Adam Chaker
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View article: A patient-centric approach to chronic rhinosinusitis with nasal polyps (CRSwNP): developing tools to improve disease management and outcomes
A patient-centric approach to chronic rhinosinusitis with nasal polyps (CRSwNP): developing tools to improve disease management and outcomes Open
Purpose Chronic rhinosinusitis with nasal polyps (CRSwNP) is an upper airways disease predominantly characterized by type 2 (T2) inflammation, leading to reduced quality of life and patient/healthcare burden. Many patients remain underdiag…
View article: GSDMB pyroptosis in NHBEs is driven independently of the inflammasome pathways and is regulated by IFNs in children with 17q21 asthma 3491
GSDMB pyroptosis in NHBEs is driven independently of the inflammasome pathways and is regulated by IFNs in children with 17q21 asthma 3491 Open
Description Recently, we have uncovered overexpression of gasdermin B (GSDMB), driven by rs7216389 SNP in the 17q21 locus, as driving gene of asthma pathophysiology. However, the direct impact of this genetic dysregulation on the airway mu…
View article: Early mucosal type 1 immunity in pre-school wheezers as protective factor for development of asthma at school-age 3090
Early mucosal type 1 immunity in pre-school wheezers as protective factor for development of asthma at school-age 3090 Open
Description Allergy and asthma are defined by local type-2 immunity at the airway barrier. However, whether immunity type-specific epithelial phenotypes can predict the persistence of asthma at school-age, remains elusive. We analyzed nasa…
View article: Real-life evaluation of the effectiveness of biologics for chronic rhinosinusitis with nasal polyps in Europe: a Delphi study to define key variables for the INVENT registry
Real-life evaluation of the effectiveness of biologics for chronic rhinosinusitis with nasal polyps in Europe: a Delphi study to define key variables for the INVENT registry Open
Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is a persistent inflammatory condition often associated with type 2 inflammation. While biologics are a promising treatment for patients with uncontrolled CRSwNP, real-world evid…
View article: Alert Card for Patients on Biologicals and Immunosuppressives: An <scp>EAACI</scp> Position Paper
Alert Card for Patients on Biologicals and Immunosuppressives: An <span>EAACI</span> Position Paper Open
the EAACI Working Group on Biologicals developed a compact, customizable, wallet- friendly PAC, con- taining concise information for patients and medical staff, treatment details, travel certificate, and physician or hospital contacts
View article: Loss of apolipoprotein E contributes to inflammatory macrophage activation and ferroptosis in NSAID-exacerbated respiratory disease
Loss of apolipoprotein E contributes to inflammatory macrophage activation and ferroptosis in NSAID-exacerbated respiratory disease Open
Our results suggest a role for myeloid ApoE in regulating the cross talk between macrophages and epithelial cells, as well as in ferroptosis during type 2 airway inflammation. ApoE deficiency may thus contribute to chronic type 2 inflammat…
View article: Otitis Media With Effusion (<scp>OME</scp>) and Eustachian Tube Dysfunction: The Role of Allergy and Immunity—An <scp>EAACI</scp> Position Paper
Otitis Media With Effusion (<span>OME</span>) and Eustachian Tube Dysfunction: The Role of Allergy and Immunity—An <span>EAACI</span> Position Paper Open
IgE‐mediated allergies play a significant role in respiratory diseases. Given the similar mucosal epithelium of the upper and lower respiratory tracts and their shared (patho)physiological immune responses, the “unified airways” concept vi…
View article: Analysis of miRNA Expression in Patients With NSAID-Exacerbated Respiratory Disease
Analysis of miRNA Expression in Patients With NSAID-Exacerbated Respiratory Disease Open
The results indicate that the miRNA profile in nasal mucosal lining fluid of patients with N-ERD differs from patients with AA, CRS, and compared to HCs. Some of the miRNAs selected on the basis of profiling may be involved in the regulati…
View article: Endotyping in Chronic Rhinosinusitis—An <scp>EAACI</scp> Task Force Report
Endotyping in Chronic Rhinosinusitis—An <span>EAACI</span> Task Force Report Open
Chronic rhinosinusitis (CRS) is a clinical syndrome defined by typical sinonasal symptoms persisting for at least 12 weeks. CRS is divided into two distinct phenotypes, CRS with nasal polyps (CRSwNP) and without (CRSsNP). The aim of the re…
View article: Nasal secretions trace epithelial type 2 response to allergen-specific immunotherapy
Nasal secretions trace epithelial type 2 response to allergen-specific immunotherapy Open
Background: Allergen-specific immunotherapy (AIT) is a disease-modifying therapy and is effective to reduce the symptoms of grass pollen-allergy. The airway epithelium of these patients releases inflammatory mediators including type-2 cyto…
View article: EUFOREUM Berlin 2023: Optimizing care for type 2 inflammatory diseases from clinic to AI: A pediatric focus
EUFOREUM Berlin 2023: Optimizing care for type 2 inflammatory diseases from clinic to AI: A pediatric focus Open
The European Forum for Research and Education in Allergy and Airways diseases (EUFOREA) organized its bi‐annual forum EUFOREUM in Berlin in November 2023. The aim of EUFOREUM 2023 was to highlight pediatric action plans for prevention and …
View article: Extracellular vesicle <scp>miRNAs</scp> drive aberrant macrophage responses in <scp>NSAID</scp>‐exacerbated respiratory disease
Extracellular vesicle <span>miRNAs</span> drive aberrant macrophage responses in <span>NSAID</span>‐exacerbated respiratory disease Open
Background Extracellular vesicles (EVs) have been implicated in the pathogenesis of asthma, however, how EVs contribute to immune dysfunction and type 2 airway inflammation remains incompletely understood. We aimed to elucidate roles of ai…
View article: Evaluation of ongoing mepolizumab treatment in chronic rhinosinusitis with nasal polyps
Evaluation of ongoing mepolizumab treatment in chronic rhinosinusitis with nasal polyps Open
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a multifactorial inflammatory disease of the mucous membranes of the nose and paranasal sinuses. Eosinophilic inflammation is described as a common endotype. The anti-interleukin-5 (IL-5…
View article: Postmortem Minimally Invasive Autopsy in Critically Ill COVID-19 Patients at the Bedside: A Proof-of-Concept Study at the ICU
Postmortem Minimally Invasive Autopsy in Critically Ill COVID-19 Patients at the Bedside: A Proof-of-Concept Study at the ICU Open
Background: Economic restrictions and workforce cuts have continually challenged conventional autopsies. Recently, the COVID-19 pandemic has added tissue quality and safety requirements to the investigation of this disease, thereby launchi…
View article: Monitoring mepolizumab treatment in chronic rhinosinusitis with nasal polyps (CRSwNP): Discontinue, change, continue therapy?
Monitoring mepolizumab treatment in chronic rhinosinusitis with nasal polyps (CRSwNP): Discontinue, change, continue therapy? Open
Understanding the immunological basis of CRSwNP opens up new non-surgical therapeutic approaches with biologics for patients with severe, uncontrolled courses. Here, we provide recommendations for follow-up, adherence to therapy intervals,…
View article: EUFOREA/EPOS2020 statement on the clinical considerations for chronic rhinosinusitis with nasal polyps care
EUFOREA/EPOS2020 statement on the clinical considerations for chronic rhinosinusitis with nasal polyps care Open
Following the European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA) treatment algorithm for chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP), patients suffering from severe uncontrolled CRSwNP are recomm…
View article: 17q21 Variants Disturb Mucosal Host Defense in Childhood Asthma
17q21 Variants Disturb Mucosal Host Defense in Childhood Asthma Open
Rationale: The strongest genetic risk factor for childhood-onset asthma, the 17q21 locus, is associated with increased viral susceptibility and disease-promoting processes.Objectives: To identify biological targets underlying the escalated…
View article: EUFOREA summit in Brussels 2023: inspiring the future of allergy & respiratory care
EUFOREA summit in Brussels 2023: inspiring the future of allergy & respiratory care Open
In March 2023, the European Forum for Research and Education in Allergy and Airways diseases (EUFOREA) organized its bi-annual Summit in Brussels with expert panel members of EUFOREA, representatives of the EUFOREA patient advisory board, …
View article: Flow-Based CL-SMIA for the Quantification of Protein Biomarkers from Nasal Secretions in Comparison with Sandwich ELISA
Flow-Based CL-SMIA for the Quantification of Protein Biomarkers from Nasal Secretions in Comparison with Sandwich ELISA Open
Protein biomarkers in nasal secretions can be used as a measure to differentiate between allergies, airway diseases and infections for non-invasive diagnostics. The point-of-care quantification of biomarker levels using flow-based microarr…
View article: EPOS/EUFOREA update on indication and evaluation of Biologics in Chronic Rhinosinusitis with Nasal Polyps 2023
EPOS/EUFOREA update on indication and evaluation of Biologics in Chronic Rhinosinusitis with Nasal Polyps 2023 Open
Severe chronic rhinosinusitis with nasal polyps (CRSwNP) is a debilitating disease with a significant impact on the quality of life (QoL). It is typically characterized by a type 2 inflammatory reaction and by comorbidities such as asthma,…
View article: European Academy of Allergy and Clinical Immunology position paper on endoscopic scoring of nasal polyposis
European Academy of Allergy and Clinical Immunology position paper on endoscopic scoring of nasal polyposis Open
Nasal endoscopy is not only used for the diagnosis of chronic rhinosinusitis with nasal polyps (CRSwNP), but also for monitoring the response to therapy playing an important role in both daily practice and research. In contrast to patient‐…
View article: Diagnosis and treatment of Hymenoptera venom allergy
Diagnosis and treatment of Hymenoptera venom allergy Open
Hymenoptera venom (HV) is injected into the skin during a sting by Hymenoptera such as bees or wasps. Some components of HV are potential allergens and can cause large local and/or systemic allergic reactions (SAR) in sensitized individual…
View article: Genome-Wide Gene Expression Analysis Reveals Unique Genes Signatures of Epithelial Reorganization in Primary Airway Epithelium Induced by Type-I, -II and -III Interferons
Genome-Wide Gene Expression Analysis Reveals Unique Genes Signatures of Epithelial Reorganization in Primary Airway Epithelium Induced by Type-I, -II and -III Interferons Open
Biosensors such as toll-like receptors (TLR) induce the expression of interferons (IFNs) after viral infection that are critical to the first step in cell-intrinsic host defense mechanisms. Their differential influence on epithelial integr…
View article: AROMA: real-world global registry of dupilumab for chronic rhinosinusitis with nasal polyps
AROMA: real-world global registry of dupilumab for chronic rhinosinusitis with nasal polyps Open
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a predominantly type 2 inflammatory disease of the nasal and paranasal sinuses. Dupilumab is a monoclonal antibody that blocks the shared receptor component for interleukin-4 and interle…
View article: Indicating biologics for chronic rhinosinusitis with nasal polyps (CRSwNP)
Indicating biologics for chronic rhinosinusitis with nasal polyps (CRSwNP) Open
Summary Background Chronic rhinosinusitis with nasal polyps (CRSwNP), an inflammatory disease of the paranasal mucosa, is primarily characterized by type 2 inflammation. Three antibodies (dupilumab, omalizumab, and mepolizumab) are now app…