Ashutosh Tewari
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View article: Predicting and correcting the influence of boundary conditions in regional inverse analyses
Predicting and correcting the influence of boundary conditions in regional inverse analyses Open
Regional inverse analyses of atmospheric trace gas observations quantify gridded two-dimensional surface fluxes by fitting the observations to simulated concentrations from a transport model, usually by Bayesian optimization regularized by…
View article: Effect of TGF-β mediated phenotypic changes on prostate cancer cell anoikis response
Effect of TGF-β mediated phenotypic changes on prostate cancer cell anoikis response Open
Epithelial mesenchymal transition (EMT) circumvents anoikis (cell death upon detachment from extracellular matrix) to promote prostate metastasis and therapy resistance. In this study, we investigated how TGF-β regulated EMT-MET (mesenchym…
View article: Y-chromosome alteration and its impact on cancer progression and metastasis
Y-chromosome alteration and its impact on cancer progression and metastasis Open
The human Y chromosome (ChrY), which confers male sex determination, contains a relatively small number of protein-coding genes compared to other chromosomes; consequently, its functional impact on adult physiology was once severely unappr…
View article: Diagnostic Value of Micro‐Ultrasound in Identifying Local Recurrence After Radical Prostatectomy
Diagnostic Value of Micro‐Ultrasound in Identifying Local Recurrence After Radical Prostatectomy Open
Purpose The limited resolution of standard transrectal ultrasound (TRUS) has made it difficult to perform biopsies of the prostate bed in cases of suspected local recurrence following radical prostatectomy. The aim of this study was to ben…
View article: Prostate cancer in situ autovaccination with the intratumoral viral mimic poly-ICLC: Modulating the cold tumor microenvironment
Prostate cancer in situ autovaccination with the intratumoral viral mimic poly-ICLC: Modulating the cold tumor microenvironment Open
This work was funded by the Arthur M. Blank Family Foundation.
View article: Circadian rhythm-related miR-6883-5p suppresses enzalutamide-resistant prostate cancer
Circadian rhythm-related miR-6883-5p suppresses enzalutamide-resistant prostate cancer Open
View article: Histologic Transformation in Cancer: The Path for Clinical Translation
Histologic Transformation in Cancer: The Path for Clinical Translation Open
Lineage plasticity, a critical hallmark of cancer progression, enables tumor cells to evade inhibition of primary oncogenic pathways through histologic transformation. This adaptive process, driven by stemness-associated features and epige…
View article: To Compare the Effectiveness of Manual Traction and Mechanical Traction in Patient with Cervicogenic Headache
To Compare the Effectiveness of Manual Traction and Mechanical Traction in Patient with Cervicogenic Headache Open
Context: - Cervicogenic headache (CGH) is a secondary headache arising from cervical spine dysfunction. Both manual traction (MT) and mechanical traction are widely used physiotherapeutic modalities for the management of CGH. Aims: - To co…
View article: Supplementary material to "Predicting and correcting the influence of boundary conditions in regional inverse analyses"
Supplementary material to "Predicting and correcting the influence of boundary conditions in regional inverse analyses" Open
View article: Predicting and correcting the influence of boundary conditions in regional inverse analyses
Predicting and correcting the influence of boundary conditions in regional inverse analyses Open
Regional inverse analyses of atmospheric trace gas observations quantify gridded two-dimensional surface fluxes by fitting the observations to simulated concentrations from a chemical transport model (CTM), usually by Bayesian optimization…
View article: Artificial Intelligence–Based Digital Histologic Classifier for Prostate Cancer Risk Stratification: Independent Blinded Validation in Patients Treated With Radical Prostatectomy
Artificial Intelligence–Based Digital Histologic Classifier for Prostate Cancer Risk Stratification: Independent Blinded Validation in Patients Treated With Radical Prostatectomy Open
PURPOSE Artificial intelligence (AI) tools that identify pathologic features from digitized whole-slide images (WSIs) of prostate cancer (CaP) generate data to predict outcomes. The objective of this study was to evaluate the clinical vali…
View article: BCL2 drives castration resistance in castration-sensitive prostate cancer by orchestrating reciprocal crosstalk between oncogenic pathways
BCL2 drives castration resistance in castration-sensitive prostate cancer by orchestrating reciprocal crosstalk between oncogenic pathways Open
View article: HAR70+W: Integrating Thigh-Back and Wrist Sensor Data for Enhanced Elderly Activity Monitoring
HAR70+W: Integrating Thigh-Back and Wrist Sensor Data for Enhanced Elderly Activity Monitoring Open
Human Activity Recognition (HAR) systems for elderly mon- itoring often rely on single-sensor datasets, limiting their ability to cap- ture full-body movement patterns critical for detecting functional de- cline. While datasets like HAR70+…
View article: Association between DNA damage repair alterations and outcomes to 177Lu-PSMA-617 in advanced prostate cancer
Association between DNA damage repair alterations and outcomes to 177Lu-PSMA-617 in advanced prostate cancer Open
View article: Multiphoton Microscopy: A Feasability Study to Explore the Potential Intraoperative Tool for TURBT Diagnosis
Multiphoton Microscopy: A Feasability Study to Explore the Potential Intraoperative Tool for TURBT Diagnosis Open
Background: Multiphoton microscopy (MPM) is a nonlinear optical imaging technology, allowing process-free imaging of fresh tissue up to a depth of 0.5 mm, with a combined signal of autofluorescence and second harmonic generation. The absen…
View article: Data from Upgrading of Grade Group 1 Prostate Cancer at Prostatectomy: Germline Risk Factors in a Prospective Cohort
Data from Upgrading of Grade Group 1 Prostate Cancer at Prostatectomy: Germline Risk Factors in a Prospective Cohort Open
Background:Localized prostate tumors show significant spatial heterogeneity, with regions of high-grade disease adjacent to lower grade disease. Consequently, prostate cancer biopsies are prone to sampling bias, potentially leading to unde…
View article: Supplementary Figure 3 from Upgrading of Grade Group 1 Prostate Cancer at Prostatectomy: Germline Risk Factors in a Prospective Cohort
Supplementary Figure 3 from Upgrading of Grade Group 1 Prostate Cancer at Prostatectomy: Germline Risk Factors in a Prospective Cohort Open
Supplementary Figure 3 displays supplementary information on ancestry calling, genetically adjusted PSA Density, and polygenic risk scoring.
View article: Supplementary Figure 1 from Upgrading of Grade Group 1 Prostate Cancer at Prostatectomy: Germline Risk Factors in a Prospective Cohort
Supplementary Figure 1 from Upgrading of Grade Group 1 Prostate Cancer at Prostatectomy: Germline Risk Factors in a Prospective Cohort Open
Supplementary Figure 1 displays sequencing, variant capture, and imputation quality control metrics.
View article: Supplementary Table 2 from Upgrading of Grade Group 1 Prostate Cancer at Prostatectomy: Germline Risk Factors in a Prospective Cohort
Supplementary Table 2 from Upgrading of Grade Group 1 Prostate Cancer at Prostatectomy: Germline Risk Factors in a Prospective Cohort Open
Supplementary Table 2 reports demographic, clinical, and genetic summaries of the genetic analysis cohort.
View article: Supplementary Table 1 from Upgrading of Grade Group 1 Prostate Cancer at Prostatectomy: Germline Risk Factors in a Prospective Cohort
Supplementary Table 1 from Upgrading of Grade Group 1 Prostate Cancer at Prostatectomy: Germline Risk Factors in a Prospective Cohort Open
Supplementary Table 1 reports results of logistic regression with two clinical predictors of upgrading.
View article: Supplementary Table 4 from Upgrading of Grade Group 1 Prostate Cancer at Prostatectomy: Germline Risk Factors in a Prospective Cohort
Supplementary Table 4 from Upgrading of Grade Group 1 Prostate Cancer at Prostatectomy: Germline Risk Factors in a Prospective Cohort Open
Supplementary Table 4 reports results of DDR pathogenic variant carrier rate t-test analyses.
View article: Supplementary Table 5 from Upgrading of Grade Group 1 Prostate Cancer at Prostatectomy: Germline Risk Factors in a Prospective Cohort
Supplementary Table 5 from Upgrading of Grade Group 1 Prostate Cancer at Prostatectomy: Germline Risk Factors in a Prospective Cohort Open
Supplementary Table 5 reports results of genetic risk of upgrading score validation in the Upgrading Reference Set.
View article: Supplementary Table 3 from Upgrading of Grade Group 1 Prostate Cancer at Prostatectomy: Germline Risk Factors in a Prospective Cohort
Supplementary Table 3 from Upgrading of Grade Group 1 Prostate Cancer at Prostatectomy: Germline Risk Factors in a Prospective Cohort Open
Supplementary Table 3 reports per-sample genetic feature information in the genetic analysis cohort.
View article: Supplementary Figure 2 from Upgrading of Grade Group 1 Prostate Cancer at Prostatectomy: Germline Risk Factors in a Prospective Cohort
Supplementary Figure 2 from Upgrading of Grade Group 1 Prostate Cancer at Prostatectomy: Germline Risk Factors in a Prospective Cohort Open
Supplementary Figure 2 displays odds ratios and 95% confidence internals of significant predictors of upgrading in multivariable regression.
View article: Supplementary Figure 4 from Upgrading of Grade Group 1 Prostate Cancer at Prostatectomy: Germline Risk Factors in a Prospective Cohort
Supplementary Figure 4 from Upgrading of Grade Group 1 Prostate Cancer at Prostatectomy: Germline Risk Factors in a Prospective Cohort Open
Supplementary Figure 4 compares carrier rates of pathogenic variants in DDR genes between the study cohort and an external cohort.
View article: Upgrading of Grade Group 1 Prostate Cancer at Prostatectomy: Germline Risk Factors in a Prospective Cohort
Upgrading of Grade Group 1 Prostate Cancer at Prostatectomy: Germline Risk Factors in a Prospective Cohort Open
Background: Localized prostate tumors show significant spatial heterogeneity, with regions of high-grade disease adjacent to lower grade disease. Consequently, prostate cancer biopsies are prone to sampling bias, potentially leading to und…
View article: Extracellular vesicles carry transcriptional ‘<i>dark matter</i>’ revealing tissue‐specific information
Extracellular vesicles carry transcriptional ‘<i>dark matter</i>’ revealing tissue‐specific information Open
From eukaryotes to prokaryotes, all cells secrete extracellular vesicles (EVs) as part of their regular homeostasis, intercellular communication, and cargo disposal. Accumulating evidence suggests that small EVs carry functional small RNAs…
View article: CD8 <sup>+</sup> T cell targeting of tumor antigens presented by HLA-E
CD8 <sup>+</sup> T cell targeting of tumor antigens presented by HLA-E Open
The nonpolymorphic major histocompatibility complex E (MHC-E) molecule is up-regulated on many cancer cells, thus contributing to immune evasion by engaging inhibitory NKG2A/CD94 receptors on NK cells and tumor-infiltrating T cells. To inv…
View article: Link between circadian rhythm and benign prostatic hyperplasia (BPH)/lower urinary tract symptoms (LUTS)
Link between circadian rhythm and benign prostatic hyperplasia (BPH)/lower urinary tract symptoms (LUTS) Open
Background Benign prostatic hyperplasia (BPH) is the most common urologic disease in aging males, affecting 50% of men over 50 and up to 80% of men over 80 years old. Its negative impact on health‐related quality of life implores further i…
View article: Validation of a Zero-Shot Learning Natural Language Processing Tool for Data Abstraction from Unstructured Healthcare Data
Validation of a Zero-Shot Learning Natural Language Processing Tool for Data Abstraction from Unstructured Healthcare Data Open
Objectives: To describe the development and validation of a zero-shot learning natural language processing (NLP) tool for abstracting data from unstructured text contained within PDF documents, such as those found within electronic health …