Anil Dhawan
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View article: Extensive and differential platinum chemotherapy mutagenesis in children
Extensive and differential platinum chemotherapy mutagenesis in children Open
SUMMARY Childhood cancer survivors often develop long-term adverse effects, which may be caused by direct mutagenesis of cytotoxic agents. Some of these agents generate distinctive DNA imprints (mutational signatures), as exemplified by pl…
View article: Digital animation as a tool to enhance informed consent when recruiting infants with biliary atresia to a clinical trial
Digital animation as a tool to enhance informed consent when recruiting infants with biliary atresia to a clinical trial Open
Objectives Participants may have a poor understanding of the research they are involved in due to the challenges of receiving information during acute illness and the complexity and length of participant information sheets. This study aime…
View article: General and Autism-Related Neurodevelopmental Difficulties in Biliary Atresia
General and Autism-Related Neurodevelopmental Difficulties in Biliary Atresia Open
High levels of neurodevelopmental difficulties in children with BA reveal a need for greater awareness and enhanced surveillance. That early identification and treatment of BA is linked to better general neurodevelopmental outcome and enco…
View article: Granulocyte Transfusions for Invasive Fungal Infections Refractory to Conventional Treatment in Pediatric Liver Transplant Recipients With Hepatitis‐Associated Aplastic Anemia
Granulocyte Transfusions for Invasive Fungal Infections Refractory to Conventional Treatment in Pediatric Liver Transplant Recipients With Hepatitis‐Associated Aplastic Anemia Open
Background Invasive fungal infections (IFI) remain a leading cause of mortality in liver transplant (LTX) patients with neutropenia. Hematopoietic growth factors and granulocyte transfusions (GTx) have been historically used in patients wi…
View article: EP5.27 A Novel Radiographic Parameter of Anterior and Posterior Acetabular Wall Intersection with the Sorcil and its Correlation with Surgical Management and Outcomes
EP5.27 A Novel Radiographic Parameter of Anterior and Posterior Acetabular Wall Intersection with the Sorcil and its Correlation with Surgical Management and Outcomes Open
Background: Hip dysplasia is characterized by joint instability and progression to osteoarthritis. The lateral center-edge angle (LCEA) is a radiographic measure of acetabular coverage where <18 degrees is diagnostic of dysplasia and 18…
View article: EP1.59 Manipulation Under Anesthesia (MUA) of the Post-Op Hip Arthroscopy Stiff Hip –Retrospective Review of Range of Motion Improvement and PROs
EP1.59 Manipulation Under Anesthesia (MUA) of the Post-Op Hip Arthroscopy Stiff Hip –Retrospective Review of Range of Motion Improvement and PROs Open
Background: Pericapsular scarring is one etiology of pain after hip arthroscopy for the treatment offemoroacetabular impingement (FAI). Hip manipulation under anesthesia (MUA) has been proposed as a potential treatment. Hip MUA is a quick,…
View article: Practical Utility of Serum Ammonia in Children With Acute Liver Failure: A Biomarker of Outcome
Practical Utility of Serum Ammonia in Children With Acute Liver Failure: A Biomarker of Outcome Open
Background. Hyperammonemia is a recognized biochemical abnormality in acute liver failure (ALF). Our aim was to determine a cutoff value for serum ammonia in children with ALF to predict their outcomes while conventional UK liver transplan…
View article: Contaminating manufacturing plasmids and disrupted vector genomes present in liver tissue following adeno-associated virus gene therapy
Contaminating manufacturing plasmids and disrupted vector genomes present in liver tissue following adeno-associated virus gene therapy Open
Adeno-associated viruses (AAVs) are the most used vectors in gene therapy but can frequently cause liver complications in patients. The mechanisms underlying AAV-related liver toxicity remain poorly understood, posing challenges for effect…
View article: Medium-chain triglyceride supplementation and the association with growth, nutritional status and clinical outcomes in infants with biliary atresia
Medium-chain triglyceride supplementation and the association with growth, nutritional status and clinical outcomes in infants with biliary atresia Open
This is the first study to investigate the association of MCT with growth, nutritional status and clinical outcomes in biliary atresia. No association was found between MCT with growth beyond 3-months, overall nutritional status or clinica…
View article: Association of gut microbiota and gut metabolites and adverse outcomes in biliary atresia: A longitudinal prospective study
Association of gut microbiota and gut metabolites and adverse outcomes in biliary atresia: A longitudinal prospective study Open
Background: The Kasai portoenterostomy (KPE) aims to re-establish bile flow in biliary atresia (BA); however, BA remains the commonest indication for liver transplantation in pediatrics. Gut microbiota-host interplay is increasingly associ…
View article: Reply: Can pFIB scores reliably exclude significant liver fibrosis in pediatric MASLD?
Reply: Can pFIB scores reliably exclude significant liver fibrosis in pediatric MASLD? Open
Lefere, Sander; Mosca, Antonella; Hudert, Christian; Dupont, Ellen; Fitzpatrick, Emer; Kyrana, Eirini; Dhawan, Anil; Kalveram, Laura; Pietrobattista, Andrea; Geerts, Anja; De Bruyne, Ruth Author Information
View article: MRI-serum–based score accurately identifies patients undergoing liver transplant without rejection avoiding the need for liver biopsy: A multisite European study
MRI-serum–based score accurately identifies patients undergoing liver transplant without rejection avoiding the need for liver biopsy: A multisite European study Open
Serum liver tests (serum tests) and histological assessment for T-cell–mediated rejection are essential for post-liver transplant monitoring. Liver biopsy carries a risk of complications that are preferably avoided in low-risk patients. Mu…