Alexander Bartelt
YOU?
Author Swipe
View article: Galectin-1 induces macrophage immunometabolic reprogramming, modulates T cell immunity and attenuates atherosclerotic plaque formation.
Galectin-1 induces macrophage immunometabolic reprogramming, modulates T cell immunity and attenuates atherosclerotic plaque formation. Open
Background And Aims Atherosclerosis is a chronic immunometabolic disease driven by lipid accumulation and immune cell infiltration. Macrophages and T cells play key roles throughout plaque development. Galectin-1 (Gal-1), a glycan-binding …
View article: ChemR23 prevents phenotypic switching of vascular smooth muscle cells into macrophage-like foam cells in atherosclerosis
ChemR23 prevents phenotypic switching of vascular smooth muscle cells into macrophage-like foam cells in atherosclerosis Open
Aims Haematopoietic ChemR23 deficiency was shown to reduce atherosclerotic lesions by increasing M2 macrophages, but conflicting results in systemically deficient mice suggest a cell-specific function of ChemR23. Therefore, we aimed to stu…
View article: Fat, stress, and survival: exploring the secret life of adipocytes
Fat, stress, and survival: exploring the secret life of adipocytes Open
Fat, stress, and survival: exploring the secret life of adipocytes Physical activity and exercise have beneficial effects on overall fitness and health. However, exercise-induced increases in metabolism require specific molecular adaptatio…
View article: The <scp>TBLR1</scp> / <scp>TBL1</scp> Co‐Factor Complex Acts as a Transcriptional Checkpoint in the Brown Adipose Tissue Response to Prolonged Cold Exposure
The <span>TBLR1</span> / <span>TBL1</span> Co‐Factor Complex Acts as a Transcriptional Checkpoint in the Brown Adipose Tissue Response to Prolonged Cold Exposure Open
Brown adipose tissue (BAT) is a key thermogenic organ, whose activation in response to cold environmental temperatures and β‐adrenergic stimulation requires the proper function of the NCOR/HDAC3 corepressor complex in brown adipocytes. The…
View article: Oxidative Phosphorylation in Uncoupled Mitochondria
Oxidative Phosphorylation in Uncoupled Mitochondria Open
Mitochondrial membrane potential is highly dependent on coupled as well as uncoupled respiration. While brown adipose tissue (BAT) mediates non‐shivering thermogenesis (NST), a highly adaptive bioenergetic process critical for energy metab…
View article: The obesity-linked peptide SP16 regulates adipocytes through GIP and insulin receptor
The obesity-linked peptide SP16 regulates adipocytes through GIP and insulin receptor Open
Obesity has emerged as a global epidemic and represents a major public health concern due to its profound implications for metabolic diseases. While recent pharmacological interventions primarily aim to reduce food intake, enhancing energy…
View article: Chronic intermittent fasting impairs β cell maturation and function in adolescent mice
Chronic intermittent fasting impairs β cell maturation and function in adolescent mice Open
Intermittent fasting (IF) is a nutritional lifestyle intervention with broad metabolic benefits, but whether the impact of IF depends on the individual's age is unclear. Here, we investigated the effects of IF on systemic metabolism and β …
View article: Hypoxia Regulates Brown Adipocyte Differentiation and Stimulates miR-210 by HIF-1α
Hypoxia Regulates Brown Adipocyte Differentiation and Stimulates miR-210 by HIF-1α Open
MicroRNAs (miRNAs) are short sequences of single-stranded non-coding RNAs that target messenger RNAs, leading to their repression or decay. Interestingly, miRNAs play a role in the cellular response to low oxygen levels, known as hypoxia, …
View article: Targeting miR-497-5p rescues human keratinocyte dysfunction upon skin exposure to sulfur mustard
Targeting miR-497-5p rescues human keratinocyte dysfunction upon skin exposure to sulfur mustard Open
Sulfur mustard (SM) is a highly toxic chemical warfare agent. Exposure to SM results in various pathologies including skin lesions with subsequent impaired wound healing. To date, there are no effective treatments available. Here we discov…
View article: Control of cholesterol-induced adipocyte inflammation by the Nfe2l1-Atf3 pathway
Control of cholesterol-induced adipocyte inflammation by the Nfe2l1-Atf3 pathway Open
While adipocytes are critical pillars of energy metabolism, their dysfunction is linked to adipose tissue (AT) inflammation, insulin resistance, and ectopic lipotoxicity in cardiometabolic diseases. However, the mechanisms causing adipocyt…
View article: Macroscopic label-free biomedical imaging with shortwave infrared Raman scattering
Macroscopic label-free biomedical imaging with shortwave infrared Raman scattering Open
Summary Shortwave infrared (SWIR) imaging provides enhanced tissue penetration and reduced autofluorescence in clinical and pre-clinical applications. However, existing applications often lack the ability to probe chemical composition and …
View article: Myeloid cannabinoid CB1 receptor deletion confers atheroprotection in male mice by reducing macrophage proliferation in a sex-dependent manner
Myeloid cannabinoid CB1 receptor deletion confers atheroprotection in male mice by reducing macrophage proliferation in a sex-dependent manner Open
Aims Although the cannabinoid CB1 receptor has been implicated in atherosclerosis, its cell-specific effects in this disease are not well understood. To address this, we generated a transgenic mouse model to study the role of myeloid CB1 s…
View article: Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function
Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function Open
Promoting brown adipose tissue (BAT) activity innovatively targets obesity and metabolic disease. While thermogenic activation of BAT is well understood, the rheostatic regulation of BAT to avoid excessive energy dissipation remains ill-de…
View article: Chronic intermittent fasting impairs β-cell maturation and function in adolescent mice
Chronic intermittent fasting impairs β-cell maturation and function in adolescent mice Open
Summary Intermittent fasting (IF) is a nutritional lifestyle intervention with broad metabolic benefits, but whether the impact of IF depends on the individual’s age is unclear. Here, we investigated the effects of IF on systemic metabolis…
View article: Cardiac proteostasis in obesity and cardiovascular disease
Cardiac proteostasis in obesity and cardiovascular disease Open
Cardiovascular diseases (CVD) are closely linked to protein homeostasis (proteostasis) and its failure. Beside genetic mutations that impair cardiac protein quality control, obesity is a strong risk factor for heart disease. In obesity, ad…
View article: Growing strong muscle for better performance and weight loss
Growing strong muscle for better performance and weight loss Open
Growing strong muscle for better performance and weight loss Physical activity and exercise have beneficial effects on overall fitness and health. However, exercise-induced increases in metabolism require specific molecular adaptation of t…
View article: The obesity‐linked human <scp>lncRNA AATBC</scp> stimulates mitochondrial function in adipocytes
The obesity‐linked human <span>lncRNA AATBC</span> stimulates mitochondrial function in adipocytes Open
Adipocytes are critical regulators of metabolism and energy balance. While white adipocyte dysfunction is a hallmark of obesity‐associated disorders, thermogenic adipocytes are linked to cardiometabolic health. As adipocytes dynamically ad…
View article: Live lean and CRISPR – Engineering metabolism with FGF21 and FNDC5
Live lean and CRISPR – Engineering metabolism with FGF21 and FNDC5 Open
Obesity and its associated comorbidities such as type 2 diabetes and cardiovascular diseases are – despite all the current efforts in research – still difficult to tackle therapeutically. For people struggling with body weight, diet and ph…
View article: Nfe2l1-mediated proteasome function controls muscle energy metabolism in obesity
Nfe2l1-mediated proteasome function controls muscle energy metabolism in obesity Open
Muscle function is an important denominator of energy balance and metabolic health. Adapting the proteome to energetic challenges, in response to diet or fasting, is facilitated by programs of proteostasis, but the adaptive role of the ubi…
View article: IF1 is a cold-regulated switch of ATP synthase to support thermogenesis in brown fat
IF1 is a cold-regulated switch of ATP synthase to support thermogenesis in brown fat Open
While mechanisms controlling mitochondrial uncoupling protein-1 (UCP1) expression and function in thermogenic adipocytes play a pivotal role in non-shivering thermogenesis (NST), it remains unclear whether F 1 F o -ATP synthase function is…
View article: Immune-mediated denervation of the pineal gland underlies sleep disturbance in cardiac disease
Immune-mediated denervation of the pineal gland underlies sleep disturbance in cardiac disease Open
Disruption of the physiologic sleep-wake cycle and low melatonin levels frequently accompany cardiac disease, yet the underlying mechanism has remained enigmatic. Immunostaining of sympathetic axons in optically cleared pineal glands from …
View article: Activating the NFE2L1-ubiquitin-proteasome system by DDI2 protects from ferroptosis
Activating the NFE2L1-ubiquitin-proteasome system by DDI2 protects from ferroptosis Open
Ferroptosis is an iron-dependent, non-apoptotic form of cell death initiated by oxidative stress and lipid peroxidation. Recent evidence has linked ferroptosis to the action of the transcription factor Nuclear factor erythroid-2 derived,-l…
View article: Activating the NFE2L1-ubiquitin-proteasome system by DDI2 protects from ferroptosis
Activating the NFE2L1-ubiquitin-proteasome system by DDI2 protects from ferroptosis Open
Ferroptosis is an iron-dependent, non-apoptotic form of cell death initiated by oxidative stress and lipid peroxidation. Recent evidence has linked ferroptosis to the action of the transcription factor Nuclear factor erythroid-2 derived,-l…