M. Arfan Ikram
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View article: Survival of Indian Honey Bee Apis Cerana indica Fabricius exposed to Microbial Control Agents: Insights into Its Pathogenicity and Toxicity under Varied Exposure Methods
Survival of Indian Honey Bee Apis Cerana indica Fabricius exposed to Microbial Control Agents: Insights into Its Pathogenicity and Toxicity under Varied Exposure Methods Open
This study investigates the effects of commercially available entomopathogenic fungal formulations on the Indian honey bee Apis cerana indica Fabricius (Hymenoptera: Apidae). A 10-day bioassay conducted under laboratory conditions used fou…
View article: Domain mapping of disease mutations reveals pathogenic SORL1 variants in Alzheimer’s disease
Domain mapping of disease mutations reveals pathogenic SORL1 variants in Alzheimer’s disease Open
View article: Hospital Volume and Health Equity in Whipple Surgery: Who Is Left Behind
Hospital Volume and Health Equity in Whipple Surgery: Who Is Left Behind Open
Background Pancreaticoduodenectomy (PD) is a complex surgery that often has the best outcomes at high-volume centers. The influence of neighborhood socioeconomic status and location of care is poorly studied. This study aims to evaluate th…
View article: Effects of Hydrocodone Rescheduling on Pain Management Practices Among Older Breast Cancer Patients
Effects of Hydrocodone Rescheduling on Pain Management Practices Among Older Breast Cancer Patients Open
Hydrocodone, a commonly prescribed opioid, was rescheduled from Schedule III to Schedule II in October 2014, imposing stricter prescribing regulations. While prior studies have examined its effects in general populations, its impact on bre…
View article: Dementia and Cancer: Unravelling Methodological Biases in a Population-Based Cohort
Dementia and Cancer: Unravelling Methodological Biases in a Population-Based Cohort Open
Background: An inverse association between dementia and cancer has been consistently reported and often attributed to opposing biological mechanisms. However, methodological biases such as collider stratification and surveillance bias may …
View article: IOT-Driven Smart farming: Enhancing mushroom cultivation with environmental control and image-based disease detection
IOT-Driven Smart farming: Enhancing mushroom cultivation with environmental control and image-based disease detection Open
Mushroom farming is a rapidly growing segment of sustainable agriculture, offering high nutritional value and commercial viability. However, maintaining optimal environmental conditions and preventing disease outbreaks are major challenges…
View article: Extreme MetaboHealth scores in three cohort studies associate with plasma protein markers for inflammation and cholesterol transport
Extreme MetaboHealth scores in three cohort studies associate with plasma protein markers for inflammation and cholesterol transport Open
The MetaboHealth score is an indicator of physiological frailty in middle aged and older individuals. The aim of the current study was to explore which molecular pathways co-vary with the MetaboHealth score. Using a Luminex cytokine assay …
View article: The impact of modifiable risk factor reduction on future dementia burden: a microsimulation modeling study
The impact of modifiable risk factor reduction on future dementia burden: a microsimulation modeling study Open
View article: Signature White Matter Hyperintensity Locations Associated With Vascular Risk Factors Derived From 15 653 Individuals
Signature White Matter Hyperintensity Locations Associated With Vascular Risk Factors Derived From 15 653 Individuals Open
BACKGROUND: White matter hyperintensities (WMHs) of presumed vascular origin are common in the elderly and are associated with vascular risk factors. There is evidence that vascular risk factors, in particular hypertension, are associated …
View article: Combined genome-wide association study of facial traits in Europeans increases explained variance and improves prediction
Combined genome-wide association study of facial traits in Europeans increases explained variance and improves prediction Open
View article: Prospective versus retrospective: a simple matter of timing?
Prospective versus retrospective: a simple matter of timing? Open
Background The terms “prospective” and “retrospective” are commonly used to describe the timing of a study. However, there is much confusion surrounding the use of these terms. In this paper we describe two common definitions used for thes…
View article: Incidence and Determinants of Nonfocal Transient Neurologic Attacks
Incidence and Determinants of Nonfocal Transient Neurologic Attacks Open
Nonfocal TNAs predominantly affect older adults and those with lower educational attainment, suggesting that these attacks originate from socioeconomic determinants rather than from established cardiovascular risk factors.
View article: Plasma microRNA signatures of aging and their links to health outcomes and mortality: findings from a population-based cohort study
Plasma microRNA signatures of aging and their links to health outcomes and mortality: findings from a population-based cohort study Open
View article: Hydrocodone Rescheduling and Opioid Prescribing Disparities in Breast Cancer Patients
Hydrocodone Rescheduling and Opioid Prescribing Disparities in Breast Cancer Patients Open
Background: Pain is a prevalent issue among breast cancer patients and survivors, with a significant proportion receiving hydrocodone for pain management. However, the rescheduling of hydrocodone from Schedule III to Schedule II by the U.S…
View article: Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids
Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids Open
View article: Neural substrates of the link between dual-task gait and dementia: an intermediary step in which direction?
Neural substrates of the link between dual-task gait and dementia: an intermediary step in which direction? Open
View article: Publisher Correction: A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids
Publisher Correction: A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids Open
View article: Correlation of Serum Creatinine, Urea, and Hemoglobin Level in Chronic Kidney Disease
Correlation of Serum Creatinine, Urea, and Hemoglobin Level in Chronic Kidney Disease Open
Background: Chronic kidney disease (CKD) is a global health concern characterized by progressive renal function decline and is commonly associated with anemia. Although creatinine and urea are established biomarkers of CKD, their correlati…
View article: Mediation of the Association Between <i>APOE</i> ε4 Genotype, Cognition, and Dementia by Neuropathology Imaging Markers in the Rotterdam Study
Mediation of the Association Between <i>APOE</i> ε4 Genotype, Cognition, and Dementia by Neuropathology Imaging Markers in the Rotterdam Study Open
In this population-based cohort study, we found that an estimated one-fourth of the effect of APOE ε4 on cognition is mediated by structural brain imaging markers, driven mainly by cerebral microbleeds. For dementia, mediation by th…
View article: A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels
A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels Open
Coagulation factor VIII (FVIII) and its carrier protein von Willebrand factor (VWF) are critical to coagulation and platelet aggregation. We leveraged whole-genome sequence data from the Trans-Omics for Precision Medicine (TOPMed) program …
View article: Trajectories of social health, cognitive, and daily functioning in community-dwelling older adults
Trajectories of social health, cognitive, and daily functioning in community-dwelling older adults Open
INTRODUCTION: Cognitive and functional impairments can both influence and stem from deteriorating social health). However, the interplay between these dimensions while aging remains poorly understood. This study investigated the concordanc…
View article: Motoric Cognitive Risk Syndrome and Risk of Cardiovascular Disease: A Population-Based Study
Motoric Cognitive Risk Syndrome and Risk of Cardiovascular Disease: A Population-Based Study Open
Background To investigate whether differences between motoric cognitive risk syndrome (MCRS) and mild cognitive impairment (MCI) are of vascular origin, we compared the risk of incident cardiovascular disease in both groups in a population…
View article: Selected social and lifestyle correlates of brain health markers: the Cross‐Cohort Collaboration Consortium
Selected social and lifestyle correlates of brain health markers: the Cross‐Cohort Collaboration Consortium Open
INTRODUCTION To investigate the associations of education level, marital status, and physical activity with dementia risk and brain MRI markers. METHODS Data from six community‐based samples from the Cross‐Cohort Collaboration Consortium w…
View article: Clinical and Imaging Markers of Cardiac Function and Brain Health
Clinical and Imaging Markers of Cardiac Function and Brain Health Open
In this large study among community-dwelling adults, subclinical cardiac dysfunction was associated with brain imaging markers of neurodegeneration. These findings encourage longitudinal investigations on the effect of maintaining cardiac …
View article: Occupational Health and Safety Risk Assessment of a Tobacco Manufacturing Industry
Occupational Health and Safety Risk Assessment of a Tobacco Manufacturing Industry Open
Occupational safety and health remain a critical challenge in the tobacco industry, where workers are exposed to a range of risks, including chemical, biological, and physical safety hazards. This study uses the Occupational Safety and Hea…
View article: Social health and prevention of dementia: Integration of human and mice studies
Social health and prevention of dementia: Integration of human and mice studies Open
These results allow us to propose evidence-based social health targets for preventive interventions.
View article: Guideline-Directed Application of Coronary Artery Calcium Scores for Primary Prevention of Atherosclerotic Cardiovascular Disease
Guideline-Directed Application of Coronary Artery Calcium Scores for Primary Prevention of Atherosclerotic Cardiovascular Disease Open
The ACC/AHA and ESC/EAS guidelines differ in the selection and application of the CAC score for primary prevention of ASCVD. Guideline-directed application of CAC score in a middle-aged apparently healthy population improved risk stratific…
View article: Long‐Term Exposure to Non‐Steroidal Anti‐Inflammatory Medication in Relation to Dementia Risk
Long‐Term Exposure to Non‐Steroidal Anti‐Inflammatory Medication in Relation to Dementia Risk Open
Background Non‐steroidal anti‐inflammatory (NSAID) medication could reduce dementia risk due to anti‐inflammatory and possibly amyloid‐lowering properties. However, the results of observational studies and short‐term randomized‐controlled …
View article: Generalizability of trial criteria on amyloid-lowering therapy against Alzheimer’s disease to individuals with mild cognitive impairment or early Alzheimer’s disease in the general population
Generalizability of trial criteria on amyloid-lowering therapy against Alzheimer’s disease to individuals with mild cognitive impairment or early Alzheimer’s disease in the general population Open
View article: Investigating the predictive role of serum amyloid A and its association with immunological and coagulation biomarkers in recurrent pregnancy loss
Investigating the predictive role of serum amyloid A and its association with immunological and coagulation biomarkers in recurrent pregnancy loss Open
To evaluate the predictive role of serum amyloid A (SAA) levels and their association with antiphospholipid antibodies (APA) and coagulation markers such as lupus anticoagulants (LA), anti-cardiolipin (ACA), protein C (PC) deficiency, prot…