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View article: RUNX2 cooperates with SREBP1 to rewire cancer metabolism and promote aggressiveness
RUNX2 cooperates with SREBP1 to rewire cancer metabolism and promote aggressiveness Open
View article: Exploring the mechanism and pattern of bone formation during RANKL inhibition in a mouse model of fibrous dysplasia
Exploring the mechanism and pattern of bone formation during RANKL inhibition in a mouse model of fibrous dysplasia Open
Fibrous dysplasia (FD) of bone is a genetic fibro-osseous disorder with increased bone remodeling activity. Inhibition of RANKL modifies FD lesions by inducing the replacement of the fibrous tissue with bone. This effect was observed in FD…
View article: CDKN2A deletion is associated with immune desertification in diffuse pleural mesothelioma
CDKN2A deletion is associated with immune desertification in diffuse pleural mesothelioma Open
View article: Endometrial carcinoma and immune escape: prognostic relevance of <scp>HLA</scp> class I loss in <scp>NSMP</scp> subtype
Endometrial carcinoma and immune escape: prognostic relevance of <span>HLA</span> class I loss in <span>NSMP</span> subtype Open
Aims This study aims to define and characterize human leukocyte antigen class I (HLA‐I) expression in a consecutive series of molecularly classified endometrial carcinomas (ECs), and to evaluate its association with clinicopathologic featu…
View article: BH3 mimetic drugs overcome the microenvironment-induced resistance to crizotinib in ALK+ anaplastic large cell lymphoma
BH3 mimetic drugs overcome the microenvironment-induced resistance to crizotinib in ALK+ anaplastic large cell lymphoma Open
Resistance to first-line chemotherapies and crizotinib in anaplastic large cell lymphoma (ALCL) represents a significant challenge, often leading to a dismal outcome. Despite recent advancements, the dissection of the intrinsic and extrins…
View article: Correction: Lysin (K)-specific demethylase 1 inhibition enhances proteasome inhibitor response and overcomes drug resistance in multiple myeloma
Correction: Lysin (K)-specific demethylase 1 inhibition enhances proteasome inhibitor response and overcomes drug resistance in multiple myeloma Open
View article: The phenogenomic landscapes of pleural mesothelioma tumor microenvironment predict clinical outcomes
The phenogenomic landscapes of pleural mesothelioma tumor microenvironment predict clinical outcomes Open
Our findings underscore the intricate interplay between the tumor genome, TME composition, and clinical outcomes in MPM. These data support the potential of integrating genomic and TME profiling to develop more precise patient stratificati…
View article: lncRNAs: the unexpected link between protein synthesis and cancer adaptation
lncRNAs: the unexpected link between protein synthesis and cancer adaptation Open
Cancer progression relies on the ability of cells to adapt to challenging environments overcoming stresses and growth constraints. Such adaptation is a multifactorial process that depends on the rapid reorganization of many basic cellular …
View article: HELLS: the transcriptional sentinel
HELLS: the transcriptional sentinel Open
View article: Metabolically activated and highly polyfunctional intratumoral VISTA+ regulatory B cells are associated with tumor recurrence in early-stage NSCLC
Metabolically activated and highly polyfunctional intratumoral VISTA+ regulatory B cells are associated with tumor recurrence in early-stage NSCLC Open
View article: Parallel single-cell metabolic analysis and extracellular vesicle profiling reveal vulnerabilities with prognostic significance in acute myeloid leukemia
Parallel single-cell metabolic analysis and extracellular vesicle profiling reveal vulnerabilities with prognostic significance in acute myeloid leukemia Open
View article: A Two-Step Protocol for Isolation and Maintenance of Lung Cancer Primary 3D Cultures
A Two-Step Protocol for Isolation and Maintenance of Lung Cancer Primary 3D Cultures Open
Background/Objectives: Despite the introduction of innovative therapeutics, lung cancer is still the leading cause of cancer-related death. For this reason, lung cancer still requires deep characterization to identify cellular and molecula…
View article: To be or not to be: The dilemma over the prognostic role of epilepsy at presentation in patients with glioblastoma – a systematic review and meta-analysis
To be or not to be: The dilemma over the prognostic role of epilepsy at presentation in patients with glioblastoma – a systematic review and meta-analysis Open
View article: Exploring the transcriptional cooperation between RUNX2 and its associated elncRNA RAIN
Exploring the transcriptional cooperation between RUNX2 and its associated elncRNA RAIN Open
View article: <scp>BET</scp> inhibitors (<scp>BETi</scp>) influence oxidative phosphorylation metabolism by affecting mitochondrial dynamics leading to alterations in apoptotic pathways in triple‐negative breast cancer (<scp>TNBC</scp>) cells
<span>BET</span> inhibitors (<span>BETi</span>) influence oxidative phosphorylation metabolism by affecting mitochondrial dynamics leading to alterations in apoptotic pathways in triple‐negative breast cancer (<span>TNBC</span>) cells Open
Repressing BET proteins' function using bromodomain inhibitors (BETi) has been shown to elicit antitumor effects by regulating the transcription of genes downstream of BRD4. We previously showed that BETi promoted cell death of triple‐nega…
View article: Editorial: Molecular characterization of thyroid lesions in the era of “next generation” techniques: volume II
Editorial: Molecular characterization of thyroid lesions in the era of “next generation” techniques: volume II Open
Editorial: Molecular characterization of thyroid lesions in the era of "next generation" techniques: volume II
View article: Molecular and Histopathological Characterization of Metastatic Cutaneous Squamous Cell Carcinomas: A Case–Control Study
Molecular and Histopathological Characterization of Metastatic Cutaneous Squamous Cell Carcinomas: A Case–Control Study Open
Background: A subset of patients affected by cutaneous squamous cell carcinoma (cSCC) can exhibit locally invasive or metastatic tumors. Different staging classification systems are currently in use for cSCC. However, precise patient risk …
View article: Linc00941 fuels ribogenesis and protein synthesis by supporting robust cMYC translation in malignant pleural mesothelioma
Linc00941 fuels ribogenesis and protein synthesis by supporting robust cMYC translation in malignant pleural mesothelioma Open
View article: HELLS regulates transcription in T-cell lymphomas by reducing unscheduled R-loops and by facilitating RNAPII progression
HELLS regulates transcription in T-cell lymphomas by reducing unscheduled R-loops and by facilitating RNAPII progression Open
Chromatin modifiers are emerging as major determinants of many types of cancers, including Anaplastic Large Cell Lymphomas (ALCL), a family of highly heterogeneous T-cell lymphomas for which therapeutic options are still limited. HELLS is …
View article: BET inhibitors drive Natural Killer activation in non-small cell lung cancer via BRD4 and SMAD3
BET inhibitors drive Natural Killer activation in non-small cell lung cancer via BRD4 and SMAD3 Open
View article: Accuracy of World Health Organisation‐grade parameters (necrosis and mitotic activity) and foci of vascular invasion in predicting prognosis of papillary thyroid carcinoma. A case–control validation study
Accuracy of World Health Organisation‐grade parameters (necrosis and mitotic activity) and foci of vascular invasion in predicting prognosis of papillary thyroid carcinoma. A case–control validation study Open
Aims Tumour necrosis and/or increased mitoses define high‐grade papillary thyroid carcinoma (PTC). It is unclear whether angioinvasion is prognostic for PTC. Cut‐offs at five or more mitoses/2 mm 2 and four or more angioinvasive foci have …
View article: The pancancer overexpressed NFYC Antisense 1 controls cell cycle mitotic progression through in cis and in trans modes of action
The pancancer overexpressed NFYC Antisense 1 controls cell cycle mitotic progression through in cis and in trans modes of action Open
Antisense RNAs (asRNAs) represent an underappreciated yet crucial layer of gene expression regulation. Generally thought to modulate their sense genes in cis through sequence complementarity or their act of transcription, asRNAs can also r…
View article: Metabolically activated and highly polyfunctional intratumoral VISTA+ regulatory B cells are associated with tumor recurrence in early stage NSCLC.
Metabolically activated and highly polyfunctional intratumoral VISTA+ regulatory B cells are associated with tumor recurrence in early stage NSCLC. Open
B cells have emerged as central players in the tumor microenvironment (TME) of non-small cell lung cancer (NSCLC). However, although there is clear evidence for their involvement in cancer immunity, scanty data exist on the characterizatio…
View article: Supplementary Figure 5 from Spatial Distribution of Immune Cells Drives Resistance to Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer
Supplementary Figure 5 from Spatial Distribution of Immune Cells Drives Resistance to Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer Open
Supplementary Figure 5. Gene expression and RCB score
View article: Supplementary Figure 4 from Spatial Distribution of Immune Cells Drives Resistance to Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer
Supplementary Figure 4 from Spatial Distribution of Immune Cells Drives Resistance to Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer Open
Supplementary Figure 4. Relevant differences between pCR and pNR samples in particular regarding immune activation
View article: Supplementary Figure 2 from Spatial Distribution of Immune Cells Drives Resistance to Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer
Supplementary Figure 2 from Spatial Distribution of Immune Cells Drives Resistance to Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer Open
Supplementary Figure 2. CD3 and CD20 expression analysis in AOIs comparing pCR and pNR patients
View article: Supplementary Figure 1 from Spatial Distribution of Immune Cells Drives Resistance to Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer
Supplementary Figure 1 from Spatial Distribution of Immune Cells Drives Resistance to Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer Open
Supplementary Figure 1. H&E stainings of Tru-Cut biopsies analyzed in the study.
View article: Supplementary Figure 7 from Spatial Distribution of Immune Cells Drives Resistance to Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer
Supplementary Figure 7 from Spatial Distribution of Immune Cells Drives Resistance to Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer Open
Supplementary Figure 7. A) Diagnostic FFPE Tru-Cut biopsies from the validation cohort were stained with H&E staining and acquired with Aperio GT450 system (Leica) (right 1x magnification with scale bar 1mm, left 20x magnification with sca…
View article: Supplementary Figure 5 from Spatial Distribution of Immune Cells Drives Resistance to Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer
Supplementary Figure 5 from Spatial Distribution of Immune Cells Drives Resistance to Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer Open
Supplementary Figure 5. Gene expression and RCB score
View article: Supplementary Figure 7 from Spatial Distribution of Immune Cells Drives Resistance to Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer
Supplementary Figure 7 from Spatial Distribution of Immune Cells Drives Resistance to Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer Open
Supplementary Figure 7. A) Diagnostic FFPE Tru-Cut biopsies from the validation cohort were stained with H&E staining and acquired with Aperio GT450 system (Leica) (right 1x magnification with scale bar 1mm, left 20x magnification with sca…