Arturo Brunetti
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View article: Predicting 10-Year Clinical Outcomes in MS with Radiomics-Based Machine Learning Models
Predicting 10-Year Clinical Outcomes in MS with Radiomics-Based Machine Learning Models Open
Building on quantitative features derived from conventional MRI scans, we obtained long-term prognostic models, potentially informing patients' stratification and clinical decision-making.
View article: Identifying neuropsychological phenotypes in multiple sclerosis using latent profile analysis
Identifying neuropsychological phenotypes in multiple sclerosis using latent profile analysis Open
Background People with Multiple Sclerosis (MS) frequently experience cognitive impairment and neurobehavioral issues including depression and fatigue. We aim to define neuropsychological phenotypes in MS based on cognitive function, depres…
View article: The Pattern and Stages of Atrophy in Spinocerebellar Ataxia Type 2: Volumetrics from <scp>ENIGMA</scp>‐Ataxia
The Pattern and Stages of Atrophy in Spinocerebellar Ataxia Type 2: Volumetrics from <span>ENIGMA</span>‐Ataxia Open
Background Spinocerebellar ataxia type 2 (SCA2) is a rare, inherited neurodegenerative disease characterized by progressive deterioration in both motor coordination and cognitive function. Atrophy of the cerebellum, brainstem, and spinal c…
View article: ALTERED FUNCTIONAL CONNECTIVITY OF FUSIFORM GYRUS AND DISORGANIZATION DOMAIN AS CORE CORRELATES OF TREATMENT- RESISTANT SCHIZOPHRENIA: A RESTING-STATE FMRI STUDY
ALTERED FUNCTIONAL CONNECTIVITY OF FUSIFORM GYRUS AND DISORGANIZATION DOMAIN AS CORE CORRELATES OF TREATMENT- RESISTANT SCHIZOPHRENIA: A RESTING-STATE FMRI STUDY Open
Background The neurobiology underlying treatment-resistant schizophrenia (TRS) has not been fully elucidated1. This project provides a preliminary dissection of the neurobiological underpinnings of cognitive dysfunction in schizophrenia (S…
View article: Conventional MRI-Based Structural Disconnection and Morphometric Similarity Networks and Their Clinical Correlates in Multiple Sclerosis
Conventional MRI-Based Structural Disconnection and Morphometric Similarity Networks and Their Clinical Correlates in Multiple Sclerosis Open
Structural disconnection and morphometric similarity networks, as assessed through conventional MRI, are sensitive to MS-related brain damage and its progression. They explain disease-related clinical disability and predict its long-term e…
View article: Altered Intracerebellar Functional Connectivity in Friedreich’s Ataxia: A Graph-Theory Functional MRI Study
Altered Intracerebellar Functional Connectivity in Friedreich’s Ataxia: A Graph-Theory Functional MRI Study Open
Historically, Friedreich’s Ataxia (FRDA) has been linked to a relatively preserved cerebellar cortex. Recent advances in neuroimaging have revealed altered cerebello-cerebral functional connectivity (FC), but the extent of intra-cerebellar…
View article: More Than the Sum of Its Parts: Disrupted Core Periphery of Multiplex Brain Networks in Multiple Sclerosis
More Than the Sum of Its Parts: Disrupted Core Periphery of Multiplex Brain Networks in Multiple Sclerosis Open
Disruptions to brain networks, measured using structural (sMRI), diffusion (dMRI), or functional (fMRI) MRI, have been shown in people with multiple sclerosis (PwMS), highlighting the relevance of regions in the core of the connectome but …
View article: Disentangling Neurodegeneration From Aging in Multiple Sclerosis Using Deep Learning
Disentangling Neurodegeneration From Aging in Multiple Sclerosis Using Deep Learning Open
The brain-predicted DD gap is sensitive to MS-related lesions and brain atrophy, adds to the brain-age paradigm in explaining physical disability both cross-sectionally and longitudinally, and may be used as an MS-specific biomarker of dis…
View article: Sex differences in deep brain shape and asymmetry persist across schizophrenia and healthy individuals: A meta-analysis from the ENIGMA-Schizophrenia Working Group
Sex differences in deep brain shape and asymmetry persist across schizophrenia and healthy individuals: A meta-analysis from the ENIGMA-Schizophrenia Working Group Open
Background Schizophrenia (SCZ) is characterized by a disconnect from reality that manifests as various clinical and cognitive symptoms, and persistent neurobiological abnormalities. Sex-related differences in clinical presentation imply se…
View article: The role of MRI in radiotherapy planning: a narrative review “from head to toe”
The role of MRI in radiotherapy planning: a narrative review “from head to toe” Open
Over the last few years, radiation therapy (RT) techniques have evolved very rapidly, with the aim of conforming high-dose volume tightly to a target. Although to date CT is still considered the imaging modality for target delineation, it …
View article: The Pattern and Staging of Brain Atrophy in Spinocerebellar Ataxia Type 2 (SCA2): MRI Volumetrics from ENIGMA-Ataxia
The Pattern and Staging of Brain Atrophy in Spinocerebellar Ataxia Type 2 (SCA2): MRI Volumetrics from ENIGMA-Ataxia Open
Objective Spinocerebellar ataxia type 2 (SCA2) is a rare, inherited neurodegenerative disease characterised by progressive deterioration in both motor coordination and cognitive function. Atrophy of the cerebellum, brainstem, and spinal co…
View article: StepBrain: A 3-Dimensionally Printed Multicompartmental Anthropomorphic Brain Phantom to Simulate PET Activity Distributions
StepBrain: A 3-Dimensionally Printed Multicompartmental Anthropomorphic Brain Phantom to Simulate PET Activity Distributions Open
An innovative multicompartmental anatomic brain phantom (StepBrain) is described to simulate the in vivo tracer uptake of gray matter, white matter, and striatum, overcoming the limitations of currently available phantoms. Methods: StepBra…
View article: Neurostructural subgroup in 4291 individuals with schizophrenia identified using the subtype and stage inference algorithm
Neurostructural subgroup in 4291 individuals with schizophrenia identified using the subtype and stage inference algorithm Open
Machine learning can be used to define subtypes of psychiatric conditions based on shared biological foundations of mental disorders. Here we analyzed cross-sectional brain images from 4,222 individuals with schizophrenia and 7038 healthy …
View article: Clinical and Pathophysiologic Correlates of Basilar Artery Measurements in Fabry Disease
Clinical and Pathophysiologic Correlates of Basilar Artery Measurements in Fabry Disease Open
Alterations of the BA in FD lack of any meaningful association with clinical, laboratory, or advanced imaging findings collected in this study. Furthermore, this lack of correlation seems constant across time, suggesting stability over tim…
View article: Gradient of microstructural damage along the dentato‐thalamo‐cortical tract in Friedreich ataxia
Gradient of microstructural damage along the dentato‐thalamo‐cortical tract in Friedreich ataxia Open
Objective The dentato‐thalamo‐cortical tract (DTT) is the main cerebellar efferent pathway. Degeneration of the DTT is a core feature of Friedreich ataxia (FRDA). However, it remains unclear whether DTT disruption is spatially specific, wi…
View article: Radiological Reporting Systems in Multiple Sclerosis
Radiological Reporting Systems in Multiple Sclerosis Open
(1) Background: Although MRI is a well-established tool in Multiple Sclerosis (MS) diagnosis and management, neuroradiological reports often lack standardization and/or quantitative information, with possible consequences in clinical care.…
View article: Mapping Structural Disconnection and Morphometric Similarity Alterations in Multiple Sclerosis
Mapping Structural Disconnection and Morphometric Similarity Alterations in Multiple Sclerosis Open
Whilst multiple sclerosis (MS) can be conceptualized as a network disorder, brain network analyses are typically dependent on advanced MRI sequences not commonly acquired in clinical practice. Here, we used conventional MRI to assess cross…
View article: Training radiology residents to evaluate deep myometrial invasion in endometrial cancer patients on MRI: A learning curve study
Training radiology residents to evaluate deep myometrial invasion in endometrial cancer patients on MRI: A learning curve study Open
The structured training program significantly enhanced radiology residents' diagnostic accuracy in assessing DMI for EC on MRI, emphasizing the effectiveness of active case-based training in refining oncologic imaging skills within radiolo…
View article: Alzheimer's Disease and Small Vessel Disease Differentially Affect White Matter Microstructure
Alzheimer's Disease and Small Vessel Disease Differentially Affect White Matter Microstructure Open
Objective Alzheimer's disease (AD) and cerebral small vessel disease (cSVD), the two most common causes of dementia, are characterized by white matter (WM) alterations diverging from the physiological changes occurring in healthy aging. Di…
View article: A case of Kennedy terminal ulcer in a 17th-century Italian mummy
A case of Kennedy terminal ulcer in a 17th-century Italian mummy Open
Giacomo Torno was born in 1539 (or 1541) in Naples. At the age of 18 he joined the Clerics Regular Theatines in San Paolo Maggiore and was welcomed on 30 October 1558. He suffered a stroke on 4 December 1608 and died 45 days later. Contemp…
View article: Assessing brain involvement in Fabry disease with deep learning and the brain‐age paradigm
Assessing brain involvement in Fabry disease with deep learning and the brain‐age paradigm Open
While neurological manifestations are core features of Fabry disease (FD), quantitative neuroimaging biomarkers allowing to measure brain involvement are lacking. We used deep learning and the brain‐age paradigm to assess whether FD patien…
View article: CHARON: An Imaging-Based Diagnostic Algorithm to Navigate Through the Sea of Hereditary Degenerative Ataxias
CHARON: An Imaging-Based Diagnostic Algorithm to Navigate Through the Sea of Hereditary Degenerative Ataxias Open
The complexity in diagnosing hereditary degenerative ataxias lies not only in their rarity, but also in the variety of different genetic conditions that can determine sometimes similar and overlapping clinical findings. In this light, Magn…
View article: A rare case of De Garengeot hernia: CT findings
A rare case of De Garengeot hernia: CT findings Open
We report a case of “De Garengeot’s hernia” (DGH), a rare condition that occurs when the inflamed appendix is localized inside a femoral hernia. The appendix may be involved in inflammatory or necrotic processes and the treatment is emerge…
View article: Structural brain abnormalities and aggressive behaviour in schizophrenia: Mega-analysis of data from 2095 patients and 2861 healthy controls via the ENIGMA consortium
Structural brain abnormalities and aggressive behaviour in schizophrenia: Mega-analysis of data from 2095 patients and 2861 healthy controls via the ENIGMA consortium Open
Background Schizophrenia is associated with an increased risk of aggressive behaviour, which may partly be explained by illness-related changes in brain structure. However, previous studies have been limited by group-level analyses, small …
View article: MR imaging characterization of pheochromocytoma: a comparison between typical and atypical tumor lesions
MR imaging characterization of pheochromocytoma: a comparison between typical and atypical tumor lesions Open
Purpose The aim of this retrospective study was to compare the MRI features between typical and atypical pheochromocytomas (Pheos) to specifically illustrate MRI features of atypical tumors for helping tumor diagnosis. Methods A total of 2…
View article: Disentangling neurodegeneration from ageing in multiple sclerosis: the brain-predicted disease duration gap
Disentangling neurodegeneration from ageing in multiple sclerosis: the brain-predicted disease duration gap Open
Disentangling brain ageing from disease-related neurodegeneration in patients with multiple sclerosis (PwMS) is increasingly topical. The brain-age paradigm offers a window into this problem but may miss disease-specific effects. Here, we …