Alberto Ortíz
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View article: A Pilot Study of Opportunistic Chronic Kidney Disease Screening in Primary Care Using a Clinical Decision Support System
A Pilot Study of Opportunistic Chronic Kidney Disease Screening in Primary Care Using a Clinical Decision Support System Open
Background/Objectives: CKD affects over 10% of adults and is often silent, delaying diagnosis. Opportunistic primary care screening supported by clinical decision support systems (CDSSs) may improve detection with minimal burden. We evalua…
View article: Systemic inflammatory profiles are associated with long-term kidney failure and patient mortality in chronic kidney disease
Systemic inflammatory profiles are associated with long-term kidney failure and patient mortality in chronic kidney disease Open
Background Chronic kidney disease (CKD) is frequently associated with systemic inflammation. However, the relationship between inflammatory cytokines and CKD progression remains incompletely understood. Methods The PROGRESER study was a mu…
View article: Gut microbiota modulation in GLP-1RA and SGLT-2i therapy: clinical implications and mechanistic insights in type 2 diabetes
Gut microbiota modulation in GLP-1RA and SGLT-2i therapy: clinical implications and mechanistic insights in type 2 diabetes Open
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter 2 inhibitors (SGLT-2is) have been shown to provide extra-glycemic advantages, such as cardiovascular and renal protection, in the treatment of type 2 dia…
View article: Circulating and Urinary CCL20 in Human Kidney Disease
Circulating and Urinary CCL20 in Human Kidney Disease Open
CC motif chemokine ligand 20 (CCL20), a chemokine involved in immune cell migration through its receptor CCR6, has been implicated in kidney inflammation in crescentic glomerulonephritis and acute kidney injury. However, clinical informati…
View article: Kidney replacement therapy for men and women according to the ERA Registry and the USRDS
Kidney replacement therapy for men and women according to the ERA Registry and the USRDS Open
Background This article compares the incidence and prevalence of kidney replacement therapy (KRT), kidney transplantation rates and mortality on KRT between Europe and the USA, including sex comparisons. Methods Data were derived for 2022 …
View article: #3802 Real-world outcomes of switching from steroidal mineralocorticoid receptor antagonists (sMRA) to finerenone in patients with chronic kidney disease and type 2 diabetes (T2DM): a multicenter study in madrid community
#3802 Real-world outcomes of switching from steroidal mineralocorticoid receptor antagonists (sMRA) to finerenone in patients with chronic kidney disease and type 2 diabetes (T2DM): a multicenter study in madrid community Open
Background and Aims Steroidal mineralocorticoid receptor antagonists (sMRAs) are commonly used in patients with chronic kidney disease (CKD) and type 2 diabetes (T2D) due to their antiproteinuric effects, hyperkalemia and poor tolerability…
View article: #3211 Incidence and outcomes of kidney replacement therapy for kidney failure due to inherited tubulopathies in Europe: findings from the ERA Registry
#3211 Incidence and outcomes of kidney replacement therapy for kidney failure due to inherited tubulopathies in Europe: findings from the ERA Registry Open
Background and Aims When patients with chronic kidney disease (CKD) undergo genetic tests, 40% might be diagnosed with monogenic diseases [1]. Inherited tubulopathies represent a broad subgroup of genetic kidney diseases. They frequently m…
View article: #1889 Inflammatory mediators predicting eGFR loss in diabetic kidney disease
#1889 Inflammatory mediators predicting eGFR loss in diabetic kidney disease Open
Background and Aims Inflammation plays a critical role in the development and progression of diabetic complications, particularly diabetic kidney disease (DKD). Elevated levels of pro-inflammatory cytokines are frequently observed in indiv…
View article: #3453 The role of centre characteristics and type of water treatment plant in the environmental impact of hemodialysis
#3453 The role of centre characteristics and type of water treatment plant in the environmental impact of hemodialysis Open
Background and Aims In-centre haemodialysis (HD) represents approximately 70% of all kidney replacement therapy. This technique requires a large amount of resources such as water and electricity. In a previous study by our research group, …
View article: #1927 Clinical characteristics and healthcare resource utilization, and costs associated in patients with diagnosed and undetected hyperkalemia: IBERIK+ study
#1927 Clinical characteristics and healthcare resource utilization, and costs associated in patients with diagnosed and undetected hyperkalemia: IBERIK+ study Open
Background and Aims Hyperkalemia (HK) is a common complication of chronic kidney disease (CKD) and heart failure (HF), particularly among patients receiving renin-angiotensin-aldosterone system inhibitors (RAASi). This study aimed to descr…
View article: #1652 Clinical characteristics and healthcare resource utilization associated with mild, moderate and severe Hyperkalemia in Spain: IBERIK+ Study
#1652 Clinical characteristics and healthcare resource utilization associated with mild, moderate and severe Hyperkalemia in Spain: IBERIK+ Study Open
Background and Aims Hyperkalemia (HK) is a frequent complication in patient with chronic kidney disease (CKD) and heart failure (HF), especially among those treated with renin-angiotensin-aldosterone system inhibitors (RAASi). This study a…
View article: #3196 Inflammatory cytokine clusters are associated with adverse outcomes in patients with CKD
#3196 Inflammatory cytokine clusters are associated with adverse outcomes in patients with CKD Open
Background and Aims Chronic kidney disease (CKD) is one of the fastest growing global causes of death, characterized by a gradual loss of renal function over time leading to kidney failure. Early detection of progression and treatment are …
View article: Finerenone: Evidence for Benefit in Early Stages of Cardiovascular-Kidney-Metabolic Syndrome
Finerenone: Evidence for Benefit in Early Stages of Cardiovascular-Kidney-Metabolic Syndrome Open
Background: Cardiovascular-kidney-metabolic (CKM) syndrome is a recently introduced concept that links chronic kidney disease (CKD), cardiovascular disease, and metabolic risk factors such as obesity or diabetes mellitus (DM). The use of e…
View article: Impact of switching from the CKD-EPI2009 to the EKFC equation on the epidemiology of chronic kidney disease and nephrology workload
Impact of switching from the CKD-EPI2009 to the EKFC equation on the epidemiology of chronic kidney disease and nephrology workload Open
Background Chronic kidney disease (CKD) can be diagnosed by estimating the glomerular filtration rate (eGFR) using serum creatinine-based equations, mainly CKD-EPI2009. The European Federation of Clinical Chemistry and Laboratory Medicine …
View article: Trends in home dialysis over the last decade in Europe: an ERA Registry study
Trends in home dialysis over the last decade in Europe: an ERA Registry study Open
Background Home dialysis therapies could offer benefits to individuals undergoing dialysis. This study examines trends of home dialysis, including home haemodialysis (HHD) and peritoneal dialysis (PD) across European countries from 2012 to…
View article: 67 national-level factors potentially related to the incidence of kidney replacement therapy across Europe
67 national-level factors potentially related to the incidence of kidney replacement therapy across Europe Open
Background Kidney replacement therapy (KRT) incidence varies considerably across European countries. We aimed to provide an overview of factors potentially related to KRT incidence for all individual European countries and across low, midd…
View article: How to interpret the number needed to treat for clinicians
How to interpret the number needed to treat for clinicians Open
The number needed to treat (NNT) is an intuitive tool for evaluating intervention effectiveness, and plays a valuable role in informed medical decision-making. This paper explains the calculation of NNT for risks estimated using both binar…
View article: <scp>STING</scp> inhibition alleviates experimental peritoneal damage: potential therapeutic relevance for peritoneal dialysis
<span>STING</span> inhibition alleviates experimental peritoneal damage: potential therapeutic relevance for peritoneal dialysis Open
Peritoneal dialysis (PD) is a widely used kidney replacement therapy for patients with end‐stage kidney disease. Nevertheless, long‐term exposure to PD fluid can damage the peritoneal membrane, leading to ultrafiltration failure and, ultim…
View article: Identification of early predictors of clinical remission in primary membranous nephropathy: a <i>post hoc</i> analysis of the STARMEN trial
Identification of early predictors of clinical remission in primary membranous nephropathy: a <i>post hoc</i> analysis of the STARMEN trial Open
Background Patients with primary membranous nephropathy may progress to advanced chronic kidney disease despite immunosuppressive therapy (IST). Prediction of treatment response based on early and combined assessment of several standard cl…
View article: Changing from the CKD-EPI to the EKFC creatinine equation to estimate glomerular filtration rate in adults in a Northern European health system
Changing from the CKD-EPI to the EKFC creatinine equation to estimate glomerular filtration rate in adults in a Northern European health system Open
Background The European Kidney Function Consortium (EKFC) 2021 equation to estimate GFR performs as well or better than the CKD-EPI 2009 equation in predominantly White adult European populations, with less bias and greater accuracy agains…
View article: But how green is it actually? Calculating the environmental footprint of kidney care environmental optimizations within haemodialysis
But how green is it actually? Calculating the environmental footprint of kidney care environmental optimizations within haemodialysis Open
Background Environmental optimizations in kidney care have been analysed as part of the European Union co-funded KitNewCare project. Methods Life Cycle Assessments (LCA) using Ecoinvent database and OpenLCA software quantified optimizing r…
View article: Evolving strategies for early diagnosis, proactive prevention and treatment of CKD
Evolving strategies for early diagnosis, proactive prevention and treatment of CKD Open
Chronic kidney disease (CKD) is among the fastest growing global causes of death, forecasted to become the third leading cause of death in Western Europe and Japan by 2050. In contrast, mortality from cardiovascular disease is decreasing. …