N.L.A. Cacheiro
YOU?
Author Swipe
View article: Heightened susceptibility to chronic gastritis, hyperplasia and metaplasia in Kcnq1 mutant mice
Heightened susceptibility to chronic gastritis, hyperplasia and metaplasia in Kcnq1 mutant mice Open
Increased susceptibility to gastric cancer has been associated with a wide range of host genetic and environmental factors, including Helicobacter pylori infection. Helicobacter pylori infection is postulated to initiate a progression thro…
View article: A New Mouse Insertional Mutation That Causes Sensorineural Deafness and Vestibular Defects
A New Mouse Insertional Mutation That Causes Sensorineural Deafness and Vestibular Defects Open
This article describes a new recessive insertional mutation in the transgenic line TgN2742Rpw that causes deafness and circling behavior in mice. Histologic analysis revealed virtually complete loss of the cochlear neuroepithelium (the org…
View article: Complementation analyses for 45 mutations encompassing the pink-eyed dilution (p) locus of the mouse.
Complementation analyses for 45 mutations encompassing the pink-eyed dilution (p) locus of the mouse. Open
The homozygous and heterozygous phenotypes are described and characterized for 45 new pink-eyed dilution (p) locus mutations, most of them radiation-induced, that affect survival at various stages of mouse development. Cytogenetically dete…
View article: Candidate Gene Associated with a Mutation Causing Recessive Polycystic Kidney Disease in Mice
Candidate Gene Associated with a Mutation Causing Recessive Polycystic Kidney Disease in Mice Open
A line of transgenic mice was generated that contains an insertional mutation causing a phenotype similar to human autosomal recessive polycystic kidney disease. Homozygotes displayed a complex phenotype that included bilateral polycystic …
View article: Molecular and genetic characterization of a radiation-induced structural rearrangement in mouse chromosome 2 causing mutations at the limb deformity and agouti loci.
Molecular and genetic characterization of a radiation-induced structural rearrangement in mouse chromosome 2 causing mutations at the limb deformity and agouti loci. Open
Molecular characterization of mutations in the mouse, particularly those involving agent-induced major structural alterations, is proving to be useful for correlating the structure and expression of individual genes with their function in …
View article: Genetic and molecular analysis of chlorambucil-induced germ-line mutations in the mouse.
Genetic and molecular analysis of chlorambucil-induced germ-line mutations in the mouse. Open
Eighteen variants recovered from specific locus mutation rate experiments involving the mutagen chlorambucil were subjected to several genetic and molecular analyses. Most mutations were found to be homozygous lethal. Because lethality is …
View article: Chlorambucil effectively induces deletion mutations in mouse germ cells.
Chlorambucil effectively induces deletion mutations in mouse germ cells. Open
The chemotherapeutic agent chlorambucil was found to be more effective than x-rays or any chemical investigated to date in inducing high yields of mouse germ-line mutations that appear to be deletions or other structural changes. Induction…
View article: DELAYED FORMATION OF CHROMOSOME ABERRATIONS IN MOUSE PACHYTENE SPERMATOCYTES TREATED WITH TRIETHYLENEMELAMINE (TEM)
DELAYED FORMATION OF CHROMOSOME ABERRATIONS IN MOUSE PACHYTENE SPERMATOCYTES TREATED WITH TRIETHYLENEMELAMINE (TEM) Open
Induction of chromosome aberrations in pachytene spermatocytes of mice by 2 mg/kg TEM was compared with induction by 400 R X rays. These doses induced comparably high dominant lethal effects in pachytene spermatocytes of mice. Cytological …
View article: Evidence that Linkage Group IV as well as Linkage Group X of the mouse are in chromosome 10
Evidence that Linkage Group IV as well as Linkage Group X of the mouse are in chromosome 10 Open
SUMMARY Four translocations in which one breakpoint was known to be at or closely linked to the LGIV marker Steel, Sl , were studied in an attempt to identify cytologically the as yet unassigned Linkage Group IV of the mouse. The cytologic…
View article: TRANSLOCATIONS, THE PREDOMINANT CAUSE OF TOTAL STERILITY IN SONS OF MICE TREATED WITH MUTAGENS
TRANSLOCATIONS, THE PREDOMINANT CAUSE OF TOTAL STERILITY IN SONS OF MICE TREATED WITH MUTAGENS Open
Histological and cytological analyses of the testes were carried out in 42 sterile sons of males treated in the spermatozoal or spermatid stage with 250 mg/kg ethyl methanesulfonate (EMS) alone or after prefeeding with butylated hydroxytol…