology, complex clinical implications, dose-based side effect and degree of pain mitigation associated with the current pharmacological therapy is incapable in complete resolution of chronic neuropathic pain patients w…
View article: Acyl pyrazole sulfonamides as new antidiabetic agents: synthesis, glucosidase inhibition studies, and molecular docking analysis
Acyl pyrazole sulfonamides as new antidiabetic agents: synthesis, glucosidase inhibition studies, and molecular docking analysis Open
Diabetes mellitus is a multi-systematic chronic metabolic disorder and life-threatening disease resulting from impaired glucose homeostasis. The inhibition of glucosidase, particularly α -glucosidase, could serve as an effective methodolog…
View article: Synthesis, Glucosidase Inhibition, and In Silico Modeling Analysis of Highly Fluorinated 2-Imino-1,3-thiazolines in Search of Potent Antidiabetic Agents
Synthesis, Glucosidase Inhibition, and In Silico Modeling Analysis of Highly Fluorinated 2-Imino-1,3-thiazolines in Search of Potent Antidiabetic Agents Open
In the present work, 2-imino-1,3-thiazolines featuring highly fluorinated fragments were synthesized through a straightforward cyclization of diversely substituted thioureas with 2-bromo-1-(4-fluorophenyl)ethan-1-one. The target compounds …
View article: Exploration of newly synthesized azo-thiohydantoins as the potential alkaline phosphatase inhibitors via advanced biochemical characterization and molecular modeling approaches
Exploration of newly synthesized azo-thiohydantoins as the potential alkaline phosphatase inhibitors via advanced biochemical characterization and molecular modeling approaches Open
In the current study, Azo-Thiohydantoins derivatives were synthesized and characterized by using various spectroscopic techniques including FTIR, 1 H-NMR, 13 C-NMR, elemental and HRMS analysis. The compounds were evaluated for alkaline pho…
View article: DABCO-PEG ionic liquid catalyzed synthesis, single-crystal structure, and antioxidant activity of a flavanone derivative
DABCO-PEG ionic liquid catalyzed synthesis, single-crystal structure, and antioxidant activity of a flavanone derivative Open
Globally, the occurrence of skin cancers has been increasing day by day due to unprotected skin and exposure to UV radiation. This research is focused toward the evaluation of the antioxidant potential of an OH-free flavanone derivative th…
View article: Synthesis, biochemical characterization and computational investigations of newly synthesized crystal structure of Dihydropyrimidin-2(1H)-thione
Synthesis, biochemical characterization and computational investigations of newly synthesized crystal structure of Dihydropyrimidin-2(1H)-thione Open
The novel 1-(2,6-dibromo-4-fluorophenyl)-4,4,6-trimethyl-3,4-dihydropyrimidine-2(1H)-thiones molecule has been synthesized through a convenient and simple protocol by the facile reaction of acetone, potassium thiocyanate and 2,6-dibromo-4-…
View article: Novel pyrazoline linked acyl thiourea pharmacophores as antimicrobial, urease, amylase and α-glucosidase inhibitors: design, synthesis, SAR and molecular docking studies
Novel pyrazoline linked acyl thiourea pharmacophores as antimicrobial, urease, amylase and α-glucosidase inhibitors: design, synthesis, SAR and molecular docking studies Open
IC 50 values of the new synthesized pyrazoline-acyl thioureas revealed 5b and 5g as potent urease inhibitors. Whilst compound 5b is a potent α-glucosidase inhibitor, compound 5f is a potent amylase inhibitor, compound 5b is a potent antiox…
View article: N-Adamantanyl-2-(2-(phenyl)hydrazone)-3-oxobutanamides endowed with dual inhibitors of urease and α-glucosidase: Design, synthesis, and computational studies
N-Adamantanyl-2-(2-(phenyl)hydrazone)-3-oxobutanamides endowed with dual inhibitors of urease and α-glucosidase: Design, synthesis, and computational studies Open
The conventional approach of drug development, which focused on inhibiting a single target, has been superseded by a more advanced strategy known as multi-target design. In this study, we describe the synthesis of new N-adamantyl-2-(2-(phe…
View article: SYNTHESIS, BIOCHEMICAL AND IN SILICO EXPLORATION OF NOVEL IMIDAZOLE BASED 1,2,3-TRIAZOLES AS POTENTIAL HIT AGAINST CARBONIC ANHYDRASE II ISOZYME
SYNTHESIS, BIOCHEMICAL AND IN SILICO EXPLORATION OF NOVEL IMIDAZOLE BASED 1,2,3-TRIAZOLES AS POTENTIAL HIT AGAINST CARBONIC ANHYDRASE II ISOZYME Open
This study aimed to synthesize novel compounds as more effective carbonic anhydrase II inhibitors. For this purpose, 2-(3-methoxy4-(prop-2-yn-1-yloxy)phenyl)-4,5-diphenyl-1H-imidazole (3) was reacted with 3-methoxy-4-(prop-2-yn-1-yloxy)ben…
View article: Facile synthesis, single crystal X-ray diffraction, Hirshfield surface analysis and quantum chemical properties of 3-hydroxybenzo[b]thiophen-2-yl)(4-(trifluoromethyl)phenyl)methanone
Facile synthesis, single crystal X-ray diffraction, Hirshfield surface analysis and quantum chemical properties of 3-hydroxybenzo[b]thiophen-2-yl)(4-(trifluoromethyl)phenyl)methanone Open
View article: Structural, Conformational Analysis and Biological Activity of 1-Acyl-Thioureas Bearing Bulky Adamantyl/Noradamantyl and 3-Tri(Halo)Benzyl Substituents
Structural, Conformational Analysis and Biological Activity of 1-Acyl-Thioureas Bearing Bulky Adamantyl/Noradamantyl and 3-Tri(Halo)Benzyl Substituents Open
View article: Newly synthesized sulfonamide derivatives explored for DNA binding, enzyme inhibitory, and cytotoxicity activities: a mixed computational and experimental analyses
Newly synthesized sulfonamide derivatives explored for DNA binding, enzyme inhibitory, and cytotoxicity activities: a mixed computational and experimental analyses Open
This work reports synthesis, characterization, DNA, enzyme binding and cytotoxicity activity of three 4-((3-arylthiazolo[3,4- d ]isoxazol-5-yl)amino)benzene sulfonamide derivatives with a thaizaole(3,4- d )isoxazole-based fused ring hetero…
View article: Review of: "Synthesis and Antibacterial Screening of Cefradine Schiff Bases and Their Metal Salts"
Review of: "Synthesis and Antibacterial Screening of Cefradine Schiff Bases and Their Metal Salts" Open
View article: CCDC 2221961: Experimental Crystal Structure Determination
CCDC 2221961: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: EFFICIENT SYNTHESIS OF 1-(BROMOMETHYL)-3,5-DIMETHOXYBENZENE: X-RAY STRUCTURE, HIRSHFELD SURFACE ANALYSIS, DFTs, AND MOLECULAR MODELLING INVESTIGATIONS AS TYROSINASE INHIBITOR
EFFICIENT SYNTHESIS OF 1-(BROMOMETHYL)-3,5-DIMETHOXYBENZENE: X-RAY STRUCTURE, HIRSHFELD SURFACE ANALYSIS, DFTs, AND MOLECULAR MODELLING INVESTIGATIONS AS TYROSINASE INHIBITOR Open
The synthesis of 1-(bromomethyl)-3,5-dimethoxybenzene, a crucial intermediate in the formation of various natural products, was carried out through a straightforward three-step procedure starting from 3,5-dihydroxybenzoic acid. The structu…
View article: Chemistry and Pharmacology of Fluorinated Drugs Approved by the FDA (2016–2022)
Chemistry and Pharmacology of Fluorinated Drugs Approved by the FDA (2016–2022) Open
Fluorine is characterized by high electronegativity and small atomic size, which provide this molecule with the unique property of augmenting the potency, selectivity, metabolic stability, and pharmacokinetics of drugs. Fluorine (F) substi…
View article: Computational and theoretical chemistry of newly synthesized and characterized 2,2’-(5,5’-(1,4-phenylene)bis(1H-tetrazole-5,1-diyl))bis-N-acetamides
Computational and theoretical chemistry of newly synthesized and characterized 2,2’-(5,5’-(1,4-phenylene)bis(1H-tetrazole-5,1-diyl))bis-N-acetamides Open
Energetic heterocycles, including pyridines, triazoles, and tetrazoles, exhibit greater density, heats of formation, and oxygen balance compared to their carbocyclic counterparts, making them a promising approach for synthesizing novel bis…
View article: Synthesis, DFT and molecular docking of novel (Z)-4-bromo-N-(4-butyl-3 (quinolin-3-yl)thiazol-2(3H)-ylidene)benzamide as elastase inhibitor
Synthesis, DFT and molecular docking of novel (Z)-4-bromo-N-(4-butyl-3 (quinolin-3-yl)thiazol-2(3H)-ylidene)benzamide as elastase inhibitor Open