Explanipedia

Serum Metabolites and Heart Failure Risk: MESA and RS Open

Fang Zhu, Arjun Sinha, Gonçalo Graça, Ian J. Neeland, Ambarish Pandey , et al. · 2025

Background The role of circulating metabolites in heart failure (HF) mechanisms and their clinical utility remain unclear. We aimed to examine the associations between serum metabolites and incident HF and assess their performance in impro…

An African ancestry-specific nonsense variant in CD36 is associated with a higher risk of dilated cardiomyopathy Open

Jennifer E. Huffman, Liam Gaziano, Zeina R. Al Sayed, Renae Judy, Laura M. Raffield , et al. · 2025

The high burden of dilated cardiomyopathy (DCM) in individuals of African descent remains incompletely explained. Here, to explore a genetic basis, we conducted a genome-wide association study in 1,802 DCM cases and 93,804 controls of Afri…

Longitudinal trajectories of albuminuria and risk of subclinical and clinical heart failure, atrial fibrillation, and coronary heart disease: the MESA study Open

Soroush Masrouri, Parag Anilkumar Chevli, Michael P. Bancks, Saeid Mirzai, João A.C. Lima , et al. · 2025

Aims We examined whether trajectories of urine albumin-creatinine ratio (UACR) over 5- and 10-year periods were associated with subclinical and clinical heart failure (HF), heart failure subtypes, atrial fibrillation (AF), and coronary hea…

Emerging cardiac CT biomarkers: a systematic review of diagnostic and prognostic utility in cardiovascular disease Open

Mubariz Ahmed Hassan, Mohammed Mhanna, Ashraf Alzahrani, Muhammad Adil Afzal, Ola Abdelkarim , et al. · 2025

Background: Cardiac computed tomography (CT) has evolved from an anatomic test to a platform that quantifies functional, inflammatory, and tissue-characterization biomarkers. We synthesized evidence on the diagnostic and prognostic value o…

Genomic and phenotypic correlates of mosaic loss of chromosome Y in blood Open

Yasminka A. Jakubek, Xiaolong Ma, Adrienne M. Stilp, Fulong Yu, Jason Bacon , et al. · 2025

Deep Learning Prediction of Left Atrial Structure and Function from 12-lead Electrocardiograms Open

Jennifer A. Brody, Vidhushei Yogeswaran, Kerri L. Wiggins, Colleen M. Sitlani, Joshua C. Bis , et al. · 2025

Abnormal cardiac atrial structure and function (atrial cardiopathy) 1 typically precedes atrial fibrillation (AF) and predicts other cardiovascular complications, yet detection is limited by the cost and limited accessibility of high-quali…

SAGCNet: Spatial-Aware Graph Completion Network for Missing Slice Imputation in Population CMR Imaging Open

Nay Aung, Theodoros N. Arvanitis, Stefan K. Piechnik, João A.C. Lima, Steffen E. Petersen , et al. · 2025

Magnetic resonance imaging (MRI) provides detailed soft-tissue characteristics that assist in disease diagnosis and screening. However, the accuracy of clinical practice is often hindered by missing or unusable slices due to various factor…

Sex-Difference of Associations between Cigarette Smoking and Myocardial Fibrosis: The Multi-Ethnic Study of Atherosclerosis Open

Elie Akl, Ralph Zeitoun, Omar Chehab, Vinithra Varadarajan, Haiou Li , et al. · 2025

Background: Extracellular volume (ECV) and native T1 time (nT1) are markers of interstitial-myocardial-fibrosis (IMF) by cardiac MRI (CMR) and are associated with CV events, heart failure and death. However, the association between smoking…

Bisphosphonate Use and Cardiovascular Outcomes According to Kidney Function Status in Post-Menopausal Women: An Emulated Target Trial from the Multi-Ethnic Study of Atherosclerosis Open

Elena Ghotbi, Naveen Subhas, Michael P. Bancks, Sammy Elmariah, Jonathan L. Halperin , et al. · 2025

Background/Objectives: Bisphosphonates may influence vascular calcification and atheroma formation via farnesyl pyrophosphate synthase inhibition in the mevalonate pathway regulating bone and lipid metabolism. However, the clinical impact …

Uso de inibidores SGLT2 na prevenção de insuficiência cardíaca em adultos com diabetes mellitus tipo 2 Open

Maria Eduarda Diniz Prudente, António Guimarães, Carlos L. César, Júlia Arantes Alvarenga, Nathália Rosa Chrisóstomo Monteiro , et al. · 2025

Objetivo: Analisar as evidências disponíveis sobre a eficácia dos inibidores de SGLT2 na prevenção da insuficiência cardíaca em adultos com diabetes mellitus tipo 2. Métodos: Trata-se de uma revisão integrativa da literatura realizada atra…

Baseline Cardiac Biomarker Levels as Predictors of Cancer Risk in the MESA Cohort Open

Xinjiang Cai, Quinn White, W. Craig Johnson, Spencer Hansen, Zeina Dardari , et al. · 2025

In the MESA cohort, higher baseline levels of hs-cTnT and NT-proBNP predicted an increased risk of incident cancer, with no significant differences by race/ethnicity or sex.

Multiorgan Imaging for Interorgan Crosstalk in Cardiometabolic Diseases Open

Ana Devesa, Victoria Delgado, Ladislav Valkovič, João A.C. Lima, Eike Nagel , et al. · 2025

Cardiometabolic diseases encompass a group of conditions characterized by metabolic and inflammatory abnormalities that increase the risk of diabetes and cardiovascular disease. These syndromes involve multiple organs, including the heart,…

Correction to: Differential Associations of Cigar, Pipe, and Smokeless Tobacco Use Versus Combustible Cigarette Use With Subclinical Markers of Inflammation, Thrombosis, and Atherosclerosis: The Cross-Cohort Collaboration–Tobacco Working Group Open

Zhiqi Yao, Erfan Tasdighi, Zeina Dardari, Kunal Jha, Ngozi Osuji , et al. · 2025

Associations between visceral adipose and renal artery calcification: Results from the multi-ethnic study of atherosclerosis Open

Harsimran Bajwa, Michael H. Criqui, Ron Blankstein, Siddique Abbasi, João A.C. Lima , et al. · 2025

Integrating ketone bodies in multi-marker risk prediction of incident heart failure in the multi-ethnic study of atherosclerosis Open

Parag Anilkumar Chevli, Senthil Selvaraj, Byron C. Jaeger, Aziz Hammoud, Margery A. Connelly , et al. · 2025

Aims Circulating ketone bodies (KB) have emerged as a potential adjunctive biomarker for incident heart failure (HF) risk and might provide incremental information beyond established biomarkers. A multi-marker risk score may improve risk s…

Cumulative Blood Pressure Exposure and Global and Regional Cardiac Structure and Function: The MESA Study Open

Soroush Masrouri, Peyman Tabnak, Parag Anilkumar Chevli, Saeid Mirzai, Leandro Slipczuk , et al. · 2025

Aims This study examined the associations between decade-long cumulative blood pressure (BP) exposure and global/regional myocardial structure and function independent of current BP levels. Methods We analyzed 3,015 adults (aged 69.0±9.2 y…

Evaluating Incident Atrial Fibrillation and Incident Heart Failure as Time-varying Covariates for Time-to-Event Analysis Among Adults 55 Years and Older in the Multi-Ethnic Study of Atherosclerosis (MESA) Open

Pierre J Amiel, Bharath Ambale‐Venkatesh, Colin O. Wu, Matthew B. Matheson, Mohammad R. Ostovaneh , et al. · 2025

Relationship between left ventricular shape and cardiovascular risk factors: comparison between the Multi-Ethnic Study of Atherosclerosis and UK Biobank Open

Avan Suinesiaputra, Kathleen Gilbert, Charlène Mauger, David A. Bluemke, Colin O. Wu , et al. · 2025

Background Statistical shape atlases have been used in large-cohort studies to investigate relationships between heart shape and risk factors. The generalisability of these relationships between cohorts is unknown. The aims of this study w…

Genomic and phenotypic correlates of mosaic loss of chromosome Y in blood Open

Yasminka A. Jakubek, Xiaolong Ma, Adrienne M. Stilp, Fulong Yu, Jason Bacon , et al. · 2025

Cigar, Pipe, and Smokeless Tobacco Use and Cardiovascular Outcomes From Cross Cohort Collaboration Open

Erfan Tasdighi, Zhiqi Yao, Kunal Jha, Zeina Dardari, Ngozi Osuji , et al. · 2025

Importance Cardiovascular health outcomes associated with noncigarette tobacco products (cigar, pipe, and smokeless tobacco) remain unclear, yet such data are required for evidence-based regulation. Objective To investigate the association…

Proteomic signature of HIV-associated subclinical left atrial remodeling and incident heart failure Open

Tess E. Peterson, Virginia S. Hahn, Ruin Moaddel, Min Zhu, Sabina Haberlen , et al. · 2025

People living with HIV are at higher risk of heart failure and associated left atrial remodeling compared to people without HIV. Mechanisms are unclear but have been linked to inflammation and premature aging. Here we obtain plasma proteom…

Biologically Older Cardiovascular System Predicts Adverse Clinical Outcome Independently of Chronological Age Open

Pier Giorgio Masci, Gianni Andreozzi, Esther Puyol‐Antón, Ashkan Abdollahi, Richard Mospan , et al. · 2025

HIV-Associated Proteomic Signature of Myocardial Fibrosis and Incident Heart Failure Open

Tess E. Peterson, Virginia S. Hahn, Ruin Moaddel, Min Zhu, Jinshui Fan , et al. · 2025

Anais da 5ª Jornada de Odontologia do Centro Universitário Fibra – V JOFIBRA Open

Jéssica Borges Moraes Amorim, João A.C. Lima, Ana Clara Pantoja Vasconcelos, Debora Barros Gonçalves, Thiago Augusto Gonçalves , et al. · 2025

Longitudinal trajectories of left ventricular myocardial remodeling: associations with cardiovascular risk factors in the multi-ethnic study of atherosclerosis Open

Charlène Mauger, Bharath Ambale‐Venkatesh, Avan Suinesiaputra, David A. Bluemke, Colin O. Wu , et al. · 2025

Trajectories of cardiovascular risk factor-related longitudinal remodeling can be examined using shape atlases. In addition to global changes, each risk factor is associated with a distinct regional remodeling of the myocardium.

Validation of normal reference ranges in cardiac magnetic resonance imaging: The Multi-Ethnic Study of Atherosclerosis Open

Nadine Kawel‐Boehm, Spencer Hansen, Bharath Ambale‐Venkatesh, J. Jeffrey Carr, J. Paul Finn , et al. · 2025

Our results support the clinical relevance of CMR normal reference ranges for LV parameters. Most LV CMR parameters beyond the normal reference range (2SD-threshold) were associated with elevated CV risk at 5 and 10 years. Elevated LVEDDi,…

Impactos Fiscais na Arrecadação Tributária do Distrito Federal Durante a Pandemia de Covid-19 - Apresentação de Resultados Open

Jeferson Teodorovicz, João A.C. Lima · 2025

Cardiac Biomarkers in a Brazilian Indigenous Population Exposed to Arboviruses: A Cross-Sectional Study Open

Jandir Mendonça Nicácio, Carlos Dornels Freire de Souza, Orlando Vieira Gomes, Bárbara Maria Paraná da Silva Souza, João A.C. Lima , et al. · 2024

Arthropod-borne viral diseases are acute febrile illnesses, sometimes with chronic effects, that can be debilitating and even fatal worldwide, affecting particularly vulnerable populations. Indigenous communities face not only the burden o…

Prognostic Value of Coronary CT Angiography–Derived Quantitative Flow Ratio in Suspected Coronary Artery Disease Open

Zehang Li, Shengxian Tu, Matthew B. Matheson, Guanyu Li, Yankai Chen , et al. · 2024

Coronary CT angiography–derived quantitative flow ratio was independently predictive of major adverse cardiovascular events, with 5-year prognostic value similar to invasive coronary angiography/SPECT in suspected coronary artery disease.

Sex differences in global electrical heterogeneity: The Hispanic Community Health Study/Study of Latinos Open

Larisa G. Tereshchenko, Kazi T. Haq, Stacey J. Howell, Evan Mitchell, Jessica Hyde , et al. · 2024

João A.C. Lima YOU? Author Swipe