Albert van den Berg
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View article: Accurate Sizing of Monodisperse Microbubble Suspensions by Optical Attenuation Spectroscopy
Accurate Sizing of Monodisperse Microbubble Suspensions by Optical Attenuation Spectroscopy Open
OAS has proven to be a versatile method for sizing monodisperse microbubble suspensions due to its convenient, label-free, and rapid acquisition within seconds.
View article: Cytokine-induced memory-like responses in endothelial cells link chronic inflammation to vascular disease risk
Cytokine-induced memory-like responses in endothelial cells link chronic inflammation to vascular disease risk Open
Chronic inflammation plays a central role in the progression of both infectious and vascular diseases, yet its impact on endothelial cells (ECs), which form the interface between blood and tissue, remains poorly understood. Given their con…
View article: Microreactor Set-Ups for Screening of Droplet-Encapsulated Catalyst Particles: Fluidic and Electronic Interfacing
Microreactor Set-Ups for Screening of Droplet-Encapsulated Catalyst Particles: Fluidic and Electronic Interfacing Open
The use of microfluidics for analysis of biological and chemical compounds is flourishing, with droplet microfluidics being well suited for high-throughput single substance analysis. Nowadays, many new experimental set-ups are reported tha…
View article: FORCETRACKER: A versatile tool for standardized assessment of tissue contractile properties in 3D Heart-on-Chip platforms
FORCETRACKER: A versatile tool for standardized assessment of tissue contractile properties in 3D Heart-on-Chip platforms Open
Engineered heart tissues (EHTs) have shown great potential in recapitulating tissue organization, functions, and cell-cell interactions of the human heart in vitro . Currently, multiple EHT platforms are used by both industry and academia …
View article: Blood-perfused Vessels-on-Chips stimulated with patient plasma recapitulate endothelial activation and microthrombosis in COVID-19
Blood-perfused Vessels-on-Chips stimulated with patient plasma recapitulate endothelial activation and microthrombosis in COVID-19 Open
COVID-19 plasma induces endothelial activation and thromboinflammation in a Vessel-on-Chip model, highlighting the causative role of systemic factors and offering a platform for studying severe COVID-19 pathophysiology and therapeutic inte…
View article: Cytokine-induced memory-like responses in endothelial cells link chronic inflammation to vascular disease risk
Cytokine-induced memory-like responses in endothelial cells link chronic inflammation to vascular disease risk Open
Repeated stimulation with TNF-α and IFN-γ induces memory-like transcriptional and chromatin responses in endothelial cells, linking inflammatory exposure to vascular dysfunction and disease risk.
View article: Functionalized monodisperse microbubble production: microfluidic method for fast, controlled, and automated removal of excess coating material
Functionalized monodisperse microbubble production: microfluidic method for fast, controlled, and automated removal of excess coating material Open
Functionalized monodisperse microbubbles have the potential to boost the sensitivity and efficacy of molecular ultrasound imaging and targeted drug delivery using bubbles and ultrasound. Monodisperse bubbles can be produced in a microfluid…
View article: Prospects of nano-lithographic tools for the fabrication of surface-enhanced Raman spectroscopy (SERS) substrates
Prospects of nano-lithographic tools for the fabrication of surface-enhanced Raman spectroscopy (SERS) substrates Open
The previous decades have seen a massive increase in the research towards reproducible and optimized surface-enhanced Raman spectroscopy (SERS) substrates. While traditional colloidal synthesis methods have commonly been used for SERS subs…
View article: Liquid organic hydrogen carriers: Process design and economic analysis for manufacturing <scp><i>N</i></scp>‐ethylcarbazole
Liquid organic hydrogen carriers: Process design and economic analysis for manufacturing <span><i>N</i></span>‐ethylcarbazole Open
This paper revisits the economics of manufacturing N ‐ethylcarbazole (NEC), a strong candidate for large‐scale liquid organic hydrogen carrier (LOHC) supply chains, because of its high H 2 storage capacity (6 wt%), selective hydrogenation …
View article: Alternative nano-lithographic tools for shell-isolated nanoparticle enhanced Raman spectroscopy substrates
Alternative nano-lithographic tools for shell-isolated nanoparticle enhanced Raman spectroscopy substrates Open
This work shows increased stability and homogeneity for shell-isolated nanoparticle enhanced Raman spectroscopy substrates fabricated by using a combination of lithography and atomic layer deposition, compared to chemically synthesized sub…
View article: Evaluation of the Structural Strength of a Prefabricated Milling Cutter with Replaceable inserts During Machining
Evaluation of the Structural Strength of a Prefabricated Milling Cutter with Replaceable inserts During Machining Open
Simulation modeling of the stress state of a prefabricated milling cutter with replaceable inserts during machining was carried out in the ABAQUS 2020 program using the finite element method. It has been established that the structural str…
View article: Embedded macrophages induce intravascular coagulation in 3D blood vessel-on-chip
Embedded macrophages induce intravascular coagulation in 3D blood vessel-on-chip Open
Macrophages are innate immune cells that prevent infections and help in wound healing and vascular inflammation. While these cells are natural helper cells, they also contribute to chronic diseases, e.g., by infiltrating the endothelial la…
View article: Cell Patterning Technology on Polymethyl Methacrylate through Controlled Physicochemical and Biochemical Functionalization
Cell Patterning Technology on Polymethyl Methacrylate through Controlled Physicochemical and Biochemical Functionalization Open
In recent years, innovative cell-based biosensing systems have been developed, showing impact in healthcare and life science research. Now, there is a need to design mass-production processes to enable their commercialization and reach soc…
View article: Tracking the dynamics of thrombus formation in a blood vessel-on-chip with visible-light optical coherence tomography
Tracking the dynamics of thrombus formation in a blood vessel-on-chip with visible-light optical coherence tomography Open
Thrombus formation is a physiological response to damage in a blood vessel that relies on a complex interplay of platelets, coagulation factors, immune cells, and the vessel wall. The dynamics of thrombus formation are essential for a deep…
View article: Low-Variance Surface-Enhanced Raman Spectroscopy Using Confined Gold Nanoparticles over Silicon Nanocones
Low-Variance Surface-Enhanced Raman Spectroscopy Using Confined Gold Nanoparticles over Silicon Nanocones Open
Surface-enhanced Raman spectroscopy (SERS) substrates are of utmost interest in the analyte detection of biological and chemical diagnostics. This is primarily due to the ability of SERS to sensitively measure analytes present in localized…
View article: Automated assessment of human engineered heart tissues using deep learning and template matching for segmentation and tracking
Automated assessment of human engineered heart tissues using deep learning and template matching for segmentation and tracking Open
The high rate of drug withdrawal from the market due to cardiovascular toxicity or lack of efficacy, the economic burden, and extremely long time before a compound reaches the market, have increased the relevance of human in vitro models l…
View article: Figure S1 from Dichotomous ALK-IHC Is a Better Predictor for ALK Inhibition Outcome than Traditional ALK-FISH in Advanced Non–Small Cell Lung Cancer
Figure S1 from Dichotomous ALK-IHC Is a Better Predictor for ALK Inhibition Outcome than Traditional ALK-FISH in Advanced Non–Small Cell Lung Cancer Open
Flow diagram of patients in study cohort and external validation
View article: Figure S1 from Dichotomous ALK-IHC Is a Better Predictor for ALK Inhibition Outcome than Traditional ALK-FISH in Advanced Non–Small Cell Lung Cancer
Figure S1 from Dichotomous ALK-IHC Is a Better Predictor for ALK Inhibition Outcome than Traditional ALK-FISH in Advanced Non–Small Cell Lung Cancer Open
Flow diagram of patients in study cohort and external validation
View article: Droplet microreactor for high-throughput fluorescence-based measurements of single catalyst particle acidity
Droplet microreactor for high-throughput fluorescence-based measurements of single catalyst particle acidity Open
The particles of heterogeneous catalysts differ greatly in size, morphology, and most importantly, in activity. Studying these catalyst particles in batch typically results in ensemble averages, without any information at the level of indi…
View article: Nanoparticle Printing for Microfluidic Applications: Bipolar Electrochemistry and Localized Raman Sensing Spots
Nanoparticle Printing for Microfluidic Applications: Bipolar Electrochemistry and Localized Raman Sensing Spots Open
The local integration of metal nanoparticle films on 3D-structured polydimethylsiloxane (PDMS)-based microfluidic devices is of high importance for applications including electronics, electrochemistry, electrocatalysis, and localized Raman…
View article: <i>In situ</i> spatiotemporal characterization and analysis of chemical reactions using an ATR-integrated microfluidic reactor
<i>In situ</i> spatiotemporal characterization and analysis of chemical reactions using an ATR-integrated microfluidic reactor Open
An ATR-integrated microreactor with the ability to spatiotemporally characterize an in situ monitored chemical reaction to obtain chemical and kinetic information.
View article: Multiplexed fluidic circuit board for controlled perfusion of 3D blood vessels-on-a-chip
Multiplexed fluidic circuit board for controlled perfusion of 3D blood vessels-on-a-chip Open
We developed a fluidic circuit board for simultaneous perfusion of up to twelve 3D vessels-on-a-chip under comparable wall shear stress using a single set of control parameters despite high intrinsic sample diameter variation.
View article: Microfluidic Impedance Cytometry for Single‐Cell Particulate Inorganic Carbon:Particulate Organic Carbon Measurements of Calcifying Algae
Microfluidic Impedance Cytometry for Single‐Cell Particulate Inorganic Carbon:Particulate Organic Carbon Measurements of Calcifying Algae Open
Calcifying algae, like coccolithophores, greatly contribute to the oceanic carbon cycle and are therefore of particular interest for ocean carbon models. They play a key role in two processes that are important for the effective CO 2 flux:…
View article: Exploring the phases of 3D artificial spin ice: From Coulomb phase to magnetic monopole crystal
Exploring the phases of 3D artificial spin ice: From Coulomb phase to magnetic monopole crystal Open
Artificial spin-ices consist of lithographic arrays of single-domain magnetic nanowires organised into frustrated lattices. These geometries are usually two-dimensional, allowing a direct exploration of physics associated with frustration,…
View article: Fabrication of Si-Au nanocone-nanoparticle array for homogeneous enhancement factor in Raman scattering
Fabrication of Si-Au nanocone-nanoparticle array for homogeneous enhancement factor in Raman scattering Open
Gold nanoparticles (AuNPs) were the basis for the earliest research in the field of surface enhanced Raman scattering (SERS). Coupling of their surface plasmon resonances creates hot-spots of high electromagnetic intensities found to be ve…
View article: Supervised machine learning in microfluidic impedance flow cytometry for improved particle size determination
Supervised machine learning in microfluidic impedance flow cytometry for improved particle size determination Open
The assessment of particle and cell size in electrical microfluidic flow cytometers has become common practice. Nevertheless, in flow cytometers with coplanar electrodes accurate determination of particle size is difficult, owing to the in…
View article: The Effect of Dynamic, In Vivo-like Oxaliplatin on HCT116 Spheroids in a Cancer-on-Chip Model Is Representative of the Response in Xenografts
The Effect of Dynamic, In Vivo-like Oxaliplatin on HCT116 Spheroids in a Cancer-on-Chip Model Is Representative of the Response in Xenografts Open
The cancer xenograft model in which human cancer cells are implanted in a mouse is one of the most used preclinical models to test the efficacy of novel cancer drugs. However, the model is imperfect; animal models are ethically burdened, a…
View article: Contractility analysis of human engineered 3D heart tissues by an automatic tracking technique using a standalone application
Contractility analysis of human engineered 3D heart tissues by an automatic tracking technique using a standalone application Open
The use of Engineered Heart Tissues (EHT) as in vitro model for disease modeling and drug screening has increased, as they provide important insight into the genetic mechanisms, cardiac toxicity or drug responses. Consequently, this has hi…
View article: Generation and Culture of Cardiac Microtissues in a Microfluidic Chip with a Reversible Open Top Enables Electrical Pacing, Dynamic Drug Dosing and Endothelial Cell Co‐Culture
Generation and Culture of Cardiac Microtissues in a Microfluidic Chip with a Reversible Open Top Enables Electrical Pacing, Dynamic Drug Dosing and Endothelial Cell Co‐Culture Open
Cardiovascular disease morbidity has increased worldwide. Organs‐on‐chips and human pluripotent stem cell (hPSC) technologies aid to overcome some of the limitations in cardiac in vitro models. Here, a bi‐compartmental, monolithic heart‐on…