Pauline Colombier
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View article: Spatiotemporal cellular dynamics of the notochord shape intervertebral disc morphogenesis in the mouse embryo through apoptosis and proliferation
Spatiotemporal cellular dynamics of the notochord shape intervertebral disc morphogenesis in the mouse embryo through apoptosis and proliferation Open
Background The notochord is a midline structure essential for vertebrate embryogenesis, contributing to the development of the nervous system, digestive tract, and vertebral column. In particular, notochord signaling is indispensable for p…
View article: An injury-responsive<i>mmp14b</i>enhancer is required for heart regeneration
An injury-responsive<i>mmp14b</i>enhancer is required for heart regeneration Open
Mammals have limited capacity for heart regeneration, whereas zebrafish have extraordinary regeneration abilities. During zebrafish heart regeneration, endothelial cells promote cardiomyocyte cell cycle reentry and myocardial repair, but t…
View article: NOTO Transcription Factor Directs Human Induced Pluripotent Stem Cell-Derived Mesendoderm Progenitors to a Notochordal Fate
NOTO Transcription Factor Directs Human Induced Pluripotent Stem Cell-Derived Mesendoderm Progenitors to a Notochordal Fate Open
The founder cells of the Nucleus pulposus, the centre of the intervertebral disc, originate in the embryonic notochord. After birth, mature notochordal cells (NC) are identified as key regulators of disc homeostasis. Better understanding o…
View article: Venous endothelin modulates responsiveness of cardiac sympathetic axons to arterial semaphorin
Venous endothelin modulates responsiveness of cardiac sympathetic axons to arterial semaphorin Open
Developing neurons of the peripheral nervous system reach their targets via cues that support directional growth, a process known as axon guidance. In investigating how sympathetic axons reach the heart in mice, we discovered that a combin…
View article: Author response: Venous endothelin modulates responsiveness of cardiac sympathetic axons to arterial semaphorin
Author response: Venous endothelin modulates responsiveness of cardiac sympathetic axons to arterial semaphorin Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Developing neurons of the peripheral nervo…
View article: Aarhus Regenerative Orthopaedics Symposium (AROS)
Aarhus Regenerative Orthopaedics Symposium (AROS) Open
The combination of modern interventional and preventive medicine has led to an epidemic of ageing. While this phenomenon is a positive consequence of an improved lifestyle and achievements in a society, the longer life expectancy is often …
View article: Biological challenges for regeneration of the degenerated disc using cellular therapies
Biological challenges for regeneration of the degenerated disc using cellular therapies Open
International audience
View article: Ageing in the musculoskeletal system
Ageing in the musculoskeletal system Open
The extent of ageing in the musculoskeletal system during the life course affects the quality and length of life. Loss of bone, degraded articular cartilage, and degenerate, narrowed intervertebral discs are primary features of an ageing s…
View article: Longitudinal Comparison of Enzyme- and Laser-Treated Intervertebral Disc by MRI, X-Ray, and Histological Analyses Reveals Discrepancies in the Progression of Disc Degeneration: A Rabbit Study
Longitudinal Comparison of Enzyme- and Laser-Treated Intervertebral Disc by MRI, X-Ray, and Histological Analyses Reveals Discrepancies in the Progression of Disc Degeneration: A Rabbit Study Open
Regenerative medicine is considered an attractive prospect for the treatment of intervertebral disc (IVD) degeneration. To assess the efficacy of the regenerative approach, animal models of IVD degeneration are needed. Among these animal m…
View article: Silica nano-carrier as a sustained delivery system of GDF5 for intervertebral disc regenerative medicine
Silica nano-carrier as a sustained delivery system of GDF5 for intervertebral disc regenerative medicine Open
Event Abstract Back to Event Silica nano-carrier as a sustained delivery system of GDF5 for intervertebral disc regenerative medicine Nina Henry1, 2, 3, Johann Clouet1, 3, 4, 5, Pauline Colombier1, 3, Eric Gautron2, Bernard Humbert2, Jean …
View article: TGF-β1 and GDF5 Act Synergistically to Drive the Differentiation of Human Adipose Stromal Cells toward <i>Nucleus Pulposus</i>-like Cells
TGF-β1 and GDF5 Act Synergistically to Drive the Differentiation of Human Adipose Stromal Cells toward <i>Nucleus Pulposus</i>-like Cells Open
Degenerative disc disease (DDD) primarily affects the central part of the intervertebral disc namely the nucleus pulposus (NP). DDD explains about 40% of low back pain and is characterized by massive cellular alterations that ultimately re…