Ann‐Marie Broome
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View article: Supplementary Figure Legend from An Optical Probe for Noninvasive Molecular Imaging of Orthotopic Brain Tumors Overexpressing Epidermal Growth Factor Receptor
Supplementary Figure Legend from An Optical Probe for Noninvasive Molecular Imaging of Orthotopic Brain Tumors Overexpressing Epidermal Growth Factor Receptor Open
PDF file, 83K.
View article: Supplementary Figure 1 from An Optical Probe for Noninvasive Molecular Imaging of Orthotopic Brain Tumors Overexpressing Epidermal Growth Factor Receptor
Supplementary Figure 1 from An Optical Probe for Noninvasive Molecular Imaging of Orthotopic Brain Tumors Overexpressing Epidermal Growth Factor Receptor Open
PDF file, 116K, A) Expression levels of the wild type EGFR determined by Western blot in A431, U87-MG, and Gli36Δ5 cell lines. Cell lysates were derived from each cell type and 50 μg of each separated using SDS-PAGE. The gels were then tra…
View article: Supplementary Figure 1 from An Optical Probe for Noninvasive Molecular Imaging of Orthotopic Brain Tumors Overexpressing Epidermal Growth Factor Receptor
Supplementary Figure 1 from An Optical Probe for Noninvasive Molecular Imaging of Orthotopic Brain Tumors Overexpressing Epidermal Growth Factor Receptor Open
PDF file, 116K, A) Expression levels of the wild type EGFR determined by Western blot in A431, U87-MG, and Gli36Δ5 cell lines. Cell lysates were derived from each cell type and 50 μg of each separated using SDS-PAGE. The gels were then tra…
View article: Data from An Optical Probe for Noninvasive Molecular Imaging of Orthotopic Brain Tumors Overexpressing Epidermal Growth Factor Receptor
Data from An Optical Probe for Noninvasive Molecular Imaging of Orthotopic Brain Tumors Overexpressing Epidermal Growth Factor Receptor Open
We have developed a near-infrared (NIR) probe that targets cells overexpressing the EGF receptor (EGFR) for imaging glioblastoma brain tumors in live subjects. A peptide specific for the EGFR was modified with various lengths of monodiscre…
View article: Supplementary Table 1 from An Optical Probe for Noninvasive Molecular Imaging of Orthotopic Brain Tumors Overexpressing Epidermal Growth Factor Receptor
Supplementary Table 1 from An Optical Probe for Noninvasive Molecular Imaging of Orthotopic Brain Tumors Overexpressing Epidermal Growth Factor Receptor Open
PDF file, 46K, Peptides were characterized and verified by MALDI mass spectrometry. Table shows the expected and observed molecular weight of the peptides.
View article: Supplementary Figure Legend from An Optical Probe for Noninvasive Molecular Imaging of Orthotopic Brain Tumors Overexpressing Epidermal Growth Factor Receptor
Supplementary Figure Legend from An Optical Probe for Noninvasive Molecular Imaging of Orthotopic Brain Tumors Overexpressing Epidermal Growth Factor Receptor Open
PDF file, 83K.
View article: Supplementary Table 2 from An Optical Probe for Noninvasive Molecular Imaging of Orthotopic Brain Tumors Overexpressing Epidermal Growth Factor Receptor
Supplementary Table 2 from An Optical Probe for Noninvasive Molecular Imaging of Orthotopic Brain Tumors Overexpressing Epidermal Growth Factor Receptor Open
PDF file, 36K, Physical properties of peptides studied in this report. RP-HPLC conditions 10-60% acetonitrile against 0.1% trifluoroacetic acid over 30 minutes through a C18 column (PROTO 300, 10 micron, 250 x 4.6 mm) where the injection p…
View article: Supplementary Table 2 from An Optical Probe for Noninvasive Molecular Imaging of Orthotopic Brain Tumors Overexpressing Epidermal Growth Factor Receptor
Supplementary Table 2 from An Optical Probe for Noninvasive Molecular Imaging of Orthotopic Brain Tumors Overexpressing Epidermal Growth Factor Receptor Open
PDF file, 36K, Physical properties of peptides studied in this report. RP-HPLC conditions 10-60% acetonitrile against 0.1% trifluoroacetic acid over 30 minutes through a C18 column (PROTO 300, 10 micron, 250 x 4.6 mm) where the injection p…
View article: Supplementary Table 1 from An Optical Probe for Noninvasive Molecular Imaging of Orthotopic Brain Tumors Overexpressing Epidermal Growth Factor Receptor
Supplementary Table 1 from An Optical Probe for Noninvasive Molecular Imaging of Orthotopic Brain Tumors Overexpressing Epidermal Growth Factor Receptor Open
PDF file, 46K, Peptides were characterized and verified by MALDI mass spectrometry. Table shows the expected and observed molecular weight of the peptides.
View article: Data from An Optical Probe for Noninvasive Molecular Imaging of Orthotopic Brain Tumors Overexpressing Epidermal Growth Factor Receptor
Data from An Optical Probe for Noninvasive Molecular Imaging of Orthotopic Brain Tumors Overexpressing Epidermal Growth Factor Receptor Open
We have developed a near-infrared (NIR) probe that targets cells overexpressing the EGF receptor (EGFR) for imaging glioblastoma brain tumors in live subjects. A peptide specific for the EGFR was modified with various lengths of monodiscre…
View article: Data from Isoflavone ME-344 Disrupts Redox Homeostasis and Mitochondrial Function by Targeting Heme Oxygenase 1
Data from Isoflavone ME-344 Disrupts Redox Homeostasis and Mitochondrial Function by Targeting Heme Oxygenase 1 Open
ME-344 is a second-generation isoflavone with unusual cytotoxic properties that is in clinical testing in cancer. To identify targets that contribute to its anticancer activity and therapeutic index, we used lung cancer cell lines that are…
View article: Supplementary Materials and Methods from Isoflavone ME-344 Disrupts Redox Homeostasis and Mitochondrial Function by Targeting Heme Oxygenase 1
Supplementary Materials and Methods from Isoflavone ME-344 Disrupts Redox Homeostasis and Mitochondrial Function by Targeting Heme Oxygenase 1 Open
Antibodies. Primers. Click Chemistry and Affinity Enrichment Mass Spectrometry. Surface Plasmon Resonance - Biacore 3000 Kinetic Determinations. Co-Immunoprecipitation. Transfections with shRNA and plasmids. Plate colony formation assay. R…
View article: Supplementary Figures S1-S5 and Tables S1-S10, S15-S23 from Isoflavone ME-344 Disrupts Redox Homeostasis and Mitochondrial Function by Targeting Heme Oxygenase 1
Supplementary Figures S1-S5 and Tables S1-S10, S15-S23 from Isoflavone ME-344 Disrupts Redox Homeostasis and Mitochondrial Function by Targeting Heme Oxygenase 1 Open
Supplementary Figure S1. Effects of HO-1 knockdown in H460 cell lines and HO-1 over-expression in H596 cell lines. Supplementary Figure S2. Affinity Enrichment Mass Spectrometry. Supplementary Figure S3. ME-344 induced apoptosis in sensiti…
View article: Supplementary Tables S11-S14 from Isoflavone ME-344 Disrupts Redox Homeostasis and Mitochondrial Function by Targeting Heme Oxygenase 1
Supplementary Tables S11-S14 from Isoflavone ME-344 Disrupts Redox Homeostasis and Mitochondrial Function by Targeting Heme Oxygenase 1 Open
Supplementary Table S11. All Proteins Identified. Supplementary Table S12. The Protein Groups text file from MaxQuant was processed using Perseus. Common contaminants, reversed database hits, and proteins identified by modified peptides we…
View article: Supplementary Materials and Methods from Isoflavone ME-344 Disrupts Redox Homeostasis and Mitochondrial Function by Targeting Heme Oxygenase 1
Supplementary Materials and Methods from Isoflavone ME-344 Disrupts Redox Homeostasis and Mitochondrial Function by Targeting Heme Oxygenase 1 Open
Antibodies. Primers. Click Chemistry and Affinity Enrichment Mass Spectrometry. Surface Plasmon Resonance - Biacore 3000 Kinetic Determinations. Co-Immunoprecipitation. Transfections with shRNA and plasmids. Plate colony formation assay. R…
View article: Supplementary Tables S11-S14 from Isoflavone ME-344 Disrupts Redox Homeostasis and Mitochondrial Function by Targeting Heme Oxygenase 1
Supplementary Tables S11-S14 from Isoflavone ME-344 Disrupts Redox Homeostasis and Mitochondrial Function by Targeting Heme Oxygenase 1 Open
Supplementary Table S11. All Proteins Identified. Supplementary Table S12. The Protein Groups text file from MaxQuant was processed using Perseus. Common contaminants, reversed database hits, and proteins identified by modified peptides we…
View article: Supplementary Figures S1-S5 and Tables S1-S10, S15-S23 from Isoflavone ME-344 Disrupts Redox Homeostasis and Mitochondrial Function by Targeting Heme Oxygenase 1
Supplementary Figures S1-S5 and Tables S1-S10, S15-S23 from Isoflavone ME-344 Disrupts Redox Homeostasis and Mitochondrial Function by Targeting Heme Oxygenase 1 Open
Supplementary Figure S1. Effects of HO-1 knockdown in H460 cell lines and HO-1 over-expression in H596 cell lines. Supplementary Figure S2. Affinity Enrichment Mass Spectrometry. Supplementary Figure S3. ME-344 induced apoptosis in sensiti…
View article: Data from Isoflavone ME-344 Disrupts Redox Homeostasis and Mitochondrial Function by Targeting Heme Oxygenase 1
Data from Isoflavone ME-344 Disrupts Redox Homeostasis and Mitochondrial Function by Targeting Heme Oxygenase 1 Open
ME-344 is a second-generation isoflavone with unusual cytotoxic properties that is in clinical testing in cancer. To identify targets that contribute to its anticancer activity and therapeutic index, we used lung cancer cell lines that are…
View article: Targeting the KRAS α4-α5 allosteric interface inhibits pancreatic cancer tumorigenesis
Targeting the KRAS α4-α5 allosteric interface inhibits pancreatic cancer tumorigenesis Open
RAS is the most frequently mutated oncogene in human cancer with nearly ~20% of cancer patients possessing mutations in one of three RAS genes (K, N or HRAS). However, KRAS is mutated in nearly 90% of pancreatic ductal carcinomas (PDAC). A…
View article: Targeting the KRAS α4-α5 allosteric interface inhibits pancreatic cancer tumorigenesis
Targeting the KRAS α4-α5 allosteric interface inhibits pancreatic cancer tumorigenesis Open
RAS is the most frequently mutated oncogene in human cancer with nearly ~20% of cancer patients possessing mutations in one of three RAS genes (K, N or HRAS). However, KRAS is mutated in nearly 90% of pancreatic ductal carcinomas (PDAC). A…
View article: Targeting the KRAS α4-α5 allosteric interface inhibits pancreatic cancer tumorigenesis
Targeting the KRAS α4-α5 allosteric interface inhibits pancreatic cancer tumorigenesis Open
RAS is the most frequently mutated oncogene in human cancer with nearly ~20% of cancer patients possessing mutations in one of three RAS genes (K, N or HRAS). However, KRAS is mutated in nearly 90% of pancreatic ductal carcinomas (PDAC). A…
View article: Voltage-Dependent Anion Channels Influence Cytotoxicity of ME-344, a Therapeutic Isoflavone
Voltage-Dependent Anion Channels Influence Cytotoxicity of ME-344, a Therapeutic Isoflavone Open
ME-344 is a second-generation cytotoxic isoflavone with anticancer activity promulgated through interference with mitochondrial functions. Using a click chemistry version of the drug together with affinity-enriched mass spectrometry, volta…
View article: Predominant Distribution of the RNAi Machinery at Apical Adherens Junctions in Colonic Epithelia Is Disrupted in Cancer
Predominant Distribution of the RNAi Machinery at Apical Adherens Junctions in Colonic Epithelia Is Disrupted in Cancer Open
The RNA interference (RNAi) machinery is an essential component of the cell, regulating miRNA biogenesis and function. RNAi complexes were thought to localize either in the nucleus, such as the microprocessor, or in the cytoplasm, such as …
View article: Isoflavone ME-344 Disrupts Redox Homeostasis and Mitochondrial Function by Targeting Heme Oxygenase 1
Isoflavone ME-344 Disrupts Redox Homeostasis and Mitochondrial Function by Targeting Heme Oxygenase 1 Open
ME-344 is a second-generation isoflavone with unusual cytotoxic properties that is in clinical testing in cancer. To identify targets that contribute to its anticancer activity and therapeutic index, we used lung cancer cell lines that are…
View article: Localized delivery of therapeutic doxorubicin dose across the canine blood–brain barrier with hyperthermia and temperature sensitive liposomes
Localized delivery of therapeutic doxorubicin dose across the canine blood–brain barrier with hyperthermia and temperature sensitive liposomes Open
Most drugs cannot penetrate the blood-brain barrier (BBB), greatly limiting the use of anti-cancer agents for brain cancer therapy. Temperature sensitive liposomes (TSL) are nanoparticles that rapidly release the contained drug in response…
View article: Organ preservation with targeted rapamycin nanoparticles: a pre-treatment strategy preventing chronic rejection <i>in vivo</i>
Organ preservation with targeted rapamycin nanoparticles: a pre-treatment strategy preventing chronic rejection <i>in vivo</i> Open
(a) Rapamycin nanotherapeutic pre-treatment improves tracheal allograft outcome after transplantation. (b) Nanotherapy reduces aortic allograft vasculopathy. (c) Dose dependency of the nanotherapy in aortic interposition allografts.
View article: Biotinylated Bioluminescent Probe for Long Lasting Targeted <i>in Vivo</i> Imaging of Xenografted Brain Tumors in Mice
Biotinylated Bioluminescent Probe for Long Lasting Targeted <i>in Vivo</i> Imaging of Xenografted Brain Tumors in Mice Open
Bioluminescence is a useful tool for imaging of cancer in in vivo animal models that endogenously express luciferase, an enzyme that requires a substrate for visual readout. Current bioluminescence imaging, using commonly available lucifer…