Andrés F. Cardona
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View article: Cancer Incidence and Mortality Estimates in Latin America and the Caribbean: A Systematic Analysis of the GLOBOCAN 2022
Cancer Incidence and Mortality Estimates in Latin America and the Caribbean: A Systematic Analysis of the GLOBOCAN 2022 Open
Cancer is a leading cause of death in Latin America and the Caribbean (LAC), and up-to-date estimates are essential to guide cancer policy. Using GLOBOCAN 2022 data, we analyzed cancer incidence and mortality across 32 LAC countries, calcu…
View article: Plain language summary of the ALINA study results: alectinib compared with chemotherapy after surgery in people with <i>ALK</i> -positive non-small cell lung cancer
Plain language summary of the ALINA study results: alectinib compared with chemotherapy after surgery in people with <i>ALK</i> -positive non-small cell lung cancer Open
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View article: Exploring the role of the oral microbiome in saliva, sputum, bronchoalveolar fluid, and lung cancer tumor tissue: A systematic review
Exploring the role of the oral microbiome in saliva, sputum, bronchoalveolar fluid, and lung cancer tumor tissue: A systematic review Open
Overgrowth of specific oral microorganisms in the saliva and BALF is associated with diagnosis, poor prognosis, and low response to immunotherapy. Veillonella could be a marker for response to ICIs therapy. Further well-designed studies sh…
View article: Molecular and clonal evolution of primary lesions vs. brain metastasis in EGFR-mutated NSCLC: a retrospective cohort study
Molecular and clonal evolution of primary lesions vs. brain metastasis in EGFR-mutated NSCLC: a retrospective cohort study Open
The molecular features of BM differ from those of the primary tumor. These results indicate that specific brain metastatic clones can also result in systemic progression.
View article: Economic Benefits of Sponsored Clinical Trials in Cancer for the Colombian Healthcare System: A Real‐World Evidence Approach
Economic Benefits of Sponsored Clinical Trials in Cancer for the Colombian Healthcare System: A Real‐World Evidence Approach Open
Purpose Clinical trials (CTs) are essential for the research and development of new cancer treatment technologies. Evaluating their economic impact and the potential cost savings for healthcare systems in low‐ and middle‐income countries i…
View article: Establishing the First Genetic Variant Registry for Breast and Ovarian Cancer in Colombia: Insights and Implications
Establishing the First Genetic Variant Registry for Breast and Ovarian Cancer in Colombia: Insights and Implications Open
Background: Genetic insights from diverse populations are key to advancing cancer detection, treatment, and prevention. Unlike other Latin American countries, Colombia lacks a centralized registry for germline and somatic mutations in brea…
View article: Visceral crisis in a patient with non-small cell lung cancer and ROS1::SDC4 fusion: intrinsic resistance to entrectinib via L2026M mutation—a case report
Visceral crisis in a patient with non-small cell lung cancer and ROS1::SDC4 fusion: intrinsic resistance to entrectinib via L2026M mutation—a case report Open
The emergence of the L2026M mutation suggests a need for next-generation TKIs and combination strategies to overcome resistance. Future studies should explore novel inhibitors targeting ROS1 resistance pathways to improve outcomes in this …
View article: Academic Collaborative Groups in Latin America: Key for High-Quality Standards and Personal and Collective Growth
Academic Collaborative Groups in Latin America: Key for High-Quality Standards and Personal and Collective Growth Open
Latin America's cultural diversity, political instability, and socioeconomic inequality contribute to fragmented health systems, hindering high-quality care and health equity. Financial limitations in health care exacerbate these issues, a…
View article: Genetic Rearrangements in Brain Tumors: A View from NTRK
Genetic Rearrangements in Brain Tumors: A View from NTRK Open
There is growing interest in targeted therapies for oncological diseases, with neurotrophic tropomyosin receptor kinase (NTRK) genes emerging as promising targets in various solid tumors. The NTRK genes are essential for central nervous sy…
View article: Case report: Chest radiotherapy-induced vertebral fractures in lung cancer patients: a case series and literature review
Case report: Chest radiotherapy-induced vertebral fractures in lung cancer patients: a case series and literature review Open
Background As survival rates for lung cancer (LC) patients continue to rise, the adverse impacts of therapies become more relevant. Radiotherapy is known to negatively affect bone health. However, radiotherapy-induced vertebral fractures i…
View article: Real-world characteristics and outcomes of <i>ERBB2-</i>mutant NSCLC in Latin American patients (CLICaP)
Real-world characteristics and outcomes of <i>ERBB2-</i>mutant NSCLC in Latin American patients (CLICaP) Open
Introduction ERBB2-mutant non-small cell lung cancer (NSCLC) represents approximately 1%-4% of all lung adenocarcinomas (LUADs) and has emerged as a distinct molecular subtype. Little is known about NSCLC harboring ERBB2 mutations in Latin…
View article: CAD-Q (COPD-Asthma Differentiation Questionnaire): Performance of a new diagnostic score to differentiate between COPD and asthma in adults
CAD-Q (COPD-Asthma Differentiation Questionnaire): Performance of a new diagnostic score to differentiate between COPD and asthma in adults Open
The CAD-Q questionnaire effectively discriminated between COPD and asthma, outperforming previous tools. These findings support further research and refinement of diagnostic tools and call for validation in diverse clinical settings.
View article: Lutetium‐177 DOTATATE for the Treatment of Esthesioneuroblastoma: A Case Report
Lutetium‐177 DOTATATE for the Treatment of Esthesioneuroblastoma: A Case Report Open
Esthesioneuroblastoma (ENB), also known as olfactory neuroblastoma, is a rare neuroendocrine malignancy arising from the olfactory neuroepithelium. It exhibits a wide range of biological behaviors, from indolent to highly aggressive diseas…
View article: Proposals for the Implementation of a Multidimensional Platform That Allows the Advancement of Oncology Nursing in the Latin American Environment (The INCREASE Proposal)
Proposals for the Implementation of a Multidimensional Platform That Allows the Advancement of Oncology Nursing in the Latin American Environment (The INCREASE Proposal) Open
PURPOSE Cancer constitutes a significant global health challenge, with projections indicating a continued increase in its prevalence in the foreseeable future. This trend is particularly pronounced in Latin America (LATAM), where the cance…
View article: Clinicogenomic and treatment outcomes in RET fusion-positive NSCLC: A multicenter study in Latin American Hispanic patients
Clinicogenomic and treatment outcomes in RET fusion-positive NSCLC: A multicenter study in Latin American Hispanic patients Open
This Latin American cohort of RET fusion-positive NSCLC patients exhibited consistent molecular features and treatment responses. Expanded access to RET-selective therapies is needed to optimize outcomes in this population.
View article: Real-World Survival Outcomes in Non–Small Cell Lung Cancer: The Impact of Genomic Testing and Targeted Therapies in a Latin American Middle-Income Country
Real-World Survival Outcomes in Non–Small Cell Lung Cancer: The Impact of Genomic Testing and Targeted Therapies in a Latin American Middle-Income Country Open
PURPOSE Targeted therapies are indicated for patients with non–small cell lung cancer (NSCLC) and driver tumor mutations. However, real-world studies on the survival benefits of these agents are limited. This study aimed to evaluate the ef…
View article: Extracellular vesicles containing SARS‐CoV‐2 proteins are associated with multi‐organ dysfunction and worse outcomes in patients with severe COVID‐19
Extracellular vesicles containing SARS‐CoV‐2 proteins are associated with multi‐organ dysfunction and worse outcomes in patients with severe COVID‐19 Open
The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) causes coronavirus disease 2019 (COVID‐19) and has been related to more than 7 million deaths globally since 2019. The association of high levels of IL‐6 with severe cases le…
View article: Evaluation of a risk-sharing agreement for atezolizumab treatment in patients with non-small cell lung cancer: a strategy to improve access in low-income countries
Evaluation of a risk-sharing agreement for atezolizumab treatment in patients with non-small cell lung cancer: a strategy to improve access in low-income countries Open
Background Using immune checkpoint inhibitors (IO) is a promising approach to maximize clinical benefits for patients with non-small cell lung cancer (NSCLC). PD-L1 expression serves as a predictive factor for treatment outcomes with IO. H…
View article: Advances in the management of high-grade glial tumors
Advances in the management of high-grade glial tumors Open
This comprehensive review delves into recent advancements in the diagnosis and treatment of gliomas, which constitute a significant portion of primary brain tumors. Recent progress in genomic, transcriptomic, and epigenetic profiling has r…
View article: CLICaP Guía CLICaP para el diagnóstico, tratamiento y seguimiento del cáncer de pulmón de células no pequeñas localmente avanzado
CLICaP Guía CLICaP para el diagnóstico, tratamiento y seguimiento del cáncer de pulmón de células no pequeñas localmente avanzado Open
Locally advanced (stage III) Non-small-cell lung cancer (LA-NSCLC) is a heterogeneous disease that represents a challenge due to its enormous clinical, diagnostic, and therapeutic complexity. LA-NSCLC affects approximately one-third of pat…