Antônio C. Santos
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View article: Cyclodextrin-Based Delivery of the Annexin A1 Mimetic Peptide Ac2-26 Enhances Anti-Inflammatory Effects and Prevents Dengue-Induced Lethality in Combination with Antiviral Therapy
Cyclodextrin-Based Delivery of the Annexin A1 Mimetic Peptide Ac2-26 Enhances Anti-Inflammatory Effects and Prevents Dengue-Induced Lethality in Combination with Antiviral Therapy Open
Severe dengue is characterized by systemic inflammation, cytokine storm, vascular leakage, and hemorrhagic manifestations, largely driven by the host immune response to dengue virus (DENV) infection. Despite its burden, no licensed antivir…
View article: A Novel In Vitro Host−Pathogen Model for <i>Felis catus</i> and <i>Sporothrix</i> Zoonotic Species Investigation
A Novel In Vitro Host−Pathogen Model for <i>Felis catus</i> and <i>Sporothrix</i> Zoonotic Species Investigation Open
Hyperendemic zoonotic sporotrichosis, attributed to Sporothrix brasiliensis , presents a significant public health challenge in Brazil. Cats exhibit severe symptoms and high fungal loads, though their susceptibility is unclear. Sporothrix …
Fraction of C. d. collilineatus venom containing crotapotin protects PC12 cells against MPP + toxicity by activating the NGF-signaling pathway Open
These findings show, for the first time, that crotapotin has neurotrophic/neuroprotective/neurorestorative potential and might be beneficial in Parkinson's disease. Additional studies are necessary to evaluate the toxicity of crotapotin in…
Obstacle Detection for Autonomous Guided Vehicles through Point Cloud Clustering Using Depth Data Open
Autonomous driving is one of the fastest developing fields of robotics. With the ever-growing interest in autonomous driving, the ability to provide robots with both efficient and safe navigation capabilities is of paramount significance. …
View article: Clinical Features, Pathobiology, Efficacy, and Toxicity of Tenofovir Disoproxil Fumarate and Emtricitabine for Mild to Moderate SARS-CoV-2 Infections
Clinical Features, Pathobiology, Efficacy, and Toxicity of Tenofovir Disoproxil Fumarate and Emtricitabine for Mild to Moderate SARS-CoV-2 Infections Open
This study evaluated the efficacy of tenofovir disoproxil fumarate (TDF) and TDF combined with emtricitabine (FTC) in patients with COVID-19 infections (ClinicalTrials.gov#NCT04712357).We conducted a randomized, double-blind, placebo-contr…
Dual effects of S-adenosyl-methyonine on PC12 cells exposed to the dopaminergic neurotoxin MPP+ Open
Objectives To investigate S-adenosyl-methyonine (SAM) effects on PC12 cells viability and neuritogenesis treated with MPP+ (1-methyl-4-phenylpyridinium). Methods PC12 cell viability test (MTT assay) in DMEM medium with SAM and/or MPP+; PC1…
Imbalance of Steroid Hormones in Hamsters Infected with <i>Schistosoma mansoni</i> Open
Objective: Schistosomiasis is a debilitating disease that affects 200 million people worldwide. Schistosoma haematobium and Schistosoma mansoni are the major causative agents of this disease. Cancer-association and infertility-association …
Special Issue on Selected Papers from e-Health Pervasive Wireless Applications and Services 2017 Open
International audience
Cover Image Open
The cover image, by Giovanni N. E. Maino et al., is based on the Randomized Clinical Trial Influence of suturing technique on wound healing and patient morbidity after connective tissue harvesting. A randomized clinical trial, DOI: 10.1111…
View article: Morphological and ultrastructural analysis of the teeth of guaiquica (Gracilinanus microtarsus, Wagner, 1842)
Morphological and ultrastructural analysis of the teeth of guaiquica (Gracilinanus microtarsus, Wagner, 1842) Open
Introduction: The guaiquica ( Gracilinanus microtarsus) is an omnivorous-frugivorous marsupial, which belongs to family Didelphidae and subfamily Didelphinae. By feeding on small fruits, it is a species of considerable ecological importanc…