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View article: Intratumoural CD103+CD56+ ILCs are associated a with dysfunctional CD8+ T cell profile in patients with ovarian epithelial carcinoma 4835
Intratumoural CD103+CD56+ ILCs are associated a with dysfunctional CD8+ T cell profile in patients with ovarian epithelial carcinoma 4835 Open
Description Innate lymphoid cells (ILCs) with inhibitory properties have recently been identified in cancer, but the specific surface markers or transcription factors distinguishing these populations from conventional ILCs are not well-def…
View article: Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel
Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel Open
Genetic testing in epithelial ovarian cancer (EOC) in Ontario includes germline next‐generation sequencing (NGS) for 19 genes. Additionally, tumor tissue undergoes reflex NGS testing for BRCA1/2 to assess eligibility for PARPi. Although pa…
View article: From Microscopes to Monitors: Unique Opportunities and Challenges in Digital Pathology Implementation in Remote Canadian Regions
From Microscopes to Monitors: Unique Opportunities and Challenges in Digital Pathology Implementation in Remote Canadian Regions Open
Background/Objectives: Digital pathology has the potential to revolutionize pathology diagnostics, especially in geo-graphically isolated and underserved regions. By leveraging technology, telepathology, and integration with computer-aided…
View article: Dissociation of SYNGAP1 enzymatic and structural roles: Intrinsic excitability and seizure susceptibility
Dissociation of SYNGAP1 enzymatic and structural roles: Intrinsic excitability and seizure susceptibility Open
SYNGAP1 is a key Ras-GAP protein enriched at excitatory synapses, with mutations causing intellectual disability and epilepsy in humans. Recent studies have revealed that in addition to its role as a negative regulator of G-protein signali…
View article: Figure S3 from Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion
Figure S3 from Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion Open
Figure S3 shows that p53 loss diminishes H3K9me3 at transcriptionally upregulated repetitive elements
View article: Data from Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion
Data from Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion Open
Epigenetic therapies facilitate transcription of immunogenic repetitive elements that cull cancer cells through “viral mimicry” responses. Paradoxically, cancer-initiating events also facilitate transcription of repetitive elements. Contri…
View article: Supplementary Table S2 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment
Supplementary Table S2 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment Open
Antibodies and materials.
View article: Supplementary Figure S7 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment
Supplementary Figure S7 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment Open
Fig. S7. Intratumoural CD103+CD56+Lin- ILCs displayed unique profile of transcription factors.
View article: Supplementary Figure S8 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment
Supplementary Figure S8 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment Open
Fig. S8. CD56+ ILCs cluster 0 from CITE-seq are composed of predominately CD103+CD49a+ expressing cells.
View article: Table S3 from Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion
Table S3 from Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion Open
Table S3: Antibodies used in this study
View article: Supplementary Figure S9 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment
Supplementary Figure S9 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment Open
Fig. S9. CD103+CD56+Lin- ILCs express distinct signatures compared to other ILC subsets.
View article: Figure S6 from Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion
Figure S6 from Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion Open
Figure S6 that shows Acquisition of viral mimicry tolerance affects antitumor adaptive immune responses
View article: Figure S7 from Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion
Figure S7 from Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion Open
Figure S7 that shows the impact of viral mimicry conditioning on therapeutic approaches
View article: Figure S2 from Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion
Figure S2 from Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion Open
Figure S2 shows that Trp53 mutation facilitates transcriptional dysregulation of retrotransposons in murine oviductal epithelial cells and ovarian surface epithelial cells.
View article: Supplementary Figure S5 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment
Supplementary Figure S5 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment Open
Fig. S5. Identifying cellular clusters from scRNA-seq of ovarian tumours.
View article: Table S4 from Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion
Table S4 from Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion Open
Table S4: Primer sequences used in this study
View article: Supplementary Table S8 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment
Supplementary Table S8 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment Open
DEGs of CD8+ T cells from tumours with a high proportion, compared to a low proportion, of CD103+CD56+ ILCs.
View article: Supplementary Figure S10 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment
Supplementary Figure S10 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment Open
Fig. S10. CD103+Lin- ILC1-like cells are associated with altered immune landscape within the TME.
View article: Supplementary Table S1 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment
Supplementary Table S1 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment Open
Patient characteristics.
View article: Data from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment
Data from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment Open
Immunotherapies have had unprecedented success in the treatment of multiple cancer types, albeit with variable response rates. Unraveling the complex network of immune cells within the tumor microenvironment (TME) may provide additional in…
View article: Supplementary Table 6 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment
Supplementary Table 6 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment Open
DEGs that characterized cell clusters from scRNA-seq and CITE-seq datasets.
View article: Supplementary Table S3 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment
Supplementary Table S3 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment Open
Differentially expressed genes of intratumoural CD103+CD56+ ILCs compared to CD103-CD56+ NK cells from HGSC tumours using bulk-RNAseq.
View article: Table S2 from Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion
Table S2 from Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion Open
Table S2: Guide RNAs used for CRISPR gene editing in this study
View article: Supplementary Table 7 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment
Supplementary Table 7 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment Open
Transcription factor regulons that were enriched in CD103+CD56+ ILCs from scRNA-seq.
View article: Figure S4 from Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion
Figure S4 from Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion Open
Figure S4 shows that p53 loss increases cytosolic accumulation of RNA:DNA and dsRNA
View article: Supplementary Figure S6 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment
Supplementary Figure S6 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment Open
Fig. S6. CD103+CD56+ ILCs have distinct transcriptional networks revealed by SCENIC analysis.
View article: Supplementary Figure S4 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment
Supplementary Figure S4 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment Open
Fig S4. CD101 and GITR expression is expressed on CD103+CD49a+CD56+Lin- ILCs but not other NK cell subsets.
View article: Supplementary Table S4 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment
Supplementary Table S4 from CD103<sup>+</sup>CD56<sup>+</sup> ILCs Are Associated with an Altered CD8<sup>+</sup> T-cell Profile within the Tumor Microenvironment Open
List of gene sets enriched in CD103+CD56+ ILCs from GSEA using bulk-RNAseq.