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View article: Spinal Cord Leptomeningeal Enhancement as a Marker of Extensive Spinal Cord Involvement in Children With MOGAD
Spinal Cord Leptomeningeal Enhancement as a Marker of Extensive Spinal Cord Involvement in Children With MOGAD Open
The presence of spinal cord LME is associated with more extensive spinal cord abnormalities on MRI in children with MOGAD and to a lesser extent in those with seronegative myelitis. The biological underpinnings of this finding and its clin…
View article: Long-term safety and efficacy of ozanimod in relapsing multiple sclerosis: Final analysis of the DAYBREAK open-label extension trial
Long-term safety and efficacy of ozanimod in relapsing multiple sclerosis: Final analysis of the DAYBREAK open-label extension trial Open
Background: Ozanimod, a selective, oral sphingosine 1-phosphate receptor 1 and 5 modulator, is approved in multiple countries for adults with relapsing forms of multiple sclerosis (RMS). Objective: To characterize the long-term safety and …
View article: Representing immune profiles with self-supervised set representation learning 4557
Representing immune profiles with self-supervised set representation learning 4557 Open
Description The immune system is a complex network of cells, orchestrating coordinated responses throughout the human body over a person’s lifetime. Cytometry enables profiling of this network, but current analytical approaches focus on en…
View article: cyMAEv2: learning robust cell representations in mass cytometry without supervision 4582
cyMAEv2: learning robust cell representations in mass cytometry without supervision 4582 Open
Description Batch effects in cytometry lead to inconsistent protein expression measurements and prevent researchers from integrating data from the most well-controlled studies. To address these challenges, we present cyMAEv2, an enhanced s…
View article: Clinical validation of a novel in vitro diagnostic neurofilament light chain assay for the prognostication of disease activity in people with relapsing multiple sclerosis
Clinical validation of a novel in vitro diagnostic neurofilament light chain assay for the prognostication of disease activity in people with relapsing multiple sclerosis Open
Background: Neurofilament light chain (NfL) is a promising marker for predicting disease activity in relapsing multiple sclerosis (RMS). To date, however, there has been no commercially available NfL assay validated in MS and intended for …
View article: 3549 Continuous ofatumumab treatment up to 7 years shows a consistent safety profile and delays disability progression in people with RMS
3549 Continuous ofatumumab treatment up to 7 years shows a consistent safety profile and delays disability progression in people with RMS Open
View article: 3591 Tolebrutinib versus placebo in non-relapsing secondary progressive multiple sclerosis: efficacy and safety results from the phase 3 HERCULES trial
3591 Tolebrutinib versus placebo in non-relapsing secondary progressive multiple sclerosis: efficacy and safety results from the phase 3 HERCULES trial Open
View article: 3478 Baseline characteristics in the tolebrutinib phase 3 primary progressive multiple sclerosis perseus clinical trial
3478 Baseline characteristics in the tolebrutinib phase 3 primary progressive multiple sclerosis perseus clinical trial Open
View article: Pro‐Inflammatory <scp>c</scp>‐Met<sup>+</sup><scp>CD4</scp> T Cells in Multiple Sclerosis
Pro‐Inflammatory <span>c</span>‐Met<sup>+</sup><span>CD4</span> T Cells in Multiple Sclerosis Open
Objective Hepatocyte growth factor (HGF) binds exclusively the c‐Met surface receptor, and the HGF/c‐Met axis regulates T cell function in autoimmune diseases. We analyzed c‐Met expression on human CD4 T cells in the blood and cerebrospina…
View article: Long <scp>COVID</scp> in People With Multiple Sclerosis and Related Disorders: A Multicenter Cross‐Sectional Study
Long <span>COVID</span> in People With Multiple Sclerosis and Related Disorders: A Multicenter Cross‐Sectional Study Open
Background Managing long COVID in people with multiple sclerosis and related disorders (pwMSRD) is complex due to overlapping symptoms. To address evidence gaps, we evaluated long COVID susceptibility in pwMSRD versus controls and its asso…
View article: Advancing multiple sclerosis management in older adults
Advancing multiple sclerosis management in older adults Open
View article: Exploring the Clinical Utility of Neurofilament Light Chain Assays in Multiple Sclerosis Management
Exploring the Clinical Utility of Neurofilament Light Chain Assays in Multiple Sclerosis Management Open
Multiple sclerosis (MS) is a chronic neuroinflammatory and neurodegenerative disease that affects nearly 1 million adults in the United States. Owing to its unpredictable disease course, diverse phenotypes, and an array of currently availa…
View article: Durable T cell immunity to COVID-19 vaccines in MS patients on B cell depletion therapy
Durable T cell immunity to COVID-19 vaccines in MS patients on B cell depletion therapy Open
View article: Investigating mood and cognition in people with multiple sclerosis: a prospective cross-sectional study protocol
Investigating mood and cognition in people with multiple sclerosis: a prospective cross-sectional study protocol Open
Introduction Multiple sclerosis (MS) is an immune-mediated neurological disorder that affects one million people in the USA. Up to 50% of patients with MS experience depression, yet the mechanisms of depression in MS remain underinvestigat…
View article: Personalized treatment decision algorithms for the clinical application of serum neurofilament light chain in multiple sclerosis: A modified Delphi Study
Personalized treatment decision algorithms for the clinical application of serum neurofilament light chain in multiple sclerosis: A modified Delphi Study Open
Background: Serum neurofilament light (sNfL) chain levels, a sensitive measure of disease activity in multiple sclerosis (MS), are increasingly considered for individual therapy optimization yet without consensus on their use for clinical …
View article: Safety and tolerability of conversion to siponimod from other disease-modifying therapies in patients with advancing forms of relapsing MS: Results from the EXCHANGE study
Safety and tolerability of conversion to siponimod from other disease-modifying therapies in patients with advancing forms of relapsing MS: Results from the EXCHANGE study Open
Background: Siponimod, a sphingosine-1-phosphate (S1P) receptor modulator, reduces relapses and delays disability progression in patients with active progressive multiple sclerosis (MS). Objective: EXCHANGE assessed the safety/tolerability…
View article: Short- and long-term effects of early versus delayed treatment with ocrelizumab on cerebellar volume loss in patients with RMS and PPMS
Short- and long-term effects of early versus delayed treatment with ocrelizumab on cerebellar volume loss in patients with RMS and PPMS Open
Background: The cerebellum is a functionally and anatomically complex structure, which, in multiple sclerosis (MS), is affected by focal white/gray matter lesions and by secondary neurodegeneration of afferent/efferent connections to the s…
View article: Uncinate Fasciculus Lesion Burden and Anxiety in Multiple Sclerosis
Uncinate Fasciculus Lesion Burden and Anxiety in Multiple Sclerosis Open
Importance Multiple sclerosis (MS) is an immune-mediated neurological disorder that affects 2.4 million people worldwide, and up to 60% experience anxiety. Objective To investigate whether anxiety in MS is associated with white matter lesi…
View article: Prospective SARS-CoV-2 Booster Vaccination in Immunosuppressant-Treated Systemic Autoimmune Disease Patients in a Randomized Controlled Trial
Prospective SARS-CoV-2 Booster Vaccination in Immunosuppressant-Treated Systemic Autoimmune Disease Patients in a Randomized Controlled Trial Open
Background. Autoimmune disease patients on immunosuppressants exhibit reduced humoral responses to primary COVID-19 vaccination. Booster vaccine responses and the effects of holding immunosuppression around vaccination are less studied. We…
View article: Pediatric cerebrospinal fluid immune profiling distinguishes pediatric-onset multiple sclerosis from other pediatric-onset acute neurological disorders
Pediatric cerebrospinal fluid immune profiling distinguishes pediatric-onset multiple sclerosis from other pediatric-onset acute neurological disorders Open
The cerebrospinal fluid (CSF) provides a unique glimpse into the central nervous system (CNS) compartment and offers insights into immune processes associated with both healthy immune surveillance as well as inflammatory disorders of the C…
View article: Effect of siponimod on retinal thickness, a marker of neurodegeneration, in participants with SPMS: Findings from the EXPAND OCT substudy
Effect of siponimod on retinal thickness, a marker of neurodegeneration, in participants with SPMS: Findings from the EXPAND OCT substudy Open
View article: Automated segmentation of multiple sclerosis lesions, paramagnetic rims, and central vein sign on MRI provides reliable diagnostic biomarkers
Automated segmentation of multiple sclerosis lesions, paramagnetic rims, and central vein sign on MRI provides reliable diagnostic biomarkers Open
Multiple sclerosis (MS) is characterized by central nervous system lesions detectable via MRI. Existing diagnostic criteria incorporate presence of white matter lesions, but specificity can be improved using MS-specific imaging biomarkers,…
View article: Factors influencing early and late B-cell repopulation after Rituximab therapy in pediatric CNS inflammatory disorders
Factors influencing early and late B-cell repopulation after Rituximab therapy in pediatric CNS inflammatory disorders Open
View article: Long COVID in people with multiple sclerosis and related disorders: a multicenter cross-sectional study
Long COVID in people with multiple sclerosis and related disorders: a multicenter cross-sectional study Open
Background Managing long COVID in people with multiple sclerosis and related disorders (pwMSRD) is complex due to overlapping symptoms. To address evidence gaps, we evaluated long COVID susceptibility in pwMSRD versus controls and its asso…
View article: Diffuse nuclear Overhauser effect MRI contrast changes detected in multiple sclerosis subjects at 7T
Diffuse nuclear Overhauser effect MRI contrast changes detected in multiple sclerosis subjects at 7T Open
Multiple sclerosis is an inflammatory demyelinating condition of the central nervous system affecting approximately 1 million people in the USA. Although standard structural MRI techniques are now the main imaging modality for multiple scl…
View article: The fungal gut microbiota in pediatric-onset multiple sclerosis
The fungal gut microbiota in pediatric-onset multiple sclerosis Open
Evidence suggests that the gut microbiome may play a role in multiple sclerosis (MS). However, the majority of the studies have focused on gut bacterial communities; none have examined the fungal microbiota (mycobiota) in persons with pedi…
View article: Real-World Safety and Effectiveness of Dimethyl Fumarate in Patients with MS: Results from the ESTEEM Phase 4 and PROCLAIM Phase 3 Studies with a Focus on Older Patients
Real-World Safety and Effectiveness of Dimethyl Fumarate in Patients with MS: Results from the ESTEEM Phase 4 and PROCLAIM Phase 3 Studies with a Focus on Older Patients Open
View article: Choroid Plexus Volume in Pediatric-Onset Multiple Sclerosis
Choroid Plexus Volume in Pediatric-Onset Multiple Sclerosis Open
CPV measured at baseline is greater in participants with POMS than in HCs. Baseline CPV did not predict higher disease activity or worse neurologic outcomes over 1 year. While higher CPV may be an early feature of inflammation in MS, its s…
View article: Relation of CMV and brain atrophy to trajectories of immunosenescence in diverse populations
Relation of CMV and brain atrophy to trajectories of immunosenescence in diverse populations Open
Summary Immunosenescence (ISC), the aging of the immune system, has largely been studied in populations of European descent. Here, circulating immune cell cytometric data from African-American, Hispanic, and non-Hispanic White participants…
View article: Association of Anxiety with Uncinate Fasciculus Lesion Burden in Multiple Sclerosis
Association of Anxiety with Uncinate Fasciculus Lesion Burden in Multiple Sclerosis Open
Importance Multiple sclerosis (MS) is an immune-mediated neurological disorder that affects 2.4 million people world-wide, and up to 60% experience anxiety. Objective We investigated how anxiety in MS is associated with white matter lesion…