Antonio La Cava
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View article: CD2-targeted nanoparticles encapsulating IL-2 induce tolerogenic Tregs and TGF-β-producing NK cells that stabilize Tregs for long-term therapeutic efficacy in immune-mediated disorders
CD2-targeted nanoparticles encapsulating IL-2 induce tolerogenic Tregs and TGF-β-producing NK cells that stabilize Tregs for long-term therapeutic efficacy in immune-mediated disorders Open
T regulatory cells (Tregs) generated in the periphery (pTregs) are initially unstable, but some of them stabilize with time. The stabilization signals, however, are poorly understood. We have previously reported that the treatment of mice …
View article: CAR immunotherapy in autoimmune diseases: promises and challenges
CAR immunotherapy in autoimmune diseases: promises and challenges Open
In recent years, the use of chimeric antigen receptor (CAR)-T cells has emerged as a promising immunotherapy in multiple diseases. CAR-T cells are T cells genetically modified to express a surface receptor, known as CAR, for the targeting …
View article: Nanoparticles loaded with IL-2 and TGF-β promote transplantation tolerance to alloantigen
Nanoparticles loaded with IL-2 and TGF-β promote transplantation tolerance to alloantigen Open
We have previously reported that nanoparticles (NPs) loaded with IL-2 and TGF-β and targeted to T cells induced polyclonal T regulatory cells (Tregs) that protected mice from graft-versus-host disease (GvHD). Here, we evaluated whether adm…
View article: Adeno‐Associated Virus Type 5 Infection via <scp>PDGFRα</scp> Is Associated With Interstitial Lung Disease in Systemic Sclerosis and Generates Composite Peptides and Epitopes Recognized by the Agonistic Immunoglobulins Present in Patients With Systemic Sclerosis
Adeno‐Associated Virus Type 5 Infection via <span>PDGFRα</span> Is Associated With Interstitial Lung Disease in Systemic Sclerosis and Generates Composite Peptides and Epitopes Recognized by the Agonistic Immunoglobulins Present in Patients With Systemic Sclerosis Open
Objective The etiopathogenesis of systemic sclerosis (SSc) is unknown. Platelet‐derived growth factor receptors (PDGFRs) are overexpressed in patients with SSc. Because PDGFRα is targeted by the adeno‐associated virus type 5 (AAV5), we inv…
View article: Low-dose interleukin-2 therapy in systemic lupus erythematosus
Low-dose interleukin-2 therapy in systemic lupus erythematosus Open
In systemic lupus erythematosus (SLE), T regulatory cells (T regs ) contribute to the inhibition of autoimmune responses by suppressing self-reactive immune cells. Interleukin (IL)-2 plays an essential role in the generation, function and …
View article: 1901 The Tolerogenic Effects of IL-2 on T Regulatory Cells (Tregs) are TGF-β Dependent
1901 The Tolerogenic Effects of IL-2 on T Regulatory Cells (Tregs) are TGF-β Dependent Open
Background We and others have previously shown that IL-2 is essential for TGF-β to allow conversion of naïve CD4+CD25- T cells into CD4+CD25+Foxp3+ Tregs. To further those studies, we recently used IL-2- loaded nanoparticles (NPs) coated w…
View article: MIS-C: A COVID-19-as sociated condition between hypoimmunity and hyperimmunity
MIS-C: A COVID-19-as sociated condition between hypoimmunity and hyperimmunity Open
Multisystem inflammatory syndrome in children (MIS-C) is a rare, severe complication of COVID-19. A better knowledge of immunological, cellular, and genetic characteristics of MIS-C could help better understand the pathogenesis of the dise…
View article: Editorial: Generating and Sustaining Stable Autoantigen-Specific CD4 and CD8 Regulatory T Cells in Lupus
Editorial: Generating and Sustaining Stable Autoantigen-Specific CD4 and CD8 Regulatory T Cells in Lupus Open
EDITORIAL article Front. Immunol., 07 March 2022Sec. Immunological Tolerance and Regulation Volume 13 - 2022 | https://doi.org/10.3389/fimmu.2022.838604
View article: Trans-spliced peptides spanning PDGFRα and Adeno-Associated Virus type 5 trigger autoimmune responses in systemic sclerosis patients
Trans-spliced peptides spanning PDGFRα and Adeno-Associated Virus type 5 trigger autoimmune responses in systemic sclerosis patients Open
The authors have requested that this preprint be removed from Research Square.
View article: 1406 Acellular artificial antigen-presenting cells induce disease-protective immunoregulatory cells in lupus
1406 Acellular artificial antigen-presenting cells induce disease-protective immunoregulatory cells in lupus Open
Background T regulatory cells (Tregs) provide beneficial effects in the suppression of autoimmune responses in systemic lupus erythematosus (SLE). We recently showed that poly(lactic-co-glycolic acid) PLGA nanoparticles (NPs) loaded with I…
View article: Editorial: The Role of Natural Killer Cells in Autoimmune Diseases
Editorial: The Role of Natural Killer Cells in Autoimmune Diseases Open
EDITORIAL article Front. Immunol., 01 November 2021Sec. NK and Innate Lymphoid Cell Biology Volume 12 - 2021 | https://doi.org/10.3389/fimmu.2021.786190
View article: Nanoparticle-mediated delivery of IL-2 to T follicular helper cells protects BDF1 mice from lupus-like disease
Nanoparticle-mediated delivery of IL-2 to T follicular helper cells protects BDF1 mice from lupus-like disease Open
We recently reported that poly lactic-co-glycolic acid (PLGA) nanoparticles (NPs) loaded with interleukin (IL)-2 and targeted to T cells inhibited the development of lupus-like disease in BDF1 mice by inducing functional T regulatory cells…
View article: Strategies to Use Nanoparticles to Generate CD4 and CD8 Regulatory T Cells for the Treatment of SLE and Other Autoimmune Diseases
Strategies to Use Nanoparticles to Generate CD4 and CD8 Regulatory T Cells for the Treatment of SLE and Other Autoimmune Diseases Open
Autoimmune diseases are disorders of immune regulation where the mechanisms responsible for self-tolerance break down and pathologic T cells overcome the protective effects of T regulatory cells (Tregs) that normally control them. The resu…
View article: Nanoparticles Engineered as Artificial Antigen-Presenting Cells Induce Human CD4+ and CD8+ Tregs That Are Functional in Humanized Mice
Nanoparticles Engineered as Artificial Antigen-Presenting Cells Induce Human CD4+ and CD8+ Tregs That Are Functional in Humanized Mice Open
Artificial antigen-presenting cells (aAPCs) are synthetic versions of naturally occurring antigen-presenting cells (APCs) that, similar to natural APCs, promote efficient T effector cell responses in vitro . This report describes a method …
View article: The pleiotropic roles of leptin in metabolism, immunity, and cancer
The pleiotropic roles of leptin in metabolism, immunity, and cancer Open
The discovery of the archetypal adipocytokine leptin and how it regulates energy homeostasis have represented breakthroughs in our understanding of the endocrine function of the adipose tissue and the biological determinants of human obesi…
View article: Systemic lupus erythematosus and coronavirus disease 2019
Systemic lupus erythematosus and coronavirus disease 2019 Open
Coronavirus disease 2019 (COVID-19) is a contagious infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It manifests with variable clinical pictures ranging from asymptomatic to mild or uncomplicated …
View article: Anti-CD2 Antibody-Coated Nanoparticles Containing IL-2 Induce NK Cells That Protect Lupus Mice via a TGF-β-Dependent Mechanism
Anti-CD2 Antibody-Coated Nanoparticles Containing IL-2 Induce NK Cells That Protect Lupus Mice via a TGF-β-Dependent Mechanism Open
We recently reported that the treatment with nanoparticles (NPs) loaded with tolerogenic cytokines suppressed the manifestations of lupus-like disease induced by the transfer of donor CD4 + T cells from DBA/2 mice into (C57BL/6 × DBA/2)F 1…
View article: DNA vaccine encoding heat shock protein 90 protects from murine lupus
DNA vaccine encoding heat shock protein 90 protects from murine lupus Open
Background Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the presence of autoantibodies to multiple self-antigens, including heat shock proteins (HSP). Because of the increased expression of HSP90 and …
View article: Serafino Zappacosta: An Enlightened Mentor and Educator
Serafino Zappacosta: An Enlightened Mentor and Educator Open
With this article, the authors aim to honor the memory of Serafino Zappacosta, who had been their mentor during the early years of their career in science. The authors discuss how the combination of Serafino Zappacosta's extraordinary comm…
View article: Editorial: Innate Immunity Pathways in Autoimmune Diseases
Editorial: Innate Immunity Pathways in Autoimmune Diseases Open
EDITORIAL article Front. Immunol., 04 June 2019Sec. Molecular Innate Immunity Volume 10 - 2019 | https://doi.org/10.3389/fimmu.2019.01245
View article: The Influence of Diet and Obesity on Gene Expression in SLE
The Influence of Diet and Obesity on Gene Expression in SLE Open
This review provides an overview of the known effects of diet, obesity, and the intake of different nutrients on systemic lupus erythematosus (SLE). It summarizes and discusses the studies in rodents that identified how different diets can…
View article: Human T cell repertoire: what happens in thymus does not stay in thymus
Human T cell repertoire: what happens in thymus does not stay in thymus Open
The T cell receptor (TCR) repertoire is diverse, thus allowing recognition of a wide range of pathogens by T cells. In humans, the study of the formation of TCR repertoires is problematic because of the difficulty in performing investigati…
View article: Brain Ischemia Induces Diversified Neuroantigen-Specific T-Cell Responses That Exacerbate Brain Injury
Brain Ischemia Induces Diversified Neuroantigen-Specific T-Cell Responses That Exacerbate Brain Injury Open
Background and Purpose— Autoimmune responses can occur when antigens from the central nervous system are presented to lymphocytes in the periphery or central nervous system in several neurological diseases. However, whether autoimmune resp…