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View article: Detection of tumor-associated tryptase-positive mast cells in sporadic medullary thyroid carcinoma
Detection of tumor-associated tryptase-positive mast cells in sporadic medullary thyroid carcinoma Open
BACKGROUND: There are currently no published studies on the role of mast cells in the pathogenesis of sporadic medullary thyroid carcinoma. However, their involvement in the progression of a variety of epithelial malignant neoplasms has be…
View article: Factors and conditions affecting transcortin production and function in blood plasma
Factors and conditions affecting transcortin production and function in blood plasma Open
It is well-established that the majority of steroid hormones in the bloodstream are in a bound state, complexed with carrier proteins. Transcortin (corticosteroid-binding globulin, SERPINA6) serves as the principal transport protein for st…
View article: Difficulty with differential diagnosis on adrenal lesions in congenital adrenal cortex dysfunction: a series of clinical cases
Difficulty with differential diagnosis on adrenal lesions in congenital adrenal cortex dysfunction: a series of clinical cases Open
Congenital adrenal hyperplasia (CAH) encompasses a group of autosomal recessive disorders characterized by defects in enzymes critical for steroidogenesis, with 21-hydroxylase deficiency due to mutations in the CYP21A2 gene being the most …
View article: Nosological verification of adrenal incidentaloma. differential diagnosis between ganglioneuroma and adrenocortiocal cancer: a clinical case
Nosological verification of adrenal incidentaloma. differential diagnosis between ganglioneuroma and adrenocortiocal cancer: a clinical case Open
Ganglioneuromas (GN) are rare benign neoplasms originating from neural crest tissue. These tumors are typically asymptomatic and are often detected incidentally during diagnostic imaging studies. Although the radiological characteristics o…
View article: C-cells etiology and calcitonin/cgrp family of peptides. Literature review
C-cells etiology and calcitonin/cgrp family of peptides. Literature review Open
Medullary thyroid cancer (MTC) is a rare form of cancer derived from parafollicular or C cells. Currently, there is an active search for predictors of the course of MTC and markers that can predict the treatment response. Understanding the…
View article: The functional role and properties of transcortin in the human body
The functional role and properties of transcortin in the human body Open
Steroid hormones take an active part in a whole complex of physiological processes that are fundamental for the normal development and functioning of the human body. In the bloodstream steroid hormones are bind with specific transport prot…
View article: Fulminant hypercorticism due to ACTG producing pheochromocytoma
Fulminant hypercorticism due to ACTG producing pheochromocytoma Open
Endogenous hypercorticism (EH) is a severe symptom complex caused by hypercortisolemia; according to the etiology, ACTH-dependent and ACTH-independent variants are distinguished, which, according to the literature, occur in 70–80% and 20–3…
View article: Approach to the patient with adrenal incidentaloma. Case series
Approach to the patient with adrenal incidentaloma. Case series Open
The formations of the adrenal glands are often detected accidentally during instrumental methods of examination of the abdominal cavity and retroperitoneal space, performed for some other reasons. Over the past 2 decades, the frequency of …
View article: Primary bilateral macronodular adrenal hyperplasia: clinical and laboratory features
Primary bilateral macronodular adrenal hyperplasia: clinical and laboratory features Open
BACKGROUND : Primary bilateral macronodular adrenal hyperplasia (PBMAH) is characterized by bilateral benign adrenocortical lesions, which in some cases lead to Cushing syndrome (CS). Due to the low detection, non-specific, erased clinical…
View article: Unilateral adrenalectomy for primary bilateral macronodular adrenal hyperplasia
Unilateral adrenalectomy for primary bilateral macronodular adrenal hyperplasia Open
BACKGROUND: To date, surgical treatment is an effective treatment of hypercortisolism in primary bilateral macronodular hyperplasia (PBMAH). Due to the bilateral lesion, the most common treatment in Russia is the bilateral adrenalectomy, w…
View article: ODP585 Occult metastatic medullary thyroid carcinoma without detectable primary tumor.
ODP585 Occult metastatic medullary thyroid carcinoma without detectable primary tumor. Open
Background Occult thyroid cancer is a particularly rare type of thyroid carcinomas. The absolute majority is presented by papillary thyroid carcinoma. We report a case of a medullary thyroid carcinoma (MTC) that was detected as a primary t…
View article: Clinical and genetic heterogeneity of micronodular adrenal hyperplasia
Clinical and genetic heterogeneity of micronodular adrenal hyperplasia Open
Micronodular adrenal hyperplasia is a rare cause of ACTH-independent Cushing syndrome. It can be divided into two entities: primary pigmented nodular adrenocortical disease (PPNAD) and non-pigmented micronodular adrenocortical disease, amo…
View article: Draft of the clinical practice guidelines “Adrenal incidentaloma”
Draft of the clinical practice guidelines “Adrenal incidentaloma” Open
The wider application and technical improvement of abdominal imaging procedures in recent years has led to an increasingly frequent detection of adrenal gland masses — adrenal incidentaloma, which have become a common clinical problem and …
View article: Mildly Elevated Basal Calcitonin Level in Patients With Thyroid Goiter: Using the Calcitonin Measurement in Fine-Needle Aspirate Washout Fluid of the Healthy Lobe to Define Medullary Thyroid Cancer and Reactive C-Cell Hyperplasia
Mildly Elevated Basal Calcitonin Level in Patients With Thyroid Goiter: Using the Calcitonin Measurement in Fine-Needle Aspirate Washout Fluid of the Healthy Lobe to Define Medullary Thyroid Cancer and Reactive C-Cell Hyperplasia Open
Background: Mildly elevated basal calcitonin level (bCT), that suggests a bCT increase up to 100 pg/ml, may testify either medullary thyroid carcinoma (MTC) or reactive thyroid C-cell hyperplasia (CCH). The latter is observed under many co…
View article: Immunohistochemical study on the expression/hyperexpression of aberrant/eutopic receptors in patients with bilateral macronodular adrenal hyperplasia
Immunohistochemical study on the expression/hyperexpression of aberrant/eutopic receptors in patients with bilateral macronodular adrenal hyperplasia Open
Bilateral macronodular adrenal hyperplasia (BMAH) is a rare cause of Cushing’s syndrome. In this case cortisol production can be regulated by both genetic factors and various molecular mechanisms. The presence of aberrant or overexpression…
View article: MON-457 Reactive Thyroid C-Cell Hyperplasia or Medullary Thyroid Cancer in a Patient with Nodular Thyroidopathy. May the Calcitonin Measurement in Fine-Needle Aspirate Washout Fluid of the Healthy Lobe Help to Define These Conditions?
MON-457 Reactive Thyroid C-Cell Hyperplasia or Medullary Thyroid Cancer in a Patient with Nodular Thyroidopathy. May the Calcitonin Measurement in Fine-Needle Aspirate Washout Fluid of the Healthy Lobe Help to Define These Conditions? Open
Background: Serum basal calcitonin (bCT) is used as a biomarker of medullary thyroid carcinoma (MTC) but bCT can also be elevated in patients with hypercalcemias, hypergastrinemias, thyroiditis, neuroendocrine tumors, renal end-stage kidne…
View article: SUN-162 Isolated Primary Pigmented Micronodular Adrenal Disease. Unilateral or Bilateral Adrenalectomy? Two Cases Report
SUN-162 Isolated Primary Pigmented Micronodular Adrenal Disease. Unilateral or Bilateral Adrenalectomy? Two Cases Report Open
Background: Isolated primary pigmented nodular adrenal disease (i-PPNAD) is a particular case of micronodular bilateral hyperplasia (MiBAH) leading to Cushing syndrome (CS). We present two patients with i-PPNAD who undergone unilateral adr…
View article: Gestational gigantomastia accompained by distal breast tissue necrosis. A case report
Gestational gigantomastia accompained by distal breast tissue necrosis. A case report Open
Rare condition characterized by an intensive and excessive breast enlargement is known as gigantomastia. Gestational gigantomastia manifests during pregnancy and could represent a life-threatening condition for both the mother and the fetu…
View article: Riedel's Thyroiditis. A Clinical Review.
Riedel's Thyroiditis. A Clinical Review. Open
Riedel`s thyroiditis is a rare disease with an unknown etiology, which is characterized by replacement of the thyroid gland tissue with a fibrous connective tissue, the main characteristic sign is the stony-hard texture of the gland, exten…