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View article: Decoding non-coding SNPs: systems genomics modelling dissects the heterogeneity of IBD
Decoding non-coding SNPs: systems genomics modelling dissects the heterogeneity of IBD Open
Genome-wide association studies have identified numerous susceptibility loci in complex diseases, such as chronic immune-mediated inflammatory disorders (IMIDs), yet their impact on pathomechanisms remains poorly understood. Low effect siz…
View article: Review Article: Extending the Frontiers of Intestinal Ultrasound Knowledge, Performance and Expansion
Review Article: Extending the Frontiers of Intestinal Ultrasound Knowledge, Performance and Expansion Open
Background Intestinal ultrasonography (IUS) is increasingly utilised for diagnosing and monitoring IBD. Despite its cost‐effectiveness, patient tolerance and suitability for serial bedside assessments, broad adoption has been limited by kn…
View article: An international consensus on the design of clinical trials for advanced combination treatment (ACT) in inflammatory bowel disease
An international consensus on the design of clinical trials for advanced combination treatment (ACT) in inflammatory bowel disease Open
None.
Development and validation of the FR-QoL-29-Dutch (Flemish) Questionnaire and assessment of clinical factors associated with food-related quality of life in a Belgian inflammatory bowel disease population: a cross-sectional study Open
Objective Food-related quality of life (FR-QoL) is the psychosocial impact of food, nutrition, eating and drinking on QoL and can be profoundly affected by inflammatory bowel disease (IBD). We aimed to translate and validate the FR-QoL-29 …
View article: Heterogeneity in Histological Evaluation of Microscopic Colitis in Randomized Clinical Trials: An Umbrella Review
Heterogeneity in Histological Evaluation of Microscopic Colitis in Randomized Clinical Trials: An Umbrella Review Open
Background The diagnosis of microscopic colitis (MC) is based on endoscopic biopsy with histological assessment. Histological outcomes (remission, response or improvement) are important treatment targets in clinical trials. Although a subs…
<span>PAVFCOS</span> : The development of a core outcome set for pouch anal and vaginal fistula Open
Aims The primary aim was to develop a patient‐centred core outcome set (COS) for interventional studies in patients with pouch anal and vaginal fistula (PAVF). Method PAVFCOS was developed using the methodology outlined by the Core Outcome…
View article: Inflammatory Bowel Disease and Risk of More than 1,500 Comorbidities: A Disease-wide Prediagnostic and Postdiagnostic Phenomic Association Study
Inflammatory Bowel Disease and Risk of More than 1,500 Comorbidities: A Disease-wide Prediagnostic and Postdiagnostic Phenomic Association Study Open
INTRODUCTION: Inflammatory bowel disease (IBD) is associated with various extraintestinal manifestations. We aimed to identify comorbidities in IBD and the timing of their development to provide potentially useful insight into the associat…
View article: Results of the Ninth Scientific Workshop of the European Crohn’s and Colitis Organisation (ECCO): Artificial intelligence in IBD surgery: opportunities and limitations
Results of the Ninth Scientific Workshop of the European Crohn’s and Colitis Organisation (ECCO): Artificial intelligence in IBD surgery: opportunities and limitations Open
In this narrative review we present the current status of developments in artificial intelligence in the filed of IBD surgery. We lay down the foundations for how IBD surgery may utilise the potential opportunities in utilizing the rapid a…
View article: Results of the 9th Scientific Workshop of the European Crohn’s and Colitis Organisation (ECCO): Artificial Intelligence in medical management and precision medicine
Results of the 9th Scientific Workshop of the European Crohn’s and Colitis Organisation (ECCO): Artificial Intelligence in medical management and precision medicine Open
Background and Aims Artificial intelligence (AI) is increasingly being applied in various fields of medicine, including Inflammatory Bowel Diseases (IBD). This systematic review, conducted as part of the ECCO 9th Scientific Workshop on AI …
View article: Results of the 9th Scientific Workshop of the European Crohn’s and Colitis Organisation (ECCO): Artificial Intelligence in Endoscopy, Radiology and Histology in IBD Diagnostics
Results of the 9th Scientific Workshop of the European Crohn’s and Colitis Organisation (ECCO): Artificial Intelligence in Endoscopy, Radiology and Histology in IBD Diagnostics Open
In this review, a comprehensive overview of the current state of artificial intelligence (AI) research in Inflammatory Bowel Disease (IBD) diagnostics in the domains of endoscopy, radiology and histology is presented. Moreover, key conside…
View article: Results of the 9th Scientific Workshop of the European Crohn’s and Colitis Organisation (ECCO): Artificial Intelligence in IBD: Regulatory and Methodological Considerations
Results of the 9th Scientific Workshop of the European Crohn’s and Colitis Organisation (ECCO): Artificial Intelligence in IBD: Regulatory and Methodological Considerations Open
With the rapid growth of artificial intelligence (AI) applications in the field of inflammatory bowel disease (IBD), an increasing number of regulatory and methodological considerations have become apparent. Currently, there remains much u…
Patient-Specific Regulatory Network Rewiring in Inflammatory Bowel Disease: How Genetic Polymorphisms Divert Incoming Signals and Contribute to Disease Pathogenesis Open
Background Intestinal cells receive incoming signals from neighboring cells and microbial communities. Upstream signaling pathways transduce these signals to reach transcription factors (TFs) that regulate gene expression. In inflammatory …
View article: Assessment of PredictSURE IBD Assay in a Multinational Cohort of Patients With Inflammatory Bowel Disease
Assessment of PredictSURE IBD Assay in a Multinational Cohort of Patients With Inflammatory Bowel Disease Open
Background and Aims PredictSURE IBD is a prognostic blood test that classifies newly diagnosed, treatment‐naïve Inflammatory Bowel Disease (IBD) patients into ‘IBDhi’ (high‐risk) or ‘IBDlo’ (low‐risk) groups (risk of future aggressive dise…
View article: The EXTENT Study: Results From an International Expert Delphi Consensus to Define Ultrasonographic Parameters for Measuring Bowel Damage in Crohn’s Disease
The EXTENT Study: Results From an International Expert Delphi Consensus to Define Ultrasonographic Parameters for Measuring Bowel Damage in Crohn’s Disease Open
This study supports intestinal ultrasonography as a promising tool for assessing bowel damage in Crohn's disease, providing an alternative to magnetic resonance imaging/computed tomography and colonoscopy. Implementing intestinal ultrasono…
Differential effects of tofacitinib on macrophage activation contribute to lack of response in ulcerative colitis patients Open
Background and Aims Tofacitinib, a Janus kinase inhibitor, is approved for the treatment of moderate-to-severe ulcerative colitis. Nonetheless, 40-60% of patients will not respond adequately. The mechanisms underlying responses to tofaciti…
View article: ECCO Topical Review on Predictive Models on Inflammatory Bowel Disease Disease Course and Treatment Response
ECCO Topical Review on Predictive Models on Inflammatory Bowel Disease Disease Course and Treatment Response Open
Background and Aims Inflammatory bowel disease (IBD) poses a clinical challenge due to its variable progression and treatment response. Despite the development of predictive models, their clinical application remains limited due to validat…
View article: Positioning Guselkumab in The Treatment Algorithm of Patients with Crohn’s Disease
Positioning Guselkumab in The Treatment Algorithm of Patients with Crohn’s Disease Open
Guselkumab, a selective interleukin-23 (IL-23) inhibitor, has emerged as a promising biologic therapy for the management of patients with moderate-to-severe Crohn's disease (CD) and has been recently approved for its treatment. Unlike conv…
View article: Cooking methods affect advanced glycation end products and lipid profiles: A randomized cross-over study in healthy subjects
Cooking methods affect advanced glycation end products and lipid profiles: A randomized cross-over study in healthy subjects Open
Thermal treatments used in ultra-processed foods (UPFs) lead to advanced glycation end products (AGEs). UPFs and serum AGEs are associated with cardiometabolic disease. We explore differential cooking methods as a mechanistic link between …
The Development of a Multidisciplinary Care Pathway for Patients with Inflammatory Bowel Disease Before, During and After Pregnancy Open
Background/Objectives: Recent advancements have significantly enhanced our understanding of the interplay between inflammatory bowel disease (IBD) and reproductive health. While international organizations provide guidelines for best pract…
The development of a multidisciplinary care pathway for patients with inflammatory bowel disease before, during and after pregnancy Open
Background Recent advancements have significantly enhanced our understanding of the interplay between inflammatory bowel disease (IBD) and reproductive health. While international organizations provide guidelines for best practices, transl…
View article: ANTI-αVβ6 AUTOANTIBODIES ARE PRESENT IN COLONIC CROHN’S DISEASE AND ASSOCIATE WITH DISEASE ACTIVITY
ANTI-αVβ6 AUTOANTIBODIES ARE PRESENT IN COLONIC CROHN’S DISEASE AND ASSOCIATE WITH DISEASE ACTIVITY Open
Anti-integrin αvβ6 autoantibodies (anti-αvβ6) are present in up to 90% of patients with ulcerative colitis (UC), but there is a paucity of data regarding anti-αvβ6 in Crohn’s disease (CD). We hypothesized that anti-αvβ6 would be present in…
View article: Individual-network based predictions of microbial interaction signatures for response to biological therapies in IBD patients
Individual-network based predictions of microbial interaction signatures for response to biological therapies in IBD patients Open
Inflammatory Bowel Disease (IBD), which includes Ulcerative Colitis (UC) and Crohn’s Disease (CD), is marked by dysbiosis of the gut microbiome. Despite therapeutic interventions with biological agents like Vedolizumab, Ustekinumab, and an…
N16 Optimizing care for women of childbearing age with Inflammatory Bowel Disease: Developing a specific pathway utilizing European Crohn's and Colitis Organisation guidelines and the American Gastroenterology Association recommendations Open
Background Recent advances have greatly improved our understanding of the interaction between Inflammatory bowel disease (IBD) and reproductive health. The European Crohn's and Colitis Organisation (ECCO) and the American Gastroenterology …
P1144 Effect of baseline disease severity on achieving efficacy endpoints in patients with Ulcerative Colitis treated with filgotinib Open
Background Data from the real-world GALOCEAN study showed that ~70% of patients have moderately active Ulcerative Colitis (UC).1 A post hoc analysis of the SELECTION study (NCT02914522) found that patients with moderately active UC were mo…
View article: DOP069 Guselkumab maintenance therapy mediates further improvements in intestinal immune homeostasis and mucosal healing in patients with ulcerative colitis
DOP069 Guselkumab maintenance therapy mediates further improvements in intestinal immune homeostasis and mucosal healing in patients with ulcerative colitis Open
Background Guselkumab (GUS) is a dual-acting IL-23p19 subunit inhibitor that potently neutralises interleukin 23 (IL-23) and binds to CD64, a receptor on cells that produce IL-23.1 The QUASAR Phase 2b/3 studies have demonstrated efficacy a…
P0828 The impact of etrasimod on neutrophils in the ELEVATE UC clinical programme Open
Background Neutrophils are thought to play a role in the pathogenesis of ulcerative colitis (UC); they are believed to be the principal source of faecal calprotectin and are a histological marker of disease activity in mucosal biopsies. Et…
View article: Diagnosing Crohn’s disease in presumed cryptoglandular perianal fistulas: an expert Delphi consensus on early identification of patients at risk of Crohn’s disease in perianal fistulas (PREFAB)
Diagnosing Crohn’s disease in presumed cryptoglandular perianal fistulas: an expert Delphi consensus on early identification of patients at risk of Crohn’s disease in perianal fistulas (PREFAB) Open
Background The aim of this Delphi study was to reach consensus on a new clinical decision tool to help identify or exclude Crohn’s disease (CD) in patients with perianal fistula(s) (PAF). Methods A panel of international experts in the fie…
View article: P0643 Development of a personalized infliximab dosing algorithm for Acute Severe Ulcerative Colitis: results of a multi-center pharmacometrics analysis
P0643 Development of a personalized infliximab dosing algorithm for Acute Severe Ulcerative Colitis: results of a multi-center pharmacometrics analysis Open
Background Acute severe ulcerative colitis (ASUC) is a medical emergency with a potential need for emergency colectomy. Infliximab (IFX) is a safe and effective rescue therapy for patients with steroid-refractory ASUC. Despite being increa…