Ali Naji
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Joint profiling of gene expression and chromatin accessibility in pancreatic lymph nodes and spleens in human type 1 diabetes Open
Type 1 diabetes (T1D) is an autoimmune disease characterized by the destruction of insulin-producing β cells in the pancreas. While current therapies focus on managing the disease, a deeper understanding of the underlying molecular mechani…
View article: Serum TNF-Alpha and IL-10 Predict Reduced Sensitivity to Fear- and Anxiety-Related Traits in Healthy Older Dogs: Preliminary Evidence for Immune–Personality Signatures in Later Life
Serum TNF-Alpha and IL-10 Predict Reduced Sensitivity to Fear- and Anxiety-Related Traits in Healthy Older Dogs: Preliminary Evidence for Immune–Personality Signatures in Later Life Open
As dogs live longer, they face an increased risk of functional age-related changes, including physiological and behavioral alterations. However, data on these age-related processes in domestic dogs remain limited. In this study, we assesse…
View article: <b>Molecular Mechanisms of Human Pancreatic Islet Dysfunction Under Overnutrition Metabolic Stress</b>
<b>Molecular Mechanisms of Human Pancreatic Islet Dysfunction Under Overnutrition Metabolic Stress</b> Open
Metabolic stress elicits functional changes in pancreatic islets, contributing to the pathogenesis of type 2 diabetes. However, the molecular mechanisms underlying overnutrition stress in islet cells is not well understood. In our study, w…
View article: <b>Molecular Mechanisms of Human Pancreatic Islet Dysfunction Under Overnutrition Metabolic Stress</b>
<b>Molecular Mechanisms of Human Pancreatic Islet Dysfunction Under Overnutrition Metabolic Stress</b> Open
Metabolic stress elicits functional changes in pancreatic islets, contributing to the pathogenesis of type 2 diabetes. However, the molecular mechanisms underlying overnutrition stress in islet cells is not well understood. In our study, w…
View article: Molecular Mechanisms of Human Pancreatic Islet Dysfunction Under Overnutrition Metabolic Stress
Molecular Mechanisms of Human Pancreatic Islet Dysfunction Under Overnutrition Metabolic Stress Open
Metabolic stress elicits functional changes in pancreatic islets, contributing to the pathogenesis of type 2 diabetes. However, the molecular mechanisms underlying overnutrition stress in islet cells is not well understood. In our study, w…
View article: Sero Positivity of Hepatitis C among Patients with β-Thalassemia Major in Karbala Center
Sero Positivity of Hepatitis C among Patients with β-Thalassemia Major in Karbala Center Open
Background: Hepatitis C virus is a major cause of post-transfusion hepatitis infection and remains a significant global health problem. Patients with thalassemia major are at high risk of HCV due to frequent blood transfusions from infecte…
View article: Acute Phase Reactants and Hematologic Profiles vs Blood Culture in Late Preterm Neonatal Sepsis
Acute Phase Reactants and Hematologic Profiles vs Blood Culture in Late Preterm Neonatal Sepsis Open
Background: Neonatal sepsis involves physical and laboratory findings due to infection within the first 30 days of life, with preterm infants being six times more at risk than term infants due to their immature immune systems and prolonged…
View article: Epigenetic adaptation of beta cells across lifespan and disease: age-related demethylation is advanced in type 2 diabetes
Epigenetic adaptation of beta cells across lifespan and disease: age-related demethylation is advanced in type 2 diabetes Open
Although the prevalence of type 2 diabetes (T2D) increases with age, most adults maintain normoglycemia despite rising insulin resistance, largely due to the adaptive capacity of pancreatic beta cells to meet increased metabolic demand. Ho…
View article: Spigelian-Cryptorchidism Syndrome: A Literature Review and Case Report of a Rare Clinical Entity
Spigelian-Cryptorchidism Syndrome: A Literature Review and Case Report of a Rare Clinical Entity Open
Spigelian-cryptorchidism syndrome is a rare and diagnostically challenging condition in neonatology that is characterized by the association of an undescended testis with a Spigelian hernia, the latter usually without radiologic evidence. …
View article: Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes
Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes Open
SUMMARY This study explores the inflammatory response observed in pancreata and pancreatic lymph node (pLN) samples obtained throughout the natural history of type 1 diabetes (T1D) including non-diabetic individuals and non-diabetic autoan…
View article: Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset
Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset Open
Autoimmune destruction of pancreatic β cells results in type 1 diabetes (T1D), with pancreatic immune infiltrate representing a key feature in this process. However, characterization of the immunological processes occurring in human pancre…
View article: SEL1L-HRD1 ER-Associated Degradation Facilitates Prohormone Convertase 2 Maturation and Glucagon Production in Islet α Cells
SEL1L-HRD1 ER-Associated Degradation Facilitates Prohormone Convertase 2 Maturation and Glucagon Production in Islet α Cells Open
Proteolytic cleavage of proglucagon by prohormone convertase 2 (PC2) is required for islet α cells to generate glucagon. However, the regulatory mechanisms underlying this process remain largely unclear. Here, we report that SEL1L-HRD1 end…
View article: Single-cell multiome analysis supports α-to-β transdifferentiation in human pancreas
Single-cell multiome analysis supports α-to-β transdifferentiation in human pancreas Open
Spontaneous transdifferentiation of pancreatic glucagon-producing alpha to insulin-secreting beta-cells has been observed in mouse but not in human islets 1 . Here, we analyzed the largest single-cell dataset of human islets to date, compo…
View article: β-Cell Secretory Capacity Predicts Metabolic Outcomes over 6 Years following Human Islet Transplantation
β-Cell Secretory Capacity Predicts Metabolic Outcomes over 6 Years following Human Islet Transplantation Open
Transplanted islet functional β-cell mass is measured by the β-cell secretory capacity derived from the acute insulin response to glucose-potentiated arginine (AIRpot), however, data are limited beyond one-year post-transplant for individu…
View article: β-Cell Secretory Capacity Predicts Metabolic Outcomes over 6 Years following Human Islet Transplantation
β-Cell Secretory Capacity Predicts Metabolic Outcomes over 6 Years following Human Islet Transplantation Open
Transplanted islet functional β-cell mass is measured by the β-cell secretory capacity derived from the acute insulin response to glucose-potentiated arginine (AIRpot), however, data are limited beyond one-year post-transplant for individu…
View article: β-Cell Secretory Capacity Predicts Metabolic Outcomes over 6 Years following Human Islet Transplantation
β-Cell Secretory Capacity Predicts Metabolic Outcomes over 6 Years following Human Islet Transplantation Open
Transplanted islet functional β-cell mass is measured by the β-cell secretory capacity derived from the acute insulin response to glucose-potentiated arginine (AIRpot), however, data are limited beyond one-year post-transplant for individu…
View article: Using of Deep Learning in Beamforming Antenna Array
Using of Deep Learning in Beamforming Antenna Array Open
Digital beamforming (DBF) is a crucial technology for large antenna arrays, offering precise control over beam steering. This research introduces a novel method to enhance millimeter wave transmission by incorporating DBF with long-term me…
View article: Clinical and Radiological Factors Associated with Nonoperative Management Failure for Small Bowel Obstruction: A Retrospective Study from a Resource-Limited Setting
Clinical and Radiological Factors Associated with Nonoperative Management Failure for Small Bowel Obstruction: A Retrospective Study from a Resource-Limited Setting Open
Poor bowel wall enhancement and significant obstruction on CT images are critical indicators for selecting SBO patients requiring urgent surgery. However, evaluating the advantages of surgical intervention versus NOM demands a comprehensiv…
View article: The IsletTester mouse: an immunodeficient model with stable hyperglycemia for the study of human islets
The IsletTester mouse: an immunodeficient model with stable hyperglycemia for the study of human islets Open
The gold standard for assessing the function of human islets or β-like cells derived from stem cells involves their engraftment under the kidney capsule of hyperglycemic, immunodeficient mice. Current models, such as Streptozotocin (STZ) t…
View article: The IsletTester mouse: an immunodeficient model with stable hyperglycemia for the study of human islets
The IsletTester mouse: an immunodeficient model with stable hyperglycemia for the study of human islets Open
The gold standard for assessing the function of human islets or β-like cells derived from stem cells involves their engraftment under the kidney capsule of hyperglycemic, immunodeficient mice. Current models, such as Streptozotocin (STZ) t…
View article: Smart navigation through a rotating barrier: Deep reinforcement learning with application to size-based separation of active microagents
Smart navigation through a rotating barrier: Deep reinforcement learning with application to size-based separation of active microagents Open
We employ deep reinforcement learning methods to investigate shortest-time navigation strategies for smart active Brownian particles (microagents), which self-propel through a rotating potential barrier in a static, viscous, fluid backgrou…
Human vascularized macrophage-islet organoids to model immune-mediated pancreatic β cell pyroptosis upon viral infection Open
There is a paucity of human models to study immune-mediated host damage. Here, we utilized the GeoMx spatial multi-omics platform to analyze immune cell changes in COVID-19 pancreatic autopsy samples, revealing an accumulation of proinflam…
View article: Human Vascularized Macrophage-Islet Organoids to Model Immune-Mediated Pancreatic β cell Pyroptosis upon Viral Infection
Human Vascularized Macrophage-Islet Organoids to Model Immune-Mediated Pancreatic β cell Pyroptosis upon Viral Infection Open
SUMMARY There is a paucity of human models to study immune-mediated host damage. Here, we utilized the GeoMx spatial multi-omics platform to analyze immune cell changes in COVID-19 pancreatic autopsy samples, revealing an accumulation of p…
View article: Aberrant TNF signaling in pancreatic lymph nodes of patients with Type 1 Diabetes
Aberrant TNF signaling in pancreatic lymph nodes of patients with Type 1 Diabetes Open
The therapeutic landscape for Type 1 Diabetes (T1D) is rapidly changing as ongoing clinical trials aim to delay beta-cell loss by inhibiting proinflammatory cytokines. However, the precise timing and cellular contexts of cytokine dysregula…