Chester A. Mathis
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View article: Surface-based morphometry reveals divergent aging trajectories in veterans with and without traumatic brain injury
Surface-based morphometry reveals divergent aging trajectories in veterans with and without traumatic brain injury Open
This study investigates how traumatic brain injury (TBI) alters cortical aging by comparing cortical thickness (CT) and surface area (SA) in 34 brain regions between TBI survivors and age-matched controls. Using a cross-sectional retrospec…
View article: Discovery of N-(6-Methoxypyridin-3-yl)quinoline-2-amine Derivatives for Imaging Aggregated α-Synuclein in Parkinson’s Disease with Positron Emission Tomography
Discovery of N-(6-Methoxypyridin-3-yl)quinoline-2-amine Derivatives for Imaging Aggregated α-Synuclein in Parkinson’s Disease with Positron Emission Tomography Open
The fibrillary aggregation of α-synuclein is a hallmark of Parkinson’s disease (PD) and a potential target for diagnostics and therapeutics. Although substantial effort has been devoted to the development of positron emission tomography (P…
View article: Structure-based optimization and binding assays for discovery of tau PET radiotracers: synthesis and in vivo evaluation of [<sup>11</sup>C]Z-3272
Structure-based optimization and binding assays for discovery of tau PET radiotracers: synthesis and in vivo evaluation of [<sup>11</sup>C]Z-3272 Open
Human tau protein has six isoforms, differing in the number of microtubule-binding repeats. Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are primarily 4-repeat (4R)-tauopathies, and Alzheimer’s disease (AD) and …
View article: Relationships of PGRN with sTREM2 in AD continuum and non-AD pathophysiology and their reciprocal roles in modulating amyloid pathology: two population-based study
Relationships of PGRN with sTREM2 in AD continuum and non-AD pathophysiology and their reciprocal roles in modulating amyloid pathology: two population-based study Open
Progranulin (PGRN) and soluble triggering receptor expressed on myeloid cells-2 (sTREM2) are emerging biomarkers of Alzheimer's disease (AD). This study explores the roles of their interplay in modulating amyloid pathology. We analyzed dat…
View article: White Matter Abnormalities and Cognition in Aging and Alzheimer Disease
White Matter Abnormalities and Cognition in Aging and Alzheimer Disease Open
Importance There has yet to be a large-scale study quantifying the association between white matter microstructure and cognitive performance and decline in aging and Alzheimer disease (AD). Objective To investigate the associations between…
View article: PET‐measured amyloid beta accumulates at an accelerated rate in Down syndrome compared to neurotypical populations
PET‐measured amyloid beta accumulates at an accelerated rate in Down syndrome compared to neurotypical populations Open
INTRODUCTION Individuals with Down syndrome (DS) have a high prevalence of Alzheimer's disease (AD) and reveal an earlier age of amyloid beta (Aβ) onset compared to sporadic AD. Differences in amyloid accumulation rates between DS and spor…
View article: An inverse association of cerebral amyloid-β deposition and serum docosahexaenoic acid levels in cognitively normal older adults in Japan
An inverse association of cerebral amyloid-β deposition and serum docosahexaenoic acid levels in cognitively normal older adults in Japan Open
Background Alzheimer's disease (AD) is driven by amyloid-β (Aβ) plaque accumulation, but the mechanisms behind this process remain unclear. Omega-3 fatty acids, particularly docosahexaenoic acid (DHA), may offer protective effects, though …
View article: Structure–Activity Relationships and Evaluation of 2-(Heteroaryl-cycloalkyl)-1<i>H</i>-indoles as Tauopathy Positron Emission Tomography Radiotracers
Structure–Activity Relationships and Evaluation of 2-(Heteroaryl-cycloalkyl)-1<i>H</i>-indoles as Tauopathy Positron Emission Tomography Radiotracers Open
Structure-activity relationship studies were performed on a library of synthesized compounds based on previously identified tau ligands. The top 13 new compounds had Ki values in the range of 5-14 nM in Alzheimer's disease (AD), progressiv…
View article: Correlating hippocampal and amygdala volumes with neuropathological burden in Down syndrome and Alzheimer’s disease and related neurodegenerative pathologies using 7T postmortem MRI
Correlating hippocampal and amygdala volumes with neuropathological burden in Down syndrome and Alzheimer’s disease and related neurodegenerative pathologies using 7T postmortem MRI Open
Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC), is common in elderly brains and often seen in conjunction with Alzheimer’s disease neuropathologic change (ADNC). LATE-NC typically begins in the amygda…
View article: Radiosynthesis, <i>In Vitro</i> Characterization, and <i>In Vivo</i> PET Neuroimaging of [<sup>18</sup>F]F-4 for Tau Protein: A First-in-Human PET Study
Radiosynthesis, <i>In Vitro</i> Characterization, and <i>In Vivo</i> PET Neuroimaging of [<sup>18</sup>F]F-4 for Tau Protein: A First-in-Human PET Study Open
[18F]PI-2620 is a promising radiopharmaceutical for positron emission tomography (PET) imaging of both Alzheimer's disease (AD) and non-Alzheimer's disease (non-AD) tauopathies in humans. An array of fluorinated derivatives of the carbazol…
View article: 18F-MK-6240 tau PET in patients at-risk for chronic traumatic encephalopathy
18F-MK-6240 tau PET in patients at-risk for chronic traumatic encephalopathy Open
Background Molecular biomarkers of chronic traumatic encephalopathy (CTE) are lacking. We evaluated 18 F-MK-6240 tau PET as a biomarker for CTE. Two studies were done: (1) 3 H-MK-6240 autoradiography and an in-vitro brain homogenate bindin…
View article: Exact Simulation of Longitudinal Data from Marginal Structural Models
Exact Simulation of Longitudinal Data from Marginal Structural Models Open
Simulating longitudinal data from specified marginal structural models is a crucial but challenging task for evaluating causal inference methods and informing study design. While data generation typically proceeds in a fully conditional ma…
View article: The development of a PET radiotracer for imaging alpha synuclein aggregates in Parkinson's disease
The development of a PET radiotracer for imaging alpha synuclein aggregates in Parkinson's disease Open
An ultrahigh throughput in silico screen was conducted on 42 M compounds in the Mcule database and led to the identification of a new lead compound for radiotracer development for use with the imaging technique, positron emission tomograph…
View article: Longitudinal beta‐amyloid measured with [C‐11]PiB accumulates at an accelerated rate in Down syndrome compared to neurotypical populations
Longitudinal beta‐amyloid measured with [C‐11]PiB accumulates at an accelerated rate in Down syndrome compared to neurotypical populations Open
Background Trisomy 21 in Down syndrome (DS) is associated with an earlier accumulation of beta‐amyloid (Aβ) plaques and a higher rate of Alzheimer’s Disease due to the triplication of the amyloid precursor protein gene. In this study we co…
View article: Assessing the correlations between imaging and plasma biomarkers within the AT(N) framework
Assessing the correlations between imaging and plasma biomarkers within the AT(N) framework Open
Background Given the increasing usage of plasma biomarkers for Alzheimer’s disease (AD) studies, it is necessary to better understand relationships between plasma biomarker and PET and MR imaging outcomes, particularly within the AT(N) fra…
View article: Longitudinal beta‐amyloid measured with [C‐11]PiB accumulates at an accelerated rate in Down syndrome compared to neurotypical populations
Longitudinal beta‐amyloid measured with [C‐11]PiB accumulates at an accelerated rate in Down syndrome compared to neurotypical populations Open
Background Trisomy 21 in Down syndrome (DS) is associated with an earlier accumulation of beta‐amyloid (Aß) plaques and a higher rate of Alzheimer’s Disease due to the triplication of the amyloid precursor protein gene. In this study we co…
View article: Evaluating impact of racialization on imaging and plasma biomarkers
Evaluating impact of racialization on imaging and plasma biomarkers Open
Background Imaging and plasma biomarkers are widely used in Alzheimer’s disease (AD) observational studies and clinical trials. Due to the lack of racial or ethnic diversity in earlier studies, a more complete understanding of biomarker di…
View article: Assessing the efficacy of BETTH‐derived tau thresholds to predict cognitive decline in non‐demented individuals
Assessing the efficacy of BETTH‐derived tau thresholds to predict cognitive decline in non‐demented individuals Open
Background Tau PET thresholds should detect early tau deposition and predict cognitive decline. We evaluated the relationships between the BETTH‐derived sensitivity and specificity tau thresholds (Gogola et al, doi:10.2967/jnumed.123.26594…
View article: Complementary value of molecular, phenotypic, and functional aging biomarkers in dementia prediction
Complementary value of molecular, phenotypic, and functional aging biomarkers in dementia prediction Open
DNA methylation age (MA), brain age (BA), and frailty index (FI) are putative aging biomarkers linked to dementia risk. We investigated their relationship and combined potential for prediction of cognitive impairment and future dementia ri…
View article: Implementation and Assessment of Tau Thresholds in Non-Demented Individuals as Predictors of Cognitive Decline in Tau Imaging Studies
Implementation and Assessment of Tau Thresholds in Non-Demented Individuals as Predictors of Cognitive Decline in Tau Imaging Studies Open
Background: Tau accumulation in Alzheimer’s disease is associated with short term clinical progression and faster rates of cognitive decline in individuals with high amyloid-β deposition. Defining an optimal threshold of tau accumulation p…
View article: Kinetic modeling of the monoamine oxidase-B radioligand [<sup>18</sup>F]SMBT-1 in human brain with positron emission tomography
Kinetic modeling of the monoamine oxidase-B radioligand [<sup>18</sup>F]SMBT-1 in human brain with positron emission tomography Open
This paper describes pharmacokinetic analyses of the monoamine-oxidase-B (MAO-B) radiotracer [ 18 F]( S)-(2-methylpyrid-5-yl)-6-[(3-fluoro-2-hydroxy)propoxy]quinoline ([ 18 F]SMBT-1) for positron emission tomography (PET) brain imaging. Br…
View article: Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer's disease: a cross-sectional study
Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer's disease: a cross-sectional study Open
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View article: A novel spatiotemporal graph convolutional network framework for functional connectivity biomarkers identification of Alzheimer’s disease
A novel spatiotemporal graph convolutional network framework for functional connectivity biomarkers identification of Alzheimer’s disease Open
Background Functional connectivity (FC) biomarkers play a crucial role in the early diagnosis and mechanistic study of Alzheimer’s disease (AD). However, the identification of effective FC biomarkers remains challenging. In this study, we …
View article: Development of Pyridothiophene Compounds for PET Imaging of α‐Synuclein
Development of Pyridothiophene Compounds for PET Imaging of α‐Synuclein Open
Aggregated α‐synuclein (α‐syn) protein is a pathological hallmark of Parkinson's disease (PD) and Lewy body dementia (LBD). Development of positron emission tomography (PET) radiotracers to image α‐syn aggregates has been a longstanding go…
View article: Characteristics of discordance between amyloid positron emission tomography and plasma amyloid-β 42/40 positivity
Characteristics of discordance between amyloid positron emission tomography and plasma amyloid-β 42/40 positivity Open
Various plasma biomarkers for amyloid-β (Aβ) have shown high predictability of amyloid PET positivity. However, the characteristics of discordance between amyloid PET and plasma Aβ42/40 positivity are poorly understood. Thorough interpreta…