Anthony Demolder
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View article: AI-Enabled ECG Analysis Improves Diagnostic Accuracy and Reduces False STEMI Activations: A Multicenter U.S. Registry
AI-Enabled ECG Analysis Improves Diagnostic Accuracy and Reduces False STEMI Activations: A Multicenter U.S. Registry Open
AI-based ECG analysis significantly improved STEMI detection reduced false activations, and enhanced recognition of non-conventional presentations. This supports integration of AI-based ECG analysis into acute chest pain pathways.
View article: Artificial Intelligence–Powered Electrocardiogram Detecting Culprit Vessel Blood Flow Abnormality: AI-ECG TIMI Study Design and Rationale
Artificial Intelligence–Powered Electrocardiogram Detecting Culprit Vessel Blood Flow Abnormality: AI-ECG TIMI Study Design and Rationale Open
AI-ECG TIMI is the first prospective registry of consecutive patients with ACS with standard 12-lead ECGs recorded at the very moment of ICA. This study will help characterize ECG findings of abnormal myocardial perfusion due to acute acti…
View article: Assessment of Myocardial Fibrosis in Marfan Syndrome Using Cardiac Magnetic Resonance Imaging
Assessment of Myocardial Fibrosis in Marfan Syndrome Using Cardiac Magnetic Resonance Imaging Open
Background Impaired myocardial function and arrhythmia are important manifestations of Marfan syndrome (MFS). Studies assessing myocardial fibrosis in relation to these manifestations are scarce. Methods This cross‐sectional, single‐center…
View article: High Precision ECG Digitization Using Artificial Intelligence
High Precision ECG Digitization Using Artificial Intelligence Open
Background The digitization of electrocardiograms (ECGs) is an important process in modern healthcare, enabling the preservation, transmission, and advanced analysis of ECG data. Traditional methods for digitizing ECGs from paper formats f…
View article: Validation of an automated artificial intelligence system for 12‑lead ECG interpretation
Validation of an automated artificial intelligence system for 12‑lead ECG interpretation Open
Our results demonstrate the AI-powered ECG model's ability to accurately identify electrocardiographic abnormalities from the 12‑lead ECG, highlighting its potential as a clinical tool for healthcare professionals.
View article: International evaluation of an artificial intelligence–powered electrocardiogram model detecting acute coronary occlusion myocardial infarction
International evaluation of an artificial intelligence–powered electrocardiogram model detecting acute coronary occlusion myocardial infarction Open
Aims A majority of acute coronary syndromes (ACS) present without typical ST elevation. One-third of non–ST-elevation myocardial infarction (NSTEMI) patients have an acutely occluded culprit coronary artery [occlusion myocardial infarction…
View article: INTERNATIONAL EVALUATION OF AN ARTIFICIAL INTELLIGENCE-POWERED ECG MODEL DETECTING OCCLUSION MYOCARDIAL INFARCTION
INTERNATIONAL EVALUATION OF AN ARTIFICIAL INTELLIGENCE-POWERED ECG MODEL DETECTING OCCLUSION MYOCARDIAL INFARCTION Open
Background One third of Non-ST-elevation myocardial infarction (NSTEMI) patients present with an acutely occluded culprit coronary artery (occlusion myocardial infarction [OMI]), which is associated with poor short and long-term outcomes d…
View article: Clinical validation of a 13-lead electrocardiogram derived from a self-applicable 3-lead recording for diagnosis of myocardial supply ischaemia and common non-ischaemic electrocardiogram abnormalities at rest
Clinical validation of a 13-lead electrocardiogram derived from a self-applicable 3-lead recording for diagnosis of myocardial supply ischaemia and common non-ischaemic electrocardiogram abnormalities at rest Open
Aims In this study, we compare the diagnostic accuracy of a standard 12-lead electrocardiogram (ECG) with a novel 13-lead ECG derived from a self-applicable 3-lead ECG recorded with the right exploratory left foot (RELF) device. The 13th l…
View article: An Electrocardiographic Characterization of Left Bundle Branch Area Pacing-Induced Right Ventricular Activation Delay: A Comparison With Native Right Bundle Branch Block
An Electrocardiographic Characterization of Left Bundle Branch Area Pacing-Induced Right Ventricular Activation Delay: A Comparison With Native Right Bundle Branch Block Open
Background Left bundle branch area pacing (LBBAP) induces delayed RV activation and is thought to be harmless, since the electrocardiographic signature is reminiscent to native RBBB. However, to what extent the delayed RV activation during…
View article: Electrocardiographic analysis of left bundle branch area pacing induced right ventricular activation delay
Electrocardiographic analysis of left bundle branch area pacing induced right ventricular activation delay Open
Funding Acknowledgements Type of funding sources: None. Background Left bundle branch area pacing (LBBAP) aims to capture the area of left bundle branch, resulting in fast activation of the left ventricle (LV) but delayed right ventricular…
View article: Arrhythmia and impaired myocardial function in heritable thoracic aortic disease: An international retrospective cohort study
Arrhythmia and impaired myocardial function in heritable thoracic aortic disease: An international retrospective cohort study Open
In patients with HTAD, arrhythmia and impaired myocardial function was reported in patients with PV/LPVs in FBN1 and in the TGF-β signaling genes and not in patients harboring PV/LPVs in ACTA2. Though infrequent, non-aortic cardiac disease…
View article: Mitral annular disjunction and cardiovascular outcome in Marfan syndrome
Mitral annular disjunction and cardiovascular outcome in Marfan syndrome Open
Background Mitral annular disjunction (MAD) has received growing interest in patients with mitral valve prolapse (MVP), ventricular tachycardia (VT) and sudden cardiac death (SCD). The clinical significance of MAD in Marfan syndrome (MFS) …
View article: Association of Mitral Annular Disjunction With Cardiovascular Outcomes Among Patients With Marfan Syndrome
Association of Mitral Annular Disjunction With Cardiovascular Outcomes Among Patients With Marfan Syndrome Open
This study suggests that MAD among patients with MFS is associated with the occurrence of arrhythmic events, a higher need for mitral valve intervention, and, among patients with extensive MAD, more aortic events. Cardiac imaging for patie…
View article: Aortic valve implantation-induced conduction block as a framework towards a uniform electrocardiographic definition of left bundle branch block
Aortic valve implantation-induced conduction block as a framework towards a uniform electrocardiographic definition of left bundle branch block Open
Introduction New-onset left bundle branch block (LBBB) following transcatheter or surgical aortic valve replacement (LBBB AVI ) implies a proximal pathogenesis of LBBB. This study compares electrocardiographic characteristics and concordan…
View article: Myocardial disease and ventricular arrhythmia in Marfan syndrome: a prospective study
Myocardial disease and ventricular arrhythmia in Marfan syndrome: a prospective study Open
Background Aortic root dilatation and—dissection and mitral valve prolapse are established cardiovascular manifestations in Marfan syndrome (MFS). Heart failure and arrhythmic sudden cardiac death have emerged as additional causes of morbi…
View article: Myocardial Function, Heart Failure and Arrhythmia in Marfan Syndrome: A Systematic Literature Review
Myocardial Function, Heart Failure and Arrhythmia in Marfan Syndrome: A Systematic Literature Review Open
Marfan syndrome (MFS) is a heritable systemic connective tissue disease with important cardiovascular involvement, including aortic root dilatation and mitral valve prolapse. Life expectancy in patients with MFS is mainly determined by car…
View article: Myocardial Disease and Ventricular Arrhythmia in Marfan Syndrome – a prospective study
Myocardial Disease and Ventricular Arrhythmia in Marfan Syndrome – a prospective study Open
Background: Aortic root dilatation and -dissection and mitral valve prolapse are established cardiovascular manifestations in Marfan syndrome (MFS). Heart failure and arrhythmic sudden cardiac death have emerged as additional causes of mor…
View article: Ambulatory Electrocardiographic Monitoring and Ectopic Beat Detection in Conscious Mice
Ambulatory Electrocardiographic Monitoring and Ectopic Beat Detection in Conscious Mice Open
Ambulatory electrocardiography (AECG) is a primary diagnostic tool in patients with potential arrhythmic disorders. To study the pathophysiological mechanisms of arrhythmic disorders, mouse models are widely implemented. The use of a techn…
View article: Myocardial Disease and Ventricullar Arrhythmia in Marfan Syndrome – A Prospective Study
Myocardial Disease and Ventricullar Arrhythmia in Marfan Syndrome – A Prospective Study Open
Background: Aortic root dilatation and -dissection and mitral valve prolapse are established cardiovascular manifestations in Marfan syndrome (MFS). Heart failure and arrhythmic sudden cardiac death have emerged as additional causes of mor…
View article: Features of Marfan syndrome not listed in the Ghent nosology – the dark side of the disease
Features of Marfan syndrome not listed in the Ghent nosology – the dark side of the disease Open
Introduction: The revised Ghent nosology presents the classical features of Marfan syndrome. However, behind its familiar face, Marfan syndrome hides less well-known features.Areas covered: The German Marfan Organization listed unusual sym…
View article: Directed Networks as a Novel Way to Describe and Analyze Cardiac Excitation: Directed Graph Mapping
Directed Networks as a Novel Way to Describe and Analyze Cardiac Excitation: Directed Graph Mapping Open
Networks provide a powerful methodology with applications in a variety of biological, technological and social systems such as analysis of brain data, social networks, internet search engine algorithms, etc. To date, directed networks have…
View article: Directed networks as a novel way to describe and analyze cardiac excitation: Directed Graph mapping
Directed networks as a novel way to describe and analyze cardiac excitation: Directed Graph mapping Open
Networks provide a powerful methodology with applications in a variety of biological, technological and social systems such as analysis of brain data, social networks, internet search engine algorithms, etc. To date, directed networks have…