Explanipedia

The kynurenine pathway in pediatric “mild-to-moderate” traumatic brain injury: translational insights from a prospective human study and a large-animal model Open

Harm J. van der Horn, Koen Visser, Samuel D. Miller, Andrew P. Gigliotti, Timothy B. Meier , et al. · 2025

Elucidating the biochemical pathways affected by pediatric traumatic brain injury (TBI) is essential for identifying informative blood-based biomarkers that may support future precision medicine and clinical trials. The kynurenine pathway …

The Relationship of Prior Concussion and Contact Sport Exposure With Cortical Macro and Microstructure Open

Timothy B. Meier, L. Tugan Muftuler, Bryna D. Goeckner, Nicholas Weyenberg, Daniel L. Huber , et al. · 2025

Changes in cortical gray matter are a key feature of neurodegenerative diseases that have been linked with concussion and repetitive head impacts (RHIs). Prior evidence implicates prior concussion and RHI in reduced cortical thickness or v…

Blunted Reward Prediction Error Encoding Drives Diminished Motivation to Explore in Apathy Associated With Traumatic Brain Injury Open

Jeremy Hogeveen, Ethan M. Campbell, D. Aragon, E. S. Pearson, C Enders , et al. · 2025

Clinical apathy might result from either a diminished willingness to exert effort for known rewards or from reduced motivation to explore potentially beneficial future opportunities. To identify the underlying cognitive and neural bases of…

A - 04 Associations of Concussion and Contact Sport Exposure History With Brain Microstructure Using Quantitative Susceptibility Mapping Open

Lezlie Y. España, Benjamin L. Brett, Andrew R. Mayer, Andrew S. Nencka, Brad Swearingen , et al. · 2025

Purpose The goal of this work was to characterize the association of prior concussion and years of contact sport exposure with quantitative susceptibility mapping (QSM) MRI. We hypothesized that concussion and contact sport exposure would …

3 (4B) Undiagnosed concussions throughout the lifespan and their associations with current symptom reporting in collegiate athletes Open

Hannah M Bartels, Kearnin M Van Bortel, Andrew R. Mayer, Benjamin L. Brett, Timothy B. Meier · 2025

Trajectories of intrinsic connectivity one year post pediatric mild traumatic brain injury: Neural injury superimposed on neurodevelopment Open

Harm J. van der Horn, Tracey V. Wick, Josef M. Ling, Jessica R. McQuaid, Upasana Nathaniel , et al. · 2025

TDCS Reverses Learning Deficits in Mild Cognitive Impairment: Results of the MEMORI Study, a Randomized Double Blind Clinical Trial Open

Vincent P. Clark, Benjamin C. Gibson, Mason Briggs, Jeremy Hogevenn, Chris Wertz , et al. · 2025

Optimizing Pediatric 'Mild' Traumatic Brain Injury Assessments: A Multi-Domain Random Forest Analysis of Diagnosis and Outcomes Open

Upasana Nathaniel, Erik B. Erhardt, Divyasree Sasi Kumar, Jingshu Wu, Samuel D. Miller , et al. · 2025

Association of concussion history with psychiatric symptoms, limbic system structure, and kynurenine pathway metabolites in healthy, collegiate-aged athletes Open

Timothy B. Meier, Jonathan Savitz, Lezlie Y. España, Bryna D. Goeckner, T. Kent Teague , et al. · 2024

Alterations of cerebrovascular reactivity following pediatric mild traumatic brain injury are independent of neurodevelopmental changes Open

Harm J. van der Horn, Andrew B. Dodd, Tracey V. Wick, Cidney R. Robertson‐Benta, Jessica R. McQuaid , et al. · 2024

Cerebrovascular dysfunction following mild traumatic brain injury (mTBI) is understudied relative to other microstructural injuries, especially during neurodevelopment. The blood-oxygen level dependent response was used to investigate cere…

Parkinson’s disease cerebrovascular reactivity pattern: A feasibility study Open

Harm J. van der Horn, Andrei A. Vakhtin, Kayla Julio, Stephanie Nitschke, Nicholas Shaff , et al. · 2024

A mounting body of research points to cerebrovascular dysfunction as a fundamental element in the pathophysiology of Parkinson’s disease (PD). In the current feasibility study, blood-oxygen-level-dependent (BOLD) MRI was used to measure ce…

Standardizing Attention Process Training-III for a Multisite Clinical Trial of Neuromodulation Open

Jessica D. Richardson, H. Isabel Hubbard, Sarah Grace Dalton, Sloan Davidson, Tiana Maple , et al. · 2024

Introduction The Control Network Neuromodulation to Enhance Cognitive Training in Complex Traumatic Brain Injury (CONNECT-TBI) study is an ongoing randomized, double-blinded, sham-controlled multisite clinical trial to determine the enhanc…

ENIGMA’s simple seven: Recommendations to enhance the reproducibility of resting-state fMRI in traumatic brain injury Open

Karen Caeyenberghs, Phoebe Imms, Andrei Irimia, Martin M. Monti, Carrie Esopenko , et al. · 2024

Resting state functional magnetic resonance imaging (rsfMRI) provides researchers and clinicians with a powerful tool to examine functional connectivity across large-scale brain networks, with ever-increasing applications to the study of n…

Dynamic phase-locking states and personality in sub-acute mild traumatic brain injury: An exploratory study Open

Harm J. van der Horn, Myrthe E. de Koning, Koen Visser, Marius G. J. Kok, Jacoba M. Spikman , et al. · 2023

Research has shown that maladaptive personality characteristics, such as Neuroticism, are associated with poor outcome after mild traumatic brain injury (mTBI). The current exploratory study investigated the neural underpinnings of this pr…

Subcortical functional connectivity and its association with walking performance following deployment related mild TBI Open

Mary R. Newsome, Sarah L. Martindale, Nicholas D. Davenport, Emily L. Dennis, Marlene Diaz , et al. · 2023

Introduction The relation between traumatic brain injury (TBI), its acute and chronic symptoms, and the potential for remote neurodegenerative disease is a priority for military research. Structural and functional connectivity (FC) of the …

4 Compensatory Functional Activation During Motion Discrimination in Parkinson’s Disease Open

Stephanie Nitschke, Nicholas Shaff, Chris Wertz, David B. Stone, Andrei A. Vakhtin , et al. · 2023

Objective: PD patients commonly exhibit executive dysfunction early in the disease course which may or may not predict further cognitive decline over time. Early emergence of visuospatial and memory impairments, in contrast, are more consi…

5 Midbrain Degeneration and Cognition in Parkinson’s Disease Open

Kayla Julio, Stephanie Nitschke, Nicholas Shaff, Christopher J. Wertz, Andrew R. Mayer , et al. · 2023

Objective: Neuromelanin imaging is an emerging biomarker for PD as it captures degeneration of the midbrain, a process which is associated with the motor symptoms of the disease. Currently, it is unknown whether this degeneration also cont…

25 Delayed Cerebrovascular Response in Parkinson's Disease Open

Sephira G. Ryman, Stephanie Nitschke, Nicholas Shaff, Kayla Julio, Christopher J. Wertz , et al. · 2023

Objective: Cardiovascular risk factors and white matter hyperintensities predict the progression and severity of cognitive symptoms in PD. While controversial, emerging evidence suggests that cerebrovascular dysfunction is an etiological d…

Spreading Depolarizations Contribute to the Acute Behavior Deficits Associated With a Mild Traumatic Brain Injury in Mice Open

Natalie Pinkowski, Betty A. Fish, Carissa J. Mehos, Victoria L. Carlson, B. Hess , et al. · 2023

Concussions or mild traumatic brain injuries (mTBIs) are often described and diagnosed by the acute signs and symptoms of neurological dysfunction including weakness, dizziness, disorientation, headaches, and altered mental state. The cell…

Sex- and Age-Related Differences in Post-Concussive Symptom Reporting Among Children and Their Parents Open

Andrew R. Mayer, Jessica R. McQuaid, Tracey V. Wick, Andrew B. Dodd, Cidney R. Robertson‐Benta , et al. · 2023

Pediatric mild traumatic brain injury (pmTBI) has received increased public attention over the past decade, especially for children who experience persistent post-concussive symptoms (PCS). Common methods for obtaining pediatric PCS rely o…

Multifaceted neural and vascular pathologies after pediatric mild traumatic brain injury Open

Andrew R. Mayer, Andrew B. Dodd, Cidney R. Robertson‐Benta, Vadim Zotev, Sephira G. Ryman , et al. · 2023

Dynamic changes in neurodevelopment and cognitive functioning occur during adolescence, including a switch from reactive to more proactive forms of cognitive control, including response inhibition. Pediatric mild traumatic brain injury (pm…

Linking Symptom Inventories using Semantic Textual Similarity Open

Eamonn Kennedy, Shashank Vadlamani, Hannah M. Lindsey, Kelly Peterson, Kristen Dams OConnor , et al. · 2023

An extensive library of symptom inventories has been developed over time to measure clinical symptoms, but this variety has led to several long standing issues. Most notably, results drawn from different settings and studies are not compar…

Head Kinematics, Blood Biomarkers, and Histology in Large Animal Models of Traumatic Brain Injury and Hemorrhagic Shock Open

Andrew R. Mayer, Andrew B. Dodd, Rebecca J. Dodd, David D. Stephenson, Josef M. Ling , et al. · 2023

Traumatic brain injury (TBI) and severe blood loss resulting in hemorrhagic shock (HS) are each leading causes of mortality and morbidity worldwide, and present additional treatment considerations when they are comorbid (TBI+HS) as a resul…

Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium Open

Dick Schijven, Merel C. Postema, Masaki Fukunaga, Junya Matsumoto, Kenichiro Miura , et al. · 2023

Left–right asymmetry is an important organizing feature of the healthy brain that may be altered in schizophrenia, but most studies have used relatively small samples and heterogeneous approaches, resulting in equivocal findings. We carrie…

Machine learning classification of chronic traumatic brain injury using diffusion tensor imaging and NODDI: A replication and extension study Open

J. Michael Maurer, Keith A. Harenski, Subhadip Paul, Victor M. Vergara, David D. Stephenson , et al. · 2023

Longitudinal hippocampal subfields, CSF biomarkers, and cognition in patients with Parkinson disease Open

Erik B. Erhardt, Anna Hörner, Nicholas Shaff, Chris Wertz, Stephanie Nitschke , et al. · 2023

Prospective Study of Gray Matter Atrophy Following Pediatric Mild Traumatic Brain Injury Open

Andrew R. Mayer, Timothy B. Meier, Andrew B. Dodd, David D. Stephenson, Cidney R. Robertson‐Benta , et al. · 2022

Current findings indicate that structural brain abnormalities may persist up to 4 months post-pmTBI and are partially mediated by initial markers of injury severity. These results contribute to a growing body of evidence suggesting prolong…

Biodistribution of Sotrovimab, a SARS-CoV-2 monoclonal antibody, using PET imaging in cynomolgus monkey Open

Tolulope A. Aweda, Shih-Hsun Cheng, Stephen C. Lenhard, Armin Sepp, Tinamarie Skedzielewski , et al. · 2022

Purpose Sotrovimab (VIR-7831), a human IgG1κ monoclonal antibody (mAb), binds to a conserved epitope on the SARS-CoV-2 spike protein receptor binding domain (RBD). The Fc region of VIR-7831 contains an LS modification to promote neonatal F…

Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium Open

Dick Schijven, Merel C. Postema, Masaki Fukunaga, Junya Matsumoto, Kenichiro Miura , et al. · 2022

Left-right asymmetry is an important organizing feature of the healthy brain that may be altered in schizophrenia, but most studies have used relatively small samples and heterogeneous approaches, resulting in equivocal findings. We carrie…

Multimodal data fusion of cortical-subcortical morphology and functional network connectivity in psychotic spectrum disorder Open

Thomas P. DeRamus, Liyao Wu, Shile Qi, Armin Iraji, Rogers F. Silva , et al. · 2022

Multiple authors have noted overlapping symptoms and alterations across clinical, anatomical, and functional brain features in schizophrenia (SZ), schizoaffective disorder (SZA), and bipolar disorder (BPI). However, regarding brain feature…

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