Anthony Atala
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Intravascular Adenomyosis in a Cynomolgus Macaque ( <span> <i>Macaca Fascicularis</i> </span> ) Open
Intravascular adenomyosis was discovered in a cynomolgus macaque, a previously unreported presentation of adenomyosis in non‐human primates that points to vascular involvement in adenomyosis etiology. Uterus gross exam was unremarkable, bu…
View article: A Bioengineered Skin Organoid Platform for Modeling Human Skin Physiology and Cytotoxicity
A Bioengineered Skin Organoid Platform for Modeling Human Skin Physiology and Cytotoxicity Open
Three-dimensional in vitro skin models are developed for studying skin physiology and drug toxicology. Most currently existing models are constructed through self-aggregation or layer-by-layer assembly of fibroblasts and keratinocytes only…
View article: Opposite regulation of immune genes in blood and skin highlights tissue-specific dynamics of mpox virus
Opposite regulation of immune genes in blood and skin highlights tissue-specific dynamics of mpox virus Open
Mpox re-emerged globally in 2022 with atypical clinical features and efficient human-to-human transmission, which underscores the need to better understand host immune responses. We conducted an integrative transcriptomic analysis of mpox …
Prenatal transplantation of a clinical cell product engineered to secrete FVIII in a sheep with Hemophilia A corrects the severe bleeding phenotype and prevents hemarthroses Open
Prenatal treatment (PNT) of people with hemophilia A (HA) is a feasible, safe, yet unexplored clinical approach, consisting of an ultrasound-guided injection at 18-24 gestational wks (gw) that poses minimal risk to the fetus and mother. We…
Transduction efficiency and vector biodistribution following prenatal vs neonatal AAV5 gene therapy for Hemophilia A in a sheep model Open
Hemophilia A (HA) patients treated with AAV-based gene therapy (GT) receive vector serotypes that preclinical studies indicated to be hepatotropic. However, the limited clinical biodistribution data available from the single FDA-approved A…
Recent advancements in tissue dissociation techniques for cell manufacturing single-cell analysis and downstream processing Open
Tissue dissociation into single-cell suspensions is a critical technique for cell therapy manufacturing, single-cell analysis, and downstream processing. The process is traditionally carried out via enzymatic and mechanical dissociation of…
View article: Physiological Relevant 3D Biomanufacturing of Pluripotent Stem Cells for Regenerative Medicine
Physiological Relevant 3D Biomanufacturing of Pluripotent Stem Cells for Regenerative Medicine Open
Purpose of Review Regenerative medicine is transforming modern healthcare by offering personalized approaches to the treatment of diseases and injuries. With rapid market growth and significant breakthroughs in cell and biomaterial technol…
Functional Imaging for Regenerative Medicine and Tissue-Engineered Constructs: Tracking Vascularization of Tissue-Engineered Small Intestine Scaffolds Open
Traditional approaches to tissue engineered small intestine (TESI) require implanting a construct in the omentum of the abdominal cavity to allow for vascularization of the construct and tissue maturation. A second operation is then needed…
Autologous muscle precursor cell injection into the bladder neck improves the symptoms of stress urinary incontinence in adult females Open
Background The transplantation of autologous muscle precursor cells (MPCs) is effective in the regeneration of muscle in multiple pathologies. This phase I clinical trial sought to use MPCs to treat stress urinary incontinence (UI). Method…
View article: Cross-modal predictive modeling of multi-omic data in 3D airway organ tissue equivalents during viral infection
Cross-modal predictive modeling of multi-omic data in 3D airway organ tissue equivalents during viral infection Open
Introduction Developing robust predictive models from multi-omics data is challenging because sample sizes are typically small (often fewer than 100) while the feature space is vast (over 20,000 molecular features such as genes, transcript…
View article: A Collaborative Data Sharing Platform to Accelerate Translation of Biomedical Innovations
A Collaborative Data Sharing Platform to Accelerate Translation of Biomedical Innovations Open
This perspective article presents an innovative concept for a biomanufacturing Knowledge Hub (KH), designed as a data-driven learning platform supporting the entire lifecycle of biomedical products. By integrating advanced data sharing and…
Derivation and Initial Characterization of Retinal Pigment Epithelium from Urine-Derived iPSCs Open
Age-related macular degeneration (AMD), particularly its dry form, is a leading cause of irreversible vision loss due to retinal pigment epithelium (RPE) dysfunction and loss. Addressing this unmet therapeutic need requires non-invasive st…
Stem Cell-Derived Corneal Epithelium: Engineering Barrier Function for Ocular Surface Repair Open
The cornea, the transparent anterior window of the eye, critically refracts light and protects intraocular structures. Corneal pathologies, including trauma, infection, chemical injury, metabolic diseases, genetic conditions, and age-relat…
View article: The need for an organoid manufacturing, preservation, and distribution center.
The need for an organoid manufacturing, preservation, and distribution center. Open
Organoids, which are tiny, lab-grown 3D structures that mimic some organizational and functional properties of human organs, are slowly transforming the face of systems and developmental biology, biomedical research, pharmaceutical testing…
View article: Multiple sclerosis: etiology in the context of neurovascular unit and immune system involvement and advancements with in vitro blood–brain barrier models
Multiple sclerosis: etiology in the context of neurovascular unit and immune system involvement and advancements with in vitro blood–brain barrier models Open
Multiple sclerosis affects a significant portion of the world’s adult population and is the most common nontraumatic neuroimmunology disorder. Although the specific etiology of multiple sclerosis remains unknown, it has been associated wit…
Three-Dimensional Trilineage Differentiation Conditions for Human Induced Pluripotent Stem Cells Open
Human induced pluripotent stem cells (hiPSCs) hold great potential for regenerative medicine. However, optimizing their differentiation into specific lineages within three-dimensional (3D) scaffold-based culture systems that mimic in vivo …
Differential Effects of Wheat Bran Antioxidants on the Growth Dynamics of Human Cancer Cells Open
Wheat bran, rich in phenolic compounds like ferulic acid, possesses notable antioxidant properties that may contribute to cancer treatment strategies. This study examined the effects of hydrolyzed arabinoxylan oligomers (HAOs) linked with …
View article: Body Fluid-Derived Stem Cells: Powering Innovative, Less-Invasive Cell Therapies
Body Fluid-Derived Stem Cells: Powering Innovative, Less-Invasive Cell Therapies Open
Stem cell therapy offers significant promise for tissue regeneration and repair. Traditionally, bone marrow- and adipose-derived stem cells have served as primary sources, but their clinical use is limited by invasiveness and low cell yiel…
Exploring the host response in infected lung organoids using NanoString technology: A statistical analysis of gene expression data Open
In this study, we used a three-dimensional airway “organ tissue equivalent” (OTE) model at an air-liquid interface (ALI) to mimic human airways. We investigated the effects of three viruses (Influenza A virus (IAV), Human metapneumovirus (…
Human placental stem cell–based therapies for prevention of abdominal adhesions: A prospective randomized preclinical trial Open
BACKGROUND Abdominal adhesions are networks of fibrotic tissues that form between organs postoperatively. Current prophylactic strategies do not reproducibly prevent adhesive small bowel obstruction across the entire abdomen. Human placent…
View article: Towards scarless repair: MMP-2 responsive drug releasing nanofibrous mat restores homeostasis via fibroblasts’ activation
Towards scarless repair: MMP-2 responsive drug releasing nanofibrous mat restores homeostasis via fibroblasts’ activation Open
http://dx.doi.org/10.13039/501100001809 National Natural Science Foundation of China