Milena De Riz
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View article: Comparative Effectiveness of Cladribine and S1P Receptor Modulators in Treatment-Naive Relapsing-Remitting MS
Comparative Effectiveness of Cladribine and S1P Receptor Modulators in Treatment-Naive Relapsing-Remitting MS Open
Importance Early treatment choice in relapsing-remitting multiple sclerosis (RRMS) is prognostically crucial, yet robust comparative data on cladribine vs sphingosine-1-phosphate receptor modulators (S1PRMs) in treatment-naive patients wit…
View article: Effect of alemtuzumab on fatigue, quality of life, and patient/caregiver-reported outcomes in relapsing-remitting multiple sclerosis—A real-world evidence study
Effect of alemtuzumab on fatigue, quality of life, and patient/caregiver-reported outcomes in relapsing-remitting multiple sclerosis—A real-world evidence study Open
This real-world study showed beneficial impact of alemtuzumab on fatigue, cognition, depression, QoL, and treatment satisfaction. Improvement in patient disability, and caregiver-reported outcomes indicated enhanced patients' QoL.
View article: Regulatory T-cells in multiple sclerosis produce IL-10 in the central 1 nervous system but are activated by Epstein-Barr Virus
Regulatory T-cells in multiple sclerosis produce IL-10 in the central 1 nervous system but are activated by Epstein-Barr Virus Open
Regulatory T-cells (Tregs) maintain immune homeostasis, but antigens activating adaptive Tregs in human pathologies are ill-defined. EOMES + type-1 regulatory (Tr1)-like T-cells had a dysregulated homeostasis in multiple sclerosis (MS), wh…
View article: Multiple Sclerosis Progression and Relapse Activity in Children
Multiple Sclerosis Progression and Relapse Activity in Children Open
Importance Although up to 20% of patients with multiple sclerosis (MS) experience onset before 18 years of age, it has been suggested that people with pediatric-onset MS (POMS) are protected against disability because of greater capacity f…
View article: Role of Chitinase 3–like 1 as a Biomarker in Multiple Sclerosis
Role of Chitinase 3–like 1 as a Biomarker in Multiple Sclerosis Open
CSF levels of CHI3L1 have a strong correlation with the MS pathologic course, in particular with the mechanism of progression of the disease; it helps to distinguish the PPMS from the RRMS. The potential role of CHI3L1 in serum needs to be…
View article: miR-150-5p and let-7b-5p in Blood Myeloid Extracellular Vesicles Track Cognitive Symptoms in Patients with Multiple Sclerosis
miR-150-5p and let-7b-5p in Blood Myeloid Extracellular Vesicles Track Cognitive Symptoms in Patients with Multiple Sclerosis Open
Cognitive deficits strongly affect the quality of life of patients with multiple sclerosis (MS). However, no cognitive MS biomarkers are currently available. Extracellular vesicles (EVs) contain markers of parental cells and are able to pa…
View article: Amyloid PET imaging and dementias: potential applications in detecting and quantifying early white matter damage
Amyloid PET imaging and dementias: potential applications in detecting and quantifying early white matter damage Open
Purpose Positron emission tomography (PET) with amyloid tracers (amy-PET) allows the quantification of pathological amyloid deposition in the brain tissues, including the white matter (WM). Here, we evaluate amy-PET uptake in WM lesions (W…
View article: CSF β-amyloid predicts prognosis in patients with multiple sclerosis
CSF β-amyloid predicts prognosis in patients with multiple sclerosis Open
Background: The importance of predicting disease progression in multiple sclerosis (MS) has increasingly been recognized, and hence reliable biomarkers are needed. Objectives: To investigate the prognostic role of cerebrospinal fluid (CSF)…
View article: Differentiating Vogt-Koyanagi-Harada syndrome from recurrent optic neuritis: a case report and review of the literature concerning Hispanic patients
Differentiating Vogt-Koyanagi-Harada syndrome from recurrent optic neuritis: a case report and review of the literature concerning Hispanic patients Open
Background First recognized at the beginning of twentieth century and named after three authors who independently described some affected patients, Vogt-Koyanagi-Harada syndrome is a rare multisystemic autoimmune disease targeting melanin-…
View article: The loss of macular ganglion cells begins from the early stages of disease and correlates with brain atrophy in multiple sclerosis patients
The loss of macular ganglion cells begins from the early stages of disease and correlates with brain atrophy in multiple sclerosis patients Open
Background: The importance of neurodegeneration in multiple sclerosis (MS) is increasingly well recognized. Objectives: To evaluate retinal pathology using optical coherence tomography (OCT) and to investigate possible associations between…
View article: CSF β-amyloid and white matter damage: a new perspective on Alzheimer’s disease
CSF β-amyloid and white matter damage: a new perspective on Alzheimer’s disease Open
Objective To assess the connection between amyloid pathology and white matter (WM) macrostructural and microstructural damage in demented patients compared with controls. Methods Eighty-five participants were recruited: 65 with newly diagn…
View article: Reversible Parkinson's Dementia Associated with Withdrawal of Androgen‐Deprivation Therapy for Prostate Cancer
Reversible Parkinson's Dementia Associated with Withdrawal of Androgen‐Deprivation Therapy for Prostate Cancer Open
To the Editor: An 80-year-old man presented because of an approximately 10-month history of increasingly slow gait, leg stiffness with nocturnal cramps, and very fine hand tremor, associated with depression. A single visual hallucination, …
View article: Neurophysiological Profile, Walking Performance Tests and Self-Reported Questionnaires in Spastic Patients with MS: A Pilot Study
Neurophysiological Profile, Walking Performance Tests and Self-Reported Questionnaires in Spastic Patients with MS: A Pilot Study Open
Nabiximols is currently being used as an add-on therapeutic option to treat severe forms of multiple sclerosis (MS) spasticity, especially in the progressive phase of the disease. The aim of this exploratory study is to evaluate the respon…