Helena Bäckman
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View article: Gestational age amplifies the risk of airflow obstruction in adult smokers with asthma
Gestational age amplifies the risk of airflow obstruction in adult smokers with asthma Open
View article: Asthma Remission in Adults: Role of Age at Asthma Onset, Smoking, Obesity, and Allergic Rhinitis
Asthma Remission in Adults: Role of Age at Asthma Onset, Smoking, Obesity, and Allergic Rhinitis Open
View article: Unsupervised Machine Learning Identifies Asthma Phenotypes in the Population‐Based West Sweden Asthma Study
Unsupervised Machine Learning Identifies Asthma Phenotypes in the Population‐Based West Sweden Asthma Study Open
View article: Childhood body size and risk of chronic obstructive pulmonary disease in adulthood: a prospective cohort study
Childhood body size and risk of chronic obstructive pulmonary disease in adulthood: a prospective cohort study Open
We found that a BMI trajectory above average throughout childhood was positively associated with COPD in adulthood. Thus, our results suggest that having overweight or obesity during this early period of life is an indicator of risk for th…
View article: Obesity and weight change during eight years in relation to asthma incidence
Obesity and weight change during eight years in relation to asthma incidence Open
View article: Reference Values and Determinants of Fractional Exhaled Nitric Oxide in a Representative Adult Population in Western Sweden
Reference Values and Determinants of Fractional Exhaled Nitric Oxide in a Representative Adult Population in Western Sweden Open
Background Fractional exhaled nitric oxide (FE NO ) is used to differentiate asthma inflammatory phenotypes and guide its management. However, data on FE NO reference values in a representative adult population is limited. We aim to derive…
View article: Late‐Onset Asthma Phenotypes by Onset Age: A Cluster Analysis in Swedish Population‐Based Cohorts
Late‐Onset Asthma Phenotypes by Onset Age: A Cluster Analysis in Swedish Population‐Based Cohorts Open
View article: Characteristics of Adult Asthma Based on Type 2 Inflammation Markers: A Population-Based Study
Characteristics of Adult Asthma Based on Type 2 Inflammation Markers: A Population-Based Study Open
View article: Exposure to vehicle traffic in childhood and lung function in young adulthood—a prospective cohort study in an area with low traffic-flows
Exposure to vehicle traffic in childhood and lung function in young adulthood—a prospective cohort study in an area with low traffic-flows Open
View article: Worsening asthma at school is associated with poor psychosocial well-being
Worsening asthma at school is associated with poor psychosocial well-being Open
Worsening asthma at school was associated with lower generic health-related quality of life, higher asthma-related worry and impact on daily activities among teenagers with asthma.
View article: Risk of exacerbations, hospitalisation, and mortality in adults with physician-diagnosed chronic obstructive pulmonary disease with normal spirometry and adults with preserved ratio impaired spirometry in Sweden: retrospective analysis of data from a nationwide cohort study
Risk of exacerbations, hospitalisation, and mortality in adults with physician-diagnosed chronic obstructive pulmonary disease with normal spirometry and adults with preserved ratio impaired spirometry in Sweden: retrospective analysis of data from a nationwide cohort study Open
View article: Late-onset asthma phenotypes by age of onset: a cluster analysis in Swedish population-based cohorts
Late-onset asthma phenotypes by age of onset: a cluster analysis in Swedish population-based cohorts Open
View article: DNA methylation changes in infants of mothers with SARS-CoV-2 infection during pregnancy
DNA methylation changes in infants of mothers with SARS-CoV-2 infection during pregnancy Open
Summary Maternal environmental exposures, including viral infections, can exert intergenerational effects on the offspring’s epigenome. Herein, based on the Swedish COVID-19 during Pregnancy and Early childhood study (COPE), we explored ho…
View article: Airflow obstruction among young adults in Europe: a Chronic Airway Diseases Early Stratification (CADSET) collaboration with 48 612 individuals across eight population-based cohorts
Airflow obstruction among young adults in Europe: a Chronic Airway Diseases Early Stratification (CADSET) collaboration with 48 612 individuals across eight population-based cohorts Open
Background The extent to which airflow obstruction, a key feature of COPD, can be already present in early adulthood is unclear. We investigated the prevalence of airflow obstruction in young adults across European populations. Methods We …
View article: Glimpses of diagnostic tools and treatment of asthma in Sweden, Norway, and Finland from a medico-historical perspective
Glimpses of diagnostic tools and treatment of asthma in Sweden, Norway, and Finland from a medico-historical perspective Open
During the last decades, there has been an accelerating development of diagnostic and treatment possibilities. This paper aims to remind readers of significant milestones in the medical history of asthma. In the early 1800s, important tool…
View article: Pharmacological pain relief and women´s birth experience: a systematic review
Pharmacological pain relief and women´s birth experience: a systematic review Open
Background There is increasing interest in health care systems worldwide for maternal satisfaction with childbirth experience. The World Health Organisation (WHO) launched a recommendation 2018 regarding women’s right to equal and fair int…
View article: All-cause and cause-specific mortality in respiratory symptom clusters: a population-based multicohort study
All-cause and cause-specific mortality in respiratory symptom clusters: a population-based multicohort study Open
Background Respiratory symptoms are common in the general adult population. Increased burden of respiratory symptoms may increase the risk of mortality. We assessed the association between respiratory symptom clusters and mortality. Method…
View article: Clinical Implications of the New Criteria for a Positive Bronchodilator Response in Children With Asthma
Clinical Implications of the New Criteria for a Positive Bronchodilator Response in Children With Asthma Open
View article: Importance of Preserved Ratio Impaired Spirometry as a Risk Factor for Development of COPD, Also in Those Who Do Not Smoke
Importance of Preserved Ratio Impaired Spirometry as a Risk Factor for Development of COPD, Also in Those Who Do Not Smoke Open
In this study, PRISm was associated with transition into AO corresponding to COPD within 1 decade, independent of smoking habits and with similar strength of association among those who have never smoked, who formerly smoked, and who curre…
View article: Blood eosinophil reference values and determinants in a representative adult population
Blood eosinophil reference values and determinants in a representative adult population Open
View article: Preserved ratio impaired spirometry, dysanapsis and airflow obstruction with low forced expiratory volume in 1 s in childhood asthma
Preserved ratio impaired spirometry, dysanapsis and airflow obstruction with low forced expiratory volume in 1 s in childhood asthma Open
Background Airway obstruction is a characteristic spirometric finding in asthma but the clinical significance of other abnormal spirometric patterns is less well described. We aimed to explore pre- and post-bronchodilator (BD) prevalences …
View article: Computational Phenotyping of Obstructive Airway Diseases: A Systematic Review
Computational Phenotyping of Obstructive Airway Diseases: A Systematic Review Open
Variations in phenotyping methods, study settings, participant profiles, and variables contribute to significant differences in characterizing asthma, severe asthma, COPD, ACO, and rhinitis phenotypes across studies. Lack of reproducibilit…
View article: Obesity and Weight Change in Relation to Asthma Incidence: An 8-Year Longitudinal Study
Obesity and Weight Change in Relation to Asthma Incidence: An 8-Year Longitudinal Study Open
View article: Childhood Body Size and Risk of Chronic Obstructive Pulmonary Disease in Adulthood: A Prospective Cohort Study
Childhood Body Size and Risk of Chronic Obstructive Pulmonary Disease in Adulthood: A Prospective Cohort Study Open
View article: Cardiac troponin and increased mortality risk among individuals with restrictive spirometric pattern on lung function testing
Cardiac troponin and increased mortality risk among individuals with restrictive spirometric pattern on lung function testing Open
Cardiac troponin was elevated more often in people with a restrictive spirometric pattern in whom it was a strong independent predictor of death.
View article: Lifetime asthma incidence is related to age at onset and allergies in western Sweden
Lifetime asthma incidence is related to age at onset and allergies in western Sweden Open
Although asthma is more frequently diagnosed in childhood, a substantial proportion of cases manifests in adulthood. Nonetheless, few studies have comprehensively examined asthma incidence across different ages, genders, and asthma phenoty…
View article: Obesity predicts mortality stronger in adult‐onset asthma than in age‐ and sex‐matched controls
Obesity predicts mortality stronger in adult‐onset asthma than in age‐ and sex‐matched controls Open
View article: Reference values and determinants of fractional exhaled nitric oxide in a representative adult population in Western Sweden
Reference values and determinants of fractional exhaled nitric oxide in a representative adult population in Western Sweden Open
Background Fractional exhaled nitric oxide (FeNO) is used to differentiate asthma inflammatory phenotypes and guide its management. However, data on FeNO reference values in a representative adult population is limited. Objective To derive…
View article: Blood Eosinophil Reference Values and Determinants in a Representative Adult Population
Blood Eosinophil Reference Values and Determinants in a Representative Adult Population Open
Background The use of blood eosinophil count (BEC) as a prognostic biomarker in the management of conditions such as asthma and chronic obstructive pulmonary disease (COPD) may be complicated by factors like atopy, age, sex, smoking, and c…
View article: Inflammatory and cardiovascular markers in placenta following SARS-CoV-2 infection during pregnancy: A Swedish prospective cohort study
Inflammatory and cardiovascular markers in placenta following SARS-CoV-2 infection during pregnancy: A Swedish prospective cohort study Open
Women with SARS-CoV-2 infection during pregnancy without clinical signs of placental insufficiency have no changes in inflammatory or cardiovascular protein patterns in placenta at time of birth regardless of the timing of the infection.