Aihua Zhang
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View article: Endothelial Lon protease 1 facilitates the redox balance to prevent glomerulosclerosis by acting on superoxide dismutase 2 ubiquitination
Endothelial Lon protease 1 facilitates the redox balance to prevent glomerulosclerosis by acting on superoxide dismutase 2 ubiquitination Open
Endothelial injury is an early event in chronic kidney disease (CKD) leading to renal hemodynamic disorders and even glomerulosclerosis. During this process, both oxidative stress and inflammation originating from injured endothelial cells…
View article: Spatial transcriptomics reveals injury-responsive compartments and coordinated immune–fibrotic signaling in ANCA-associated renal vasculitis
Spatial transcriptomics reveals injury-responsive compartments and coordinated immune–fibrotic signaling in ANCA-associated renal vasculitis Open
ANCA-associated vasculitis (AAV) often presents with rapidly progressive glomerulonephritis, yet how immune and stromal programmes are organised within kidney tissue remains unclear. We applied spatial transcriptomics to renal cortex biops…
View article: From Mutation to Symptoms: A Multi-Center Study on HNF1B-Related Nephropathy in Chinese Children
From Mutation to Symptoms: A Multi-Center Study on HNF1B-Related Nephropathy in Chinese Children Open
Background Hepatocyte nuclear factor 1β ( HNF1B ) pathogenic variants constitute a major genetic contributor to congenital anomalies of the kidney and urinary tract (CAKUT), with patients simultaneously exhibiting distinct extrarenal featu…
View article: Exploring the Causal Relationship Between Plasma Proteins and Obstructive Sleep Apnea: A Study Using Genome-Wide Mendelian Randomization, Single-Cell RNA Sequencing Analysis, and Network Pharmacology
Exploring the Causal Relationship Between Plasma Proteins and Obstructive Sleep Apnea: A Study Using Genome-Wide Mendelian Randomization, Single-Cell RNA Sequencing Analysis, and Network Pharmacology Open
Observational studies suggest that plasma proteins play a crucial role in the development and progression of obstructive sleep apnea (OSA); however, the causal relationship between plasma proteins and OSA remains controversial. This study …
View article: A meta-analysis on the effectiveness of Traditional Chinese Medicine Emotional Nursing in improving anxiety and depression symptoms in elderly patients
A meta-analysis on the effectiveness of Traditional Chinese Medicine Emotional Nursing in improving anxiety and depression symptoms in elderly patients Open
Background This study used meta-analysis to explore the effectiveness of Traditional Chinese Medicine (TCM) emotional nursing intervention on the anxiety and depression of the elderly and factors that might influence this intervention, so …
View article: A comprehensive splicing characterization of COL4A5 mutations and prognostic significance in a single cohort with X-linked alport syndrome
A comprehensive splicing characterization of COL4A5 mutations and prognostic significance in a single cohort with X-linked alport syndrome Open
Introduction X-linked Alport syndrome (XLAS), caused by mutations in the COL4A5 gene, is an X-linked hereditary disease typically characterized by renal failure, hearing loss, and ocular abnormalities. It is a leading hereditary cause of e…
View article: Endothelial MicroRNA-214 Confers Angiotensin II Hypertension by Targeting eNOS in Mice
Endothelial MicroRNA-214 Confers Angiotensin II Hypertension by Targeting eNOS in Mice Open
Introduction: MicroRNAs have been increasingly recognized for their roles in cardiovascular diseases. Among these microRNAs, miR-214 was reported to be involved in hypertension. However, the role of endothelial miR-214 in hypertension is s…
View article: Spatially segregated multiomics decodes metformin-mediated functional-specific metabolic characteristics in diabetic kidney disease
Spatially segregated multiomics decodes metformin-mediated functional-specific metabolic characteristics in diabetic kidney disease Open
Understanding the specific metabolic changes in multiple regions of the kidney is crucial to revealing the underlying mechanism and developing effective targets for diabetic nephropathy (DN). In this study, integrated spatially resolved me…
View article: Dynamic graph convolutional networks with Temporal representation learning for traffic flow prediction
Dynamic graph convolutional networks with Temporal representation learning for traffic flow prediction Open
In the realm of traffic prediction, emerging are methodologies founded on graph convolutional networks. Nonetheless, existing approaches grapple with issues encompassing insufficient sharing patterns, dependence on static relationship pres…
View article: Inhibition of P2Y2 Attenuates Cisplatin-Induced AKI via Reduced Oxidative Stress, Inflammation and Cell Death
Inhibition of P2Y2 Attenuates Cisplatin-Induced AKI via Reduced Oxidative Stress, Inflammation and Cell Death Open
Introduction: Purinergic signaling has been recognized as important extracellular regulator in multiple physiological and pathophysiological conditions. Adenosine triphosphate–purinergic receptor P2Y2 signaling pathway is associated with g…
View article: Performance of EMA algorithm, 2022 ACR/EULAR criteria, and EMA-ACR/EULAR algorithm in classifying pediatric ANCA-associated vasculitis: a national cohort study in China
Performance of EMA algorithm, 2022 ACR/EULAR criteria, and EMA-ACR/EULAR algorithm in classifying pediatric ANCA-associated vasculitis: a national cohort study in China Open
Background Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) is a type of necrotizing vasculitis with poor prognosis, which is more severe in children. Classifying AAV patients may be helpful for diagnosis and management. Ho…
View article: HNF3α Targets Nckap1l and Promotes Renal Fibrosis Following Ischemia‐Reperfusion Injury
HNF3α Targets Nckap1l and Promotes Renal Fibrosis Following Ischemia‐Reperfusion Injury Open
Chronic Kidney Disease (CKD) is a global health challenge, with acute kidney injury (AKI) from ischemia‐reperfusion injury (IRI) as a common cause. This study explored the role of Hepatocyte Nuclear Factor 3 alpha (HNF3α/FOXA1) in renal fi…
View article: Disease burden and health-related quality of life among children with X-linked hypophosphataemia in China: a national cross-sectional survey
Disease burden and health-related quality of life among children with X-linked hypophosphataemia in China: a national cross-sectional survey Open
Background X-linked hypophosphataemia (XLH) is a rare inherited disorder often misdiagnosed and lacking sufficient aetiological treatment. Previous studies have shown that XLH is associated with worse health-related quality of life (HRQoL)…
View article: Copula-Based Risk Aggregation and the Significance of Reinsurance
Copula-Based Risk Aggregation and the Significance of Reinsurance Open
Insurance companies need to calculate solvency capital requirements in order to ensure that they can meet their future obligations to policyholders and beneficiaries. The solvency capital requirement is a risk management tool essential for…
View article: Copula-Based Risk Aggregation and the Significance of Reinsurance
Copula-Based Risk Aggregation and the Significance of Reinsurance Open
Insurance companies need to calculate solvency capital requirements in order to ensure that they can meet their future obligations to policyholders and beneficiaries. The solvency capital requirement is a risk management tool essential for…
View article: Integrated metabolomics and proteomics revealed astragaloside IV inhibiting Pdxk-mediated vitamin B6 metabolism based on liquid chromatography-tandem mass spectrometry combined with pattern recognition and correlation analysis
Integrated metabolomics and proteomics revealed astragaloside IV inhibiting Pdxk-mediated vitamin B6 metabolism based on liquid chromatography-tandem mass spectrometry combined with pattern recognition and correlation analysis Open
Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite accumulation or deficiency which is well-recognized hallmarks of diseases. Unique metabolic needs of cells highlight the potential for fruitful drug and t…
View article: Slc25a21 in cisplatin-induced acute kidney injury: a new target for renal tubular epithelial protection by regulating mitochondrial metabolic homeostasis
Slc25a21 in cisplatin-induced acute kidney injury: a new target for renal tubular epithelial protection by regulating mitochondrial metabolic homeostasis Open
Acute kidney injury (AKI) is a significant global health issue, which is often caused by cisplatin therapy and characterized by mitochondrial dysfunction. Restoring mitochondrial homeostasis in tubular cells could exert therapeutic effects…
View article: Molecular and Clinical Profiles of Pediatric Monogenic Diabetes Subtypes: Comprehensive Genetic Analysis of 138 Patients
Molecular and Clinical Profiles of Pediatric Monogenic Diabetes Subtypes: Comprehensive Genetic Analysis of 138 Patients Open
Background Single gene variants that give rise to neonatal diabetes mellitus (NDM), maturity onset diabetes of the young (MODY), and syndromic forms of diabetes mellitus (SDM) are responsible for 3.1% to 4.2% of all diabetes cases. This si…
View article: Copula-Based Risk Aggregation and the Significance of Reinsurance
Copula-Based Risk Aggregation and the Significance of Reinsurance Open
Insurance companies need to calculate solvency capital requirements in order to ensure that they can meet their future obligations to policyholders and beneficiaries. The solvency capital requirement is a risk management tool essential for…
View article: Meis1 Targets Protein Tyrosine Phosphatase Receptor J in Fibroblast to Retard Chronic Kidney Disease Progression
Meis1 Targets Protein Tyrosine Phosphatase Receptor J in Fibroblast to Retard Chronic Kidney Disease Progression Open
Renal fibrosis is a common pathological feature of chronic kidney disease (CKD) with the proliferation and activation of myofibroblasts being definite effectors and drivers. Here, increased expression of Meis1 (myeloid ecotropic viral inte…
View article: [Retrospective study on the diagnosis, treatment, and follow-up of 85 cases of hypophosphatemic rickets in children].
[Retrospective study on the diagnosis, treatment, and follow-up of 85 cases of hypophosphatemic rickets in children]. Open
For children presenting with lower limb deformities, short stature, and slow growth, early testing for blood levels of phosphate, calcium, and ALP, along with imaging examinations of the lower limbs, can aid in the early diagnosis of HR. G…
View article: Compound heterozygous variants of ANKFY1 in a child with infantile-onset proteinuria and movement disorder
Compound heterozygous variants of ANKFY1 in a child with infantile-onset proteinuria and movement disorder Open
The ANKFY1 gene encodes a protein that belongs to double zinc finger proteins involved in endocytosis. Only one family with steroid-resistant nephrotic syndrome has been reported carrying a homozygous variant in ANKFY1 so far. Here we desc…
View article: The application of nomogram model integrating clinical factors and multi-modal MRI radiomics features for predicting cervical lymph nodes metastasis for patients with oral tongue squamous cell carcinoma: a multicenter study
The application of nomogram model integrating clinical factors and multi-modal MRI radiomics features for predicting cervical lymph nodes metastasis for patients with oral tongue squamous cell carcinoma: a multicenter study Open
Background The aim of this study was to build and test the nomogram model integrating clinical factors and multi-modal MRI radiomics features to predict the risk of cervical lymph nodes metastasis (CLNM) in oral tongue squamous cell carcin…
View article: Olesoxime protects against cisplatin-induced acute kidney injury by attenuating mitochondrial dysfunction
Olesoxime protects against cisplatin-induced acute kidney injury by attenuating mitochondrial dysfunction Open
The results of this study suggest that olesoxime is a viable and efficient therapeutic agent in the treatment of cisplatin-induced acute kidney injury presumably by alleviating mitochondrial dysfunction.
View article: GolpHCat (TMEM87A), a unique voltage-dependent cation channel in Golgi apparatus, contributes to Golgi-pH maintenance and hippocampus-dependent memory
GolpHCat (TMEM87A), a unique voltage-dependent cation channel in Golgi apparatus, contributes to Golgi-pH maintenance and hippocampus-dependent memory Open
Impaired ion channels regulating Golgi pH lead to structural alterations in the Golgi apparatus, such as fragmentation, which is found, along with cognitive impairment, in Alzheimer’s disease. However, the causal relationship between alter…