Laura A. Colangelo
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View article: Prepregnancy Cardiovascular Health, Gestational Diabetes, and Coronary Artery Calcium
Prepregnancy Cardiovascular Health, Gestational Diabetes, and Coronary Artery Calcium Open
Importance Poor cardiovascular health (CVH) and gestational diabetes (GD) are each associated with higher risk for cardiovascular disease (CVD). Individuals with poor CVH also have a higher risk of GD, but it remains unclear if GD mediates…
View article: Molecular architecture of human atherosclerosis revealed through integrative human genetics
Molecular architecture of human atherosclerosis revealed through integrative human genetics Open
Current genetic discovery methods are largely restricted to profiling circulating molecules or genetic architecture, limited in use of tissue-based molecular genetics to identify pathogenic and therapeutic targets. Here, we leverage a mult…
View article: Person‐Centered Approach to Understanding Psychosocial Stressor Subgroups and Cardiovascular Disease: New Perspectives From the Multi‐Ethnic Study of Atherosclerosis Study
Person‐Centered Approach to Understanding Psychosocial Stressor Subgroups and Cardiovascular Disease: New Perspectives From the Multi‐Ethnic Study of Atherosclerosis Study Open
Background This study examined the longitudinal associations of psychosocial stress subgroups with cardiovascular disease (CVD) events and whether social support, neighborhood cohesion, and physical activity modified these associations in …
View article: Proteomic Risk Score of Increased Respiratory Susceptibility: A Multicohort Study
Proteomic Risk Score of Increased Respiratory Susceptibility: A Multicohort Study Open
Rationale: Accelerated decline in lung function is associated with incident chronic obstructive pulmonary disease (COPD), hospitalization, and death. However, identifying this trajectory with longitudinal spirometry measurements is challen…
View article: Proteomic analysis of cardiorespiratory fitness for prediction of mortality and multisystem disease risks
Proteomic analysis of cardiorespiratory fitness for prediction of mortality and multisystem disease risks Open
Despite the wide effects of cardiorespiratory fitness (CRF) on metabolic, cardiovascular, pulmonary and neurological health, challenges in the feasibility and reproducibility of CRF measurements have impeded its use for clinical decision-m…
View article: Fatherhood and Cardiovascular Health, Disease, and Mortality: Associations From the Multi-Ethnic Study of Atherosclerosis
Fatherhood and Cardiovascular Health, Disease, and Mortality: Associations From the Multi-Ethnic Study of Atherosclerosis Open
Fatherhood is a social determinant of health, and understanding its influence may provide opportunities to improve men's health, particularly among men of color.
View article: Proteomics, Human Environmental Exposure, and Cardiometabolic Risk
Proteomics, Human Environmental Exposure, and Cardiometabolic Risk Open
BACKGROUND: The biological mechanisms linking environmental exposures with cardiovascular disease pathobiology are incompletely understood. We sought to identify circulating proteomic signatures of environmental exposures and examine their…
View article: Association between secondhand smoke exposure and incident heart failure: The <scp>Multi‐Ethnic</scp> Study of Atherosclerosis ( <scp>MESA</scp> )
Association between secondhand smoke exposure and incident heart failure: The <span>Multi‐Ethnic</span> Study of Atherosclerosis ( <span>MESA</span> ) Open
Aims There are no studies on the association between secondhand smoke (SHS) exposure and incident heart failure (HF). This cohort study aimed to examine the associations of self‐reported and urinary cotinine‐assessed SHS exposure with inci…
View article: Implications of metabolism on multi‐systems healthy aging across the lifespan
Implications of metabolism on multi‐systems healthy aging across the lifespan Open
Aging is increasingly thought to involve dysregulation of metabolism in multiple organ systems that culminate in decreased functional capacity and morbidity. Here, we seek to understand complex interactions among metabolism, aging, and sys…
View article: A prognostic molecular signature of hepatic steatosis is spatially heterogeneous and dynamic in human liver
A prognostic molecular signature of hepatic steatosis is spatially heterogeneous and dynamic in human liver Open
SUMMARY Metabolic dysfunction-associated steatotic liver disease (MASLD) prevalence is increasing in parallel with an obesity pandemic, calling for novel strategies for prevention and treatment. We defined a circulating proteome of human M…
View article: Association of 20-Year Longitudinal Depressive Symptoms With Left Ventricular Geometry Outcomes in the Coronary Artery Risk Development in Young Adults Study: A Role for Androgens?
Association of 20-Year Longitudinal Depressive Symptoms With Left Ventricular Geometry Outcomes in the Coronary Artery Risk Development in Young Adults Study: A Role for Androgens? Open
Objective Depression is a risk factor for coronary heart disease and left ventricular hypertrophy (LVH) is a potent predictor of coronary heart disease events. Whether depression is associated with LVH has received limited investigation. T…
View article: Low-Normal FVC Trajectory Starting in Early Adulthood and Risk of Future Interstitial Abnormalities
Low-Normal FVC Trajectory Starting in Early Adulthood and Risk of Future Interstitial Abnormalities Open
"Low-Normal FVC Trajectory Starting in Early Adulthood and Risk of Future Interstitial Abnormalities." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.
View article: Computed tomography measure of lung injury and future interstitial features: the CARDIA Lung Study
Computed tomography measure of lung injury and future interstitial features: the CARDIA Lung Study Open
Introduction Visually normal areas of the lung with high attenuation on computed tomography (CT) imaging, termed CT lung injury, may represent injured but not yet remodelled lung parenchyma. This prospective cohort study examined if CT lun…
View article: Blood‐Based Fingerprint of Cardiorespiratory Fitness and Long‐Term Health Outcomes in Young Adulthood
Blood‐Based Fingerprint of Cardiorespiratory Fitness and Long‐Term Health Outcomes in Young Adulthood Open
Background Cardiorespiratory fitness is a powerful predictor of health outcomes that is currently underused in primary prevention, especially in young adults. We sought to develop a blood‐based biomarker of cardiorespiratory fitness that i…
View article: Comparing Racial Differences in Emphysema Prevalence Among Adults With Normal Spirometry: A Secondary Data Analysis of the CARDIA Lung Study
Comparing Racial Differences in Emphysema Prevalence Among Adults With Normal Spirometry: A Secondary Data Analysis of the CARDIA Lung Study Open
National Institutes of Health.
View article: Associations of Chronic Burden, Sleep Characteristics, and Metabolic Syndrome in the Coronary Artery Risk Development in Young Adults Study
Associations of Chronic Burden, Sleep Characteristics, and Metabolic Syndrome in the Coronary Artery Risk Development in Young Adults Study Open
Objective Chronic exposure to stress is associated with metabolic syndrome (MetS), but the mechanism is unclear. We investigated the associations between chronic burden, sleep, and MetS in the Coronary Artery Risk Development in Young Adul…
View article: Genetic variation in sodium glucose co‐transporter 1 and cardiac structure and function at middle age
Genetic variation in sodium glucose co‐transporter 1 and cardiac structure and function at middle age Open
Aims The effects of inhibition of sodium glucose cotransporter (SGLT)‐1, as opposed to SGLT2, on cardiovascular structure and function are not well known. We assessed the associations of a missense genetic variant of SGLT1 with cardiac str…
View article: PDAY risk score predicts cardiovascular events in young adults: the CARDIA study
PDAY risk score predicts cardiovascular events in young adults: the CARDIA study Open
Aims Atherosclerotic cardiovascular disease (ASCVD) risk prediction equations apply to older adults. For this study, the Pathobiologic Determinants of Atherosclerosis in Youth (PDAY) risk score, based on post-mortem measurements of atheros…
View article: Association of Premature Menopause With Coronary Artery Calcium: The CARDIA Study
Association of Premature Menopause With Coronary Artery Calcium: The CARDIA Study Open
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View article: Does Lowering Low‐Density Lipoprotein Cholesterol With Statin Restore Low Risk in Middle‐Aged Adults? Analysis of the Observational MESA Study
Does Lowering Low‐Density Lipoprotein Cholesterol With Statin Restore Low Risk in Middle‐Aged Adults? Analysis of the Observational MESA Study Open
Background It is unclear if statin therapy in midlife can restore low cardiovascular risk in hypercholesterolemic individuals. Methods and Results At baseline, we grouped 5687 MESA (Multi‐Ethnic Study of Atherosclerosis) participants aged …
View article: Association between Cardiorespiratory Fitness and Bronchiectasis at CT: A Long-term Population-based Study of Healthy Young Adults Aged 18–30 Years in the CARDIA Study
Association between Cardiorespiratory Fitness and Bronchiectasis at CT: A Long-term Population-based Study of Healthy Young Adults Aged 18–30 Years in the CARDIA Study Open
Background Protective factors against the risk of bronchiectasis are unknown. A high level of cardiorespiratory fitness is associated with a lower risk of chronic obstructive pulmonary disease. But whether fitness relates to bronchiectasis…
View article: Urinary sodium and potassium excretions in young adulthood and blood pressure by middle age: the Coronary Artery Risk Development in Young Adults (CARDIA) Study
Urinary sodium and potassium excretions in young adulthood and blood pressure by middle age: the Coronary Artery Risk Development in Young Adults (CARDIA) Study Open
Objective: Data are sparse regarding the impact of sodium and potassium intakes on serial blood pressure (BP) levels during long-term follow-up. Methods: Among 1007 Coronary Artery Risk Development in Young Adults participants (mean age, 3…
View article: The presence of emphysema on chest imaging and mid-life cognition
The presence of emphysema on chest imaging and mid-life cognition Open
Background Airflow obstruction is associated with cognitive dysfunction but studies have not assessed how emphysema, a structural phenotype of lung disease, might be associated with cognitive function independent from pulmonary function me…