Toru Aoyama
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View article: Efficacy and safety of oral 5‐ <scp>FU</scp> ‐based adjuvant chemotherapy for geriatric patients with colorectal cancer: Integrated analysis of seven clinical trials conducted at the Japanese Foundation for Multidisciplinary Treatment of Cancer
Efficacy and safety of oral 5‐ <span>FU</span> ‐based adjuvant chemotherapy for geriatric patients with colorectal cancer: Integrated analysis of seven clinical trials conducted at the Japanese Foundation for Multidisciplinary Treatment of Cancer Open
Background Adjuvant chemotherapy after radical resection is recommended for patients with high‐risk Stages II and III colorectal cancer (CRC). However, the efficacy and safety of adjuvant chemotherapy in geriatric patients require elucidat…
View article: Adverse events of postoperative adjuvant chemotherapy predict survival outcomes in locally advanced colorectal cancer: a pooled analysis of Japanese clinical trials
Adverse events of postoperative adjuvant chemotherapy predict survival outcomes in locally advanced colorectal cancer: a pooled analysis of Japanese clinical trials Open
The severity of adverse events during adjuvant chemotherapy correlated with survival outcomes in advanced colorectal cancer. Mild to moderate events were linked to improved prognosis, while absence suggested poorer outcomes, indicating a n…
View article: Mapping the human epigenetic landscape across three generations: A DNA methylation resource from TMM BirThree
Mapping the human epigenetic landscape across three generations: A DNA methylation resource from TMM BirThree Open
Transgenerational epigenetic inheritance has been demonstrated in rodent models but not in humans. To address this gap, we established a comprehensive DNA methylation resource derived from 158 three-generation Japanese families. The datase…
View article: Clinical Significance of the Geriatric Nutritional Risk Index in the Evaluation of Outcomes of Patients After Radical Gastrectomy
Clinical Significance of the Geriatric Nutritional Risk Index in the Evaluation of Outcomes of Patients After Radical Gastrectomy Open
GNRI is an objective, noninvasive, and easily accessible prognostic biomarker for gastric cancer patients. Patient stratification using the GNRI and preoperative nutritional interventions may improve prognosis.
View article: Mobile and Wireless Technologies for Gastrointestinal Cancer Treatment
Mobile and Wireless Technologies for Gastrointestinal Cancer Treatment Open
Rapid technological developments and numerous mobile and wireless technologies for cancer treatment have been developed and tested for various diseases. Wearable digital therapeutics have emerged as useful tools for managing the clinical c…
View article: A multicenter randomized open-label phase 2 study investigating optimal antiemetic therapy for patients with advanced/recurrent gastric cancer treated with trastuzumab deruxtecan: the EN-hance study
A multicenter randomized open-label phase 2 study investigating optimal antiemetic therapy for patients with advanced/recurrent gastric cancer treated with trastuzumab deruxtecan: the EN-hance study Open
Background Trastuzumab deruxtecan (T-DXd) has been approved for the treatment of human epidermal growth factor receptor-2 (HER2)-positive gastric cancer and other indications in several countries and is considered moderately or highly emet…
View article: The Global Immune-Nutrition-Information Index (GINI) Is an Independent Prognostic Factor for Esophageal Cancer Patients Who Receive Curative Treatment
The Global Immune-Nutrition-Information Index (GINI) Is an Independent Prognostic Factor for Esophageal Cancer Patients Who Receive Curative Treatment Open
Background/Aim: The aim of the present study was to evaluate the clinical impact of the Global Immune-Nutrition-Information Index (GINI) in patients with esophageal cancer (EC) who received curative treatment and to clarify the potential o…
View article: The Clinical Impact of the Systemic Immune-inflammation Index in Esophageal Cancer Patients Receiving Curative Treatment
The Clinical Impact of the Systemic Immune-inflammation Index in Esophageal Cancer Patients Receiving Curative Treatment Open
The preoperative SII was an independent prognostic factor for OS and RFS in patients with EC who underwent curative resection. Thus, the SII can be a useful marker for the treatment and management of EC.
View article: Prognostic value of computed tomography‑derived skeletal muscle index and radiodensity in patients with gastric cancer after curative gastrectomy
Prognostic value of computed tomography‑derived skeletal muscle index and radiodensity in patients with gastric cancer after curative gastrectomy Open
The association of computed tomography (CT)-derived skeletal muscle index (SMI) and skeletal muscle radiodensity (SMD) with postoperative prognosis in patients with gastric cancer (GC) remains unknown. Therefore, the present study aimed to…
View article: A propensity‑matched analysis of the prognostic value of advanced lung cancer inflammation index in patients with gastric cancer after curative resection
A propensity‑matched analysis of the prognostic value of advanced lung cancer inflammation index in patients with gastric cancer after curative resection Open
The prognostic significance of inflammation, immune response and nutritional status in patients with cancer is well-documented. The advanced lung cancer inflammation index (ALI) has emerged as a novel prognostic indicator, reflecting both …
View article: Clinical Impact of Nutrition and Inflammation Assessment Tools in Colorectal Cancer Treatment
Clinical Impact of Nutrition and Inflammation Assessment Tools in Colorectal Cancer Treatment Open
For resectable colorectal cancer (CRC), the standard treatment is perioperative adjuvant treatment and complete resection. For unresectable CRC, the standard treatment is systemic chemotherapy. The detection of promising biomarkers is nece…
View article: Non-invasive intraductal oncocytic papillary neoplasm forming a protruding lesion toward the duodenum from the accessory papilla: a case report
Non-invasive intraductal oncocytic papillary neoplasm forming a protruding lesion toward the duodenum from the accessory papilla: a case report Open
Background Intraductal oncocytic papillary neoplasm (IOPN), previously classified as a subtype of intraductal papillary mucinous neoplasm (IPMN), has been described as an independent disease by the WHO since 2019. IOPN is a rare tumor, wit…
View article: Clinical Impact of the C-reactive Protein-albumin-lymphocyte Index in Post-gastrectomy Patients With Gastric Cancer
Clinical Impact of the C-reactive Protein-albumin-lymphocyte Index in Post-gastrectomy Patients With Gastric Cancer Open
Preoperative CALLY levels may be a useful prognostic predictor in patients with GC after curative gastrectomy.
View article: The Systemic Immune-inflammation Index Is an Independent Prognostic Factor for Gastric Cancer Patients Who Receive Curative Treatment
The Systemic Immune-inflammation Index Is an Independent Prognostic Factor for Gastric Cancer Patients Who Receive Curative Treatment Open
The SII was an independent prognostic factor for GC. Thus, the SII may be a promising biomarker for the treatment and management of GC.
View article: The Clinical Benefit of the Modified Neutrophil-Platelet Score as a Surrogate Prognostic Marker in Patients With Resectable Gastric Cancer
The Clinical Benefit of the Modified Neutrophil-Platelet Score as a Surrogate Prognostic Marker in Patients With Resectable Gastric Cancer Open
mNPS is a potential prognostic marker for patients with gastric cancer who underwent curative gastrectomy. Higher mNPS values were associated with lower 3- and 5-year OS and RFS rates, indicating a potential correlation between elevated mN…
View article: The Naples Prognostic Score Is an Independent Prognostic Factor for Gastric Cancer Patients Who Receive Curative Treatment
The Naples Prognostic Score Is an Independent Prognostic Factor for Gastric Cancer Patients Who Receive Curative Treatment Open
The NPS was a significant prognostic factor in patients with gastric cancer who received curative treatment. The NPS may be a promising biomarker for the treatment and management of gastric cancer.
View article: The Clinical Impact of the Pretreatment Albumin to Fibrinogen Ratio in Esophageal Cancer Patients Who Receive Curative Treatment
The Clinical Impact of the Pretreatment Albumin to Fibrinogen Ratio in Esophageal Cancer Patients Who Receive Curative Treatment Open
The AFR is a significant risk factor in patients with esophageal cancer, holding promise as a valuable prognostic factor.
View article: Effect of Preoperative Gastric Shape on Loss of Lean Body Mass After Distal Gastrectomy
Effect of Preoperative Gastric Shape on Loss of Lean Body Mass After Distal Gastrectomy Open
Gastric shape may be a useful independent predictor of postoperative LBM loss in patients with gastric cancer undergoing distal gastrectomy.
View article: Clinical Significance of Prealbumin Level Measurement Before Neoadjuvant Chemotherapy in Elderly Patients With Locally Advanced Esophageal Cancer
Clinical Significance of Prealbumin Level Measurement Before Neoadjuvant Chemotherapy in Elderly Patients With Locally Advanced Esophageal Cancer Open
In elderly patients with locally advanced ESCC, serum prealbumin level before NAC may be a useful prognostic factor and may be important in selecting a treatment strategy that considers individual organ function.
View article: Significance of Preoperative Modified Nutritional Risk Index in Patients With Gastric Cancer After Curative Resection
Significance of Preoperative Modified Nutritional Risk Index in Patients With Gastric Cancer After Curative Resection Open
Preoperative mNRI may be a useful recurrence and prognostic biomarker in patients with GC who have undergone curative resection.
View article: The clinical impacts of the prognostic nutritional index for the esophageal cancer patients who received curative treatment
The clinical impacts of the prognostic nutritional index for the esophageal cancer patients who received curative treatment Open
Background: We investigated the impact of the prognostic nutritional index (PNI) on esophageal cancer survival and recurrence after curative treatment. Methods: This study included 120 patients who underwent curative surgery followed by th…
View article: A case of esophageal cancer in a diverticulum treated by surgical resection: a case report
A case of esophageal cancer in a diverticulum treated by surgical resection: a case report Open
Background An esophageal diverticulum is a relatively rare disease, with reports of treatment for esophageal cancer in the diverticulum even rarer. Case presentation The case involved a 72-year-old male with a chief complaint of dysphagia.…
View article: P2.02-03 Association of irAEs with the Efficacy of PACIFIC Regimen in Patients with Unresectable Stage III NSCLC: WJOG11518L/SUBMARINE
P2.02-03 Association of irAEs with the Efficacy of PACIFIC Regimen in Patients with Unresectable Stage III NSCLC: WJOG11518L/SUBMARINE Open
View article: The Clinical Impact of Change in the Neutrophil to Lymphocyte Ratio During the Perioperative Period in Gastric Cancer Patients Who Receive Curative Gastrectomy
The Clinical Impact of Change in the Neutrophil to Lymphocyte Ratio During the Perioperative Period in Gastric Cancer Patients Who Receive Curative Gastrectomy Open
Aim Recently, change in the neutrophil to lymphocyte ratio (cNLR) has been shown to be a promising prognostic inflammation marker in some malignancies. The aim of the present study was to evaluate the clinical impact of the cNLR in gastric…
View article: The Clinical Impact of Change in the C-Reactive Protein/Albumin Ratio in Gastric Cancer Patients Who Receive Curative Treatment
The Clinical Impact of Change in the C-Reactive Protein/Albumin Ratio in Gastric Cancer Patients Who Receive Curative Treatment Open
Background Recently, change in the C-reactive protein/albumin ratio (CAR) has become a promising prognostic marker in some malignancies. The aim of the present study was to evaluate the clinical impact of change in the CAR in gastric cance…
View article: Long‐term treatment outcomes in gastric cancer with oligometastasis
Long‐term treatment outcomes in gastric cancer with oligometastasis Open
Aim While surgery is essential for curative treatment of gastric cancer with oligometastasis, its target, timing, and possibility of combination with other treatments are unclear. We herein investigated the clinical course and long‐term ou…
View article: The clinical impact of change in the neutrophil to lymphocyte ratio during the perioperative period in gastric cancer patients who receive curative treatment
The clinical impact of change in the neutrophil to lymphocyte ratio during the perioperative period in gastric cancer patients who receive curative treatment Open
Aim Recently, change in the neutrophil to lymphocyte ratio (cNLR) has been shown to be a promising prognostic marker in some malignancies. The aim of the present study was to evaluate the clinical impact of the cNLR in gastric cancer patie…
View article: Feasibility and Safety of Adjuvant Chemotherapy for Resected Colorectal Cancer in Patients With Renal Insufficiency: A Pooled Analysis of Individual Patient Data from Five Japanese Large-scale Clinical Trials
Feasibility and Safety of Adjuvant Chemotherapy for Resected Colorectal Cancer in Patients With Renal Insufficiency: A Pooled Analysis of Individual Patient Data from Five Japanese Large-scale Clinical Trials Open
Adverse events of adjuvant chemotherapy in patients with resected colorectal cancer were associated with renal insufficiencies. Since adverse events have the potential to shorten the duration of treatment, especially when using chemotherap…
View article: Clinical Effect of the C-Reactive Protein to Serum Albumin Ratio in Patients with Metastatic Gastric or Gastroesophageal Junction Cancer Treated with Trifluridine/Tipiracil
Clinical Effect of the C-Reactive Protein to Serum Albumin Ratio in Patients with Metastatic Gastric or Gastroesophageal Junction Cancer Treated with Trifluridine/Tipiracil Open
Trifluridine/tipiracil (FTD/TPI) is an oral anticancer agent used as a third- or later-line treatment for patients with metastatic gastric cancer/gastroesophageal junction cancer (mGC/GEJC). The C-reactive protein-to-serum albumin ratio (C…
View article: The clinical impacts of postoperative complications after colon cancer surgery for the clinical course of adjuvant treatment and survival
The clinical impacts of postoperative complications after colon cancer surgery for the clinical course of adjuvant treatment and survival Open
Aim We investigated whether or not postoperative complications (POCs) themselves have a negative survival impact or indirectly worsen the survival due to insufficient adjuvant chemotherapy in a pooled analysis of two large phase III studie…