Arun B. Taly
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View article: Chronic Granulomatous Herpes Simplex Encephalitis: An Unusual Manifestation of an Enduring Viral Infection
Chronic Granulomatous Herpes Simplex Encephalitis: An Unusual Manifestation of an Enduring Viral Infection Open
Chronic granulomatous herpes simplex encephalitis (CGHSVE) is a rare viral encephalitis phenotype that occurs due to granulomatous inflammation in the brain, mounted in response to persisting herpes virus antigens. Our case is that of a yo…
View article: Clinicopathological Features of Amyloid Neuropathy: A Four Decade Experience
Clinicopathological Features of Amyloid Neuropathy: A Four Decade Experience Open
Background: Peripheral neuropathy is one of the manifestations of primary or familial amyloidosis. Published studies from India are limited. Materials and Methods: We reviewed the clinical and pathological features of amyloid neuropathy di…
View article: Sexual dysfunction and sexual concerns among persons with disability due to myelopathy: A cross-sectional study
Sexual dysfunction and sexual concerns among persons with disability due to myelopathy: A cross-sectional study Open
Objectives: We have very little information about sexual activity and concerns of patients with myelopathy from India. The objectives of this study were to assess the sexual dysfunction and sexual concerns among patients with myelopathy du…
View article: Sexual Dysfunction and Sexual Concerns among Persons with Disability Due to Myelopathy: A Cross-Sectional Study
Sexual Dysfunction and Sexual Concerns among Persons with Disability Due to Myelopathy: A Cross-Sectional Study Open
Background We have very little information about sexual activity and concerns of patients with myelopathy from India. Objectives This article assesses the sexual dysfunction and sexual concerns among patients with myelopathy due to spinal …
View article: Leukodystrophy Due to <i>eIF2B</i> Mutations in Adults
Leukodystrophy Due to <i>eIF2B</i> Mutations in Adults Open
Vanishing white matter disease (VWMD) due to eIF2B mutations is a common leukodystrophy characterised by childhood onset, autosomal recessive inheritance, and progressive clinical course with episodic worsening. There are no reports of gen…
View article: Whole exome sequencing reveals a homozygous C1QBP deletion as the cause of progressive external ophthalmoplegia and multiple mtDNA deletions
Whole exome sequencing reveals a homozygous C1QBP deletion as the cause of progressive external ophthalmoplegia and multiple mtDNA deletions Open
Whole exome sequencing (WES), analyzed with GENESIS and WeGET, revealed a homozygous deletion in the C1QBP gene in a patient with progressive external ophthalmoplegia (PEO) and multiple mtDNA deletions. The gene encodes the mitochondria-lo…
View article: Child Neurology: Hereditary Folate Malabsorption
Child Neurology: Hereditary Folate Malabsorption Open
Hereditary folate malabsorption (HFM, congenital folate malabsorption; OMIM#229050) is a rare, potentially treatable autosomal recessive disorder with multisystem involvement.1 It is caused by homozygous or compound heterozygous mutations …
View article: Clinical Profile and Treatment Response in Patients with CASPR2 Antibody-Associated Neurological Disease
Clinical Profile and Treatment Response in Patients with CASPR2 Antibody-Associated Neurological Disease Open
Background: The clinical spectrum of contactin-associated protein-like 2 (CASPR2) antibody-associated disease is wide and includes Morvan syndrome. Studies describing treatment and long-term outcome are limited. Aims: We report the clinica…
View article: Spectrum and Evolution of EEG Changes in Anti-NMDAR Encephalitis
Spectrum and Evolution of EEG Changes in Anti-NMDAR Encephalitis Open
Background: NMDA receptor encephalitis (NMDARE) is the most prevalent autoimmune encephalitis and it encompasses a spectrum of clinical features. It is most commonly associated with alteration in consciousness, seizures, neuro-psychiatric …
View article: Case Report: Chronic Fungal Meningitis Masquerading as Tubercular Meningitis
Case Report: Chronic Fungal Meningitis Masquerading as Tubercular Meningitis Open
Phaeohyphomycosis causes a wide spectrum of systemic manifestations and can affect even the immunocompetent hosts. Involvement of the central nervous system is rare. A 48-year-old farmer presented with chronic headache, fever, and impaired…
View article: Vogt-Koyanagi-Harada Syndrome - A Neurologist's Perspective
Vogt-Koyanagi-Harada Syndrome - A Neurologist's Perspective Open
Vogt-Koyanagi-Harada (VKH) syndrome is an immune-mediated granulomatous disease which affects melanin-rich organs like eyes, skin, nervous system, and ears. Neurological and auditory manifestations usually precede the involvement of other …
View article: Child Neurology: Ethylmalonic encephalopathy
Child Neurology: Ethylmalonic encephalopathy Open
Ethylmalonic encephalopathy (EE; OMIM #602473) is an autosomal recessive disorder characterized by (1) progressive neurologic impairment, including global developmental delay with periods of regression during illness, progressive pyramidal…
View article: Genetic analysis of ATP7B in 102 south Indian families with Wilson disease
Genetic analysis of ATP7B in 102 south Indian families with Wilson disease Open
Wilson disease (WD) is an autosomal recessive disorder, characterized by excessive deposition of copper in various parts of the body, mainly in the liver and brain. It is caused by mutations in ATP7B. We report here the genetic analysis of…
View article: Clinical Reasoning: West syndrome, pontocerebellar hypoplasia, and hypomyelination in a 6-month-old boy
Clinical Reasoning: West syndrome, pontocerebellar hypoplasia, and hypomyelination in a 6-month-old boy Open
A 6-month-old boy born to nonconsanguineous parents presented with intractable seizures from the fourth month of age. Oligohydramnios was detected in the last trimester of pregnancy. He was born at term by normal delivery (birthweight 2.9 …
View article: Urinary symptoms in patients with Parkinson's disease and progressive supranuclear palsy: Urodynamic findings and management of bladder dysfunction
Urinary symptoms in patients with Parkinson's disease and progressive supranuclear palsy: Urodynamic findings and management of bladder dysfunction Open
Patients with PD/PSP are known to develop urinary symptoms during illness. Clinical complaints and UDS findings do not necessarily match. UDS is required to manage urinary symptoms. Most of the patients respond to oral antimuscarinic medic…
View article: Author Response: Penetrance of the LHON Mutation m.11778G>A May Depend on Factors Other Than Haplotype or Heteroplasmy Rate
Author Response: Penetrance of the LHON Mutation m.11778G>A May Depend on Factors Other Than Haplotype or Heteroplasmy Rate Open
We appreciate the effort shown by the authors and their comments on our article ‘‘Leber’s Hereditary Optic Neuropathy-Specific Mutation m.11778G>A Exists on Diverse Mitochondrial Haplogroups in India.’’ Leber’s hereditary optic neuropathy …
View article: Palatal Tremor Revisited: Disorder with Nosological Diversity and Etiological Heterogeneity
Palatal Tremor Revisited: Disorder with Nosological Diversity and Etiological Heterogeneity Open
This case series aimed to describe clinicoradiological, electromyographic, and etiological spectra in palatal tremor (essential=1; symptomatic=26). Patients with symptomatic palatal tremor had 2 to 10 Hz arrhythmic electromyographic bursts…
View article: Leber's Hereditary Optic Neuropathy–Specific Mutation m.11778G>A Exists on Diverse Mitochondrial Haplogroups in India
Leber's Hereditary Optic Neuropathy–Specific Mutation m.11778G>A Exists on Diverse Mitochondrial Haplogroups in India Open
The first detailed study of Indian LHON patients confirm that the m.11778G>A-related LHON in India coexists with multiple different mtDNA haplogroups, unlike the preferential association of west Eurasian haplogroup J and the reported incre…
View article: Pulmonary Involvement in Patients with Guillain–Barré Syndrome in Subacute Phase
Pulmonary Involvement in Patients with Guillain–Barré Syndrome in Subacute Phase Open
Objectives: To evaluate the pulmonary function in Guillain�Barre syndrome (GBS) patients in subacute phase and find clinical correlates of pulmonary dysfunction. Methods: This was a single-center, prospective, cross-sectional, hospital-bas…
View article: Cognitive and Functional Outcomes following Inpatient Rehabilitation in Patients with Acquired Brain Injury: A Prospective Follow-up Study
Cognitive and Functional Outcomes following Inpatient Rehabilitation in Patients with Acquired Brain Injury: A Prospective Follow-up Study Open
Objectives: To study the effects of cognitive retraining and inpatient rehabilitation to study the effects of cognitive retraining and inpatient rehabilitation in patients with acquired brain injury (ABI). Design and Setting: This was a pr…
View article: Guillain–Barre Syndrome in Postpartum Period: Rehabilitation Issues and Outcome – Three Case Reports
Guillain–Barre Syndrome in Postpartum Period: Rehabilitation Issues and Outcome – Three Case Reports Open
We report three females who developed Guillain–Barre Syndrome in postpartum period (within 6 weeks of delivery) and were admitted in the Neurological Rehabilitation Department for rehabilitation after the initial diagnosis and treatment in…
View article: Complications in mechanically ventilated patients of Guillain–Barre syndrome and their prognostic value
Complications in mechanically ventilated patients of Guillain–Barre syndrome and their prognostic value Open
Introduction: The spectrum of various complications in critically ill Guillain–Barre syndrome (GBS) and its effect on the prognosis is lacking in literature. This study aimed at enumerating the complications in such a cohort and their sign…
View article: Urodynamic profile in acute transverse myelitis patients: Its correlation with neurological outcome
Urodynamic profile in acute transverse myelitis patients: Its correlation with neurological outcome Open
Objective: The objective of this study was to observe urodynamic profile of acute transverse myelitis (ATM) patients and its correlation with neurological outcome. Patients and Methods: This prospective study was conducted in the neuroreha…
View article: Genetic Analysis of PLA2G6 in 22 Indian Families with Infantile Neuroaxonal Dystrophy, Atypical Late-Onset Neuroaxonal Dystrophy and Dystonia Parkinsonism Complex
Genetic Analysis of PLA2G6 in 22 Indian Families with Infantile Neuroaxonal Dystrophy, Atypical Late-Onset Neuroaxonal Dystrophy and Dystonia Parkinsonism Complex Open
Mutations in PLA2G6 were identified in patients with a spectrum of neurodegenerative conditions, such as infantile neuroaxonal dystrophy (INAD), atypical late-onset neuroaxonal dystrophy (ANAD) and dystonia parkinsonism complex (DPC). Howe…
View article: Role of ankle foot orthosis in improving locomotion and functional recovery in patients with stroke: A prospective rehabilitation study
Role of ankle foot orthosis in improving locomotion and functional recovery in patients with stroke: A prospective rehabilitation study Open
Objective: To study role of ankle foot orthosis (AFO) in improving locomotion and functional recovery after stroke. Setting: Neurological Rehabilitation Department of a university research tertiary hospital. Patients and Methods: AFO and a…