Vasco Azevedo
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View article: Genomic and In Vivo Characterization of Antimicrobial Resistance and Virulence in UPEC <i>Escherichia coli</i> Isolated from Brazilian Cases of UTI
Genomic and In Vivo Characterization of Antimicrobial Resistance and Virulence in UPEC <i>Escherichia coli</i> Isolated from Brazilian Cases of UTI Open
With the growing global prevalence of antimicrobial resistance, the treatment of urinary tract infections caused by Escherichia coli is becoming increasingly challenging. Uropathogenic E. coli (UPEC) is responsible for approximately 80% of…
View article: Virulence and mutations analysis based on the whole genome of a Brazilian Corynebacterium diphtheriae strain isolated from a cutaneous infection
Virulence and mutations analysis based on the whole genome of a Brazilian Corynebacterium diphtheriae strain isolated from a cutaneous infection Open
Corynebacterium diphtheriae is the main etiological agent of diphtheria, a potentially fatal disease whose most severe signs and symptoms result from the action of an exotoxin, the diphtheria toxin (DT). Although non-toxigenic C. diphtheri…
View article: <b> <i>Staphylococcus aureus </i> </b> <b>derived extracellular vesicles trigger multiple inflammatory pathways in host cells and deliver their RNA cargo following their internalization and lysis within late endosomes</b>
<b> <i>Staphylococcus aureus </i> </b> <b>derived extracellular vesicles trigger multiple inflammatory pathways in host cells and deliver their RNA cargo following their internalization and lysis within late endosomes</b> Open
Staphylococcus aureus is a major opportunistic Gram-positive pathogen whose virulence can be partly mediated by extracellular vesicles (EVs). These nanosized particles carry a diverse cargo and can play key roles in host-pathogen interacti…
View article: Interactions of Linalool and Linalyl Acetate with Selected Dog Cytochrome P450 (CYP) Proteins Identified by In Silico Drug Discovery Followed by Molecular Docking Analysis
Interactions of Linalool and Linalyl Acetate with Selected Dog Cytochrome P450 (CYP) Proteins Identified by In Silico Drug Discovery Followed by Molecular Docking Analysis Open
Background: Cytochrome P450 (CYP450) enzymes play a central role in the metabolism of xenobiotics, including plant-derived compounds such as terpenoids. Objectives: This study aimed to predict the molecular interactions of linalool (LIN) a…
View article: Salivary Biomarkers for Screening and Monitoring of Oral Diseases
Salivary Biomarkers for Screening and Monitoring of Oral Diseases Open
Salivary analysis tool for disease diagnostics has garnered growing scientific interest. The key advantages and the wide range of components consistently associated with oral diseases were discussed. A variety of salivary diagnostic techno…
View article: Quinolone Resistance and Zoonotic Potential of Corynebacterium ulcerans from Domestic Animals in Brazil
Quinolone Resistance and Zoonotic Potential of Corynebacterium ulcerans from Domestic Animals in Brazil Open
Background: Corynebacterium ulcerans is an emerging zoonotic pathogen capable of cau-sing diphtheria-like infections in humans. Objectives: we report, for the first time in Brazil, the detection and phenotypic/genomic characterization of t…
View article: Oral Treatment With Heat Shock Protein 65‐Producing <i>Lactococcus lactis</i> Induces Regulatory T Cells, Modulating Inflammatory Response in <i>Leishmania braziliensis</i> Infection
Oral Treatment With Heat Shock Protein 65‐Producing <i>Lactococcus lactis</i> Induces Regulatory T Cells, Modulating Inflammatory Response in <i>Leishmania braziliensis</i> Infection Open
Cutaneous leishmaniasis (CL), a neglected tropical disease prevalent in Brazil, is caused by Leishmania braziliensis ( L. braziliensis ) and is marked by ulcerative skin lesions and an exacerbated Th1‐driven inflammatory response. This stu…
View article: Comparative, Pangenomic and Functional Analyses of two Bacillus paralicheniformis Soil- Isolated Strains from Bahia Sequenced by WGS Reveal Species Homogeneity and Bioactive Metabolites with Biotechnological Potential
Comparative, Pangenomic and Functional Analyses of two Bacillus paralicheniformis Soil- Isolated Strains from Bahia Sequenced by WGS Reveal Species Homogeneity and Bioactive Metabolites with Biotechnological Potential Open
The Bacillus genus includes plant growth-promoting rhizobacteria (PGPR), and the discovery of new strains within this group is of great biotechnological interest due to their ability to produce antimicrobial compounds (AMCs), vitamins, enz…
View article: Systematic review on chitosan dressings for diabetic and burn wound healing: preclinical outcomes and limitations
Systematic review on chitosan dressings for diabetic and burn wound healing: preclinical outcomes and limitations Open
This systematic review evaluates the effectiveness and physicochemical properties of chitosan-based wound dressings used to treat diabetic and burn wounds, focusing on how different therapeutic combinations influence healing outcomes. Lite…
View article: Genomic islands and mobilome demonstrate a potential pathogen, the Plesiomonas shigelloides, as in Nile tilapia (Oreochromis niloticus)
Genomic islands and mobilome demonstrate a potential pathogen, the Plesiomonas shigelloides, as in Nile tilapia (Oreochromis niloticus) Open
Plesiomonas shigelloides is a common opportunistic pathogen of fish that may result in significant economic losses during outbreak periods. The infection is revealed by several clinical signs, including pericarditis, multifocal necrosis, h…
View article: Genotypic and Phenotypic Characterization of Corynebacterium ulcerans Strains Isolated from Domestic Animals in Brazil and Structural Implications of Mutations Conferring Quinolone-Resistance
Genotypic and Phenotypic Characterization of Corynebacterium ulcerans Strains Isolated from Domestic Animals in Brazil and Structural Implications of Mutations Conferring Quinolone-Resistance Open
Corynebacterium ulcerans is an emerging zoonotic pathogen that can cause diphtheria-like infections in humans. In this study, we report the novel detection and comprehensive phenotypic and genomic characterization of three atoxigenic C. ul…
View article: First case report of Corynebacterium pseudotuberculosis biovar equi in semiarid region of Brazil
First case report of Corynebacterium pseudotuberculosis biovar equi in semiarid region of Brazil Open
Corynebacterium pseudotuberculosis is a bacterium that causes significant economic damage to farmers, mainly in the semiarid region of Northeastern Brazil. In this context, only biovar ovis has been reported, and it is widespread in small …
View article: The Microbial Anti-Inflammatory Molecule (MAM) is a key protein processed and exported to <i>Faecalibacterium duncaniae</i> envelope
The Microbial Anti-Inflammatory Molecule (MAM) is a key protein processed and exported to <i>Faecalibacterium duncaniae</i> envelope Open
MAM (Microbial-Anti-Inflammatory Molecule) is a key effector protein with anti-inflammatory properties in Faecalibacterium duncaniae, a critical human gut microbiota species. Despite its importance, MAM function and molecular features rema…
View article: Microbiota and Postmenopause: The resilience of intestinal bacteria in the face of female hormonal aging
Microbiota and Postmenopause: The resilience of intestinal bacteria in the face of female hormonal aging Open
Background Female aging is characterized by a decline in ovarian function until the establishment of the post-menopausal state. Other research lines seek to understand how the gut microbiota contributes to these diseases at all stages of l…
View article: Genomic Characterization of Carbapenem-Resistant Acinetobacter baumannii (OXA-23) and Klebsiella pneumoniae (KPC-2) Causing Hospital-Acquired Infections in Dogs
Genomic Characterization of Carbapenem-Resistant Acinetobacter baumannii (OXA-23) and Klebsiella pneumoniae (KPC-2) Causing Hospital-Acquired Infections in Dogs Open
Background/Objectives: Antimicrobial resistance is a major global health threat. Among the most problematic pathogens are carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae, which are significant causes of mortality in …
View article: ANÁLISIS DE GENOTIPO Y FENOTIPO DE LOS MECANISMOS DE RESISTENCIA A LOS ANTIMICROBIANOS EN Corynebacterium pseudotuberculosis
ANÁLISIS DE GENOTIPO Y FENOTIPO DE LOS MECANISMOS DE RESISTENCIA A LOS ANTIMICROBIANOS EN Corynebacterium pseudotuberculosis Open
Background. Corynebacterium pseudotuberculosis (C. pseudotuberculosis) is a Gram-positive intracellular bacterium that causes caseous lymphadenitis and causes significant economic damage to the livestock industry by affecting animal physic…
View article: In Silico Characterization of Resistance and Virulence Genes in Aeromonas jandaei Strains Isolated from Oreochromis niloticus in Brazil
In Silico Characterization of Resistance and Virulence Genes in Aeromonas jandaei Strains Isolated from Oreochromis niloticus in Brazil Open
Understanding the genetic characteristics of Aeromonas jandaei in Brazilian aquaculture is crucial for developing effective control strategies against this fish pathogen. The present study conducted a genomic analysis of Brazilian A. janda…
View article: Bacterial Foodborne Diseases in Central America and the Caribbean: A Systematic Review
Bacterial Foodborne Diseases in Central America and the Caribbean: A Systematic Review Open
Foodborne diseases (FBDs) represent a significant public health concern, particularly in regions like Central America and the Caribbean (CAC), where surveillance gaps due to a lack of resources, knowledge, and technical abilities hinder co…
View article: Exploring Bacillus velezensis in a biomedical context: a systematic review
Exploring Bacillus velezensis in a biomedical context: a systematic review Open
Bacillus velezensis is associated with producing secondary metabolites with antifungal, anti-inflammatory, antagonistic, and antimicrobial activities that have multiple applications in the food industry, agriculture, and farming. This stud…
View article: Whole-Genome Sequence Reveals Genetic Determinants of the Colonization of Shiga Toxin-Producing Escherichia coli O22:H8 Isolates in Cattle
Whole-Genome Sequence Reveals Genetic Determinants of the Colonization of Shiga Toxin-Producing Escherichia coli O22:H8 Isolates in Cattle Open
Shiga toxin-producing Escherichia coli (STEC) is a zoonotic foodborne pathogen responsible for different cases and outbreaks of severe enteric diseases in humans worldwide. Our group previously showed that Argentine O22:H8 isolates (155 an…
View article: An outbreak in week-old broiler chicks caused by a highly virulent and multidrug-resistant strain of <i>Salmonella</i> Gallinarum
An outbreak in week-old broiler chicks caused by a highly virulent and multidrug-resistant strain of <i>Salmonella</i> Gallinarum Open
Salmonella Gallinarum is a bacterium that causes significant economic losses in poultry farming and usually infects adult birds. This study aimed to characterize the unusual histological findings and genetic profile of a Salmonella Gallina…
View article: Bacterial Foodborne Diseases in Central America and the Caribbean: A Systematic Review
Bacterial Foodborne Diseases in Central America and the Caribbean: A Systematic Review Open
Foodborne diseases (FBD) represent a significant public health concern, particularly in regions like Central America and the Caribbean (CAC), where surveillance gaps due to lack of resources, knowledge and technical abilities, hinder contr…
View article: Genomic and phenotypic insight into antimicrobial resistance of Pseudomonas fluorescens from King George Island, Antarctica
Genomic and phenotypic insight into antimicrobial resistance of Pseudomonas fluorescens from King George Island, Antarctica Open
The genus Pseudomonas includes metabolically versatile microorganisms occupying diverse niches, from environmental habitats to plant pathogens, and has clinically significant strains. For this reason, Pseudomonas spp. might act as a reserv…
View article: The Critical Role of Penicillin in Syphilis Treatment and Emerging Resistance Challenges
The Critical Role of Penicillin in Syphilis Treatment and Emerging Resistance Challenges Open
Syphilis, a global healthcare burden, is a sexually transmitted infection caused by the spirochete Treponema pallidum, a spiral-shaped, Gram-negative obligate human pathogen. Despite its easy identification and treatability, the disease af…
View article: Dynamics of Salmonella Dublin infection and antimicrobial resistance in a dairy herd endemic to salmonellosis
Dynamics of Salmonella Dublin infection and antimicrobial resistance in a dairy herd endemic to salmonellosis Open
Salmonella Dublin is a serovar that causes severe infections and cattle. Despite the importance of this agent, research on achieving its elimination from dairy farms is limited, which complicates risk mitigation and control efforts. This s…
View article: In silico construction of a multi-epitope vaccine (RGME-VAC/ATS-1) against the Rickettsia genus using immunoinformatics
In silico construction of a multi-epitope vaccine (RGME-VAC/ATS-1) against the Rickettsia genus using immunoinformatics Open
BACKGROUND Rickettsia is a genus of Gram-negative bacteria that causes various diseases, including epidemic typhus, Rocky Mountain spotted fever, and Mediterranean spotted fever. Ticks transmit these diseases and commonly found in developi…
View article: Intra-familial phenotype variant in hypoplastic amelogenesis imperfecta under a complex genetic component: a family report, whole-exome sequencing, and literature review
Intra-familial phenotype variant in hypoplastic amelogenesis imperfecta under a complex genetic component: a family report, whole-exome sequencing, and literature review Open
Amelogenesis imperfecta (AI) encompasses a group of conditions characterized by abnormalities in the development or function of tooth enamel. Clinical manifestations include different forms and degrees of enamel frailty, associated with se…