Abdullah A. Alshudukhi
YOU?
Author Swipe
View article: Lipin1 plays complementary roles in myofibre stability and regeneration in dystrophic muscles
Lipin1 plays complementary roles in myofibre stability and regeneration in dystrophic muscles Open
Duchenne muscular dystrophy (DMD) is a severe muscle wasting disorder caused by dystrophin mutations, leading to the loss of sarcolemmal integrity, and resulting in progressive myofibre necrosis and impaired muscle function. Our previous s…
View article: Automated Image Analysis Pipeline Development to Monitor Disease Progression in Muscular Dystrophy Using Cell Profiler
Automated Image Analysis Pipeline Development to Monitor Disease Progression in Muscular Dystrophy Using Cell Profiler Open
Muscular dystrophies are inherited disorders that are characterized by progressive muscle degeneration. These disorders are caused by mutations in the genes encoding structural elements within the muscle, which leads to increased vulnerabi…
View article: Automated Image Analysis Pipeline Development to Monitor Disease Progression in Muscular Dystrophy Using CellProfiler
Automated Image Analysis Pipeline Development to Monitor Disease Progression in Muscular Dystrophy Using CellProfiler Open
Muscular dystrophies are inherited disorders that are characterized by progressive muscle degeneration. These disorders are caused by mutation in the genes encoding structural elements within the muscle, which leads to increased vulnerabil…
View article: Loss of membrane integrity drives myofiber death in lipin1‐deficient skeletal muscle
Loss of membrane integrity drives myofiber death in lipin1‐deficient skeletal muscle Open
Mutations in lipin1 are suggested to be a common cause of massive rhabdomyolysis episodes in children; however, the molecular mechanisms involved in the regulation of myofiber death caused by the absence of lipin1 are not fully understood.…
View article: Lipin1 is required for skeletal muscle development by regulating MEF2c and MyoD expression
Lipin1 is required for skeletal muscle development by regulating MEF2c and MyoD expression Open
Key points Lipin1 is critical for skeletal muscle development. Lipin1 regulates MyoD and myocyte‐specific enhancer factor 2C (MEF2c) expression via the protein kinase C (PKC)/histone deacetylase 5‐mediated pathway. Inhibition of PKCμ activ…
View article: Lipin‐1 regulates Bnip3–mediated mitophagy in glycolytic muscle
Lipin‐1 regulates Bnip3–mediated mitophagy in glycolytic muscle Open
Autophagy of mitochondria (mitophagy) is essential for maintaining muscle mass and healthy skeletal muscle. Patients with heritable phosphatidic acid phosphatase lipin‐1–null mutations present with severe rhabdomyolysis and muscle atrophy …
View article: Exploring the Role of lipin1 in Mitophagy Process Using lipin1 Deficient-EGFP Tagged lC3 Transgenic Mice
Exploring the Role of lipin1 in Mitophagy Process Using lipin1 Deficient-EGFP Tagged lC3 Transgenic Mice Open
Lipin1 (phosphatidic acid phosphatase) is a key molecule in the cells with two functions: first, it converts phosphatidic acid into diacylglycerol in the cytosol which in turn makes triglycerides. Second, in nucleus lipin1 acts as a transc…