Guillaume Savoye
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Prognosis of pediatric‐onset inflammatory bowel disease associated with primary sclerosing cholangitis: A population‐based study Open
Objectives To assess whether the prognosis of pediatric‐onset inflammatory bowel disease (IBD) is influenced by its association with primary sclerosing cholangitis (PSC) considering medical treatment, bowel resection, risk of cancer, and m…
Young Adult Patients With Paediatric‐Onset Inflammatory Bowel Disease Have a Higher Educational Level and a Higher Employment Rate Than the General Population Open
Background & Aims There are few published data on the impact of paediatric‐onset inflammatory bowel diseases on education and employment. The objective of the present cross‐sectional study was to assess the educational level and occupation…
P0135 Effect of human recombinant IL-33 on fibrosis markers in colonic fibroblasts Open
Background IBD is frequently complicated by intestinal fibrosis and strictures formation, occurring in more than 50% of Crohn’s disease (CD) and 5% of ulcerative colitis. Intestinal fibrosis leads to surgery in CD and strictures frequently…
P1272 Spatio-temporal distribution of IBD incidence at a territorial level in northern France using the EPIMAD registry (2000-2017): analysis of environmental determinants suggests influence of agricultural practices. Open
Background Crohn’s disease (CD) and ulcerative colitis (UC) are chronic inflammatory bowel diseases (IBDs) with complex and multifactorial etiologies. Genetic factors have been identified but cannot fully account for disease incidence. Spa…
View article: P0177 Dietary prevention of undernutrition reduces intestinal inflammation in a DSS-induced model of colitis and is associated with anti-inflammatory metabolites-producing bacteria
P0177 Dietary prevention of undernutrition reduces intestinal inflammation in a DSS-induced model of colitis and is associated with anti-inflammatory metabolites-producing bacteria Open
Background Patients with inflammatory bowel diseases (IBD) have a high-risk for undernutrition1. Undernutrition is associated with higher complications such as an increased mortality rate, a higher disease activity and an impaired quality …
P0191 The role of myeloid mineralocorticoid receptor and its target neutrophil gelatinase-associated lipocalin in mice with colitis Open
Background Intestinal fibrosis is a common complication in IBD patients with no specific treatment. In extra-intestinal conditions, mineralocorticoid receptor (MR) antagonism inhibits inflammation and fibrosis in different pathophysiologic…
View article: Risk of Incident Cancer in Patients With Inflammatory Bowel Disease With Prior Breast Cancer: A Multicenter Cohort Study
Risk of Incident Cancer in Patients With Inflammatory Bowel Disease With Prior Breast Cancer: A Multicenter Cohort Study Open
We did not find a statistically significant increase in incident breast cancer related to IBD treatment beyond the already known poor prognostic factors of breast cancer.
Incidence and risk factors for thromboembolic events in pediatric-onset inflammatory bowel disease: A French population-based study Open
The risk of TE was low in this population. VTE were strongly associated with active disease, surgery and hospitalization.
View article: P1122 Comorbidities Associated with Pediatric Onset Inflammatory Bowel Diseases: A Population-Based Study
P1122 Comorbidities Associated with Pediatric Onset Inflammatory Bowel Diseases: A Population-Based Study Open
Background Inflammatory bowel disease (IBD) can be associated with various disorders, including dermatological, rheumatological, or psychiatric conditions. However, little is known about the incidence of these co-morbidities in paediatric-…
View article: P1125 Incidence and Neoplastic Risk Associated with Colonic Stricture in Pediatric-Onset Crohn's Disease: A Population-based Study
P1125 Incidence and Neoplastic Risk Associated with Colonic Stricture in Pediatric-Onset Crohn's Disease: A Population-based Study Open
Background The identification of colonic stricture in patients with Crohn's disease (CD) often leads to surgery due to concerns about associated neoplasia. Nevertheless, information regarding the neoplastic risk associated to colonic stric…
View article: P1071 Patient preferences for adalimumab in inflammatory bowel disease: a nationwide study from the GETAID
P1071 Patient preferences for adalimumab in inflammatory bowel disease: a nationwide study from the GETAID Open
Background Several adalimumab preparations are now available on the market for patients with inflammatory bowel disease. Comparative satisfaction and tolerability are unknown. The aim of this study was to investigate inflammatory bowel dis…
View article: P857 Effectiveness and safety of subcutaneous infliximab in perianal Crohn's disease: a multicentre cohort study
P857 Effectiveness and safety of subcutaneous infliximab in perianal Crohn's disease: a multicentre cohort study Open
Background Infliximab (IFX) demonstrated its effectiveness in perianal CD (pCD) and represents the first-line medical treatment. A subcutaneous (SC) formulation has recently been developed, however so far it has not been specifically inves…
View article: Patient preferences for adalimumab in inflammatory bowel disease: a nationwide study from the GETAID
Patient preferences for adalimumab in inflammatory bowel disease: a nationwide study from the GETAID Open
Background: Several adalimumab preparations are now available for patients with inflammatory bowel disease (IBD). Comparative satisfaction and tolerability are unknown. Objectives: This study investigated IBD patient satisfaction with appr…
View article: P1151 Incidence and risk factors of thromboembolic events in Pediatric-Onset Inflammatory Bowel Disease: a population-based study
P1151 Incidence and risk factors of thromboembolic events in Pediatric-Onset Inflammatory Bowel Disease: a population-based study Open
Background Patients with inflammatory bowel disease (IBD) are known to be more susceptible to thromboembolic events. However, limited data on the incidence and risk factors for both venous (VTE) and arterial thromboembolic events (ATE) hav…
«Digesting Crohn’s Disease»: The Journey of Young Adults since Diagnosis Open
Crohn’s disease affects 2.5 million people in Europe (more than 100,000 people in France) and often occurs between the ages of 15 and 30, a period marked by self-construction. However, few studies have focused on the experience of the diag…
Lymphoma in Patients with Inflammatory Bowel Disease: A Multicentre Collaborative Study Between GETAID and LYSA Open
Background Inflammatory bowel disease [IBD] is associated with an increased risk of developing lymphoma. Although recent data have clarified the epidemiology of lymphoma in IBD patients, the clinical and pathological characteristics of lym…
View article: Tofacitinib for Patients with Anti-TNF Refractory Ulcerative Proctitis: A Multicentre Cohort Study from the GETAID
Tofacitinib for Patients with Anti-TNF Refractory Ulcerative Proctitis: A Multicentre Cohort Study from the GETAID Open
Background Although ulcerative proctitis [UP] can dramatically impair quality of life, treatment efficacy has been poorly investigated in UP as it was historically excluded from phase 2/3 randomised controlled trials in ulcerative colitis.…
View article: Prevalence of and Factors Associated With Extraintestinal Manifestations and Their Remission in Inflammatory Bowel Disease: The EXTRA-Intestinal Manifestation Prospective Study From the Groupe d'Etude Thérapeutique des Affections Inflammatoires du Tube Digestif
Prevalence of and Factors Associated With Extraintestinal Manifestations and Their Remission in Inflammatory Bowel Disease: The EXTRA-Intestinal Manifestation Prospective Study From the Groupe d'Etude Thérapeutique des Affections Inflammatoires du Tube Digestif Open
INTRODUCTION: Extraintestinal manifestations (EIMs) of inflammatory bowel disease (IBD) are challenging clinical situation. No prospective study assessed remission risk factors of EIMs. The aim of this study was to prospectively investigat…
Crohn’s disease: Why the ileum? Open
Crohn's disease (CD) is an inflammatory bowel disease characterized by immune-mediated flares affecting any region of the intestine alternating with remission periods. In CD, the ileum is frequently affected and about one third of patients…
View article: Prevalence and Determinants of Fatigue in Patients with IBD: A Cross-Sectional Survey from the GETAID
Prevalence and Determinants of Fatigue in Patients with IBD: A Cross-Sectional Survey from the GETAID Open
Background Fatigue is commonly reported by patients with inflammatory bowel disease [IBD], but the determinants of IBD-related fatigue have yet to be determined. Aims To identify the factors associated with fatigue in a large population of…
View article: P207 Colonic location at diagnosis of pediatric-onset Crohn’s disease is associated with a pejorative disease course: a two decades population-based study
P207 Colonic location at diagnosis of pediatric-onset Crohn’s disease is associated with a pejorative disease course: a two decades population-based study Open
Background Crohn's disease (CD) location would influence the risk of complications and therapeutic strategies. The objective of this study was to compare the clinical presentation at diagnosis and the natural history of colonic CD in compa…
P876 Disease course of Inflammatory Bowel Disease Unclassified in adult patients : a population-based study (1988-2014) Open
Background Inflammatory bowel disease unclassified (IBDU) represents 1 to 20 % of inflammatory bowel disease (IBD). There are few data on the natural history of IBDU. The aim of this study was to evaluate the disease course of IBDU in a po…
View article: P155 Natural history of anal stricture in pediatric-onset Crohn’s disease: a two-decades population-based study
P155 Natural history of anal stricture in pediatric-onset Crohn’s disease: a two-decades population-based study Open
Background The natural history of anal stricture complicating pediatric-onset Crohn’s disease (CD) is poorly known. The aims of this study were: to determine in a population-based study the risk of anal stricture in pediatric-onset CD; to …