Andrea B. Maier
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View article: Oral short-chain fatty acid-producing bacteria may be associated with biological age and cognition among the oldest old
Oral short-chain fatty acid-producing bacteria may be associated with biological age and cognition among the oldest old Open
Our findings highlight that, as far as we aware, previously unrecognized oral microbiome composition links to lower mAge deviation and better cognitive function among the oldest-old, suggesting a potential role of the oral microbiome in pr…
View article: Multivitamin and mineral use: A rapid review of meta-analyses on health outcomes
Multivitamin and mineral use: A rapid review of meta-analyses on health outcomes Open
Multivitamin and mineral (MVM) supplements are among the most widely used dietary supplements globally, however, their role in promoting healthspan and longevity remains unclear. This review evaluated comprehensive findings from meta-analy…
View article: Intrapulmonary intra-arterial malposition of a port catheter—an exceptionally rare complication
Intrapulmonary intra-arterial malposition of a port catheter—an exceptionally rare complication Open
Summary Although port system implantations have been established as standardized surgical procedures, they may be associated with significant risks and complications. Therefore, both the planning and the correct execution of the implantati…
View article: Open problems in ageing science: a roadmap for biogerontology
Open problems in ageing science: a roadmap for biogerontology Open
The field of ageing science has gone through remarkable progress in recent decades, yet many fundamental questions remain unanswered or unexplored. Here we present a curated list of 100 open problems in ageing and longevity science. These …
View article: How Tea Consumption Interacts with Genetics to Affect Cardiovascular Biomarkers in Older Adults? Findings from the CLHLS
How Tea Consumption Interacts with Genetics to Affect Cardiovascular Biomarkers in Older Adults? Findings from the CLHLS Open
Background/Objectives Cardiovascular disease (CVD) has become the leading cause of mortality and disability worldwide. Tea is one of the most common consumed beverages worldwide. Studies have demonstrated that tea consumption has an impact…
View article: Public Views towards Lifespan, Healthspan, and Healthy Longevity Medicine in Singapore: A Qualitative Study from the Healthy Longevity (HELO) Initiatives
Public Views towards Lifespan, Healthspan, and Healthy Longevity Medicine in Singapore: A Qualitative Study from the Healthy Longevity (HELO) Initiatives Open
Introduction: Healthy Longevity Medicine (HLM) offers a strategy to reduce the healthspan-lifespan gap, yet public perspectives remain unclear. This study refines the Healthy Longevity (HELO) framework through a qualitative exploration of …
View article: Biological age measured by DNA methylation clocks and frailty: a systematic review and meta-analysis
Biological age measured by DNA methylation clocks and frailty: a systematic review and meta-analysis Open
National University of Singapore.
View article: Reference values for handgrip strength in Europe: analysis of individual participant data from 27 countries
Reference values for handgrip strength in Europe: analysis of individual participant data from 27 countries Open
We aimed to determine reference values for handgrip strength in Europe. Data from the Survey of Health, Ageing and Retirement in Europe were used, involving adults aged 50 + years. Reference values were expressed as weighted percentiles fo…
View article: Methylphenidate and Its Impact on Redox Balance and Behavior
Methylphenidate and Its Impact on Redox Balance and Behavior Open
Methylphenidate (MPH) and its active enantiomer, dexmethylphenidate, are widely prescribed as first-line therapies for attention deficit hyperactivity disorder (ADHD), yet their increasing non-medical use highlights significant clinical an…
View article: Trends in cognitive impairment among older adults in China from 2002 to 2022: Evaluating the impact of the COVID-19 pandemic
Trends in cognitive impairment among older adults in China from 2002 to 2022: Evaluating the impact of the COVID-19 pandemic Open
The study suggests that the COVID-19 pandemic may have contributed to the observed increase in cognitive impairment prevalence in China, underscoring the importance of further research into the long-term cognitive effects of global health …
View article: Reference values for the five-times-sit-to-stand test: a pooled analysis including 45,470 participants from 14 countries
Reference values for the five-times-sit-to-stand test: a pooled analysis including 45,470 participants from 14 countries Open
The aim of this study was to establish reference values for the Five-Times-Sit-to-Stand Test (FTSST) in a large, population-representative sample from 14 European countries. Data were collected among 45,470 participants aged 50 + years, as…
View article: Knowledge of lifespan and healthspan and interest in Healthy Longevity Medicine among the general population in Singapore: The Singapore HEalthy LOngevity (HELO) survey
Knowledge of lifespan and healthspan and interest in Healthy Longevity Medicine among the general population in Singapore: The Singapore HEalthy LOngevity (HELO) survey Open
Given the growing global interest in Healthy Longevity Medicine (HLM), the field lacks understanding about public knowledge and interest, which are crucial to consider for any public health intervention relying on HLM. This study presents …
View article: Open problems in ageing science: A roadmap for biogerontology
Open problems in ageing science: A roadmap for biogerontology Open
The field of ageing science has gone through remarkable progress in recent decades, yet many fundamental questions remain unanswered or unexplored. Here we present a curated list of 100 open problems in ageing and longevity science. These …
View article: Energy and protein intake adequacy in geriatric rehabilitation inpatients: A descriptive cohort study
Energy and protein intake adequacy in geriatric rehabilitation inpatients: A descriptive cohort study Open
Background Indirect calorimetry (IC) provides an accurate measure of energy expenditure, which informs energy requirements. Achieving energy and protein requirements is fundamental in nutrition care. This study aims to determine if the ene…
View article: Targeting cognitive aging with curcumin supplementation: A systematic review and meta-analysis
Targeting cognitive aging with curcumin supplementation: A systematic review and meta-analysis Open
Preclinical in vivo evidence suggests curcumin enhances cognitive function in AD models. However, human studies show inconsistent findings with benefits limited to specific cognitive domains. Larger, well-designed randomized controlled tri…
View article: Biomarkers of Aging–<scp>NIA</scp> Joint Symposium 2024: New Insights Into Aging Biomarkers
Biomarkers of Aging–<span>NIA</span> Joint Symposium 2024: New Insights Into Aging Biomarkers Open
The second Biomarkers of Aging Symposium, jointly hosted by the National Institute on Aging (NIA) Intramural Research Program and the Biomarkers of Aging Consortium (BAC) on September 12, 2024, in Baltimore, MD, convened leading researcher…
View article: Definitions of healthspan: A systematic review
Definitions of healthspan: A systematic review Open
The term healthspan has been widely used in academic literature, technical reports and brochures, however, it is unclear if the same definitions and operationalizations for healthspan are being used. The objective of the systematic review …
View article: White Matter Abnormalities and Cognition in Aging and Alzheimer Disease
White Matter Abnormalities and Cognition in Aging and Alzheimer Disease Open
Importance There has yet to be a large-scale study quantifying the association between white matter microstructure and cognitive performance and decline in aging and Alzheimer disease (AD). Objective To investigate the associations between…
View article: Digital biomarkers of ageing for monitoring physiological systems in community-dwelling adults
Digital biomarkers of ageing for monitoring physiological systems in community-dwelling adults Open
Digital health technologies are transforming health care and personal health management by providing quantifiable data on physiological, behavioural, and environmental health parameters using digital biomarkers. This narrative review class…
View article: Towards Precision Geromedicine in Singapore
Towards Precision Geromedicine in Singapore Open
Since the discovery that ageing is a modifiable process in animal models, significant advancements in geroscience have led to the emergence of the field of Precision Geromedicine, which aims to optimise health and healthspan by targeting a…
View article: DNAm age differences between infinium methylationEPICv1 vs EPICv2 in buffy coat, PBMC, and saliva samples
DNAm age differences between infinium methylationEPICv1 vs EPICv2 in buffy coat, PBMC, and saliva samples Open
This study aims to evaluate differences between Infinium MethylationEPIC (EPICv1) and Infinium MethylationEPICv2 (EPICv2) arrays in estimating DNAm age with eleven DNAm clocks using buffy coat, peripheral blood mononuclear cell (PBMC), and…
View article: Towards defining optimal concentrations of micronutrients in adults to optimize health
Towards defining optimal concentrations of micronutrients in adults to optimize health Open
Micronutrients are essential for maintaining physiological homeostasis and optimizing healthspan, defined as the years lived in good health without chronic diseases or disabilities. Despite increasing global life expectancy, improvements i…
View article: eHealth in geriatric rehabilitation: an international consensus study
eHealth in geriatric rehabilitation: an international consensus study Open
Purpose Current evidence on the use of eHealth in geriatric rehabilitation is limited. This aim of this study was to achieve international consensus on three key eHealth-related topics in geriatric rehabilitation: the use, domains, and sci…