A. E. Ades
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View article: Multilevel network meta-regression for general likelihoods: synthesis of individual and aggregate data with applications to survival analysis
Multilevel network meta-regression for general likelihoods: synthesis of individual and aggregate data with applications to survival analysis Open
Network meta-analysis combines aggregate data (AgD) from multiple randomized controlled trials, assuming that any effect modifiers are balanced across populations. Individual participant data (IPD) meta-regression is the ‘gold standard’ me…
View article: Treatment recommendations based on network meta-analysis: Rules for risk-averse decision-makers
Treatment recommendations based on network meta-analysis: Rules for risk-averse decision-makers Open
The treatment recommendation based on a network meta-analysis (NMA) is usually the single treatment with the highest expected value (EV) on an evaluative function. We explore approaches that recommend multiple treatments and that penalise …
View article: Synthesis of depression outcomes reported on different scales: A comparison of methods for modelling mean differences
Synthesis of depression outcomes reported on different scales: A comparison of methods for modelling mean differences Open
Several methods have been proposed for the synthesis of continuous outcomes reported on different scales, including the Standardised Mean Difference (SMD) and the Ratio of Means (RoM). SMDs can be formed by dividing the study mean treatmen…
View article: Effect modification and non-collapsibility together may lead to conflicting treatment decisions: A review of marginal and conditional estimands and recommendations for decision-making
Effect modification and non-collapsibility together may lead to conflicting treatment decisions: A review of marginal and conditional estimands and recommendations for decision-making Open
Effect modification occurs when a covariate alters the relative effectiveness of treatment compared to control. It is widely understood that, when effect modification is present, treatment recommendations may vary by population and by subg…
View article: Effect modification and non-collapsibility leads to conflicting treatment decisions: a review of marginal and conditional estimands and recommendations for decision-making
Effect modification and non-collapsibility leads to conflicting treatment decisions: a review of marginal and conditional estimands and recommendations for decision-making Open
Effect modification occurs when a covariate alters the relative effectiveness of treatment compared to control. It is widely understood that, when effect modification is present, treatment recommendations may vary by population and by subg…
View article: Mapping between measurement scales in meta‐analysis, with application to measures of body mass index in children
Mapping between measurement scales in meta‐analysis, with application to measures of body mass index in children Open
Quantitative evidence synthesis methods aim to combine data from multiple medical trials to infer relative effects of different interventions. A challenge arises when trials report continuous outcomes on different measurement scales. To in…
View article: Response to discussant comments on “NMA, the first 20 years”
Response to discussant comments on “NMA, the first 20 years” Open
We respond to discussant comments on our paper “ Twenty years of network meta‐analysis: Continuing controversies and recent developments ” ( https://doi.org/10.1002/jrsm.1700 ) and raise some additional points for consideration, including:…
View article: Treatment recommendations based on Network Meta-Analysis: rules for risk-averse decision-makers
Treatment recommendations based on Network Meta-Analysis: rules for risk-averse decision-makers Open
Background The treatment recommendation based on a Network Meta-analysis (NMA) is usually the single treatment with the highest Expected Value (EV) on an evaluative function. We explore approaches which recommend multiple treatments and wh…
View article: Modelling the potential clinical and economic impact of universal antenatal hepatitis C (HCV) screening and providing treatment for pregnant women with HCV and their infants in Egypt: a cost-effectiveness study
Modelling the potential clinical and economic impact of universal antenatal hepatitis C (HCV) screening and providing treatment for pregnant women with HCV and their infants in Egypt: a cost-effectiveness study Open
Backgrounds and aims Pregnant women and children are not included in Egypt’s hepatitis C virus (HCV) elimination programmes. This study assesses the cost-effectiveness of several screening and treatment strategies for pregnant women and in…
View article: Mapping between measurement scales in meta-analysis, with application to measures of body mass index in children
Mapping between measurement scales in meta-analysis, with application to measures of body mass index in children Open
Quantitative evidence synthesis methods aim to combine data from multiple medical trials to infer relative effects of different interventions. A challenge arises when trials report continuous outcomes on different measurement scales. To in…
View article: The cost effectiveness of psychological and pharmacological interventions for social anxiety disorder: A model-based economic analysis
The cost effectiveness of psychological and pharmacological interventions for social anxiety disorder: A model-based economic analysis Open
Background: Social anxiety disorder is one of the most persistent and common anxiety disorders. Individually delivered psychological therapies are the most effective treatment options for adults with social anxiety disorder, but they are a…
View article: Multilevel network meta-regression for general likelihoods: synthesis of individual and aggregate data with applications to survival analysis
Multilevel network meta-regression for general likelihoods: synthesis of individual and aggregate data with applications to survival analysis Open
Network meta-analysis combines aggregate data (AgD) from multiple randomised controlled trials, assuming that any effect modifiers are balanced across populations. Individual patient data (IPD) meta-regression is the "gold standard" method…
View article: Twenty years of network meta‐analysis: Continuing controversies and recent developments
Twenty years of network meta‐analysis: Continuing controversies and recent developments Open
Network meta‐analysis (NMA) is an extension of pairwise meta‐analysis (PMA) which combines evidence from trials on multiple treatments in connected networks. NMA delivers internally consistent estimates of relative treatment efficacy, need…
View article: Corrigendum to “Modelling the potential effectiveness of hepatitis C screening and treatment strategies during pregnancy in Egypt and Ukraine” [J Hepatol (2023) 937–946]
Corrigendum to “Modelling the potential effectiveness of hepatitis C screening and treatment strategies during pregnancy in Egypt and Ukraine” [J Hepatol (2023) 937–946] Open
Modelling the potential effectiveness of hepatitis C screening and treatment strategies during pregnancy in Egypt and UkraineJournal of HepatologyVol. 78Issue 5PreviewHCV test and treat campaigns currently exclude pregnant women. Pregnancy…
View article: Modelling the potential effectiveness of hepatitis C screening and treatment strategies during pregnancy in Egypt and Ukraine
Modelling the potential effectiveness of hepatitis C screening and treatment strategies during pregnancy in Egypt and Ukraine Open
In the context of two lower middle-income countries with high HCV burdens (Egypt and Ukraine), we designed a decision analytic model to explore five different HCV testing and treatment strategies for pregnant women, with the assumption tha…
View article: Validating the Assumptions of Population Adjustment: Application of Multilevel Network Meta-regression to a Network of Treatments for Plaque Psoriasis
Validating the Assumptions of Population Adjustment: Application of Multilevel Network Meta-regression to a Network of Treatments for Plaque Psoriasis Open
Background Network meta-analysis (NMA) and indirect comparisons combine aggregate data (AgD) from multiple studies on treatments of interest but may give biased estimates if study populations differ. Population adjustment methods such as m…
View article: Overall Vertical Transmission of Hepatitis C Virus, Transmission Net of Clearance, and Timing of Transmission
Overall Vertical Transmission of Hepatitis C Virus, Transmission Net of Clearance, and Timing of Transmission Open
Background It is widely accepted that the risk of hepatitis C virus (HCV) vertical transmission (VT) is 5%–6% in monoinfected women, and that 25%–40% of HCV infection clears spontaneously within 5 years. However, there is no consensus on h…
View article: Spontaneous Clearance of Vertically Acquired Hepatitis C Infection: Implications for Testing and Treatment
Spontaneous Clearance of Vertically Acquired Hepatitis C Infection: Implications for Testing and Treatment Open
Background Current guidelines recommend that infants born to women with hepatitis C virus (HCV) viremia be screened for HCV antibody at age 18 months and, if positive, referred for RNA testing at 3 years to confirm chronic infection. This …
View article: Antenatal Seroprevalence of Zika and Chikungunya Viruses, Kingston Metropolitan Area, Jamaica, 2017–2019
Antenatal Seroprevalence of Zika and Chikungunya Viruses, Kingston Metropolitan Area, Jamaica, 2017–2019 Open
To determine the extent of exposure to Zika virus (ZIKV) and chikungunya virus (CHIKV) in Jamaica, we collected serum from 584 pregnant women during 2017-2019. We found that 15.6% had antibodies against ZIKV and 83.6% against CHIKV. These …
View article: A non‐parametric approach for jointly combining evidence on progression free and overall survival time in network meta‐analysis
A non‐parametric approach for jointly combining evidence on progression free and overall survival time in network meta‐analysis Open
Randomised controlled trials of cancer treatments typically report progression free survival (PFS) and overall survival (OS) outcomes. Existing methods to synthesise evidence on PFS and OS either rely on the proportional hazards assumption…
View article: Spontaneous Clearance of Vertically Acquired Hepatitis C Infection: Implications for Testing and Treatment
Spontaneous Clearance of Vertically Acquired Hepatitis C Infection: Implications for Testing and Treatment Open
Background Current guidelines recommend that infants born to women with hepatitis C (HCV) viremia are screened for HCV antibody at age 18 months, and if positive, referred for RNA testing at 3 years to confirm chronic infection. This polic…
View article: Overall vertical transmission of HCV, transmission net of clearance, and timing of transmission
Overall vertical transmission of HCV, transmission net of clearance, and timing of transmission Open
Background It is widely accepted that the risk of HCV vertical transmission (VT) is 5-6% in mono-infected women, and that 25-40% of HCV infection clears spontaneously within 5 years. However, VT and clearance rates have not been estimated …
View article: Target estimands for efficient decision making: Response to comments on “Assessing the performance of population adjustment methods for anchored indirect comparisons: A simulation study”
Target estimands for efficient decision making: Response to comments on “Assessing the performance of population adjustment methods for anchored indirect comparisons: A simulation study” Open
We thank Remiro-Azócar, Heath, and Baio (R-AHB) for their letter to the editor,1 in response to our recent article presenting a simulation study comparing the performance of methods for population-adjusted indirect comparison.2 R-AHB discu…
View article: Accuracy of four lateral flow immunoassays for anti SARS-CoV-2 antibodies: a head-to-head comparative study
Accuracy of four lateral flow immunoassays for anti SARS-CoV-2 antibodies: a head-to-head comparative study Open
Background SARS-CoV-2 antibody tests are used for population surveillance and might have a future role in individual risk assessment. Lateral flow immunoassays (LFIAs) can deliver results rapidly and at scale, but have widely varying accur…
View article: Zika virus infection in pregnancy: a protocol for the joint analysis of the prospective cohort studies of the ZIKAlliance, ZikaPLAN and ZIKAction consortia
Zika virus infection in pregnancy: a protocol for the joint analysis of the prospective cohort studies of the ZIKAlliance, ZikaPLAN and ZIKAction consortia Open
Introduction Zika virus (ZIKV) infection in pregnancy has been associated with microcephaly and severe neurological damage to the fetus. Our aim is to document the risks of adverse pregnancy and birth outcomes and the prevalence of laborat…