Arthur Chiou
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View article: High-viscosity driven modulation of biomechanical properties of human mesenchymal stem cells promotes osteogenic lineage
High-viscosity driven modulation of biomechanical properties of human mesenchymal stem cells promotes osteogenic lineage Open
Biomechanical cues could effectively govern cell gene expression to direct the differentiation of specific stem cell lineage. Recently, the medium viscosity has emerged as a significant mechanical stimulator that regulates the cellular mec…
View article: Early committed polarization of intracellular tension in response to cell shape determines the osteogenic differentiation of mesenchymal stromal cells
Early committed polarization of intracellular tension in response to cell shape determines the osteogenic differentiation of mesenchymal stromal cells Open
Within the heterogeneous tissue architecture, a comprehensive understanding of how cell shapes regulate cytoskeletal mechanics by adjusting focal adhesions (FAs) signals to correlate with the lineage commitment of mesenchymal stromal cells…
View article: Snail Augments Nuclear Deformability to Promote Lymph Node Metastasis of Head and Neck Squamous Cell Carcinoma
Snail Augments Nuclear Deformability to Promote Lymph Node Metastasis of Head and Neck Squamous Cell Carcinoma Open
Up to 50% of head and neck squamous cell carcinoma (HNSCC) patients have lymph node (LN) metastasis, resulting in poor survival rate. Numerous studies have supported the notion that the alterations of gene expression and mechanical propert…
View article: Alteration of 3D Matrix Stiffness Regulates Viscoelasticity of Human Mesenchymal Stem Cells
Alteration of 3D Matrix Stiffness Regulates Viscoelasticity of Human Mesenchymal Stem Cells Open
Human mesenchymal stem cells (hMSCs) possess potential of bone formation and were proposed as ideal material against osteoporosis. Although interrogation of directing effect on lineage specification by physical cues has been proposed, how …
View article: Alteration of 3d Matrix Stiffness Regulates Viscoelasticity of Human Mesenchymal Stem Cells
Alteration of 3d Matrix Stiffness Regulates Viscoelasticity of Human Mesenchymal Stem Cells Open
Background: Human mesenchymal stem cells (hMSCs) possess potential of bone formation and were proposed as ideal material for tissue regeneration against osteoporosis. Although a plethora of elucidation regarding the directing effect on lin…
View article: Centrosome guides spatial activation of Rac to control cell polarization and directed cell migration
Centrosome guides spatial activation of Rac to control cell polarization and directed cell migration Open
Directed cell migration requires centrosome-mediated cell polarization and dynamical control of focal adhesions (FAs). To examine how FAs cooperate with centrosomes for directed cell migration, we used centrosome-deficient cells and found …
View article: Epithelial‐mesenchymal transition softens head and neck cancer cells to facilitate migration in 3D environments
Epithelial‐mesenchymal transition softens head and neck cancer cells to facilitate migration in 3D environments Open
The biological impact and signalling of epithelial‐mesenchymal transition (EMT) during cancer metastasis has been established. However, the changes in biophysical properties of cancer cells undergoing EMT remain elusive. Here, we measured,…
View article: Musashi-1 Enhances Glioblastoma Cell Migration and Cytoskeletal Dynamics through Translational Inhibition of Tensin3
Musashi-1 Enhances Glioblastoma Cell Migration and Cytoskeletal Dynamics through Translational Inhibition of Tensin3 Open
The RNA-binding protein Musashi-1 (MSI1) exerts essential roles in multiple cellular functions, such as maintenance of self-renewal and pluripotency of stem cells. MSI1 overexpression has been observed in several tumor tissues, including g…
View article: 5D imaging via light sheet microscopy reveals cell dynamics during the eye-antenna disc primordium formation in Drosophila
5D imaging via light sheet microscopy reveals cell dynamics during the eye-antenna disc primordium formation in Drosophila Open
5D images of engrailed (en ) and eye gone (eyg ) gene expressions during the course of the eye-antenna disc primordium (EADP) formation of Drosophila embryos from embryonic stages 13 through 16 were recorded via light sheet microscopy and …
View article: Bio- chemical and physical characterizations of mesenchymal stromal cells along the time course of directed differentiation
Bio- chemical and physical characterizations of mesenchymal stromal cells along the time course of directed differentiation Open
Cellular biophysical properties are novel biomarkers of cell phenotypes which may reflect the status of differentiating stem cells. Accurate characterizations of cellular biophysical properties, in conjunction with the corresponding bioche…
View article: Automatic and objective oral cancer diagnosis by Raman spectroscopic detection of keratin with multivariate curve resolution analysis
Automatic and objective oral cancer diagnosis by Raman spectroscopic detection of keratin with multivariate curve resolution analysis Open
We have developed an automatic and objective method for detecting human oral squamous cell carcinoma (OSCC) tissues with Raman microspectroscopy. We measure 196 independent Raman spectra from 196 different points of one oral tissue sample …
View article: Raman spectroscopy for grading of live osteosarcoma cells
Raman spectroscopy for grading of live osteosarcoma cells Open
Introduction Osteosarcoma is the most common primary malignant bone tumor, and the grading of osteosarcoma cells relies on traditional histopathology and molecular biology methods, which require RNA extraction, protein isolation and immuno…
View article: β‐<scp>PIX</scp> controls intracellular viscoelasticity to regulate lung cancer cell migration
β‐<span>PIX</span> controls intracellular viscoelasticity to regulate lung cancer cell migration Open
Cancer metastasis occurs via a progress involving abnormal cell migration. Cell migration, a dynamic physical process, is controlled by the cytoskeletal system, which includes the dynamics of actin organization and cellular adhesive organe…