David D. McPherson
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View article: Effects of color-enhancing filters on color salience in normal trichromats
Effects of color-enhancing filters on color salience in normal trichromats Open
Notch filters can alter color contrasts by selectively filtering different spectral bands of the stimulus and have been developed to enhance reddish-greenish contrasts for color-deficient observers with anomalous trichromacy. We examined t…
View article: Clinical outcomes of tumor-agnostic targeting of BRAF, tumor mutation burden-high, and RET
Clinical outcomes of tumor-agnostic targeting of BRAF, tumor mutation burden-high, and RET Open
BRAF V600E, TMB-H, and RET fusion were found in a wide variety of advanced cancers. Improved oncological outcomes with tumor type-agnostic GMT support the value of integrating comprehensive NGS testing and GMT administration for the aforem…
View article: STUDIES ON CAESALPINIA PULCHERRIMA AND DNA-LIGAND INTERACTIONS.
STUDIES ON CAESALPINIA PULCHERRIMA AND DNA-LIGAND INTERACTIONS. Open
STUDIES ON CAESALPINIA PULCHERRIMA AND DNA-LIGAND INTERACTIONS.
View article: Absolute concentration estimation of COVID-19 convalescent and post-vaccination IgG antibodies
Absolute concentration estimation of COVID-19 convalescent and post-vaccination IgG antibodies Open
Soon after commencement of the SARS-CoV-2 disease outbreak of 2019 (COVID-19), it became evident that the receptor-binding domain of the viral spike protein is the target of neutralizing antibodies that comprise a critical element of prote…
View article: Efficient Gene Editing for Heart Disease via ELIP-Based CRISPR Delivery System
Efficient Gene Editing for Heart Disease via ELIP-Based CRISPR Delivery System Open
Liposomes as carriers for CRISPR/Cas9 complexes represent an attractive approach for cardiovascular gene therapy. A critical barrier to this approach remains the efficient delivery of CRISPR-based genetic materials into cardiomyocytes. Ech…
View article: Simultaneous submission of seven CTSA proposals: UM1, K12, R25, T32-predoctoral, T32-postdoctoral, and RC2: strategies, evaluation, and lessons learned
Simultaneous submission of seven CTSA proposals: UM1, K12, R25, T32-predoctoral, T32-postdoctoral, and RC2: strategies, evaluation, and lessons learned Open
Translation is the process of turning observations in the research laboratory, clinic, and community into interventions that improve people’s health. The Clinical and Translational Science Awards (CTSA) program is a National Center for Adv…
View article: COVID-19 Convalescent Plasma Therapy: Long-term Implications
COVID-19 Convalescent Plasma Therapy: Long-term Implications Open
Background The long-term effect of coronavirus disease 2019 (COVID-19) acute treatments on postacute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (PASC) is unknown. The CONTAIN-Extend study explores th…
View article: Biomechanical Evaluation of Mitral Valve Repair: Virtual Chordal Transposition to Restore Anterior Leaflet Prolapse
Biomechanical Evaluation of Mitral Valve Repair: Virtual Chordal Transposition to Restore Anterior Leaflet Prolapse Open
This virtual MV surgery strategy offers a valuable means to predict, evaluate, and quantify functional and biomechanical improvements before and after MV repair, thereby empowering informed decision-making in the planning of chordal transp…
View article: Storage Stability of Atheroglitatide, an Echogenic Liposomal Formulation of Pioglitazone Targeted to Advanced Atheroma with a Fibrin-Binding Peptide
Storage Stability of Atheroglitatide, an Echogenic Liposomal Formulation of Pioglitazone Targeted to Advanced Atheroma with a Fibrin-Binding Peptide Open
We have conducted a stability study of a complex liposomal pharmaceutical product, Atheroglitatide (AGT), stored at three temperatures, 4, 24, and 37 °C, for up to six months. The six parameters measured were functions of liposomal integri…
View article: A Two-Step Transcriptome Analysis of the Human Heart Reveals Broad and Disease-Responsive Expression of Ectopic Olfactory Receptors
A Two-Step Transcriptome Analysis of the Human Heart Reveals Broad and Disease-Responsive Expression of Ectopic Olfactory Receptors Open
G-protein-coupled receptors (GPCRs) are critical regulators of cardiac physiology and a key therapeutic target for the treatment of heart disease. Ectopic olfactory receptors (ORs) are GPCRs expressed in extra-nasal tissues which have rece…
View article: Enhanced Cerebroprotection of Xenon-Loaded Liposomes in Combination with rtPA Thrombolysis for Embolic Ischemic Stroke
Enhanced Cerebroprotection of Xenon-Loaded Liposomes in Combination with rtPA Thrombolysis for Embolic Ischemic Stroke Open
Xenon (Xe) has shown great potential as a stroke treatment due to its exceptional ability to protect brain tissue without inducing side effects. We have previously developed Xe-loaded liposomes for the ultrasound-activated delivery of Xe i…
View article: Liposome-Based Carriers for CRISPR Genome Editing
Liposome-Based Carriers for CRISPR Genome Editing Open
The CRISPR-based genome editing technology, known as clustered regularly interspaced short palindromic repeats (CRISPR), has sparked renewed interest in gene therapy. This interest is accompanied by the development of single-guide RNAs (sg…
View article: Co-Delivery of Therapeutics and Bioactive Gas Using a Novel Liposomal Platform for Enhanced Treatment of Acute Arterial Injury
Co-Delivery of Therapeutics and Bioactive Gas Using a Novel Liposomal Platform for Enhanced Treatment of Acute Arterial Injury Open
Atherosclerosis is a complex, multi-stage disease characterized by pathological changes across the vascular wall. Endothelial dysfunction, inflammation, hypoxia, and vascular smooth muscle cell proliferation contribute to its progression. …
View article: Initiating and imaging cavitation from infused echo contrast agents through the EkoSonic catheter
Initiating and imaging cavitation from infused echo contrast agents through the EkoSonic catheter Open
Ultrasound-enhanced delivery of therapeutic-loaded echogenic liposomes is under development for vascular applications using the EkoSonic Endovascular System. In this study, fibrin-targeted echogenic liposomes loaded with an anti-inflammato…
View article: Assessment of bubble activity generated by histotripsy combined with echogenic liposomes
Assessment of bubble activity generated by histotripsy combined with echogenic liposomes Open
Objective. Histotripsy is a form of focused ultrasound therapy that uses the mechanical activity of bubbles to ablate tissue. While histotripsy alone degrades the cellular content of tissue, recent studies have demonstrated it effectively …
View article: Improving transcatheter aortic valve interventional predictability via fluid–structure interaction modelling using patient-specific anatomy
Improving transcatheter aortic valve interventional predictability via fluid–structure interaction modelling using patient-specific anatomy Open
Transcatheter aortic valve replacement (TAVR) is now a standard treatment for high-surgical-risk patients with severe aortic valve stenosis. TAVR is being explored for broader indications including degenerated bioprosthetic valves, bicuspi…
View article: Repetitive xenon treatment improves post-stroke sensorimotor and neuropsychiatric dysfunction
Repetitive xenon treatment improves post-stroke sensorimotor and neuropsychiatric dysfunction Open
Stroke is a life-changing event as stroke survivors experience changes in personality, emotions and mood. We investigated the effect of xenon gas encapsulated in liposomes on stroke-generated sensorimotor impairments, and anxiety- and depr…
View article: The CTSA University of Texas Health Science Center (UTHSC) Northeast—Tyler and Rio Grande Valley Success Story: How Rural, Underserved Academic Communities Rapidly Built a Robust Engine for Collaborative COVID-19 Clinical Research
The CTSA University of Texas Health Science Center (UTHSC) Northeast—Tyler and Rio Grande Valley Success Story: How Rural, Underserved Academic Communities Rapidly Built a Robust Engine for Collaborative COVID-19 Clinical Research Open
In 2018, The University of Texas Health Science Center-Tyler and University of Texas Rio Grande Valley were invited to develop clinical research units for an existing Clinical and Translational Science Award (CTSA) consortium with the obje…
View article: Efficacy and Safety of COVID-19 Convalescent Plasma in Hospitalized Patients
Efficacy and Safety of COVID-19 Convalescent Plasma in Hospitalized Patients Open
ClinicalTrials.gov Identifier: NCT04364737.
View article: Risk factors for changes in carotid intima media thickness and plaque over 5 years in women with systemic lupus erythematosus
Risk factors for changes in carotid intima media thickness and plaque over 5 years in women with systemic lupus erythematosus Open
Objective To investigate the occurrence of and risk factors for progression of carotid intima media thickness (IMT) and plaque in women with and without SLE. Methods A cohort of 149 women with SLE and 126 controls participated in SOLVABLE …
View article: Protective characteristics of COVID-19 convalescent and post-vaccination IgG antibodies
Protective characteristics of COVID-19 convalescent and post-vaccination IgG antibodies Open
Soon after commencement of the SARS-CoV-2 disease outbreak of 2019 (COVID-19), it became evident that the receptor-binding domain of the viral spike protein is the target of neutralizing antibodies that comprise a critical element of prote…
View article: Effect of Antithrombotic Therapy on Clinical Outcomes in Outpatients With Clinically Stable Symptomatic COVID-19
Effect of Antithrombotic Therapy on Clinical Outcomes in Outpatients With Clinically Stable Symptomatic COVID-19 Open
ClinicalTrials.gov Identifier: NCT04498273.
View article: Relative Mutant N501Y SARS-CoV-2 Spike Protein RBD Inhibition of Anti-Spike Protein IgG and ACE-2 Binding to Spike Protein Species
Relative Mutant N501Y SARS-CoV-2 Spike Protein RBD Inhibition of Anti-Spike Protein IgG and ACE-2 Binding to Spike Protein Species Open
In the SARS-CoV-2 coronavirus pandemic of 2019 (COVID-19), it has become evident that the ACE-2 receptor-binding domain (RBD) of the viral spike protein (SP) is the target of neutralizing antibodies that comprise a critical element of prot…
View article: Association of Visceral Adipose Tissue and Subclinical Atherosclerosis in US‐Born Mexican Americans but not First Generation Immigrants
Association of Visceral Adipose Tissue and Subclinical Atherosclerosis in US‐Born Mexican Americans but not First Generation Immigrants Open
Background Excess visceral adipose tissue (VAT) is a primary driver for the cardiometabolic complications of obesity; VAT‐associated cardiovascular disease risk varies by race, but most studies have been done on Non‐Hispanics. This study a…