Aditya K. Gupta
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View article: Infection Risk in Dermatology Patients Receiving Next-Generation Medication: A Meta-Analysis of JAK Inhibitors and Biologics
Infection Risk in Dermatology Patients Receiving Next-Generation Medication: A Meta-Analysis of JAK Inhibitors and Biologics Open
Background/Objectives: Next-generation drugs, such as JAK inhibitors and biologics, have proved to be very effective treatment choices in several autoimmune and autoinflammatory skin disorders. However, these drugs are not without risk. Du…
View article: A Novel Topical Nitric Oxide Releasing Gel Demonstrates Effective Nail Penetration and Potent Antifungal Activity in Onychomycosis
A Novel Topical Nitric Oxide Releasing Gel Demonstrates Effective Nail Penetration and Potent Antifungal Activity in Onychomycosis Open
Introduction: Onychomycosis remains a difficult-to-treat fungal infection due to nail plate impermeability, high recurrence, and limited efficacy of topical agents. Systemic antifungals are effective but constrained by safety and drug inte…
View article: Review of the Clinical Efficacy and Safety of Efinaconazole 10% Topical Solution for Onychomycosis Across Subgroups
Review of the Clinical Efficacy and Safety of Efinaconazole 10% Topical Solution for Onychomycosis Across Subgroups Open
Introduction: Onychomycosis treatment can be challenging, and factors like disease severity and age can affect treatment response. Topical efinaconazole 10%—approved in 2014 in the US for once-daily toenail onychomycosis treatment—demonstr…
View article: Global Patterns of Comorbidities Among Patients With Hidradenitis Suppurativa: A Systematic Review and Meta‐Analysis
Global Patterns of Comorbidities Among Patients With Hidradenitis Suppurativa: A Systematic Review and Meta‐Analysis Open
Background Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder increasingly recognized as a systemic disease with diverse comorbidities. While several comorbid conditions are well documented, regional differences in preva…
View article: Penetration and Preliminary Efficacy of a Novel Nitric Oxide-Releasing Gel for Onychomycosis
Penetration and Preliminary Efficacy of a Novel Nitric Oxide-Releasing Gel for Onychomycosis Open
Onychomycosis is a therapeutically challenging fungal infection. Systemic antifungals are limited by adverse effects and drug interactions, while topical therapies may fail to achieve therapeutic nail bed concentrations. Nitric oxide (NO),…
View article: Treating onychomycosis in diabetic patients: risk, therapy, and topical opportunity
Treating onychomycosis in diabetic patients: risk, therapy, and topical opportunity Open
In view of the expanding aging population and increasing comorbidity burden, physicians should remain cognizant about diagnosing and treating onychomycosis in diabetic patients. An interdisciplinary approach to management is advisable.
View article: Deep and disseminated dermatophytosis in immunocompromised populations—A systematic review
Deep and disseminated dermatophytosis in immunocompromised populations—A systematic review Open
Background Dermatophytes—a group of obligate keratinophilic fungi that infect the skin, hair and nails—represent the most common cause of fungal infections worldwide. In immunocompromised individuals, a growing body of literature has docum…
View article: Efficacy and Safety of Voriconazole for Difficult-to-Treat Distal Lateral Subungual Onychomycosis (DLSO)
Efficacy and Safety of Voriconazole for Difficult-to-Treat Distal Lateral Subungual Onychomycosis (DLSO) Open
This retrospective case series evaluated off-label voriconazole for distal lateral subungual onychomycosis (DLSO) unresponsive to standard therapy. Twenty-nine culture-confirmed patients who had failed terbinafine (250 mg daily × 12 weeks)…
View article: Genetics by genetic algorithm: Defining an ideal platelet donor population to support patients with <scp>HLA</scp>‐mediated alloimmune refractoriness
Genetics by genetic algorithm: Defining an ideal platelet donor population to support patients with <span>HLA</span>‐mediated alloimmune refractoriness Open
Background Immune factors underlie approximately 20% of patients exhibiting platelet transfusion refractoriness (PTR). PTR can be mitigated by supplying HLA‐A and B compatible platelets to these patients. Since 2019, Canadian Blood Service…
View article: Relative Efficacy of Conventional Monotherapies and Select Nonconventional, Over‐the‐Counter Products for Male Androgenetic Alopecia: A Network Meta‐Analysis Study
Relative Efficacy of Conventional Monotherapies and Select Nonconventional, Over‐the‐Counter Products for Male Androgenetic Alopecia: A Network Meta‐Analysis Study Open
Background Society values a full head of hair. Therefore, androgenetic hair loss (AGA), though medically benign, can cause significant emotional distress. There is strong demand for alternative (nonconventional, over‐the‐counter) AGA treat…
View article: Understanding the evolving treatment landscape of hidradenitis suppurativa: An analysis of All of Us
Understanding the evolving treatment landscape of hidradenitis suppurativa: An analysis of All of Us Open
Background Hidradenitis suppurativa (HS) is a chronic skin condition with significant burden for affected patients. The development of new therapies in the last decade has brought hope for better patient outcomes, but understanding the use…
View article: Comparative Effect of Conventional and Non-Conventional Over-the-Counter Treatments for Male Androgenetic Alopecia: A Systematic Review and Network Meta-Analysis
Comparative Effect of Conventional and Non-Conventional Over-the-Counter Treatments for Male Androgenetic Alopecia: A Systematic Review and Network Meta-Analysis Open
The expanding literature on nutraceuticals for male androgenetic alopecia (AGA) has inadvertently created knowledge gaps on the relative efficacy of conventional and non-conventional over-the-counter (OTC) treatments. We conducted a Bayesi…
View article: Onychomycosis in Diabetics: A Common Infection with Potentially Serious Complications
Onychomycosis in Diabetics: A Common Infection with Potentially Serious Complications Open
Onychomycosis is a prevalent and clinically relevant complication among individuals with diabetes. It is associated with an elevated risk of secondary fungal and bacterial infections, foot ulceration, and, in advanced cases, amputation. Fa…
View article: Hygiene Practices Against Dermatophytic Fungi: A Review of Strategies to Combat Antifungal Resistance
Hygiene Practices Against Dermatophytic Fungi: A Review of Strategies to Combat Antifungal Resistance Open
Superficial fungal infections of the feet, such as tinea pedis and onychomycosis, are highly prevalent and frequently recurrent, often due to persistent contamination of footwear, textiles, and foot care instruments. Despite growing concer…
View article: Artificial Intelligence and Large Language Models in the Fight Against Superficial Fungal Infections: Friend or Foe?
Artificial Intelligence and Large Language Models in the Fight Against Superficial Fungal Infections: Friend or Foe? Open
Superficial fungal infections can have significant physical and psychological consequences for affected patients. These painful infections have become more prevalent and the rise of antifungal resistant strains is of great concern. New too…
View article: Is the Safety of Finasteride Correlated With Its Route of Administration: Topical Versus Oral? A Pharmacovigilance Study With Data From the United States Food and Drug Administration Adverse Event Reporting System
Is the Safety of Finasteride Correlated With Its Route of Administration: Topical Versus Oral? A Pharmacovigilance Study With Data From the United States Food and Drug Administration Adverse Event Reporting System Open
Background The United States Food and Drug Administration (FDA) approved oral finasteride for androgenetic alopecia. In 2022, approximately 2.6 million U.S. men used it for hair loss and prostate conditions. Post‐finasteride syndrome (PFS)…
View article: Global onychomycosis management and the challenges of antifungal stewardship
Global onychomycosis management and the challenges of antifungal stewardship Open
As a reservoir for resistant strains, onychomycosis represents a significant future medical/economic burden. Future onychomycosis guidelines must address the challenge of resource limitations experienced by clinicians, as well as the chall…
View article: <i>Trichophyton indotineae</i>: Epidemiology, antifungal resistance and antifungal stewardship strategies
<i>Trichophyton indotineae</i>: Epidemiology, antifungal resistance and antifungal stewardship strategies Open
There has been a recent shift in the epidemiology of superficial fungal infections (tinea, dermatophytosis, dermatomycoses). Trichophyton indotineae is an emerging dermatophyte species of significant global concern for its contagious natur…
View article: Sexually Transmitted Dermatophyte Infections—A Scoping Review
Sexually Transmitted Dermatophyte Infections—A Scoping Review Open
Sexually transmitted dermatophyte infections are an emerging public health concern, with increasing incidence reported across multiple countries. These infections are mainly spread through direct skin‐to‐skin contact during sexual activity…
View article: Beyond antibiotics: A clinical insight into homoeopathy&rsquo;s role in recurrent respiratory infections in children
Beyond antibiotics: A clinical insight into homoeopathy’s role in recurrent respiratory infections in children Open
View article: Comparative Efficacy of Minoxidil and 5‐Alpha Reductase Inhibitors Monotherapy for Male Pattern Hair Loss: Network Meta‐Analysis Study of Current Empirical Evidence
Comparative Efficacy of Minoxidil and 5‐Alpha Reductase Inhibitors Monotherapy for Male Pattern Hair Loss: Network Meta‐Analysis Study of Current Empirical Evidence Open
Background Treatment options for male androgenetic alopecia (AGA) range from pharmacologic agents—such as minoxidil, finasteride, and dutasteride—to newer procedural and experimental therapies. Aims We determined the relative effect of the…
View article: Examining the Relationship Between Alopecia Areata and Mental Health: An Investigation of the Global Burden of Disease Study 2021
Examining the Relationship Between Alopecia Areata and Mental Health: An Investigation of the Global Burden of Disease Study 2021 Open
Background Alopecia areata (AA), an autoimmune hair loss disorder, can significantly alter a person's appearance and cause emotional distress. This disorder has been linked to anxiety and depression, but most work has been done on either o…
View article: The comparative effectiveness of prescription and selected alternative therapies for pattern hair loss: protocol for a multiple treatment comparison meta-analysis
The comparative effectiveness of prescription and selected alternative therapies for pattern hair loss: protocol for a multiple treatment comparison meta-analysis Open
View article: Climate Change, Natural Disasters, and Cutaneous Fungal Infections
Climate Change, Natural Disasters, and Cutaneous Fungal Infections Open
Fungal infections are an important source of morbidity and mortality that can manifest as superficial or invasive diseases. Diagnostic techniques for human fungal pathogens remain problematic, and multi‐drug resistance is emerging. This re…
View article: A network meta-analysis study of monotherapies for hidradenitis suppurativa: analyses of the current evidence base
A network meta-analysis study of monotherapies for hidradenitis suppurativa: analyses of the current evidence base Open
The current NMA provides comparative evidence on systematic immunomodulatory HS monotherapies from the most up-to-date trial evidence.
View article: Terbinafine Resistance in Trichophyton rubrum and Trichophyton indotineae: A Literature Review
Terbinafine Resistance in Trichophyton rubrum and Trichophyton indotineae: A Literature Review Open
Background/Objectives: Terbinafine has been the gold standard for the management of superficial fungal infections. The etiological agent generally is Trichophyton rubrum (T. rubrum); however, there has been increased reporting of a new ter…
View article: Menopause and hair loss in women: Exploring the hormonal transition
Menopause and hair loss in women: Exploring the hormonal transition Open
Menopause, which is defined as the cessation of menstruation, may be preceded by hormonal fluctuations during the transition to menopause, up to 10 years prior. During this time, hormonal changes, including the relative increase in androge…
View article: Efficacy and Safety of Efinaconazole 10% Topical Solution for Treatment of Onychomycosis in Older Adults: A Post Hoc Analysis of Two Phase 3 Randomised Trials
Efficacy and Safety of Efinaconazole 10% Topical Solution for Treatment of Onychomycosis in Older Adults: A Post Hoc Analysis of Two Phase 3 Randomised Trials Open
Background Onychomycosis is common in older adults and can be difficult to treat owing to slower nail growth, increased nail thickness, comorbidities, and concomitant medications. Oral treatments can be complicated by contraindications, dr…
View article: Relative efficacy of monotherapies for male pattern hair loss: protocol for a network meta-analysis study
Relative efficacy of monotherapies for male pattern hair loss: protocol for a network meta-analysis study Open
View article: Monotherapies for hidradenitis suppurativa: protocol for a multiple treatment meta-analysis study
Monotherapies for hidradenitis suppurativa: protocol for a multiple treatment meta-analysis study Open