Christopher A. Haiman
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View article: Dietary Patterns and Prostate Cancer Risk in the Multiethnic Cohort Study
Dietary Patterns and Prostate Cancer Risk in the Multiethnic Cohort Study Open
Background: Healthy dietary patterns have been linked to reduced cancer risk, but evidence for prostate cancer remains inconsistent, especially across diverse populations. Methods: In the multiethnic cohort study, we examined associations …
View article: Different diabetes types and pancreatic ductal adenocarcinoma: a Mendelian randomization and pathway/gene-set analysis
Different diabetes types and pancreatic ductal adenocarcinoma: a Mendelian randomization and pathway/gene-set analysis Open
Background The associations between different types of diabetes, characterized by distinct pathophysiology and genetic architecture, and pancreatic ductal adenocarcinoma (PDAC) risk are not understood. Methods We investigated associations …
View article: Ancestry-specific genetic effects on urinary 6-sulfatoxymelatonin: a multi-ancestry GWAS meta-analysis
Ancestry-specific genetic effects on urinary 6-sulfatoxymelatonin: a multi-ancestry GWAS meta-analysis Open
Melatonin regulates circadian rhythms, metabolism, and immunity. Its primary metabolite, 6-sulfatoxymelatonin (aMT6s), is a biomarker linked to cancer risk and metabolic disorders. However, genetic determinants of aMT6s remain poorly under…
View article: Novel colon cancer susceptibility variants identified from a genome‐wide association study in African Americans
Novel colon cancer susceptibility variants identified from a genome‐wide association study in African Americans Open
Genome-wide association studies (GWAS) in ethnic/racial minority populations can help to fine-map previously identified risk regions or discover new risk loci because of the genetic diversity in these populations. We conducted a GWAS of co…
View article: Supplemental Table 1 from Adherence to World Cancer Research Fund/American Institute for Cancer Research Guidelines and Mortality among Participants with Colorectal Cancer in the MEC
Supplemental Table 1 from Adherence to World Cancer Research Fund/American Institute for Cancer Research Guidelines and Mortality among Participants with Colorectal Cancer in the MEC Open
Supplemental Table 1 shows comparisons of characteristics between eligible participants (all those diagnosed with colorectal cancer between enrollment and Q3) and those included in the final study sample.
View article: Figure S1 from The African-Specific Variant in the Duffy Antigen Receptor for Chemokines Gene, CD8<sup>+</sup> T-Cell Density, and Aggressive Breast Cancer Subtypes in Black Women
Figure S1 from The African-Specific Variant in the Duffy Antigen Receptor for Chemokines Gene, CD8<sup>+</sup> T-Cell Density, and Aggressive Breast Cancer Subtypes in Black Women Open
Supplemental Figure S1. Log-transformed CD8+ T-cell density per mm2 by ACKR1/DARC genotype. Figure displays box plot distribution of CD8+ T-cell density per mm2 according to ACKR1/DARC genotype (N=428).
View article: Supplemental Table 2 from Adherence to World Cancer Research Fund/American Institute for Cancer Research Guidelines and Mortality among Participants with Colorectal Cancer in the MEC
Supplemental Table 2 from Adherence to World Cancer Research Fund/American Institute for Cancer Research Guidelines and Mortality among Participants with Colorectal Cancer in the MEC Open
Supplemental Table 2 shows details of how WCRF/AICR scores were calculated in our study.
View article: Data from The African-Specific Variant in the Duffy Antigen Receptor for Chemokines Gene, CD8<sup>+</sup> T-Cell Density, and Aggressive Breast Cancer Subtypes in Black Women
Data from The African-Specific Variant in the Duffy Antigen Receptor for Chemokines Gene, CD8<sup>+</sup> T-Cell Density, and Aggressive Breast Cancer Subtypes in Black Women Open
Background:Immune response in blood varies by ancestry, linked to an African-specific variant (rs2814778) in the Duffy Antigen Receptor for Chemokines (DARC/ACKR1) gene. We examined associations between rs2814778, CD8+ T-cell density in br…
View article: Supplemental Table 4 from Adherence to World Cancer Research Fund/American Institute for Cancer Research Guidelines and Mortality among Participants with Colorectal Cancer in the MEC
Supplemental Table 4 from Adherence to World Cancer Research Fund/American Institute for Cancer Research Guidelines and Mortality among Participants with Colorectal Cancer in the MEC Open
Supplemental Table 4 shows the associations between adherence to the WCRF/AICR health behavior recommendations and risk of mortality by stage, sex, and cancer site.
View article: Supplemental Figure 1 from Adherence to World Cancer Research Fund/American Institute for Cancer Research Guidelines and Mortality among Participants with Colorectal Cancer in the MEC
Supplemental Figure 1 from Adherence to World Cancer Research Fund/American Institute for Cancer Research Guidelines and Mortality among Participants with Colorectal Cancer in the MEC Open
Supplemental Figure 1 shows derivation of the analytic sample of colorectal cancer survivors in the MultiEthnic Cohort study.
View article: Data from Adherence to World Cancer Research Fund/American Institute for Cancer Research Guidelines and Mortality among Participants with Colorectal Cancer in the MEC
Data from Adherence to World Cancer Research Fund/American Institute for Cancer Research Guidelines and Mortality among Participants with Colorectal Cancer in the MEC Open
Background:Racial and ethnic minority patients with colorectal cancer are underrepresented in studies on health behavior and mortality.Methods:We examined the association between postdiagnosis health behavior and mortality in the Multiethn…
View article: Supplemental Table 3 from Adherence to World Cancer Research Fund/American Institute for Cancer Research Guidelines and Mortality among Participants with Colorectal Cancer in the MEC
Supplemental Table 3 from Adherence to World Cancer Research Fund/American Institute for Cancer Research Guidelines and Mortality among Participants with Colorectal Cancer in the MEC Open
Supplemental Table 3 shows the associations between adherence to the WCRF/AICR health behavior recommendations and risk of mortality after excluding participants who died within 6, or 12, or 24 months of diagnosis; or those with distant di…
View article: Supplemental Figure 2 from Adherence to World Cancer Research Fund/American Institute for Cancer Research Guidelines and Mortality among Participants with Colorectal Cancer in the MEC
Supplemental Figure 2 from Adherence to World Cancer Research Fund/American Institute for Cancer Research Guidelines and Mortality among Participants with Colorectal Cancer in the MEC Open
Supplemental Figure 2 shows the association between individual WCRF/AICR score components and mortality among colorectal cancer survivors in the MultiEthnic Cohort study.
View article: Figure S2 from The African-Specific Variant in the Duffy Antigen Receptor for Chemokines Gene, CD8<sup>+</sup> T-Cell Density, and Aggressive Breast Cancer Subtypes in Black Women
Figure S2 from The African-Specific Variant in the Duffy Antigen Receptor for Chemokines Gene, CD8<sup>+</sup> T-Cell Density, and Aggressive Breast Cancer Subtypes in Black Women Open
Supplemental Figure S2. Meta-analysis full forest plots from AABCG for rs2814778 in relation to risk of breast cancer overall, ER- and TNBC. Figure shows non-significant odds ratio (OR) estimates for breast cancer risk overall, ER- and TNB…
View article: An Efficient Lasso Framework for Admixture-Aware Polygenic Scores
An Efficient Lasso Framework for Admixture-Aware Polygenic Scores Open
Polygenic scores (PGS) have promising clinical applications for risk stratification, disease screening, and personalized medicine. However, most PGS are trained on predominantly European ancestry cohorts and have limited portability to ext…
View article: Genetic and Cellular Architecture of Breast Cancer Risk in Multi-Ancestry Studies of 159,297 Cases and 212,102 Controls
Genetic and Cellular Architecture of Breast Cancer Risk in Multi-Ancestry Studies of 159,297 Cases and 212,102 Controls Open
SUMMARY Breast cancer genome-wide association studies (GWAS) have identified over 200 independent genome-wide significant susceptibility markers. However, most studies have focused on one or two ancestral groups. We examined breast cancer …
View article: Integrating multi‐ancestry genomic and proteomic data to identify blood risk biomarkers and target proteins for breast cancer genetic risk loci
Integrating multi‐ancestry genomic and proteomic data to identify blood risk biomarkers and target proteins for breast cancer genetic risk loci Open
Genome‐wide association studies (GWAS) have identified more than 200 risk loci for breast cancer. However, target genes and their encoded proteins in these loci remain largely unknown. In this study, we utilized genetic prediction models f…
View article: Adherence to World Cancer Research Fund/American Institute for Cancer Research Guidelines and Mortality among Participants with Colorectal Cancer in the MEC
Adherence to World Cancer Research Fund/American Institute for Cancer Research Guidelines and Mortality among Participants with Colorectal Cancer in the MEC Open
Background: Racial and ethnic minority patients with colorectal cancer are underrepresented in studies on health behavior and mortality. Methods: We examined the association between postdiagnosis health behavior and mortality in the Multie…
View article: The African-Specific Variant in the Duffy Antigen Receptor for Chemokines Gene, CD8+ T-Cell Density, and Aggressive Breast Cancer Subtypes in Black Women
The African-Specific Variant in the Duffy Antigen Receptor for Chemokines Gene, CD8+ T-Cell Density, and Aggressive Breast Cancer Subtypes in Black Women Open
Background: Immune response in blood varies by ancestry, linked to an African-specific variant (rs2814778) in the Duffy Antigen Receptor for Chemokines (DARC/ACKR1) gene. We examined associations between rs2814778, CD8+ T-cell density in b…
View article: African Genetic Ancestry, Structural and Social Determinants of Health, and Mortality in Black Adults
African Genetic Ancestry, Structural and Social Determinants of Health, and Mortality in Black Adults Open
Importance Although structural and social determinants of health (SSDH) have been consistently associated with health disparities, percentage African genetic ancestry (AGA) has been suggested as a risk factor associated with common disease…
View article: Large-scale multi-omics analyses in Hispanic/Latino populations identify genes for cardiometabolic traits
Large-scale multi-omics analyses in Hispanic/Latino populations identify genes for cardiometabolic traits Open
Here, we present a multi-omics study of type 2 diabetes and quantitative blood lipid and lipoprotein traits conducted to date in Hispanic/Latino populations (nmax = 63,184). We conduct a meta-analysis of 16 type 2 diabetes and 19 lipid tra…
View article: Type 2 diabetes polygenic risk score demonstrates context-dependent effects and associations with type 2 diabetes-related risk factors and complications across diverse populations
Type 2 diabetes polygenic risk score demonstrates context-dependent effects and associations with type 2 diabetes-related risk factors and complications across diverse populations Open
Polygenic risk scores (PRS) hold prognostic value for identifying individuals at higher risk of type 2 diabetes (T2D). However, further characterization is needed to understand the generalizability of T2D PRS in diverse populations across …
View article: Data from Evaluation of Multiple Breast Cancer Polygenic Risk Score Panels in Women of Latin American Heritage
Data from Evaluation of Multiple Breast Cancer Polygenic Risk Score Panels in Women of Latin American Heritage Open
Background:A substantial portion of the genetic predisposition for breast cancer is explained by multiple common genetic variants of relatively small effect. A subset of these variants, which have been identified mostly in individuals of E…
View article: Supplemental Figure S1 from Evaluation of Multiple Breast Cancer Polygenic Risk Score Panels in Women of Latin American Heritage
Supplemental Figure S1 from Evaluation of Multiple Breast Cancer Polygenic Risk Score Panels in Women of Latin American Heritage Open
Supplemental Figure S1 shows global ancestry distribution of individuals by countries across seven studies included in this analysis.