A.D. Fryer
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View article: Update to RIFM fragrance ingredient safety assessment, 3-octanone, CAS registry number 106-68-3
Update to RIFM fragrance ingredient safety assessment, 3-octanone, CAS registry number 106-68-3 Open
View article: Maternal high-fat diet programs offspring airway hyperinnervation and hyperresponsiveness
Maternal high-fat diet programs offspring airway hyperinnervation and hyperresponsiveness Open
The impact of diet-induced maternal obesity on offspring airway hyperresponsiveness was studied in a diversity outbred mouse model that mirrors human genetic diversity. Female mice were started on high-fat or regular diet 8 weeks before br…
View article: Eosinophils prevent diet-induced airway hyperresponsiveness in mice on a high-fat diet
Eosinophils prevent diet-induced airway hyperresponsiveness in mice on a high-fat diet Open
This study investigates how eosinophils influence systemic metabolism and airway function in obesity. Known for their immune functions, eosinophils also mitigate obesity-related hyperinsulinemia, reducing airway hyperresponsiveness in obes…
View article: Biologic therapy in rare eosinophil-associated disorders: remaining questions and translational research opportunities
Biologic therapy in rare eosinophil-associated disorders: remaining questions and translational research opportunities Open
Rare eosinophil-associated disorders (EADs), including hypereosinophilic syndrome, eosinophilic granulomatosis with polyangiitis, and eosinophilic gastrointestinal disorders, are a heterogeneous group of conditions characterized by blood a…
View article: Grandmaternal allergen sensitization reprograms epigenetic and airway responses to allergen in second-generation offspring
Grandmaternal allergen sensitization reprograms epigenetic and airway responses to allergen in second-generation offspring Open
Asthma susceptibility is influenced by environmental, genetic, and epigenetic factors. This study shows that maternal allergen exposure during pregnancy promotes unique epigenetic trajectories in second-generation offspring at baseline and…
View article: Grandmaternal allergen sensitization reprograms epigenetic and airway responses to allergen in second generation offspring
Grandmaternal allergen sensitization reprograms epigenetic and airway responses to allergen in second generation offspring Open
SUPPLEMENTARY FIGURE LEGEND Supplemental Figure 1. Grandmaternal allergen exposure regulates differentially methylated cytosines in airway epithelium of second-generation offspring at baseline and after allergen se…
View article: Grandmaternal allergen sensitization reprograms epigenetic and airway responses to allergen in second generation offspring
Grandmaternal allergen sensitization reprograms epigenetic and airway responses to allergen in second generation offspring Open
SUPPLEMENTARY FIGURE LEGEND Supplemental Figure 1. Grandmaternal allergen sensitization during pregnancy regulates differentially methylated cytosines in airway epithelium of second-generation offspring at baseline…
View article: Grandmaternal allergen sensitization reprograms epigenetic and airway responses to allergen in second generation offspring
Grandmaternal allergen sensitization reprograms epigenetic and airway responses to allergen in second generation offspring Open
SUPPLEMENTARY FIGURE LEGEND Supplemental Figure 1. Grandmaternal allergen sensitization during pregnancy regulates differentially methylated cytosines in airway epithelium of second-generation offspring at baseline…
View article: Maternal high-fat diet increases airway sensory innervation and reflex bronchoconstriction in adult offspring
Maternal high-fat diet increases airway sensory innervation and reflex bronchoconstriction in adult offspring Open
Our study reveals a novel potential mechanism, by which maternal high-fat diet increases the risk and severity of asthma in offspring. We found that exposure to maternal high-fat diet in mice leads to hyperinnervation of airway sensory ner…
View article: Insulin increases sensory nerve density and reflex bronchoconstriction in obese mice
Insulin increases sensory nerve density and reflex bronchoconstriction in obese mice Open
Obesity-induced asthma responds poorly to all current pharmacological interventions, including steroids, suggesting that classic, eosinophilic inflammation is not a mechanism. Since insulin resistance and hyperinsulinemia are common in obe…
View article: Mechanisms of Obesity-related Asthma: Is Insulin Getting on Your Nerves?
Mechanisms of Obesity-related Asthma: Is Insulin Getting on Your Nerves? Open
View article: RIFM fragrance ingredient safety assessment, isopropyl 2-methylbutyrate, CAS Registry Number 66576-71-4
RIFM fragrance ingredient safety assessment, isopropyl 2-methylbutyrate, CAS Registry Number 66576-71-4 Open
View article: RIFM fragrance ingredient safety assessment, phenylacetic acid, CAS Registry Number 103-82-2
RIFM fragrance ingredient safety assessment, phenylacetic acid, CAS Registry Number 103-82-2 Open
View article: RIFM fragrance ingredient safety assessment, carvyl propionate, CAS Registry Number 97-45-0
RIFM fragrance ingredient safety assessment, carvyl propionate, CAS Registry Number 97-45-0 Open
View article: RIFM fragrance ingredient safety assessment, 8-nonenal, CAS Registry number 39770-04-2
RIFM fragrance ingredient safety assessment, 8-nonenal, CAS Registry number 39770-04-2 Open
View article: RIFM fragrance ingredient safety assessment, 4-heptenal diethyl acetal, CAS Registry Number 18492-65-4
RIFM fragrance ingredient safety assessment, 4-heptenal diethyl acetal, CAS Registry Number 18492-65-4 Open
View article: RIFM fragrance ingredient safety assessment, ethyl 3,7-dimethylocta-2,6-dienoate, CAS Registry Number 13058-12-3
RIFM fragrance ingredient safety assessment, ethyl 3,7-dimethylocta-2,6-dienoate, CAS Registry Number 13058-12-3 Open
View article: RIFM fragrance ingredient safety assessment, 1,6-octadien-3-ol, 3,7-dimethyl-, acid-isomerized, CAS Registry Number 73018-51-6
RIFM fragrance ingredient safety assessment, 1,6-octadien-3-ol, 3,7-dimethyl-, acid-isomerized, CAS Registry Number 73018-51-6 Open
View article: RIFM fragrance ingredient safety assessment, myrcenyl acetate, CAS Registry Number 1118-39-4
RIFM fragrance ingredient safety assessment, myrcenyl acetate, CAS Registry Number 1118-39-4 Open
View article: RIFM fragrance ingredient safety assessment, cedrol, CAS Registry Number 77-53-2
RIFM fragrance ingredient safety assessment, cedrol, CAS Registry Number 77-53-2 Open
View article: RIFM fragrance ingredient safety assessment, eugenyl phenylacetate, CAS Registry Number 10402-33-2
RIFM fragrance ingredient safety assessment, eugenyl phenylacetate, CAS Registry Number 10402-33-2 Open
View article: RIFM fragrance ingredient safety assessment, 5-cyclotetradecen-1-one, 3-methyl-,(5E)-, CAS Registry Number 259854-70-1
RIFM fragrance ingredient safety assessment, 5-cyclotetradecen-1-one, 3-methyl-,(5E)-, CAS Registry Number 259854-70-1 Open
View article: RIFM fragrance ingredient safety assessment, phenethyl formate, CAS Registry Number 104-62-1
RIFM fragrance ingredient safety assessment, phenethyl formate, CAS Registry Number 104-62-1 Open
View article: RIFM fragrance ingredient safety assessment, phenylethyl isoamyl ether, CAS Registry Number 56011-02-0
RIFM fragrance ingredient safety assessment, phenylethyl isoamyl ether, CAS Registry Number 56011-02-0 Open
View article: Multicolor labeling of airway neurons and analysis of parasympathetic heterogeneity
Multicolor labeling of airway neurons and analysis of parasympathetic heterogeneity Open
We report subpopulations of airway parasympathetic neurons expressing substance P, neuronal nitric oxide synthase, and tyrosine hydroxylase, highlighting unexplored heterogeneity in this population. These neurotransmitter-specific subpopul…
View article: RIFM fragrance ingredient safety assessment, phenethyl benzoate, CAS Registry Number 94-47-3
RIFM fragrance ingredient safety assessment, phenethyl benzoate, CAS Registry Number 94-47-3 Open
View article: RIFM fragrance ingredient safety assessment, hexadecanolide, CAS Registry Number 109-29-5
RIFM fragrance ingredient safety assessment, hexadecanolide, CAS Registry Number 109-29-5 Open
View article: RIFM fragrance ingredient safety assessment, tetrahydro-4-methyl-2-propyl-2H-pyran-4-yl acetate, CAS Registry Number 131766-73-9
RIFM fragrance ingredient safety assessment, tetrahydro-4-methyl-2-propyl-2H-pyran-4-yl acetate, CAS Registry Number 131766-73-9 Open
View article: RIFM fragrance ingredient safety assessment, isoeugenyl ethyl ether, CAS Registry Number 7784-67-0
RIFM fragrance ingredient safety assessment, isoeugenyl ethyl ether, CAS Registry Number 7784-67-0 Open
View article: RIFM fragrance ingredient safety assessment, octyl isobutyrate, CAS Registry Number 109-15-9
RIFM fragrance ingredient safety assessment, octyl isobutyrate, CAS Registry Number 109-15-9 Open