A. G. Buckley
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View article: Automated computer vision and dose–response modeling improve throughput and accuracy of an ex vivo functional precision medicine platform
Automated computer vision and dose–response modeling improve throughput and accuracy of an ex vivo functional precision medicine platform Open
Functional Precision Medicine platforms face significant obstacles to clinical translation, including stringent requirements for analytical consistency. In this study, we present an automated data analysis workflow for an organotypic brain…
View article: Enabling stable preservation of ML algorithms in high-energy physics with petrifyML
Enabling stable preservation of ML algorithms in high-energy physics with petrifyML Open
Machine learning (ML) in high-energy physics (HEP) has moved in the LHC era from an internal detail of experiment software, to an unavoidable public component of many physics data-analyses. Scientific reproducibility thus requires that it …
View article: Rivet
Rivet Open
The Rivet toolkit (Robust Independent Validation of Experiment and Theory) is a system for validation of Monte Carlo event generators. It provides a large (and ever growing) set of experimental analyses useful for MC generator development,…
View article: Constraints On New Theories Using Rivet : CONTUR version 3 release note
Constraints On New Theories Using Rivet : CONTUR version 3 release note Open
The CONTUR toolkit exploits RIVET and its library of more than a thousand energy-frontier differential cross-section measurements from the Large Hadron Collider to allow rapid limit-setting and consistency checks for new physics models. In…
View article: Reinterpretation and preservation of data and analyses in HEP
Reinterpretation and preservation of data and analyses in HEP Open
Data from particle physics experiments are unique and are often the result of a very large investment of resources. Given the potential scientific impact of these data, which goes far beyond the immediate priorities of the experimental col…
View article: Interview with an Anonymous Graphics Reporter
Interview with an Anonymous Graphics Reporter Open
A conversation with a graphics reporter for a widely circulated American newspaper revealed the unique nature of the role, work, and ethics of graphics reporting. Operating under intense deadlines, graphics reporters must carefully balance…
View article: YODA
YODA Open
YODA -- Yet more Objects for Data Analysis -- is a lightweight C++ and Python package for weighted histogramming and reference data manipulation. It is particularly associated with the Rivet MC event analysis framework for High-Energy Phys…
View article: Probing the sensitivity of semi-visible jets to current LHC measurements using the CONTUR toolkit
Probing the sensitivity of semi-visible jets to current LHC measurements using the CONTUR toolkit Open
Semi-visible jets arise from a hypothetical, strongly interacting ``dark sector'' -- a dark counterpart of quantum chromodynamics whose partial decays back to Standard Model particles introduce new types of collider BSM signature. CMS and …
View article: Consistent, multidimensional differential histogramming and summary statistics with YODA 2
Consistent, multidimensional differential histogramming and summary statistics with YODA 2 Open
Histogramming is often taken for granted, but the power and compactness of partially aggregated, multidimensional summary statistics, and their fundamental connection to differential and integral calculus make them formidable statistical o…
View article: Codebase release 2.0 for YODA
Codebase release 2.0 for YODA Open
Histogramming is often taken for granted, but the power and compactness of partially aggregated, multidimensional summary statistics, and their fundamental connection to differential and integral calculus make them formidable statistical o…
View article: Physics Briefing Book: Input for the 2026 update of the European Strategy for Particle Physics
Physics Briefing Book: Input for the 2026 update of the European Strategy for Particle Physics Open
The European Strategy for Particle Physics (ESPP) reflects the vision and presents concrete plans of the European particle physics community for advancing human knowledge in fundamental physics. The ESPP is updated every five-to-six years …
View article: Les Houches guide to reusable ML models in LHC analyses
Les Houches guide to reusable ML models in LHC analyses Open
With the increasing usage of machine-learning in high-energy physics analyses, the publication of the trained models in a reusable form has become a crucial question for analysis preservation and reuse. The complexity of these models creat…
View article: Robust independent validation of experiment and theory: Rivet version 4 release note
Robust independent validation of experiment and theory: Rivet version 4 release note Open
The Rivet toolkit is the primary mechanism for phenomenological preservation of collider-physics measurements, containing both a computational core and API for analysis implementation, and a large collection of more than a thousand preserv…
View article: Codebase release 4.0 for RIVET
Codebase release 4.0 for RIVET Open
The Rivet toolkit is the primary mechanism for phenomenological preservation of collider-physics measurements, containing both a computational core and API for analysis implementation, and a large collection of more than a thousand preserv…
View article: Review of Particle Physics
Review of Particle Physics Open
The summarizes much of particle physics and cosmology. Using data from previous editions, plus 2,717 new measurements from 869 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs bos…
View article: MODL-13. ORGANOTYPIC BRAIN SLICE CULTURE PLATFORM AS A MODEL OF PEDIATRIC LOW GRADE GLIOMAS
MODL-13. ORGANOTYPIC BRAIN SLICE CULTURE PLATFORM AS A MODEL OF PEDIATRIC LOW GRADE GLIOMAS Open
BACKGROUND Pediatric low grade glioma (pLGG), the most common subgroup of central nervous system tumors in children, suffers from a paucity of models that support pLGG biological discovery, preclinical target identification, and drug scree…
View article: Auto-loaded TRAIL-exosomes derived from induced neural stem cells for brain cancer therapy
Auto-loaded TRAIL-exosomes derived from induced neural stem cells for brain cancer therapy Open
Transdifferentiation (TD), a somatic cell reprogramming process that eliminates pluripotent intermediates, creates cells that are ideal for personalized anti-cancer therapy. Here, we provide the first evidence that extracellular vesicles (…
View article: Event generators for high-energy physics experiments
Event generators for high-energy physics experiments Open
We provide an overview of the status of Monte-Carlo event generators for high-energy particle physics. Guided by the experimental needs and requirements, we highlight areas of active development, and opportunities for future improvements. …
View article: Utilizing induced neural stem cell-based delivery of a cytokine cocktail to enhance chimeric antigen receptor-modified T-cell therapy for brain cancer
Utilizing induced neural stem cell-based delivery of a cytokine cocktail to enhance chimeric antigen receptor-modified T-cell therapy for brain cancer Open
Chimeric antigen receptor (CAR)-modified T-cell therapy has shown enormous clinical promise against blood cancers, yet efficacy against solid tumors remains a challenge. Here, we investigated the potential of a new combination cell therapy…
View article: Towards better discrimination and improved modelling of dark-sector showers
Towards better discrimination and improved modelling of dark-sector showers Open
As no evidence for classic WIMP-based signatures of dark matter have been found at the LHC, several phenomenological studies have raised the possibility of accessing a strongly-interacting dark sector through new collider-event topologies.…
View article: Les Houches 2023: Physics at TeV Colliders: Standard Model Working Group Report
Les Houches 2023: Physics at TeV Colliders: Standard Model Working Group Report Open
This report presents a short summary of the activities of the 'Standard Model' working group for the 'Physics at TeV Colliders' workshop (Les Houches, France, 12-30 June, 2023).
View article: Les Houches guide to reusable ML models in LHC analyses
Les Houches guide to reusable ML models in LHC analyses Open
With the increasing usage of machine-learning in high-energy physics analyses, the publication of the trained models in a reusable form has become a crucial question for analysis preservation and reuse. The complexity of these models creat…
View article: MODL-44. DEVELOPMENT OF A NOVEL, PERSONALIZED DRUG SENSITIVITY SCORE TO ASSESS TUMOR KILLING AND TOXICITY WITHIN AN ORGANOTYPIC BRAIN SLICE CULTURE PLATFORM
MODL-44. DEVELOPMENT OF A NOVEL, PERSONALIZED DRUG SENSITIVITY SCORE TO ASSESS TUMOR KILLING AND TOXICITY WITHIN AN ORGANOTYPIC BRAIN SLICE CULTURE PLATFORM Open
Development of new therapeutics for clinical use requires balancing tumor killing and off-target toxicity to normal tissue. We have established an organotypic brain slice culture (OBSC) platform which enables us to assess both on- and off-…
View article: CNSC-39. GENERATION AND CHARACTERIZATION OF LIVING ORGANOTYPIC BRAIN SLICE CULTURES AS A NOVEL PRE-CLINICAL MODEL FOR BRAIN CANCER
CNSC-39. GENERATION AND CHARACTERIZATION OF LIVING ORGANOTYPIC BRAIN SLICE CULTURES AS A NOVEL PRE-CLINICAL MODEL FOR BRAIN CANCER Open
A challenge in cancer research is developing reproducible, reliable, and practical models which can capture the complexity of cancer development and treatment. The development of functional precision medicine platforms is emerging as a pro…
View article: MODL-48. AUTOMATING ANALYSIS OF ORGANOTYPIC BRAIN SLICE CULTURE USING MACHINE LEARNING-POWERED COMPUTER VISION
MODL-48. AUTOMATING ANALYSIS OF ORGANOTYPIC BRAIN SLICE CULTURE USING MACHINE LEARNING-POWERED COMPUTER VISION Open
The difficulty of image labeling and analysis poses a problem for many areas of scientific research, including the recently developed Organotypic Brain Slice Culture (OBSC) tumor characterization platform. An OBSC experiment generates doze…
View article: Accelerating $\\mathrm{LHC}$ event generation with simplified pilot runs and fast $\\mathrm{PDF}$s
Accelerating $\\mathrm{LHC}$ event generation with simplified pilot runs and fast $\\mathrm{PDF}$s Open
Poor computing efficiency of precision event generators for LHC physics has become a bottleneck for Monte-Carlo event simulation campaigns. We provide solutions to this problem by focusing on two major components of general-purpose event g…